Delayed repair: The role of glutathione in a rat incisional wound model

Journal of Surgical Research

Volumn 62, Issue 2, 1996, Pages 159-164

  Adamson, Belinda ^a,b   Schwarz, Daniel ^a,b   Klugston, Patty ^c   Gilmont, Robert ^a,b   Perry, Larry ^c   Fisher, Jack ^c   Lindblad, William ^d   Rees, Riley ^a,b  

^a UNIVERSITY OF MICHIGAN   (United States)

^b VA ANN ARBOR HEALTHCARE SYSTEM   (United States)

^c MEHARRY MEDICAL COLLEGE   (United States)

^d WAYNE STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOPURINOL; BUTHIONINE SULFOXIMINE; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; SKIN INCISION; TISSUE REPAIR; WOUND HEALING;

EID: 0029988199     PISSN: 00224804     EISSN: None     Source Type: Journal    
DOI: 10.1006/jsre.1996.0189     Document Type: Article

References (19)

1. Kelner, M. J., and Bagnell, R. Glutathione-dependent enzymes alone can produce paraquat resistance. Free Radical Biol. Med. 9: 149, 1990.
2. Black, S. M., and Wolf, C. R. The role of glutathione-dependent enzymes in drug resistance. Pharmacol. Ther. 51: 139, 1991.
3. Mandel, L., Schnellmann, R., and Jacobs, W. Intracellular glutathione in the protection from anoxic injury in renal proximal tubules. J. Clin. Invest. 85: 316, 1990.
4. Lu, S., and Ge, J.-L. Loss of suppression of GSH synthesis at low cell density of primary cultures of rat hepatocytes. Am. J. Physiol. 263: C1181, 1992.
5. Rees, R., Smith, D., Cashmer, B., Im, M. J., and Hinshaw, D. E. Oxidant stress: The role of the glutathione redox cycle in skin preconditioning. J. Surg. Res. 58: 395, 1995.
6. Atzori, L., Dypbukt, J. M., Sundqvist, K., Cotgreave, C., Edman, C., Moldeus, P., and Grafstrom, R. C. Growth-associated modification of low-molecular weight thiols and protein sulfhydryls in human bronchial fibroblasts. J. Cell Physiol. 143: 165, 1990.
7. Hamilos, D. L., Zelarney, P., and Mascali, J. Lymphocyte proliferation in glutathione-depleted lymphocytes: Direct relationship between glutathione availability and the proliferation response. Immunopharmacology 18: 223, 1989.
8. Habuchi, O., Miyachi, T., Kaigawa, S., Nakashima, S., Fujiwara, C., and Hisada, M. Effects of glutathione depletion on the synthesis of proteoglycan and collagen in cultured chondrocytes. Biochem. Biophys. Acta 1093: 153, 1991.
9. Charles, D., Williams, D., Perry, L. C., Fisher, J., and Rees, R. S. An improved method of in vivo wound disruption and measurement. J. Surg. Res. 52: 214, 1992.
10. Lindblad, W. J., and Diegelmann, R. F. Quantitation of hydroxyproline isomers in acid hydrolysates by high performance liquid chromatography. Anal. Biochem. 138: 390, 1984.
11. Takeuchi, K., Okada, M., Ueshima, K., Ohuchi, T., and Okabe, S. Endogenous sulfhydryls in healing gastric mucosal injury induced by HCL in the rat. Digestion 54: 91, 1995.
12. Rees, R. S., Smith, D., Li, T. D., Cashmer, B., Garner, W., Punch, J., and Smith, D. J., Jr. The role of xanthine oxidase and xanthine dehydrogenase in skin ischemia. J. Surg. Res. 56(2): 162, 1994.
13. Rees, R. S., Punch, J., Shaheen, K., Cashmer, B., Guice, K., and Smith, D. J., Jr. The stress response in skin: The role of neutrophil recruitment in pre-conditioning. Plast. Reconstruct. Surg. 92(1): 110, 1993.
14. Schwarz, D., Lindblad, W. J., and Rees, R. S. Altered collagen metabolism and delayed healing in a novel model of ischemic wounds. Wound Repair Regul. 3: 1, 1995.
15. Huang, C. S., Chang, L. S., Anderson, M. E., and Meister, A. Catalytic and regulatory properties of the heavy subunit of rat kidney gamma glutamylcysteine synthetase. J. Biol. Chem. 268: 19675, 1993.
16. Borroz, K. I., Buetler, T. M., and Eaton, D. L. Modulation of gamma-glutamylcysteine synthetase large subunit mRNA expression by butylated hydrooxyanisole. Toxicol. Appl. Pharmacol. 126: 150, 1995.
17. Hiranruengchok, R., and Harris, C. Formation of protein-glutathione mixed disulfides in the developing rat conceptus following diamide treatment in vitro. Teratology 52: 196, 1995.
18. Hwang, C., Sinskey, A. J., and Lodish, H. F. Oxidized redox state of glutathione in the endoplasmic reticulum. Science 257: 1496, 1992.
19. Schwarz, D. A., Thul, J., Lindblad, W. J., and Rees, R. S. Prolonged collagenase activity is associated with delayed wound healing and decreased collagen deposition in rat flap wounds. Surg. Forum 46: 716, 1995.