Xenobiotic metabolism capacities of human skin in comparison with a 3D-epidermis model and keratinocyte-based cell culture as in vitro alternatives for chemical testing: Phase II enzymes

Experimental Dermatology

Volumn 21, Issue 5, 2012, Pages 364-369

  Götz, Christine ^a   Pfeiffer, Roland ^a   Tigges, Julia ^a   Ruwiedel, Karsten ^a   Hübenthal, Ulrike ^a   Merk, Hans F ^b   Krutmann, Jean ^a   Edwards, Robert J ^c   Abel, Josef ^a   Pease, Camilla ^d   Goebel, Carsten ^e   Hewitt, Nicola ^f   Fritsche, Ellen ^a,b  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

^c IMPERIAL COLLEGE LONDON   (United Kingdom)

^d UNILEVER RESEARCH   (United Kingdom)

^e PROCTER AND GAMBLE COMPANY   (United States)

^f Nicky Hewitt Scientific Writing Services   (Germany)

Author keywords

Glutathione S transferase; N acetyltransferase; Skin; UDP glucuronosyltransferase; Xenobiotic metabolism

Indexed keywords

ACYLTRANSFERASE; COSMETIC; GLUCURONOSYLTRANSFERASE; GLUTATHIONE TRANSFERASE;

ARTICLE; CELL IMMORTALIZATION; CHEMICAL ANALYSIS; CONTROLLED STUDY; ENZYME ASSAY; EPIDERMIS; EPIDERMIS CELL; EX VIVO STUDY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IN VITRO STUDY; IN VIVO STUDY; KERATINOCYTE; XENOBIOTIC METABOLISM;

ACETYLTRANSFERASES; ANIMAL TESTING ALTERNATIVES; CELL LINE; CELLS, CULTURED; COSMETICS; DERMOTOXINS; EPIDERMIS; GLUCURONOSYLTRANSFERASE; GLUTATHIONE TRANSFERASE; HUMANS; KERATINOCYTES; MODELS, BIOLOGICAL; SKIN; TOXICOLOGY; XENOBIOTICS;

EID: 84859914215     PISSN: 09066705     EISSN: 16000625     Source Type: Journal    
DOI: 10.1111/j.1600-0625.2012.01478.x     Document Type: Article

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