Regulation of cutaneous drug-metabolizing enzymes and cytoprotective gene expression by topical drugs in human skin in vivo

British Journal of Dermatology

Volumn 155, Issue 2, 2006, Pages 275-281

  Smith, G ^a   Ibbotson, S H ^a   Comrie, M M ^a   Dawe, R S ^a   Bryden, A ^a   Ferguson, J ^a   Wolf, C R ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

Clobetasol 17 propionate; Coal tar; Drug metabolism; Gene expression; Retinoic acid

Indexed keywords

CLOBETASOL PROPIONATE; COAL TAR; COMPLEMENTARY DNA; CYCLOOXYGENASE 2; CYTOCHROME P450; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 1B1; CYTOCHROME P450 2C; CYTOCHROME P450 3A5; DRUG METABOLIZING ENZYME; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE PEROXIDASE 1; GLUTATHIONE TRANSFERASE; GLUTATHIONE TRANSFERASE P1; HEME OXYGENASE 1; LIQUID PARAFFIN; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN 1; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE FERRIHEMOPROTEIN REDUCTASE; RETINOIC ACID; RNA;

ADULT; ARITHMETIC; ARTICLE; BUTTOCK; CELL PROTECTION; CLINICAL PRACTICE; COMPARATIVE STUDY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; FEMALE; FLUORESCENCE; GENE CONTROL; GENE EXPRESSION; HUMAN; MALE; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PUNCH BIOPSY; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION; RNA EXTRACTION; STUDENT T TEST;

ADMINISTRATION, CUTANEOUS; ADULT; CLOBETASOL; COAL TAR; CYTOCHROME P-450 ENZYME SYSTEM; CYTOPROTECTION; DERMATOLOGIC AGENTS; FEMALE; GENE EXPRESSION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLUTATHIONE TRANSFERASE; HUMANS; MALE; MIDDLE AGED; SKIN; TRETINOIN;

EID: 33745898860     PISSN: 00070963     EISSN: 13652133     Source Type: Journal    
DOI: 10.1111/j.1365-2133.2006.07317.x     Document Type: Article

References (35)

1. Nebert DW. Drug metabolising enzymes, polymorphisms and interindividual response to environmental toxicants. Clin Chem Lab Med 2000; 38:857-61.
2. Wolf CR. Cytochrome P450s: polymorphic multigene families involved in carcinogen activation. Trends Genet 1986; 2:209-14.
3. Wolf CR. The Gerhard Zbinden memorial lecture - application of biochemical and genetic approaches to understanding pathways of chemical toxicity. Proceedings of EUROTOX 2001. Toxicol Lett 2002; 127:3-17.
4. Wolf CR, Smith G. Pharmacogenetics. Br Med Bull 1999; 55:366-86.
5. Wolf CR, Smith G, Smith RL. Science, medicine and the future: pharmacogenetics. BMJ 2000; 320:987-90.
6. Tanaka E. Clinically important pharmacokinetic drug-drug interactions: role of cytochrome P450 enzymes. J Clin Pharm Ther 1998; 23:403-16.
7. Smith G, Dawe RS, Clark C et al. Quantitative real-time RT-PCR analysis of drug metabolising and cytoprotective genes in psoriasis and regulation by ultraviolet radiation. J Invest Dermatol 2003; 121:390-8.
8. Smith G, Wolf CR, Deeni YY et al. Cutaneous expression of cytochrome P450 CYP2S1: individuality in regulation by therapeutic agents for psoriasis and other skin diseases. Lancet 2003; 361:1336-43.
9. Gibson GG, Skett P. Introduction to Drug Metabolism, 3rd edn. Glasgow: Blackie Academic & Professional, 2001.
10. Bickers DR, Kappas A. Human skin aryl hydrocarbon hydroxylase. Induction by coal tar. J Clin Invest 1978; 62:1061-8.
11. Lawrence CM, Finnen MJ, Shuster S. Effect of coal tar on cutaneous aryl hydrocarbon hydroxylase induction and anthralin irritancy. Br J Dermatol 1984; 110:671-5.
12. Ray WJ, Bain G, Yao M, Gottlieb DI. CYP26, a novel mammalian cytochrome P450, is induced by retinoic acid and defines a new family. J Biol Chem 1997; 272:18702-8.
13. Popa C, Dicker AJ, Dahler AL, Saunders N. Cytochrome P450, CYP26AI, is expressed at low levels in human epidermal keratinocytes and is not retinoic acid-inducible. Br J Dermatol 1999; 141:460-8.
14. Tyrrell RM, Keyse SM, Moraes EC. Cellular defence against UVA (320-380 nm) and UVB (290-320 nm) radiations. In: Photobiology (Riklis E, ed.). New York: Plenum Press, 1991; 861-71.
15. Hayes JD, Strange RC. Glutathione S-transferase polymorphisms and their biological consequences. Pharmacology 2000; 61:154-66.
16. Ho RH, Kim RB. Transporters and drug therapy: implications for drug disposition and disease. Clin Pharmacol Ther 2005; 78:260-77.
17. Baron JM, Holler D, Schiffer R et al. Expression of multiple cytochrome P450 enzymes and multidrug resistance-associated transport proteins in human skin keratinocytes. J Invest Dermatol 2001; 116:541-8.
18. Shimada T, Yamazaki H, Mimura M et al. Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians. J Pharmacol Exp Ther 1994; 270:414-23.
19. Li X-Y, Astrom A, Duell EA et al. Retinoic acid antagonizes basal as well as coal tar and glucocorticoid-induced cytochrome P4501A1 expression in human skin. Carcinogenesis 1995; 16:519-24.
20. Tian Y, Rabson AB, Gallo MA. Ah receptor and NF-κB interactions: mechanisms and physiological implications. Chem Biol Interact 2002; 141:97-115.
21. Nguyen T, Sherratt PJ, Pickett CB. Regulatory mechanisms controlling gene expression mediated by the antioxidant response element. Annu Rev Pharmacol Toxicol 2003; 43:233-60.
22. Henderson CJ, Smith AG, Ure J et al. Increased skin tumorigenesis in mice lacking pi class glutathione S-transferases. Proc Natl Acad Sci USA 1998; 95:5275-80.
23. Favatier F, Polla BS. Tobacco-smoke-inducible human haem oxygenase-1 gene expression: role of distinct transcription factors and reactive oxygen intermediates. Biochem J 2001; 353:475-82.
24. Wei L-N. Retinoid receptors and their coregulators. Annu Rev Pharmacol Toxicol 2003; 43:47-72.
25. Coumoul X, Diry M, Robillot C, Barouki R. Differential regulation of cytochrome P450 1A1 and 1B1 by a combination of dioxin and pesticides in the breast tumor cell line MCF-7. Cancer Res 2001; 61:3942-8.
26. Xia C, Taylor JB, Spencer SR, Ketterer B. The human glutathione S-transferase P1-1 gene: modulation of expression by retinoic acid and insulin. Biochem J 1993; 292:845-50.
27. Elder JT, Fisher GJ, Zhang QY et al. Retinoic acid receptor gene expression in human skin. J Invest Dermatol 1991; 96:425-33.
28. Goodwin B, Redinbo MR, Kliewer SA. Regulation of CYP3A gene transcription by the pregnane X receptor. Annu Rev Pharmacol Toxicol 2002; 42:1-23.
29. Rahmann I, Antonicelli F, MacNee W. Molecular mechanism of the regulation of glutathione synthesis by tumor necrosis factor-alpha and dexamethasone in human alveolar epithelial cells. J Biol Chem 1999; 27:5088-96.
30. Yamane Y, Furuichi M, Song R et al. Expression of multidrug resistance protein/GS-X pump and gamma-glutamylcysteine synthetase genes is regulated by oxidative stress. J Biol Chem 1998; 273:31075-85.
31. Tirona RG, Lee W, Leake BF et al. The orphan nuclear receptor HNF4alpha determines PXR- and CAR-mediated xenobiotic induction of CYP3A4. Nat Med 2003; 9:220-4.
32. Kerb R, Brockmoller J, Schlagenhaufer R et al. Influence of GSTT1 and GSTM1 genotypes on sunburn sensitivity. Am J Pharmacogenomics 2002; 2:147-54.
33. Lear JT, Smith AG, Strange RC, Fryer AA. Detoxifying enzyme genotypes and susceptibility to cutaneous malignancy. Br J Dermatol 1984; 110:671-5.
34. Sachse C, Smith G, Wilkie MJ et al. A pharmacogenetic study to investigate the role of dietary carcinogens in the etiology of colorectal cancer. Carcinogenesis 2002; 23:1839-49.
35. Garte S, Ganguly S, Taioli E. Effect of genotype on steady-state CYP1A1 gene expression in human peripheral lymphocytes. Biochem Pharmacol 2003; 66:441-5.