Constitutive expression and changes of cytochrome P450 isozymes mRNAs by vehicles (Petrolatum, DMSO, Ethanol) in rat skin using semi-quantitative RT-PCR

Korean Journal of Physiology and Pharmacology

Volumn 5, Issue 5, 2001, Pages 407-412

  Lee, A Y ^a   Lee, K H ^a   Ko, D S ^a   Chey, W Y ^a  

^a Eulji University School of Medicine   (South Korea)

Author keywords

Cytochrome P450 (CYP) mRNAs; DMSO; Ethanol; Liver; Skin; White petrolatum

Indexed keywords

ALCOHOL; ALLERGEN; BROMETHOL; CYTOCHROME P450; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 2C11; CYTOCHROME P450 2E1; CYTOCHROME P450 3A1; CYTOCHROME P450 4A1; CYTOCHROME P450 ISOENZYME; DIMETHYL SULFOXIDE; DRUG METABOLITE; DRUG VEHICLE; MESSENGER RNA; PENTOXYRESORUFIN DEALKYLASE; UNCLASSIFIED DRUG; WHITE PETROLATUM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG ERUPTION; DRUG FORMULATION; DRUG METABOLISM; ENZYME INDUCTION; ENZYME INHIBITION; ENZYME MODIFICATION; LIVER; NONHUMAN; PROTEIN EXPRESSION; QUANTITATIVE ASSAY; RAT; RAT STRAIN; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SKIN; SKIN TEST; TISSUE LEVEL;

EID: 0035185062     PISSN: 12264512     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Effect of methanol, ethanol, dimethyl sulfoxide, and acetonitrile on in vitro activities of cDNA-expressed human cytochromes P-450
2. Co-expression of human CYP1A1 and a human analog of cytochrome P450-EF in response to 2, 3, 7, 8-tetrachloro-dibenzo-p-dioxin in the human mammary carcinoma-derived MCF-7 cells
3. Influence of oral isotretinoin on hepatic and cutaneous P-450-dependent isozyme activities
4. Effects of human recombinant interferon-alpha 2b on P450-dependent isozymes in rat liver and skin
5. Human cytochromes P450: Problems and prospects
6. Purification and characterization of cytochrome P-450 induced by benz (a) anthracene in mouse skin microsomes
7. A physiologically based pharmacokinetic model for 2, 3, 7, 8-tetrabromodibenzo-p-dioxin (TBDD) in the rat: Tissue distribution and CYP1A induction
8. Induction of CYP1A1 mRNA in rat epidermis and cultured human epidermal keratinocytes by benz (a) anthracene and beta-naphthoflavone
9. Epidermal cytochrome P-450: Immunochemical characterization of isoform induced by topical application of 3-methylcholanthrene to neonatal rat
10. Jute batching oil: A tumor promoter on mouse skin
11. Lymphocyte activation in allergic reactions elicited by small-molecular-weight compounds
12. Effects of topical application of clotrimazole to rats on epidermal and hepatic monooxygenase activities and cytochrome P-450
13. Analysis of rat cytochrome P450 isoenzyme expression using semi-quantitative reverse transcriptase-polymerase chain reaction (RT-PCR)
14. Characterization of distinct forms of cytochromes P-450, epoxide metabolizing enzymes and UDP-glucuronosyltransferases in rat skin
15. Purification and molecular characterization of beta-naphthoflavone-inducible cytochrome P-450 from rat epidermis
16. Differences in inducibility of cytochrome P-4501A1, monooxygenases and glutathione S-transferase in cutaneous and extracutaneous tissues after topical and parenteral administration of β-naphthoflavone to rats
17. Flow cytometry reveals subpopulations of murine epidermal cells that are refractory to induction of cytochrome P-4501A1 by β-naphthoflavone
18. Effects of oral thalidomide on rat liver and skin microsomal P450 isozyme activities and on urinary porphyrin excretion: Interaction with oral hexachlorobenzene
19. Inducibility of drug-metabolizing enzymes in the rat skin