Use of human in Vitro skin models for accurate and ethical risk assessment: Metabolic considerations

Toxicological Sciences

Volumn 133, Issue 2, 2013, Pages 209-217

  Hewitt, Nicola J ^a   Edwards, Robert J ^b   Fritsche, Ellen ^c   Goebel, Carsten ^d   Aeby, Pierre ^e   Scheel, Julia ^f   Reisinger, Kerstin ^f   Ouédraogo, Gladys ^g   Duche, Daniel ^g   Eilstein, Joan ^g   Latil, Alain ^h   Kenny, Julia ⁱ   Moore, Claire ^j   Kuehnl, Jochen ^k   Barroso, Joao ^l   Fautz, Rolf ^m   Pfuhler, Stefan ⁿ  

^a SWS   (Germany)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

^c IUF LEIBNIZ RESEARCH INSTITUTE FOR ENVIRONMENTAL MEDICINE   (Germany)

^d P and G Service   (Germany)

^e Henkel AG and Co KGaA ^*  (Sweden)

^f HENKEL KGAA   (Germany)

^g BL'Oreal Research and Innovation   (France)

^h Centre d'Immunologie Pierre Fabre   (France)

ⁱ GLAXOSMITHKLINE   (United Kingdom)

^j UNILEVER RESEARCH   (United Kingdom)

^k BEIERSDORF AG   (Germany)

^l Kao Germany GmbH ^*  (Belgium)

^m KAO GERMANY GMBH   (Germany)

ⁿ PROCTER AND GAMBLE COMPANY   (United States)

more..

Author keywords

Cosmetics europe; Human 3D skin models; Keratinocytes; Phase I and II metabolism; Proteomics

Indexed keywords

ALCOHOL DEHYDROGENASE; ALCOHOL DEHYDROGENASE 1B; ALCOHOL DEHYDROGENASE 3; AMINE OXIDASE (FLAVIN CONTAINING); CATALASE; CYCLOOXYGENASE 2; CYTOCHROME P450; CYTOCHROME P450 2B6; CYTOCHROME P450 3A; EPOXIDE HYDROLASE; EPOXIDE HYDROLASE 1; GLUCURONOSYLTRANSFERASE; GLUTATHIONE TRANSFERASE ALPHA; GLUTATHIONE TRANSFERASE P1; GLUTATHIONE TRANSFERASE T1; SULFOTRANSFERASE; SULFOTRANSFERASE 2B1; UNCLASSIFIED DRUG;

ARTICLE; ENZYME ACTIVITY; GENE EXPRESSION; GENOTOXICITY; HUMAN; HUMAN CELL; IN VITRO STUDY; KERATINOCYTE; METABOLIC CAPACITY; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEOMICS; RISK ASSESSMENT; SKIN; XENOBIOTIC METABOLISM;

COSMETICS EUROPE.; HUMAN 3D SKIN MODELS; KERATINOCYTES; PHASE I AND II METABOLISM; PROTEOMICS;

ANIMAL TESTING ALTERNATIVES; CELL LINE; CYTOCHROME P-450 ENZYME SYSTEM; GENE EXPRESSION; HUMANS; MODELS, BIOLOGICAL; PROTEOMICS; REPRODUCIBILITY OF RESULTS; RISK ASSESSMENT; SKIN; TOXICITY TESTS; XENOBIOTICS;

EID: 84878475361     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kft080     Document Type: Article

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