Diphenylthiourea, a common rubber chemical, is bioactivated to potent skin sensitizers

Chemical Research in Toxicology

Volumn 24, Issue 1, 2011, Pages 35-44

  Samuelsson, Kristin ^a   Bergström, Moa Andresen ^b   Jonsson, Charlotte A ^a   Westman, Gunnar ^c   Karlberg, Ann Therese ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b ASTRAZENECA R AND D   (Sweden)

^c CHALMERS UNIVERSITY OF TECHNOLOGY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

BENZYLAMINE; CARBON 14; CONTACT ALLERGEN; CYTOCHROME P450; CYTOCHROME P450 1A1; CYTOCHROME P450 1B1; CYTOCHROME P450 2B6; CYTOCHROME P450 3A5; GLUTATHIONE; HAPTEN; METHOXYAMINE; RUBBER; SULFOXIDE; THIOCARBANILIDE; THIOUREA DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DERMATITIS; INCUBATION TEMPERATURE; LIQUID CHROMATOGRAPHY; LIVER MICROSOME; MASS SPECTROMETRY; MOUSE; NONHUMAN; SENSITIZATION; SKIN;

ANIMALS; BENZYLAMINES; CYTOCHROME P-450 ENZYME SYSTEM; DERMATITIS, ALLERGIC CONTACT; DISEASE MODELS, ANIMAL; GLUTATHIONE; HUMANS; HYDROXYLAMINES; ISOTHIOCYANATES; MICE; MICROSOMES, LIVER; PROTEIN BINDING; RUBBER; SKIN; THIOUREA;

MURINAE;

EID: 78651485313     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/tx100241z     Document Type: Article

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