Comparison of xenobiotic metabolizing enzyme activities in ex vivo human skin and reconstructed human skin models from SkinEthic

Archives of Toxicology

Volumn 88, Issue 9, 2014, Pages 1681-1694

  Eilstein, Joan ^a   Léreaux, Guillaume ^a   Budimir, Natali ^a   Hussler, Georges ^a   Wilkinson, Simon ^b   Duché, Daniel ^a  

^a L ORÉAL RECHERCHE   (France)

^b NONE

Author keywords

Conjugation reactions and enzymes; Cytochrome P450; Extrahepatic metabolism; Reconstructed human skin models

Indexed keywords

BIOMATERIAL; COSMETIC; CYTOCHROME P450 1A1; CYTOCHROME P450 1B1; CYTOCHROME P450 2B6; CYTOCHROME P450 2C18; CYTOCHROME P450 2E1; CYTOCHROME P450 3A5; CYTOCHROME P450 3A7; DRUG METABOLIZING ENZYME; ESTER; ESTERASE; GLUTATHIONE SYNTHASE; SULFOTRANSFERASE 1A1; XENOBIOTIC AGENT; CYTOCHROME P450; ISOENZYME;

ACETYLATION; ADULT; ARTICLE; COMPARATIVE STUDY; CYTOTOXICITY; DETOXIFICATION; ENZYME ACTIVITY; ENZYME SUBSTRATE; EX VIVO STUDY; FEMALE; FULL THICKNESS SKIN GRAFT; GLUCURONIDATION; GLUTATHIONE METABOLISM; HUMAN; HUMAN CELL; HUMAN TISSUE; HYDROLYSIS; LIMIT OF DETECTION; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; SKIN CULTURE; SKIN FUNCTION; SULFATION; SULFONATION; BIOLOGICAL MODEL; BIOTRANSFORMATION; CELL CULTURE; CYTOLOGY; ENZYMOLOGY; KERATINOCYTE; METABOLISM; SKIN; TISSUE CULTURE TECHNIQUE; TISSUE ENGINEERING; TOXICOKINETICS; VALIDATION STUDY;

BIOTRANSFORMATION; CELLS, CULTURED; CYTOCHROME P-450 ENZYME SYSTEM; FEMALE; HUMANS; ISOENZYMES; KERATINOCYTES; LIMIT OF DETECTION; MALE; MODELS, BIOLOGICAL; SKIN; TISSUE CULTURE TECHNIQUES; TISSUE ENGINEERING; TOXICOKINETICS; XENOBIOTICS;

EID: 84906267321     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-014-1218-6     Document Type: Article

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