Comparative in vitro skin absorption and metabolism of coumarin (1,2-benzopyrone) in human, rat, and mouse

Toxicology and Applied Pharmacology

Volumn 145, Issue 1, 1997, Pages 34-42

  Beckley Kartey, Senam A J ^a   Hotchkiss, Sharon A M ^a   Capel, Margred ^a  

^a IMPERIAL COLLEGE SCHOOL OF MEDICINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

COUMARIN;

ADULT; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CLINICAL TRIAL; CONCENTRATION RESPONSE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIFFUSION; DRUG METABOLISM; FEMALE; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; MALE; MOUSE; NONHUMAN; RAT; SKIN ABSORPTION; SKIN PENETRATION; SPECIES DIFFERENCE; TOPICAL DRUG ADMINISTRATION;

ANIMALIA;

EID: 0031194863     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.1997.8154     Document Type: Article

References (48)

1. Bartek M. J., La Budde J. A., Maibach H. I. Skin permeability in vivo: Comparison in rat, rabbit, pig, and man. J. Invest. Dermatol. 58:1972;114-123.
2. Beckley-Kartey S. A. J., Swales N. J., Hotchkiss S. A. M. The cutaneous metabolism of testosterone. Hum. Exp. Toxicol. 16:1997;51.
3. Bronaugh R. L., Stewart R. F., Congdon E. R. Methods for in vitro percutaneous absorption studies. II. Animal models for human skin. Toxicol. Appl. Pharmacol. 62:1982;481-488.
4. Bronaugh R. L., Stewart R. F. Methods for in vitro percutaneous absorption studies. IV. The flow-through diffusion cell. J. Pharm. Sci. 74:1985;64-67.
5. D. A. W. Bucks, H. I. Maibach, R. H. Guy, 1989, Occlusion does not uniformly enhance penetration in vivo, Percutaneous Absorption, Mechanisms, Methodology, Drug Delivery, 77, 93, Dekker, New York.
6. Carlton B. D., Aubrun J.-C., Simon G. S. Effects of coumarin following perinatal and chronic exposure in Sprague-Dawley rats and CD1 mice. Fundam. Appl. Toxicol. 30:1996;145-151.
7. Casely-Smith J. R., Wang C. T., Casely-Smith J. R., Zi-Hai C. Treatment of filarial lymphoedema and elephantiasis with 5,6-benzo-[alpha]-pyrone (coumarin). Br. Med. J. 307:1993;1037-1041.
8. Cohen A. J. Critical review of the toxicology of coumarin with special reference to interspecies differences in metabolism and hepatotoxic response and their significance to man. Food Chem. Toxicol. 17:1979;277-289.
9. Den Besten C., Korosi S. A., Beamand J. A., Walters D. G., Lake B. G. Studies on the mechanism of coumarin-induced toxicity in rat hepatocytes. Toxicol. in Vitro. 4:1990;518-521.
10. Dexeus F. H., Logothetis C. J., Sella A., Fitz K., Amato R., Reuben J. M., Dozier N. Phase II study of coumarin and cimetidine in patients with metastatic renal-cell carcinoma. J. Clin. Oncol. 8:1990;325-329.
11. Egan D., O'Kennedy R., Moran E., Cox D., Prosser E., Thornes R. D. The pharmacology, metabolism, analysis, and applications of coumarin and coumarin related compounds. Drug Metab. Rev. 22:1990;503-529.
12. Evans J. G., Gaunt I. F., Lake B. G. 2-Year toxicity study on coumarin in the baboon. Food Cosmet. Toxicol. 17:1979;187-193.
13. Evans J. G., Appleby E. C., Lake B. G., Canning D. M. Studies on the induction of cholangiofibrosis by coumarin in the rat. Toxicology. 55:1989;207-224.
14. Gangolli S. D., Schilling W. H., Grasso P., Gaint I. F. Studies on the metabolism and hepatotoxicity of coumarin in the baboon. Biochem. Soc. Trans. 2:1974;310-312.
15. Gibbs P. A., Janakidevi K., Feuer G. Metabolism of coumarin and 4-methylcoumarin by rat liver microsomes. Can. J. Biochem. 49:1971;177-184.
16. Hagan E. C., Hansen W. H., Fitzhugh O. G., Jenner P. M., Jones W. I., Taylor J. M., Lang E. L., Nelson A. A., Bronwer J. B. Food flavourings and compounds of related structure. II Subacute and chronic toxicity. Food Chem. Toxicol. 5:1967;141-157.
17. Hazelton L. W., Tusing T. W., Zeitlin B. R., Thiessen R. Jr., Murer H. K. Toxicity of coumarin. J. Pharmacol. Exp. Ther. 118:1956;348-358.
18. S. A. M. Hotchkiss, 1992, The skin as a xenobiotic metabolising organ, Progress in Drug Metabolism, G. G. Gibson, 13, 217, 262, Taylor & Francis, London.
19. Hotchkiss S. A., Chidgey M. A. J., Rose S., Caldwell J. Percutaneous absorption of benzyl acetate through rat skin in vivo. 1. Validation of an in vitro model against in vivo data. Food Chem. Toxicol. 28:1990;443-447.
20. Hotchkiss S. A. M., Hewitt P., Caldwell J. Percutaneous absorption of 4,4′-methylene-bis-(2-chloroaniline) and 4,4′-methylenedianiline through rat and human skin in vitro. Toxicol. in Vitro. 7:1993;141-148.
21. Hotchkiss S. A. M., Hewitt P., Caldwell J., Chen W. L., Rowe R. R. Percutaneous absorption of nicotinic acid, phenol, benzoic acid and triclopyr butoxyethyl ester through rat and human skin in vitro: Further validation of an in vitro model by comparison with in vivo data. Food Chem. Toxicol. 30:1992a;891-899.
22. Hotchkiss S. A. M., Miller J. M., Caldwell J. Percutaneous absorption of benzyl acetate through rat skin in vivo. 2. Effect of vehicle and occlusion. Food Chem. Toxicol. 30:1992b;145-153.
23. Kao J., Carver M. P. Cutaneous metabolism of xenobiotics. Drug Metab. Dispos. 22:1990;363-410.
24. Kao J., Hall J., Helman G. In vitro percutaneous absorption in mouse skin: Influence of skin appendages. Toxicol. Appl. Pharmacol. 94:1988;93-103.
25. 14. J. Med. Chem. 3:1961;25-43.
26. Lake B. G. Investigations into the mechanisms of coumarin-induced hepatotoxicity in the rat. Arch. Toxicol. 1984;16-29.
27. Lake B. G., Gray T. J. B., Evans J. G., Lewis D. F. V., Beamand J. A., Hue K. L. Studies on the mechanism of coumarin-induced toxicity in rat hepatocytes: Comparison with dihydrocoumarin and other coumarin metabolites. Toxicol. Appl. Pharmacol. 97:1989b;311-323.
28. Lake B. G., Evans J. G., Walters D. G., Price R. J. Studies on the hepatotoxicity and metabolism of coumarin in the rat and syrian hamster. Hum. Exp. Toxicol. 9:1990;356.
29. Lake B. G., Evans J. G., Lewis D. F., Price R. J. Studies on the acute effects of coumarin and some other coumarin derivatives in the rat. Food Chem. Toxicol. 32:1994a;357-363.
30. Lake B. G., Evans J. G., Lewis D. F., Price R. J. Comparison of the hepatic effects of coumarin, 3,4-dimethylcoumarin, dihydrocoumarin and 6-methylcoumarin in the rat. Food Chem. Toxicol. 32:1994b;743-751.
31. Lush I. E., Andrews K. M. Genetic variation between mice in their metabolism of coumarin and its derivatives. Genet. Res. 31:1978;177-186.
32. Marshall E. M., Mendelsoln L., Butler K., Riley K., Cantrell J., Harvey J., Wiseman C., Taylor T., Macdonald J. S. Treatment of metastatic renal cell carcinoma with coumarin (1,2-benzopyrone) and cimetidine: A pilot study. J. Clin. Oncol. 5:1987;862-866.
33. 14, 1, 93.
34. 14C-Coumarin: Studies on the dermal absorption in the rat. Study No. RIF 28/943265, 1, 55.
35. Miles J. S., Mclaren A. W., Forrester L. M., Glancey M. J., Lang M. A., Wolf C. R. Identification of the human liver cytochrome P450 responsible for coumarin 7-hydroxylase activity. Biochem. J. 267:1990;365-371.
36. National Toxicology Program, 1993, Toxicology and carcinogenesis studies of coumarin (CAS No. 91-64-5) in F344/N rats and B6C3F1 mice (gavage studies), U.S. Department of Health and Human Services, National Institute of Health, Research Triangle Park, NC.
37. Opdyke D. L. J. Monographs of fragrance raw materials: Coumarin. Food Chem. Toxicol. 12:1974;385-388.
38. 14. Xenobiotica. 21:1991;499-514.
39. Raunio H., Syngelma T., Pasanen M., Juvonen R., Honkakoski P., Kairaluoma M. A., Sotaniemi E., Lang M. A., Pelkonen O. Immunochemical and catalytic studies on hepatic coumarin 7-hydroxylase in man, rat and mouse. Biochem. Pharmacol. 37:1988;3889-3895.
40. Rettie A. E., Williams F. M., Rawlins M. D., Mayer R. T., Burke D. T. Major differences between lung, skin and liver in the microsomal metabolism of homologous series of resorufin and coumarin ethers. Biochem. Pharmacol. 20:1986;3495-3500.
41. Ritschel W. A., Brady M. E., Tan H. S. I. First-pass effect of coumarin in man. Int. J. Clin. Pharmacol. 17:1979;99-103.
42. Ritschel W. A., Hussain S. A. Transdermal absorption and topical availability of coumarin. Methods Find. Exp. Clin. Pharmacol. 10:1988;165-169.
43. Ritschel W. A., Sabouni A., Hussain S. A. Percutaneous absorption of coumarin, griseofulvin and propranolol across human scalp and abdominal skin. Methods Find. Exp. Clin. Pharmacol. 11:1989;643-646.
44. Schilling W. H., Crampton R. F., Longland R. C. Metabolism of coumarin in man. Nature. 221:1969;664-665.
45. Sesardic D., Boobis A. R., Murray B. P., Murrey S., Segura J., De La Torre R., Davies D. S. Furafylline is a potent and selective inhibitor of cytochrome P4501A2 in man. Br. J. Clin. Pharmacol. 29:1990;651-663.
46. Swales N. J., Johnson T., Caldwell J. Cryopreservation of rat and mouse hepatocytes. II. Assessment of metabolic capacity using testosterone metabolism. Drug Metab. Dispos. 24:1996;1224-1230.
47. Thornes D., Daly L., Lynch G. Prevention of early recurrence of high risk malignant melanoma by coumarin. Eur. J. Surg. Oncol. 15:1989;431-435.
48. Ueno I., Hirono I. Noncarcinogenic response to coumarin in Syrian golden hamsters. Food Cosmet. Toxicol. 19:1981;353-355.