Stereoselective characteristics and mechanisms of epidermal carboxylesterase metabolism observed in HaCaT keratinocytes

Biological and Pharmaceutical Bulletin

Volumn 30, Issue 3, 2007, Pages 532-536

  Zhu, Quan Gang ^a   Hu, Jin Hong ^a   Liu, Ji Yong ^a   Lu, Song Wei ^a   Liu, Yan Xia ^a   Wang, Jin ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

HaCaT keratinocyte; Human carboxylesterase; Ketoprofen ethyl ester; Stereoselectivity

Indexed keywords

CARBOXYLESTERASE; CARBOXYLESTERASE 1; CARBOXYLESTERASE 2; KETOPROFEN; KETOPROFEN ETHYL ESTER; PRODRUG; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG HYDROLYSIS; DRUG METABOLISM; ENZYME METABOLISM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; KERATINOCYTE; LIVER CELL; NUCLEOTIDE SEQUENCE; PROTEIN ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STEREOCHEMISTRY;

CARBOXYLESTERASE; CARBOXYLIC ESTER HYDROLASES; CELL LINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; EPIDERMIS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HEPATOCYTES; HUMANS; HYDROLYSIS; KERATINOCYTES; KETOPROFEN; PRODRUGS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; STEREOISOMERISM; SUBSTRATE SPECIFICITY;

EID: 33847647629     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.30.532     Document Type: Article

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