Hypoxia perturbs aryl hydrocarbon receptor signaling and CYP1A1 expression induced by PCB 126 in human skin and liver-derived cell lines

Toxicology and Applied Pharmacology

Volumn 274, Issue 3, 2014, Pages 408-416

  Vorrink, Sabine U ^a,b   Severson, Paul L ^c   Kulak, Mikhail V ^a   Futscher, Bernard W ^c   Domann, Frederick E ^a,b  

^a UNIVERSITY OF IOWA   (United States)

^b UNIVERSITY OF IOWA   (United States)

^c UNIVERSITY OF ARIZONA   (United States)

Author keywords

AhR; ARNT; CYP1A1; HIF 1 ; Hypoxia; PCB 126

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; 3,3',4,4',5 PENTACHLOROBIPHENYL; AROMATIC HYDROCARBON RECEPTOR; CYTOCHROME P450 1A1; DIOXIN; MESSENGER RNA; XENOBIOTIC AGENT;

ARTICLE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; GEL MOBILITY SHIFT ASSAY; GENE OVEREXPRESSION; GENE TARGETING; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPOXIA; KERATINOCYTE; LIVER CELL; LIVER CELL CARCINOMA; METABOLISM; OXYGEN TENSION; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; SKIN CELL; TRANSACTIVATION; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION; WESTERN BLOTTING;

2,2′,4,4′,5,5′-HEXACHLOROBIPHENYL; 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN; 3,3′,4,4′,5-PENTACHLOROBIPHENYL; 6,2′,4′-TRIMETHOXYFLAVONE; AHR; ARNT; ARYL HYDROCARBON RECEPTOR; ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR; BASIC HELIX-LOOP-HELIX/PER-ARNT-SIM; BHLH/PAS; CHIP; CHROMATIN IMMUNOPRECIPITATION; CYP1A1; CYTOCHROME P450 1A1; DIMETHYL SULFOXIDE; DMSO; ELECTROPHORETIC MOBILITY SHIFT ASSAY; EMSA; HIF-1Α; HRE; HYPOXIA; HYPOXIA RESPONSE ELEMENT; HYPOXIA-INDUCIBLE FACTOR-1Α; PCB; PCB 126; PCB 153; POLYCHLORINATED BIPHENYL; QRT-PCR; QUANTITATIVE REAL-TIME REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RIBOSOMAL PROTEIN, LARGE, P0; RPLP0; TCDD; TMF; XENOBIOTIC RESPONSE ELEMENT; XRE;

ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELL HYPOXIA; CYTOCHROME P-450 CYP1A1; HEP G2 CELLS; HEPATOCYTES; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; LIVER; POLYCHLORINATED BIPHENYLS; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; RECEPTORS, ARYL HYDROCARBON; RNA, MESSENGER; SIGNAL TRANSDUCTION; SKIN; TETRACHLORODIBENZODIOXIN; TRANSCRIPTIONAL ACTIVATION;

EID: 84892458589     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2013.12.002     Document Type: Article

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