Percutaneous absorption and metabolism of dinitrochlorobenzene in vitro

Archives of Toxicology

Volumn 74, Issue 7, 2000, Pages 356-365

  Jewell, Christopher ^a   Heylings, Jon ^b   Clowes, Helen M ^b   Williams, Faith M ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b ASTRAZENECA   (United Kingdom)

Author keywords

Dinitrochlorobenzene; DNCB; Glutathione; Glutathione S transferase; Percutaneous penetration

Indexed keywords

1 CHLORO 2,4 DINITROBENZENE; ACETONE; GLUTATHIONE; GLUTATHIONE DERIVATIVE; GLUTATHIONE TRANSFERASE;

ADOLESCENT; ANIMAL TISSUE; ARTICLE; CONJUGATION; ENZYME ACTIVITY; FEMALE; HUMAN; HUMAN TISSUE; MALE; MOUSE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT; SKIN ABSORPTION; SKIN PENETRATION; SURVIVAL; SWINE; XENOBIOTIC METABOLISM;

ADMINISTRATION, CUTANEOUS; ANIMAL; ANIMALS, NEWBORN; CELL SURVIVAL; COMPARATIVE STUDY; DINITROCHLOROBENZENE; FEMALE; GLUTATHIONE; GLUTATHIONE TRANSFERASE; HUMAN; IN VITRO; MALE; MICE; MICE, INBRED BALB C; RATS; RATS, WISTAR; SKIN; SKIN ABSORPTION; SPECIES SPECIFICITY; SUPPORT, NON-U.S. GOV'T; SWINE;

ANIMALIA; SUS SCROFA;

EID: 0033832843     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002040000123     Document Type: Article

References (32)

1. Percutaneous absorption of nitroaromatic compounds-in vivo and in vitro studies in human and monkey
2. Methods for in vitro percutaneous absorption studies. II. Animal models for human skin
3. Maintenance of skin viability in skin absorption systems
4. Fate of fluazifop butyl in rat and human skin in vitro
5. Skin absorption: Flow-through or static diffusion cells
6. Maintenance of skin viability during in vitro percutaneous absorption/metabolism studies
7. Foreign compound metabolism by isolated skin cells from the hairless mouse
8. Methodologies for the application of monobromobimane to the simultaneous analysis of soluble and protein thiol components of biological systems
9. Dermal tumour necrosis factor α induces dendritic cell migration to draining lymph nodes and possibly one stimulus for Langerhans' cell migration
10. Skin sensitisation is associated with induced changes in cutaneous cytokine expression
11. The influence of different strain and age on rat skin permeability
12. Pig ears as an in vitro model for human permeability
13. Absorption of some organic compounds through the skin of man
14. Quantitative relationships between sensitising dose of DNCB and reactivity in normal subjects
15. Glutathione S-transferases. The first enzymatic step in mercapturic acid formation
16. Sensitization to 2,4-dinitrochlorobenzene: Influence of vehicle on absorption and lymph node activation
17. Absorption and metabolism of dinitrochlorobenzene through mouse skin in vitro
18. Epidermal cytokines in contact hypersensitivity: Immunological roles and practical applications
19. Drug-protein conjugates X
20. The skin of domestic mammals as a model for the human skin, with special reference to the domestic pig
21. Comparative anatomy, physiology, and biochemistry of mammalian skin
22. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxic assays
23. Distribution of xenobiotic metabolising enzymes in skin
24. Glutathione S-transferases in human and rodent skin: Multiple forms and species-specific expression
25. Evaluation of animal models for predicting skin penetration in man
26. An electrochemical approach to the study of prohapten activation: A possible nitroreductase model
27. A comparison of the permeability properties of human and some laboratory animal skins
28. The influence of skin structure on permeability: An intersite and interspecies comparison with hydrophobic penetrants
29. Glutathione S-transferases of human skin: Qualitative and quantitative differences in men and women
30. Measurement of protein using bicinchoninic acid
31. Species specific cutaneous biotransformation of the pesticide propoxur during percutaneous absorption in vitro