Xenobiotic metabolism capacities of human skin in comparison with a 3D epidermis model and keratinocyte-based cell culture as in vitro alternatives for chemical testing: Activating enzymes (Phase I)

Experimental Dermatology

Volumn 21, Issue 5, 2012, Pages 358-363

  Götz, Christine ^a   Pfeiffer, Roland ^a   Tigges, Julia ^a   Blatz, Veronika ^b   Jäckh, Christine ^b   Freytag, Eva Maria ^a   Fabian, Eric ^b   Landsiedel, Robert ^b   Merk, Hans F ^c   Krutmann, Jean ^a   Edwards, Robert J ^d   Pease, Camilla ^e   Goebel, Carsten ^f   Hewitt, Nicola ^g   Fritsche, Ellen ^a,c  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b BASF SE   (Germany)

^c UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

^d IMPERIAL COLLEGE LONDON   (United Kingdom)

^e UNILEVER RESEARCH   (United Kingdom)

^f PROCTER AND GAMBLE COMPANY   (United States)

^g Nicky Hewitt Scientific Writing Services   (Germany)

Author keywords

Cyclooxygenase; Cytochrome P450 monooxygenase; Skin; Xenobiotic metabolism

Indexed keywords

3 METHYLCHOLANTHRENE; CYTOCHROME P450; PROSTAGLANDIN SYNTHASE; XENOBIOTIC AGENT;

ADULT; ARTICLE; CELL LINE; ENZYME ACTIVITY; ENZYME METABOLISM; EPIDERMIS; EX VIVO STUDY; FEMALE; GENOTOXICITY; HUMAN; HUMAN CELL; IN VITRO STUDY; KERATINOCYTE; MONOLAYER CULTURE; SIGNAL TRANSDUCTION; SKIN; SKIN TOXICITY; XENOBIOTIC METABOLISM;

ANIMAL TESTING ALTERNATIVES; BENZ(A)ANTHRACENES; CELL LINE; CELLS, CULTURED; CYTOCHROME P-450 ENZYME SYSTEM; DERMOTOXINS; DINOPROSTONE; EPIDERMIS; HUMANS; KERATINOCYTES; METHYLCHOLANTHRENE; MODELS, BIOLOGICAL; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; SKIN; TOXICOLOGY; XENOBIOTICS;

EID: 84859909277     PISSN: 09066705     EISSN: 16000625     Source Type: Journal    
DOI: 10.1111/j.1600-0625.2012.01486.x     Document Type: Article

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