Quantification and cellular localization of expression in human skin of genes encoding flavin-containing monooxygenases and cytochromes P450

Biochemical Pharmacology

Volumn 62, Issue 6, 2001, Pages 777-786

  Janmohamed, Azara ^a   Dolphin, Colin T ^b   Phillips, Ian R ^b   Shephard, Elizabeth A ^a,c  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^c Tel: +44 20 7976 2321 ^*  (United Kingdom)

Author keywords

Cytochrome P450; Flavin containing monooxygenases; Human; In vitro; Keratinocyte; Skin

Indexed keywords

CYTOCHROME P450; CYTOCHROME P450 2A6; CYTOCHROME P450 2B6; CYTOCHROME P450 3A4; DIMETHYLANILINE MONOOXYGENASE; ISOENZYME; MESSENGER RNA; RIBONUCLEASE;

ADULT; AGE; ARTICLE; CELL CULTURE; CELL IMMORTALIZATION; CELL LINE; CELLULAR DISTRIBUTION; COMPARATIVE STUDY; CONTROLLED STUDY; ENZYME ASSAY; EPIDERMIS; EPIDERMIS CELL; GENE EXPRESSION; HAIR FOLLICLE; HUMAN; HUMAN CELL; HUMAN TISSUE; IN SITU HYBRIDIZATION; KERATINOCYTE; MULTIGENE FAMILY; PRIORITY JOURNAL; PROTEIN CONTENT; SEBACEOUS GLAND; TISSUE DISTRIBUTION;

CELLS, CULTURED; CYTOCHROME P-450 ENZYME SYSTEM; HUMANS; KERATINOCYTES; OXYGENASES; RNA, MESSENGER; SKIN; SUBCELLULAR FRACTIONS;

EID: 0035885281     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(01)00718-3     Document Type: Article

References (56)

1. Mechanism, multiple forms and substrate speceficities of flavin-containing monooxygenases
2. Recent studies on the structure and function of multisubstrate flavin-containing monooxygenases
3. The molecular biology of Cytochrome P450s
4. S-oxygenation of 7 alpha-thiomethylspironolactone by the flavin-containing monooxygenase
5. N-Oxygenation of stobadine, a gamma-carboline antiarrhythmic and cardioprotective agent. The role of flavin-containing monooxygenase
6. Enantioselective N-oxygenation of chlorpheniramine by the flavin-containing monooxygenase from hog liver
7. Chemical, enzymatic, and human enantioselective S-oxygenation of cimetidine
8. Oxidation of desmethylpromethazine catalyzed by pig liver flavin-containing monooxygenase. Number and nature of metabolites
9. Flavin adenine dinucleotide-dependent monooxygenase: Its role in the sulfoxidation of pesticides in mammals
10. Pesticide-metabolizing enzymes
11. Pesticides - An important but underused model for the Health Sciences
12. Trimethylaminuria: The use of choline as an aid to diagnosis
13. Trimethylaminuria (fish-odour syndrome): An inborn error of oxidative metabolism
14. A genetic polymorphism of the N-oxidation of trimethylamine in humans
15. Trimethylaminuria ('fish-odour syndrome'): A study of an affected family
16. The molecular biology of the flavin-containing monooxygenases of man
17. Differential developmental and tissue-specific regulation of expression of the genes encoding three members of the flavin-containing monooxygenase family of man, FMO1, FMO3 and FMO4
18. Expression of members of the FMO gene family in the brain and other tissues of humans
19. Selectivity of flavin-containing monooxygenase 5 for the (S)-sulfoxidation of short-chain aralkyl sulfides
20. Structural and catalytic properties of the mammalian flavin-containing monooxygenase
21. Isoform specificity of trimethylamine N-oxygenation by human flavin-containing monooxygenase (FMO) and P450 enzymes: Selective catalysis by FMO3
22. Missense mutation in flavin-containing monooxygenase 3 gene, FMO3, underlies fish-odour syndrome
23. The flavin-containing monooxygenase 2 gene (FMO2) of humans, but not of other primates, encodes a truncated, nonfunctional protein
24. The flavin-containing monooxygenase enzymes expressed in rabbit liver and lung are products of related but distinctly different genes
25. Metabolism of nicotine by human liver microsomes. Stereoselective formation of trans-nicotine N′-oxide
26. Stereospecificity in the oxidation of phorate and phorate sulphoxide by purified FAD-containing mono-oxygenase and cytochrome P-450 isozymes
27. Cytochrome P450 and the individuality of species
28. Extrahepatic metabolism of drugs in humans
29. Cutaneous toxicity kinetic and metabolic determinants
30. Cytochrome P-450 and drug development for skin diseases
31. Pharmacological modification of epidermal detoxification systems
32. The effect of foreign-substance-metabolizing enzymes on skin diseases
33. Constitutive and inducible expression of drug metabolizing enzymes in cultured human keratinocytes
34. Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line
35. A method for isolation of intact, translationally active ribonucleic acid
36. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease
37. Quantification of cytochrome P450 reductase gene expression in human tissues
38. Localization of cytochrome P-450 gene expression in normal and diseased human liver by in situ hybridization of wax-embedded archival material
39. Maintenance and induction in co-cultured rat hepatocytes of components of the cytochrome P450-mediated mono-oxygenase
40. Detection of single base substitutions by ribonuclease cleavage at mismatches in RNA:DNA duplexes
41. Application of plasmids containing promoters specific for phage-encoded RNA polymerases
42. Demonstration of tissue-specific gene expression by in situ hybridization
43. Inter-individual variation in the expression of human cytochrome P-450 genes
44. A genetic polymorphism in coumarin 7-hydroxylation: Sequence of the human CYP2A genes and identification of variant CYP2A6 alleles
45. Sequence, chromosome localization, and direct evidence through cDNA expression that P450PCN1 is nifedipine oxidase
46. Cytochrome P-450 hPCN3, a novel cytochrome P-450 IIIA gene product that is differentially expressed in adult human liver. cDNA and deduced amino acid sequence and distinct specificities of cDNA-hPCN1 and hPCN3 for the metabolism of steroid hormones and cyclosporine
47. Molecular cloning and sequence analysis of cDNA containing the entire coding region for human fetal liver cytochrome P-450
48. Exacerbation of symptoms of fish-odour syndrome during menstruation
49. Progesterone regulated expression of flavin-containing monooxygenase 5 by the B-isoform of progesterone receptors: Implications for tamoxifen carcinogenicity
50. Quantitation and kinetic properties of hepatic microsomal and recombinant flavin-containing monooxygenases 3 and 5 from humans
51. In vivo age-related changes in hepatic drug-oxidizing capacity in humans
52. Enzymatic and immunohistochemical studies on the role of cytochrome P450 and the flavin-containing monooxygenase of mouse skin in the metabolism of pesticides and other xenobiotics
53. Distribution of xenobiotic-metabolizing enzymes in skin
54. The immunocytochemical localisation and distribution of cytochrome P-450 in normal human hepatic and extrahepatic tissues with a monoclonal antibody to human cytochrome P-450
55. Measurement and modulation of cytochrome-P450-dependent activity in cultured human keratinocytes