Percutaneous penetration and dermal metabolism of triclosan (2,4,4'- trichloro-2'-hydroxydiphenyl ether)

Food and Chemical Toxicology

Volumn 38, Issue 4, 2000, Pages 361-370

  Moss, T ^a   Howes, D ^b   Williams, F M ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b UNILEVER RESEARCH   (United Kingdom)

Author keywords

Absorption; Dermal metabolism; Percutaneous penetration; Triclosan

Indexed keywords

ADENOSINE 3' PHOSPHATE 5' PHOSPHOSULFATE; GLUCURONIDE; TRICLOSAN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD FLOW; CHROMATOGRAPHY; CONSUMER; DRUG METABOLISM; NONHUMAN; RADIOACTIVITY; RAT; SKIN ABSORPTION; SKIN PENETRATION; SKIN SURFACE; STRATUM CORNEUM;

ADMINISTRATION, CUTANEOUS; ANIMALS; ANTI-INFECTIVE AGENTS, LOCAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FECES; HUMANS; LIVER; MALE; RATS; RATS, WISTAR; SKIN; SKIN ABSORPTION; SPECIES SPECIFICITY; TISSUE DISTRIBUTION; TRICLOSAN;

ANIMALIA;

EID: 0034018448     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0278-6915(99)00164-7     Document Type: Article

References (27)

1. Black J. G., Howes D. Percutaneous absorption of triclosan from toilet preparations. Journal of the Society of Cosmetic Chemists. 26:1975;205-215.
2. Black J. G., Howes D., Rutherford T. Percutaneous absorption and metabolism of Irgasan DP300. Toxicology. 3:1975;33-47.
3. Clark N. W. E., Scott R. C., Blain P. G. and Williams F. M. (1991) Maintenance of skin viability in skin absorption systems. In Prediction of Percutaneous Penetration, ed. R. C. Scott, R. H. Guy, J. Hadgraft and H. E. Bodde, Vol. 2, pp. 541-554. IBC Technical Services, London.
4. Clowes H. M., Scott R. C., Heylings J. R. Skin absorption: flow-through or static diffusion cells. Toxicology in Vitro. 8:1994;827-830.
5. Dick I. P., Blain P. G. and Williams F. M. (1996) Improved in vitro skin absorption of lipophilic compounds following addition of albumin to receptor fluid in flow through system. In Prediction of Percutaneous Penetration, ed. K. R. Brain, V. J. James and K. A. Walters, Vol. 4b, pp. 267-270. STS Publishing, Cardiff.
6. Dick I. P., Blain P. G. and Williams F. M. (1998) Usefulness of animal models in predicting human skin permeability for a series of chemicals of different lipophilicities. In Prediction of Percutaneous Penetration, ed. K. R. Brain, V. J. James and K. A. Walters, Vol. 5b, pp. 73-75. STS Publishing, Cardiff.
7. Dooley T. P., Walker C. J., Hirshey S. J., Falany C. A., Diani A. R. Localisation of minoxidil sulfotransferase in rat liver and the outer root sheath of pelage. Journal of Investigative Dermatology. 96:1991;65-70.
8. Epstein E. H., Williams M. L., Elias P. M. The epidermal cholesterol cycle. Journal of the American Academy of Dermatology. 10:1984;866-868.
9. Henrikus B. M., Breuer W., Kampffmeyer H. G. Dermal metabolism of 4-nitrophenol and 4-nitroanisole in single-pass perfused rabbit ears. Xenobiotica. 21:1991;1229-1241.
10. Hirel B., Chesne C., Pailhere J. P., Guillouzo A. In vitro expression of drug-metabolizing enzyme activities in human adult keratinocytes under various culture conditions and their response to inducers. Toxicology in Vitro. 9:1995;49-56.
11. Howes D., Black J. G. Percutaneous absorption of 2-nitro-p-phenylenediamine. International Journal of Cosmetic Science. 5:1983;215-225.
12. Howes D., Guy R., Hadgraft J., Heylings J., Hoeck U., Kemper F., Maibach H., Marty J-P., Merk H., Parra J., Rekkas D., Rondelli I., Schaefer H., Tauber U., Verbiese N. Methods for assessing percutaneous absorption. ATLA. 24:1996;81-106.
13. Jewell C., Heylings J. R., Blain P. G., Williams F. M. Factors influencing the viability and metabolic capacity of rat skin when maintained in vitro. Human and Experimental Toxicology. 15:1995;160.
14. Johnson G. A., Baker C. A., Knight K. A. Minoxidil sulfotransferase, a marker of human keratinocyte dfferentiation. Journal of Investigative Dermatology. 98:1992;730-733.
15. Johnson G. A., Barsuhn K. J. Minoxidil sulfate, a metabolite of minoxidil. Drug Metabolism and Disposition. 11:1983;507-508.
16. Minter H. J., Shaw A., Howes D. and Pendlington R. U. (1998) The use of microautoradiography to show the distribution of substances topically applies to skin. In Prediction of Percutaneous Penetration, ed. K. R. Brain, V. J. James and K. A. Walters, Vol. 5b, pp. 73-75. STS Publishing, Cardiff.
17. Moss T. (1997) Phase II metabolism during percutaneous penetration. PhD Thesis. University of Newcastle.
18. Moss T., Howes D. and Williams F. M. (1996) Characteristics of sulfotransferases in human skin. In Prediction of Percutaneous Penetration, ed. K. R. Brain, V. J. James and K. A. Walters, Vol. 4b, pp. 307-311. STS Publishing, Cardiff.
19. Pendlington R. U., Williams D. L., Naik J. T., Sharma R. K. Distribution of xenobiotic metabolizing enzymes in skin. Toxicology in Vitro. 8:1994;525-527.
20. Pham M-A., Magdalou J., Totis M., Fournel-Gigleux S., Siest G., Hammock B. D. Characterization of distinct forms of cytochromes P-450, epoxide metabolizing enzymes and UDP-glucuronosyl transferases in rat skin. Biochemical Pharmacology. 38:1989;2187-2194.
21. Roper C. S., Howes D., Blain P. G., Williams F. M. Prediction of the percutaneous penetration and metabolism of dodecyl decaethoxylate in rats using in vitro models. Archives of Toxicology. 69:1995;649-654.
22. Roper C. S., Howes D., Blain P. G., Williams F. M. Percutaneous penetration of 2-phenoxyethanol through rat and human skin. Food and Chemical Toxicology. 35:1997;1009-1016.
23. Roper C. S., Howes D., Blain P. G., Williams F. M. A comparison of the absorption of a series of ethoxylates through rat skin in vitro. Toxicology in Vitro. 12:1998;57-65.
24. Scott R. C., Walker M., Dugard P. H. A comparison of the permeability properties of human and some laboratory animal skins. International Journal of Pharmacology. 8:1986;189-194.
25. Steinkjer B., Braathen L. Contact dermatitis from triclosan (Irgasan DP 300). Contact Dermatitis. 18:1988;243-244.
26. Veronisi S., De Padova M. P., Vanni D., Melino M. Contact dermatitis to triclosan. Contact Dermatitis. 16:1986;257.
27. Williams F. M. (1998) The role of skin metabolism in percutaneous absorption. In Perspectives of Percutaneous Penetration, ed. K. R. Brain, V. J. James and K. A. Walters, Vol. 5b, pp. 41-44. STS Publishing, Cardiff.