Disposition and biotransformation of 14C-Benzo(a)pyrene in a pig ear skin model: Ex vivo and in vitro approaches

Toxicology Letters

Volumn 199, Issue 1, 2010, Pages 22-33

  Jacques, Carine ^a   Perdu, Elisabeth ^a   Duplan, Hélène ^b   Jamin, Emilien L ^a   Canlet, Cécile ^a   Debrauwer, Laurent ^a   Cravedi, Jean Pierre ^a   Mavon, Alain ^b   Zalko, Daniel ^a  

^a CNRS   (France)

^b Centre d'Immunologie Pierre Fabre   (France)

Author keywords

Alternative model; Benzo(a)pyrene; Biotransformation; Cytochrome P450; Dermal absorption; Pig skin

Indexed keywords

CARBON 14 BENZO(A)PYRENE; PYRENE DERIVATIVE; UNCLASSIFIED DRUG; BENZO[A]PYRENE; CARBON; CARCINOGEN; DIAGNOSTIC AGENT;

ABSORPTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOTRANSFORMATION; CHEMICAL STRUCTURE; CONTROLLED STUDY; DIFFUSION; EX VIVO STUDY; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; HYDROLYSIS; IN VITRO SELECTION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; SWINE; ANIMAL; DRUG EFFECT; ELECTROSPRAY MASS SPECTROMETRY; EXTERNAL EAR; IN VITRO STUDY; INTRADERMAL DRUG ADMINISTRATION; LIVER MICROSOME; MALE; METABOLISM; PHYSIOLOGY; SKIN; SKIN ABSORPTION; TANDEM MASS SPECTROMETRY;

SUIDAE;

ADMINISTRATION, CUTANEOUS; ANIMALS; BENZO(A)PYRENE; BIOTRANSFORMATION; CARBON RADIOISOTOPES; CARCINOGENS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; EAR, EXTERNAL; FEMALE; HUMANS; MALE; MICROSOMES, LIVER; SKIN; SKIN ABSORPTION; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SWINE; TANDEM MASS SPECTROMETRY;

EID: 77957114668     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2010.08.001     Document Type: Article

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