Simultaneous transport and metabolism of ethyl nicotinate in hairless rat skin after its topical application: The effect of enzyme distribution in skin

Journal of Controlled Release

Volumn 62, Issue 1-2, 1999, Pages 201-208

  Sugibayashi, Kenji ^a   Hayashi, Teruaki ^a   Morimoto, Yasunori ^a  

^a JOSAI UNIVERSITY   (Japan)

Author keywords

Enzyme distribution; Ethyl nicotinate; Metabolic saturation; Nicotinic acid; Skin metabolism; Skin permeation

Indexed keywords

ESTERASE; NICOTINIC ACID; NICOTINIC ACID ETHYL ESTER;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG METABOLISM; DRUG PENETRATION; DRUG TRANSPORT; ENZYME ACTIVITY; ENZYME LOCALIZATION; MALE; MICHAELIS CONSTANT; NONHUMAN; PRIORITY JOURNAL; RAT; SKIN; TISSUE HOMOGENATE;

ADMINISTRATION, CUTANEOUS; ANIMALS; BIOLOGICAL TRANSPORT; ESTERASES; HAIR; MALE; MODELS, STATISTICAL; NICOTINIC ACIDS; PRODRUGS; RATS; SKIN;

EID: 0032883599     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-3659(99)00039-5     Document Type: Article

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