A potential in vitro epidermal equivalent assay to determine sensitizer potency

Toxicology in Vitro

Volumn 25, Issue 1, 2011, Pages 347-357

  dos Santos, Guilherme G ^a   Spiekstra, Sander W ^a   Sampat Sardjoepersad, Shakun C ^a   Reinders, Judith ^a   Scheper, Rik J ^a   Gibbs, Susan ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Cell viability; Cytotoxicity; Epidermal equivalent; Potency; Sensitizer

Indexed keywords

1 CHLORO 2,4 DINITROBENZENE; 2 BROMO 2 (BROMOMETHYL)PENTANEDINITRILE; 2 MERCAPTOBENZOTHIAZOLE; 4 NITROBENZYLBROMIDE; CINNAMALDEHYDE; CINNAMYL ALCOHOL; EUGENOL; GLYOXAL; INTERLEUKIN 1ALPHA; IRRITANT AGENT; ISOEUGENOL; OXAZOLONE; PHENYLENEDIAMINE; RESORCINOL; UNCLASSIFIED DRUG;

ARTICLE; ASSAY; CELL VIABILITY; CLASSIFICATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOTOXICITY; HUMAN; HUMAN CELL; HUMAN EPIDERMAL EQUIVALENT ASSAY; IN VITRO STUDY; INTERMETHOD COMPARISON; KERATINOCYTE; LOCAL LYMPH NODE ASSAY; MEDIAN EFFECTIVE CONCENTRATION; PATCH TEST; SKIN SENSITIZATION; TECHNOLOGY; TOXICITY TESTING;

ALLERGENS; ANIMAL TESTING ALTERNATIVES; CELL SURVIVAL; CELLS, CULTURED; DERMATITIS, ALLERGIC CONTACT; DINITROCHLOROBENZENE; EPIDERMIS; FORESKIN; HUMANS; INFANT, NEWBORN; INHIBITORY CONCENTRATION 50; INTERLEUKIN-1ALPHA; IRRITANTS; KERATINOCYTES; MALE; OSMOLAR CONCENTRATION; REPRODUCIBILITY OF RESULTS; RESORCINOLS; TECHNOLOGY TRANSFER; TOXICITY TESTS;

EID: 78650521576     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2010.10.008     Document Type: Article

References (40)

1. Agner T., Johansen J.D., Overgaard L., Volund A., Basketter D., Menne T. Combined effects of irritants and allergens. Synergistic effects of nickel and sodium lauryl sulfate in nickel-sensitized individuals. Contact Dermatitis 2002, 47(1):21-26.
2. Basketter D.A., Clapp C., Jefferies D., Safford B., Ryan C.A., Gerberick F., Dearman R.J., Kimber I. Predictive identification of human skin sensitization thresholds. Contact Dermatitis 2005, 53(5):260-267.
3. Basketter D.A., Gerberick F., Kimber I. The local lymph node assay and the assessment of relative potency: status of validation. Contact Dermatitis 2007, 57(2):70-75.
4. Basketter D.A., Kan-King-Yu D., Dierkes P., Jowsey I.R. Does irritation potency contribute to the skin sensitization potency of contact allergens?. Cutan. Ocul. Toxicol. 2007, 26(4):279-286.
5. Bruze M., Gruvberger B., Zimerson E. A clinically relevant contact allergy to methyldibromo glutaronitrile at 1% (0.32mg/cm) detected by a patch test. Contact Dermatitis 2006, 54(1):14-17.
6. Buehler E.V. Delayed contact hypersensitivity in the guinea pig. Arch. Dermatol. 1965, 91:171-177.
7. Corsini E., Mitjans M., Galbiati V., Lucchi L., Galli C.L., Marinovich M. Use of IL-18 production in a human keratinocyte cell line to discriminate contact sensitizers from irritants and low molecular weight respiratory allergens. Toxicol. In Vitro 2009, 23(5):789-796.
8. Dos Santos G.G., Reinders J., Ouwehand K., Rustemeyer T., Scheper R.J., Gibbs S. Progress on the development of human in vitro dendritic cell based assays for assessment of the sensitizing potential of a compound. Toxicol. Appl. Pharmacol. 2009, 236(3):372-382.
9. Edele F., Esser P.R., Lass C., Laszczyk M.N., Oswald E., Struh C.M., Rensing-Ehl A., Martin S.F. Innate and adaptive immune responses in allergic contact dermatitis and autoimmune skin diseases. Inflamm. Allergy Drug Targets 2007, 6(4):236-244.
10. Gerberick G.F., Ryan C.A., Kern P.S., Schlatter H., Dearman R.J., Kimber I., Patlewicz G.Y., Basketter D.A. Compilation of historical local lymph node data for evaluation of skin sensitization alternative methods. Dermatitis 2005, 16(4):157-202.
11. Gerberick G.F., Troutman J.A., Foertsch L.M., Vassallo J.D., Quijano M., Dobson R.L., Goebel C., Lepoittevin J.P. Investigation of peptide reactivity of pro-hapten skin sensitizers using a peroxidase-peroxide oxidation system. Toxicol. Sci. 2009, 112(1):164-174.
12. Gerberick G.F., Vassallo J.D., Foertsch L.M., Price B.B., Chaney J.G., Lepoittevin J.P. Quantification of chemical peptide reactivity for screening contact allergens: a classification tree model approach. Toxicol. Sci. 2007, 97(2):417-427.
13. Goldberg A.M., Hartung T. Protecting more than animals. Sci. Am. 2006, 294(1):84-91.
14. Kern P.S., Gerberick G.F., Ryan C.A., Kimber I., Aptula A., Basketter D.A. Local lymph node data for the evaluation of skin sensitization alternatives: a second compilation. Dermatitis 2010, 21(1):8-32.
15. Kimber I., Basketter D.A., Butler M., Gamer A., Garrigue J.L., Gerberick G.F., Newsome C., Steiling W., Vohr H.W. Classification of contact allergens according to potency: proposals. Food Chem. Toxicol. 2003, 41(12):1799-1809.
16. Kimber I., Basketter D.A., Gerberick G.F., Dearman R.J. Allergic contact dermatitis. Int. Immunopharmacol. 2002, 2(2-3):201-211.
17. Kimber I., Hilton J., Weisenberger C. The murine local lymph node assay for identification of contact allergens: a preliminary evaluation of in situ measurement of lymphocyte proliferation. Contact Dermatitis 1989, 21(4):215-220.
18. Magnusson B., Kligman A.M. The identification of contact allergens by animal assay. The guinea pig maximization test. J. Invest. Dermatol. 1969, 52(3):268-276.
19. McLelland J., Shuster S., Matthews J.N. 'Irritants' increase the response to an allergen in allergic contact dermatitis. Arch. Dermatol. 1991, 127(7):1016-1019.
20. Mekenyan, O., Patlewicz, G., Dimitrova, G., Kuseva, C., Todorov, M., Stoeva, S., Kotov, S., Donner, E.M., 2010. Use of genotoxicity information in the development of integrated testing strategies (ITS) for skin sensitization. Chem. Res. Toxicol. E-pub. doi:10.1021/tx100161j.
21. Messi M., Giacchetto I., Nagata K., Lanzavecchia A., Natoli G., Sallusto F. Memory and flexibility of cytokine gene expression as separable properties of human T(H)1 and T(H)2 lymphocytes. Nat. Immunol. 2003, 4(1):78-86.
22. Mitjans M., Viviani B., Lucchi L., Galli C.L., Marinovich M., Corsini E. Role of p38 MAPK in the selective release of IL-8 induced by chemical allergen in naive THp-1 cells. Toxicol. In Vitro 2008, 22(2):386-395.
23. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods 1983, 65(1-2):55-63.
24. Natsch A., Emter R. Skin sensitizers induce antioxidant response element dependent genes: application to the in vitro testing of the sensitization potential of chemicals. Toxicol. Sci. 2008, 102(1):110-119.
25. Ouwehand K., Santegoets S.J., Bruynzeel D.P., Scheper R.J., de Gruijl T.D., Gibbs S. CXCL12 is essential for migration of activated Langerhans cells from epidermis to dermis. Eur. J. Immunol. 2008, 38(11):3050-3059.
26. Ouwehand K., Spiekstra S.W., Reinders J., Scheper R.J., de Gruijl T.D., Gibbs S. Comparison of a novel CXCL12/CCL5 dependent migration assay with CXCL8 secretion and CD86 expression for distinguishing sensitizers from non-sensitizers using MUTZ-3 Langerhans cells. Toxicol. In Vitro 2010, 24(2):578-585.
27. Pedersen L.K., Johansen J.D., Held E., Agner T. Augmentation of skin response by exposure to a combination of allergens and irritants - a review. Contact Dermatitis 2004, 50(5):265-273.
28. Roberts D.W., Patlewicz G., Kern P.S., Gerberick F., Kimber I., Dearman R.J., Ryan C.A., Basketter D.A., Aptula A.O. Mechanistic applicability domain classification of a local lymph node assay dataset for skin sensitization. Chem. Res. Toxicol. 2007, 20(7):1019-1030.
29. Saint-Mezard P., Rosieres A., Krasteva M., Berard F., Dubois B., Kaiserlian D., Nicolas J.F. Allergic contact dermatitis. Eur. J. Dermatol. 2004, 14(5):284-295.
30. Sakaguchi H., Ashikaga T., Miyazawa M., Kosaka N., Ito Y., Yoneyama K., Sono S., Itagaki H., Toyoda H., Suzuki H. The relationship between CD86/CD54 expression and THP-1 cell viability in an in vitro skin sensitization test-human cell line activation test (h-CLAT). Cell Biol. Toxicol. 2009, 25(2):109-126.
31. Schneider K., Akkan Z. Quantitative relationship between the local lymph node assay and human skin sensitization assays. Regul. Toxicol. Pharmacol. 2004, 39(3):245-255.
32. Spiekstra S.W., Breetveld M., Rustemeyer T., Scheper R.J., Gibbs S. Wound-healing factors secreted by epidermal keratinocytes and dermal fibroblasts in skin substitutes. Wound Repair Regen. 2007, 15(5):708-717.
33. Spiekstra S.W., Dos Santos G.G., Scheper R.J., Gibbs S. Potential method to determine irritant potency in vitro - Comparison of two reconstructed epidermal culture models with different barrier competency. Toxicol. In Vitro 2009, 23(2):349-355.
34. Spiekstra S.W., Toebak M.J., Sampat-Sardjoepersad S., van Beek P.J., Boorsma D.M., Stoof T.J., von Blomberg B.M., Scheper R.J., Bruynzeel D.P., Rustemeyer T., Gibbs S. Induction of cytokine (interleukin-1alpha and tumor necrosis factor-alpha) and chemokine (CCL20, CCL27, and CXCL8) alarm signals after allergen and irritant exposure. Exp. Dermatol. 2005, 14(2):109-116.
35. Spielmann H., Hoffmann S., Liebsch M., Botham P., Fentem J.H., Eskes C., Roguet R., Cotovio J., Cole T., Worth A., Heylings J., Jones P., Robles C., Kandarova H., Gamer A., Remmele M., Curren R., Raabe H., Cockshott A., Gerner I., Zuang V. The ECVAM international validation study on in vitro tests for acute skin irritation: report on the validity of the EPISKIN and EpiDerm assays and on the Skin Integrity Function Test. Altern. Lab. Anim. 2007, 35(6):559-601.
36. Toebak M.J., Pohlmann P.R., Sampat-Sardjoepersad S.C., von Blomberg B.M., Bruynzeel D.P., Scheper R.J., Rustemeyer T., Gibbs S. CXCL8 secretion by dendritic cells predicts contact allergens from irritants. Toxicol. In Vitro 2006, 20(1):117-124.
37. Villablanca E.J., Mora J.R. A two-step model for Langerhans cell migration to skin-draining LN. Eur. J. Immunol. 2008, 38(11):2975-2980.
38. Welss T., Matthies W., Schroeder K.R. Compatibility testing in vitro: a comparison with in vivo patch test data. Int. J. Cosmet. Sci. 2007, 29(2):143.
39. Weltzien H.U., Moulon C., Martin S., Padovan E., Hartmann U., Kohler J. T cell immune responses to haptens. Structural models for allergic and autoimmune reactions. Toxicology 1996, 107(2):141-151.
40. Williams E.S., Panko J., Paustenbach D.J. The European Union's REACH regulation: a review of its history and requirements. Crit. Rev. Toxicol. 2009, 39(7):553-575.