A role for bioactivation and covalent binding within epidermal keratinocytes in sulfonamide-induced cutaneous drug reactions

Journal of Investigative Dermatology

Volumn 114, Issue 6, 2000, Pages 1164-1173

  Reilly, Timothy P ^a,d   Lash, Lawrence H ^b   Doll, Mark A ^c   Hein, David W ^c   Woster, Patrick M ^a   Svensson, Craig K ^a,d  

^a WAYNE STATE UNIVERSITY   (United States)

^b WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c University of Louisville School of Medicine   (United States)

^d NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

Author keywords

Gtutathione; Hydroxylamine metabolites; Hypersensitivity; Sulfamethoxazole

Indexed keywords

ACYLTRANSFERASE; DAPSONE; GLUTATHIONE PEROXIDASE; HYDROXYLAMINE; MESSENGER RNA; SULFAMETHOXAZOLE; SULFONAMIDE;

ADULT; ARTICLE; COVALENT BOND; DRUG HYPERSENSITIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; EPIDERMIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; KERATINOCYTE; NEWBORN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; SKIN ALLERGY;

EID: 0034123730     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1747.2000.00985.x     Document Type: Article

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