Evaluation of cytochrome P450 1 (CYP1) and N-acetyltransferase 1 (NAT1) activities in HaCaT cells: Implications for the development of in vitro techniques for predictive testing of contact sensitizers

Toxicology in Vitro

Volumn 24, Issue 3, 2010, Pages 973-980

  Bonifas, Jutta ^a   Hennen, Jenny ^a   Dierolf, Dorothea ^a   Kalmes, Michaela ^a   Blömeke, Brunhilde ^a  

^a UNIVERSITY OF TRIER   (Germany)

Author keywords

CYP1; Epidermal biotransformation; HaCaT; Keratinocytes; N acetyltransferase; NAT1

Indexed keywords

CYTOCHROME P450 1; DRUG METABOLIZING ENZYME; MESSENGER RNA; N ACETYLTRANSFERASE 1; TUBERCULIN; UNCLASSIFIED DRUG;

ACETYLATION; ARTICLE; CONTACT ALLERGY; CONTACT SENSITIZATION; CONTROLLED STUDY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IN VITRO STUDY; KERATINOCYTE; PREDICTION; PROMOTER REGION; SKIN SENSITIZATION;

4-AMINOBENZOIC ACID; ACETYLATION; ALLERGENS; ARYLAMINE N-ACETYLTRANSFERASE; CELL LINE; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 ENZYME SYSTEM; DERMATITIS, CONTACT; HUMANS; INFANT, NEWBORN; ISOENZYMES; KERATINOCYTES; PHENYLENEDIAMINES; PROMOTER REGIONS, GENETIC; RNA, MESSENGER; TOXICITY TESTS;

EID: 77649182330     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2009.12.023     Document Type: Article

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