Progress on the development of human in vitro dendritic cell based assays for assessment of the sensitizing potential of a compound

Toxicology and Applied Pharmacology

Volumn 236, Issue 3, 2009, Pages 372-382

  dos Santos, G Galvão ^a   Reinders, J ^a   Ouwehand, K ^a   Rustemeyer, T ^a   Scheper, R J ^a   Gibbs, S ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Allergen; Animal alternative; Biomarker; CD34+ derived dendritic cell; EU Directive 76 768 EEC; Irritant; Monocyte derived dendritic cell; MUTZ 3; Non sensitizer; Research; Sensitizer; Test; THP 1; U 937; Validation

Indexed keywords

1 CHLORO 2,4 DINITROBENZENE; 1 FLUORO 2,4 DINITROBENZENE; 1,4 BENZOQUINONE; 2 METHYL 4 ISOTHIAZOLIN 3 ONE; 4 AMINOPHENOL; ALLERGEN; ANILINE; BIOLOGICAL MARKER; CHEMOKINE; CITRAL; CITRONELLAL; COPPER CHLORIDE; CYTOKINE; DIAZOLIDINYL UREA; DICHROMATE POTASSIUM; DIPHENYLMETHANE 4,4' DIISOCYANATE; EUGENOL; FORMALDEHYDE; GERANIOL; GLUTARALDEHYDE; HYDROXYCITRONELLAL; MANGANESE CHLORIDE; MERCURY CHLORIDE; NICKEL CHLORIDE; OXAZOLONE; PENICILLIN G; PHOSPHOTRANSFERASE; PHTHALIC ANHYDRIDE; PYRIDINE; UNINDEXED DRUG;

ADAPTIVE IMMUNITY; ANIMAL TESTING ALTERNATIVE; ASSAY; CELL LINE; CELL STRAIN HL 60; CELL STRAIN K 562; CELL STRAIN U937; DENDRITIC CELL; GENOMICS; HUMAN; HUMAN CELL; IN VITRO STUDY; LOCAL LYMPH NODE ASSAY; MONOCYTE; NONHUMAN; PROTEOMICS; REVIEW; SENSITIVITY AND SPECIFICITY; SKIN ALLERGY; SKIN SENSITIZATION;

ANIMAL TESTING ALTERNATIVES; ANIMALS; BIOLOGICAL MARKERS; DENDRITIC CELLS; HUMANS; MODELS, ANIMAL;

ANIMALIA;

EID: 63649098913     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2009.02.004     Document Type: Review

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