Characterization of enzyme activities of Cytochrome P450 enzymes, Flavin-dependent monooxygenases, N-acetyltransferases and UDP-glucuronyltransferases in human reconstructed epidermis and full-thickness skin models

Toxicology in Vitro

Volumn 25, Issue 6, 2011, Pages 1209-1214

  Jäckh, Christine ^a   Blatz, Veronika ^a   Fabian, Eric ^a   Guth, Katharina ^a   van Ravenzwaay, Ben ^a   Reisinger, Kerstin ^b   Landsiedel, Robert ^a  

^a BASF SE   (Germany)

^b HENKEL KGAA   (Germany)

Author keywords

CYP; FMO; NAT; Reconstructed skin models; UDP GT; Xenobiotic metabolism

Indexed keywords

4 AMINOBENZOIC ACID; ACYLTRANSFERASE; BENZYDAMINE; BENZYLOXYRESORUFIN; CYTOCHROME P450; CYTOCHROME P450 1A; CYTOCHROME P450 2B; CYTOCHROME P450 3A; DIMETHYLANILINE MONOOXYGENASE; ETHOXYRESORUFIN; GLUCURONOSYLTRANSFERASE; HYMECROMONE; RESORUFIN DERIVATIVE; UNCLASSIFIED DRUG;

ACETYLATION; ANIMAL TISSUE; ARTICLE; CATALYSIS; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME SUBSTRATE; EPIDERMIS; FULL THICKNESS SKIN GRAFT; GLUCURONIDATION; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; MICROSOME; NONHUMAN; OXYGENATION; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; TISSUE DISTRIBUTION; XENOBIOTIC METABOLISM;

ACETYLTRANSFERASES; CYTOCHROME P-450 ENZYME SYSTEM; EPIDERMIS; GENE EXPRESSION PROFILING; GLUCURONOSYLTRANSFERASE; HUMANS; MUTAGENICITY TESTS; OXYGENASES; SKIN; XENOBIOTICS;

EID: 79960905490     PISSN: 08872333     EISSN: 18793177     Source Type: Journal    
DOI: 10.1016/j.tiv.2011.03.012     Document Type: Article

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