Relevance of xenobiotic enzymes in human skin in vitro models to activate pro-sensitizers

Journal of Immunotoxicology

Volumn 9, Issue 4, 2012, Pages 426-438

  Jäckh, Christine ^a   Fabian, Eric ^a   Van Ravenzwaay, Bennard ^a   Landsiedel, Robert ^a  

^a BASF SE   (Germany)

Author keywords

Full thickness; in vitro; Langerhans cells; LLNA; Metabolic activation; Organ culture; Performance standards; Pro sensitizer; Sensitization; Skin enzymes

Indexed keywords

3 METHYLCHOLANTHRENE; ALCOHOL DEHYDROGENASE; ANILINE; CARBOXYLESTERASE; CHLORZOXAZONE; CINNAMALDEHYDE; CINNAMYL ALCOHOL; CYCLOPHOSPHAMIDE; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 1B1; CYTOCHROME P450 2A6; CYTOCHROME P450 2B6; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 2E1; CYTOCHROME P450 3A; CYTOCHROME P450 3A4; CYTOCHROME P450 3A5; DIAMINE DERIVATIVE; ESTRAGOLE; ETHYLENDIAMINE; EUGENOL; FLUORESCEIN DIACETATE; GALLIC ACID PROPYL ESTER; ISOEUGENOL; MIDAZOLAM; PARA PHENYLENDIAMINE; QUERCETIN; UNCLASSIFIED DRUG; XENOBIOTIC AGENT;

CELL PROLIFERATION; CELL STRAIN; ENZYME ACTIVATION; FIBROBLAST; HUMAN; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; KERATINOCYTE; MICROARRAY ANALYSIS; MICROSOME; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; REVIEW; SENSITIZATION; SKIN; SKIN BIOPSY; SKIN CELL; SKIN SENSITIZATION; WESTERN BLOTTING;

ALLERGENS; ANIMALS; BIOTRANSFORMATION; CYTOCHROME P-450 ENZYME SYSTEM; DERMATITIS, ALLERGIC CONTACT; EUGENOL; HAPTENS; HUMANS; IMMUNIZATION; ORGAN CULTURE TECHNIQUES; OXIDOREDUCTASES; PATHOLOGY, MOLECULAR; SKIN; XENOBIOTICS;

EID: 84868701703     PISSN: 1547691X     EISSN: None     Source Type: Journal    
DOI: 10.3109/1547691X.2012.664578     Document Type: Review

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