-
1
-
-
27144488229
-
Novel role of p53 in maintaining mitochondrial genetic stability through interaction with DNA Pol gamma
-
Achanta G., Sasaki R., Feng L., Carew J.S., Lu W., Pelicano H., Keating M.J., Huang P. Novel role of p53 in maintaining mitochondrial genetic stability through interaction with DNA Pol gamma. EMBO J. 2005, 24:3482-3492.
-
(2005)
EMBO J.
, vol.24
, pp. 3482-3492
-
-
Achanta, G.1
Sasaki, R.2
Feng, L.3
Carew, J.S.4
Lu, W.5
Pelicano, H.6
Keating, M.J.7
Huang, P.8
-
2
-
-
84855417557
-
Somatic progenitor cell vulnerability to mitochondrial DNA mutagenesis underlies progeroid phenotypes in Polg mutator mice
-
Ahlqvist K.J., Hamalainen R.H., Yatsuga S., Uutela M., Terzioglu M., Gotz A., Forsstrom S., Salven P., Angers-Loustau A., Kopra O.H., Tyynismaa H., Larsson N.G., Wartiovaara K., Prolla T., Trifunovic A., Suomalainen A. Somatic progenitor cell vulnerability to mitochondrial DNA mutagenesis underlies progeroid phenotypes in Polg mutator mice. Cell Metab. 2012, 15:100-109.
-
(2012)
Cell Metab.
, vol.15
, pp. 100-109
-
-
Ahlqvist, K.J.1
Hamalainen, R.H.2
Yatsuga, S.3
Uutela, M.4
Terzioglu, M.5
Gotz, A.6
Forsstrom, S.7
Salven, P.8
Angers-Loustau, A.9
Kopra, O.H.10
Tyynismaa, H.11
Larsson, N.G.12
Wartiovaara, K.13
Prolla, T.14
Trifunovic, A.15
Suomalainen, A.16
-
3
-
-
43149087522
-
Telomerase does not counteract telomere shortening but protects mitochondrial function under oxidative stress
-
Ahmed S., Passos J.F., Birket M.J., Beckmann T., Brings S., Peters H., Birch-Machin M.A., von Zglinicki T., Saretzki G. Telomerase does not counteract telomere shortening but protects mitochondrial function under oxidative stress. J. Cell Sci. 2008, 121:1046-1053.
-
(2008)
J. Cell Sci.
, vol.121
, pp. 1046-1053
-
-
Ahmed, S.1
Passos, J.F.2
Birket, M.J.3
Beckmann, T.4
Brings, S.5
Peters, H.6
Birch-Machin, M.A.7
von Zglinicki, T.8
Saretzki, G.9
-
4
-
-
0037471674
-
The function of genomes in bioenergetic organelles
-
(discussion 37-18)
-
Allen J.F. The function of genomes in bioenergetic organelles. Philos. Trans. R. Soc. London, Ser. B: Biol. Sci. 2003, 358:19-37. (discussion 37-18).
-
(2003)
Philos. Trans. R. Soc. London, Ser. B: Biol. Sci.
, vol.358
, pp. 19-37
-
-
Allen, J.F.1
-
5
-
-
0026460896
-
Telomere length predicts replicative capacity of human fibroblasts
-
Allsopp R.C., Vaziri H., Patterson C., Goldstein S., Younglai E.V., Futcher A.B., Greider C.W., Harley C.B. Telomere length predicts replicative capacity of human fibroblasts. Proc. Nat. Acad. Sci. U.S.A. 1992, 89:10114-10118.
-
(1992)
Proc. Nat. Acad. Sci. U.S.A.
, vol.89
, pp. 10114-10118
-
-
Allsopp, R.C.1
Vaziri, H.2
Patterson, C.3
Goldstein, S.4
Younglai, E.V.5
Futcher, A.B.6
Greider, C.W.7
Harley, C.B.8
-
6
-
-
79953735503
-
Ultra-deep sequencing of mouse mitochondrial DNA: mutational patterns and their origins
-
Ameur A., Stewart J.B., Freyer C., Hagstrom E., Ingman M., Larsson N.G., Gyllensten U. Ultra-deep sequencing of mouse mitochondrial DNA: mutational patterns and their origins. PLoS Genet. 2011, 7:e1002028.
-
(2011)
PLoS Genet.
, vol.7
-
-
Ameur, A.1
Stewart, J.B.2
Freyer, C.3
Hagstrom, E.4
Ingman, M.5
Larsson, N.G.6
Gyllensten, U.7
-
7
-
-
0344809962
-
Glutamine, as a precursor of glutathione, and oxidative stress
-
Amores-Sanchez M.I., Medina M.A. Glutamine, as a precursor of glutathione, and oxidative stress. Mol. Genet. Metab. 1999, 67:100-105.
-
(1999)
Mol. Genet. Metab.
, vol.67
, pp. 100-105
-
-
Amores-Sanchez, M.I.1
Medina, M.A.2
-
8
-
-
84871320315
-
P53 orchestrates the PGC-1alpha-mediated antioxidant response upon mild redox and metabolic imbalance
-
Aquilano K., Baldelli S., Pagliei B., Cannata S.M., Rotilio G., Ciriolo M.R. p53 orchestrates the PGC-1alpha-mediated antioxidant response upon mild redox and metabolic imbalance. Antioxid. Redox Signal. 2012, 18:386-399.
-
(2012)
Antioxid. Redox Signal.
, vol.18
, pp. 386-399
-
-
Aquilano, K.1
Baldelli, S.2
Pagliei, B.3
Cannata, S.M.4
Rotilio, G.5
Ciriolo, M.R.6
-
9
-
-
33745849998
-
The structure and function of telomerase reverse transcriptase
-
Autexier C., Lue N.F. The structure and function of telomerase reverse transcriptase. Annu. Rev. Biochem. 2006, 75:493-517.
-
(2006)
Annu. Rev. Biochem.
, vol.75
, pp. 493-517
-
-
Autexier, C.1
Lue, N.F.2
-
10
-
-
79960140833
-
MiR-335 and miR-34a Promote renal senescence by suppressing mitochondrial antioxidative enzymes
-
Bai X.Y., Ma Y., Ding R., Fu B., Shi S., Chen X.M. miR-335 and miR-34a Promote renal senescence by suppressing mitochondrial antioxidative enzymes. J. Am. Soc. Nephrol. 2011, 22:1252-1261.
-
(2011)
J. Am. Soc. Nephrol.
, vol.22
, pp. 1252-1261
-
-
Bai, X.Y.1
Ma, Y.2
Ding, R.3
Fu, B.4
Shi, S.5
Chen, X.M.6
-
11
-
-
80855138775
-
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
-
Baker D.J., Wijshake T., Tchkonia T., LeBrasseur N.K., Childs B.G., van de Sluis B., Kirkland J.L., van Deursen J.M. Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders. Nature 2011, 479:232-236.
-
(2011)
Nature
, vol.479
, pp. 232-236
-
-
Baker, D.J.1
Wijshake, T.2
Tchkonia, T.3
LeBrasseur, N.K.4
Childs, B.G.5
van de Sluis, B.6
Kirkland, J.L.7
van Deursen, J.M.8
-
12
-
-
0034850266
-
Exonucleolytic proofreading by p53 protein
-
Bakhanashvili M. Exonucleolytic proofreading by p53 protein. Eur. J. Biochem. 2001, 268:2047-2054.
-
(2001)
Eur. J. Biochem.
, vol.268
, pp. 2047-2054
-
-
Bakhanashvili, M.1
-
13
-
-
67649647889
-
Excision of nucleoside analogs in mitochondria by p53 protein
-
Bakhanashvili M., Grinberg S., Bonda E., Rahav G. Excision of nucleoside analogs in mitochondria by p53 protein. AIDS 2009, 23:779-788.
-
(2009)
AIDS
, vol.23
, pp. 779-788
-
-
Bakhanashvili, M.1
Grinberg, S.2
Bonda, E.3
Rahav, G.4
-
14
-
-
79958737573
-
Nuclear outsourcing of RNA interference components to human mitochondria
-
Bandiera S., Ruberg S., Girard M., Cagnard N., Hanein S., Chretien D., Munnich A., Lyonnet S., Henrion-Caude A. Nuclear outsourcing of RNA interference components to human mitochondria. PLoS One 2011, 6:e20746.
-
(2011)
PLoS One
, vol.6
-
-
Bandiera, S.1
Ruberg, S.2
Girard, M.3
Cagnard, N.4
Hanein, S.5
Chretien, D.6
Munnich, A.7
Lyonnet, S.8
Henrion-Caude, A.9
-
15
-
-
0025309791
-
Mitochondrial mutations may increase oxidative stress: Implications for carcinogenesis and aging?
-
Bandy B., Davison A.J. Mitochondrial mutations may increase oxidative stress: implications for carcinogenesis and aging?. Free Radical Biol. Med. 1990, 8:523-539.
-
(1990)
Free Radical Biol. Med.
, vol.8
, pp. 523-539
-
-
Bandy, B.1
Davison, A.J.2
-
16
-
-
67649829751
-
A metabolic and functional overview of brain aging linked to neurological disorders
-
Baquer N.Z., Taha A., Kumar P., McLean P., Cowsik S.M., Kale R.K., Singh R., Sharma D. A metabolic and functional overview of brain aging linked to neurological disorders. Biogerontology 2009, 10:377-413.
-
(2009)
Biogerontology
, vol.10
, pp. 377-413
-
-
Baquer, N.Z.1
Taha, A.2
Kumar, P.3
McLean, P.4
Cowsik, S.M.5
Kale, R.K.6
Singh, R.7
Sharma, D.8
-
17
-
-
84857288275
-
Reactive oxygen species in skeletal muscle signaling
-
Barbieri E., Sestili P. Reactive oxygen species in skeletal muscle signaling. J. Signal Transduction 2012, 2012:982794.
-
(2012)
J. Signal Transduction
, vol.2012
, pp. 982794
-
-
Barbieri, E.1
Sestili, P.2
-
18
-
-
84885217983
-
Updating the mitochondrial free radical theory of aging: an integrated view, key aspects, and confounding concepts
-
Barja G. Updating the mitochondrial free radical theory of aging: an integrated view, key aspects, and confounding concepts. Antioxid. Redox Signal. 2013, 19:1420-1445.
-
(2013)
Antioxid. Redox Signal.
, vol.19
, pp. 1420-1445
-
-
Barja, G.1
-
19
-
-
0033972463
-
Oxidative damage to mitochondrial DNA is inversely related to maximum life span in the heart and brain of mammals
-
Barja G., Herrero A. Oxidative damage to mitochondrial DNA is inversely related to maximum life span in the heart and brain of mammals. FASEB J. 2000, 14:312-318.
-
(2000)
FASEB J.
, vol.14
, pp. 312-318
-
-
Barja, G.1
Herrero, A.2
-
20
-
-
79957575344
-
Pre-microRNA and mature microRNA in human mitochondria
-
Barrey E., Saint-Auret G., Bonnamy B., Damas D., Boyer O., Gidrol X. Pre-microRNA and mature microRNA in human mitochondria. PLoS One 2011, 6:e20220.
-
(2011)
PLoS One
, vol.6
-
-
Barrey, E.1
Saint-Auret, G.2
Bonnamy, B.3
Damas, D.4
Boyer, O.5
Gidrol, X.6
-
21
-
-
84857353838
-
Global DNA methylation levels are modulated by mitochondrial DNA variants
-
Bellizzi D., D'Aquila P., Giordano M., Montesanto A., Passarino G. Global DNA methylation levels are modulated by mitochondrial DNA variants. Epigenomics 2012, 4:17-27.
-
(2012)
Epigenomics
, vol.4
, pp. 17-27
-
-
Bellizzi, D.1
D'Aquila, P.2
Giordano, M.3
Montesanto, A.4
Passarino, G.5
-
22
-
-
84882889657
-
The control region of mitochondrial DNA shows an unusual CpG and non-CpG methylation pattern
-
Bellizzi D., D'Aquila P., Scafone T., Giordano M., Riso V., Riccio A., Passarino G. The control region of mitochondrial DNA shows an unusual CpG and non-CpG methylation pattern. DNA Res. 2013, 20:537-547.
-
(2013)
DNA Res.
, vol.20
, pp. 537-547
-
-
Bellizzi, D.1
D'Aquila, P.2
Scafone, T.3
Giordano, M.4
Riso, V.5
Riccio, A.6
Passarino, G.7
-
23
-
-
33646375711
-
High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease
-
Bender A., Krishnan K.J., Morris C.M., Taylor G.A., Reeve A.K., Perry R.H., Jaros E., Hersheson J.S., Betts J., Klopstock T., Taylor R.W., Turnbull D.M. High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease. Nat. Genet. 2006, 38:515-517.
-
(2006)
Nat. Genet.
, vol.38
, pp. 515-517
-
-
Bender, A.1
Krishnan, K.J.2
Morris, C.M.3
Taylor, G.A.4
Reeve, A.K.5
Perry, R.H.6
Jaros, E.7
Hersheson, J.S.8
Betts, J.9
Klopstock, T.10
Taylor, R.W.11
Turnbull, D.M.12
-
24
-
-
84874700585
-
MicroRNA-34a regulates cardiac ageing and function
-
Boon R.A., Iekushi K., Lechner S., Seeger T., Fischer A., Heydt S., Kaluza D., Treguer K., Carmona G., Bonauer A., Horrevoets A.J., Didier N., Girmatsion Z., Biliczki P., Ehrlich J.R., Katus H.A., Muller O.J., Potente M., Zeiher A.M., Hermeking H., Dimmeler S. MicroRNA-34a regulates cardiac ageing and function. Nature 2013, 495:107-110.
-
(2013)
Nature
, vol.495
, pp. 107-110
-
-
Boon, R.A.1
Iekushi, K.2
Lechner, S.3
Seeger, T.4
Fischer, A.5
Heydt, S.6
Kaluza, D.7
Treguer, K.8
Carmona, G.9
Bonauer, A.10
Horrevoets, A.J.11
Didier, N.12
Girmatsion, Z.13
Biliczki, P.14
Ehrlich, J.R.15
Katus, H.A.16
Muller, O.J.17
Potente, M.18
Zeiher, A.M.19
Hermeking, H.20
Dimmeler, S.21
more..
-
26
-
-
84878097979
-
Effects of airborne pollutants on mitochondrial DNA methylation
-
Byun H.M., Panni T., Motta V., Hou L., Nordio F., Apostoli P., Bertazzi P.A., Baccarelli A.A. Effects of airborne pollutants on mitochondrial DNA methylation. Part. Fibre Toxicol. 2013, 10:18.
-
(2013)
Part. Fibre Toxicol.
, vol.10
, pp. 18
-
-
Byun, H.M.1
Panni, T.2
Motta, V.3
Hou, L.4
Nordio, F.5
Apostoli, P.6
Bertazzi, P.A.7
Baccarelli, A.A.8
-
27
-
-
70349478990
-
MicroRNA-210 controls mitochondrial metabolism during hypoxia by repressing the iron-sulfur cluster assembly proteins ISCU1/2
-
Chan S.Y., Zhang Y.Y., Hemann C., Mahoney C.E., Zweier J.L., Loscalzo J. MicroRNA-210 controls mitochondrial metabolism during hypoxia by repressing the iron-sulfur cluster assembly proteins ISCU1/2. Cell Metab. 2009, 10:273-284.
-
(2009)
Cell Metab.
, vol.10
, pp. 273-284
-
-
Chan, S.Y.1
Zhang, Y.Y.2
Hemann, C.3
Mahoney, C.E.4
Zweier, J.L.5
Loscalzo, J.6
-
28
-
-
0036316413
-
Age-dependent decline of DNA repair activity for oxidative lesions in rat brain mitochondria
-
Chen D., Cao G., Hastings T., Feng Y., Pei W., O'Horo C., Chen J. Age-dependent decline of DNA repair activity for oxidative lesions in rat brain mitochondria. J. Neurochem. 2002, 81:1273-1284.
-
(2002)
J. Neurochem.
, vol.81
, pp. 1273-1284
-
-
Chen, D.1
Cao, G.2
Hastings, T.3
Feng, Y.4
Pei, W.5
O'Horo, C.6
Chen, J.7
-
29
-
-
84866786229
-
Mitochondrial localization of telomeric protein TIN2 links telomere regulation to metabolic control
-
Chen L.Y., Zhang Y., Zhang Q., Li H., Luo Z., Fang H., Kim S.H., Qin L., Yotnda P., Xu J., Tu B.P., Bai Y., Songyang Z. Mitochondrial localization of telomeric protein TIN2 links telomere regulation to metabolic control. Mol. Cell 2011, 47:839-850.
-
(2011)
Mol. Cell
, vol.47
, pp. 839-850
-
-
Chen, L.Y.1
Zhang, Y.2
Zhang, Q.3
Li, H.4
Luo, Z.5
Fang, H.6
Kim, S.H.7
Qin, L.8
Yotnda, P.9
Xu, J.10
Tu, B.P.11
Bai, Y.12
Songyang, Z.13
-
30
-
-
77952474499
-
Glutathione S-transferase P1 (GSTP1) gene polymorphism increases age-related susceptibility to hepatocellular carcinoma
-
Chen Y.L., Tseng H.S., Kuo W.H., Yang S.F., Chen D.R., Tsai H.T. Glutathione S-transferase P1 (GSTP1) gene polymorphism increases age-related susceptibility to hepatocellular carcinoma. BMC Med. Genet. 2010, 11:46.
-
(2010)
BMC Med. Genet.
, vol.11
, pp. 46
-
-
Chen, Y.L.1
Tseng, H.S.2
Kuo, W.H.3
Yang, S.F.4
Chen, D.R.5
Tsai, H.T.6
-
31
-
-
38949156672
-
TERT promotes epithelial proliferation through transcriptional control of a Myc- and Wnt-related developmental program
-
Choi J., Southworth L.K., Sarin K.Y., Venteicher A.S., Ma W., Chang W., Cheung P., Jun S., Artandi M.K., Shah N., Kim S.K., Artandi S.E. TERT promotes epithelial proliferation through transcriptional control of a Myc- and Wnt-related developmental program. PLoS Genet. 2008, 4:e10.
-
(2008)
PLoS Genet.
, vol.4
-
-
Choi, J.1
Southworth, L.K.2
Sarin, K.Y.3
Venteicher, A.S.4
Ma, W.5
Chang, W.6
Cheung, P.7
Jun, S.8
Artandi, M.K.9
Shah, N.10
Kim, S.K.11
Artandi, S.E.12
-
32
-
-
84866239743
-
FOXO3 signalling links ATM to the p53 apoptotic pathway following DNA damage
-
Chung Y.M., Park S.H., Tsai W.B., Wang S.Y., Ikeda M.A., Berek J.S., Chen D.J., Hu M.C. FOXO3 signalling links ATM to the p53 apoptotic pathway following DNA damage. Nat. Commun. 2012, 3:1000.
-
(2012)
Nat. Commun.
, vol.3
, pp. 1000
-
-
Chung, Y.M.1
Park, S.H.2
Tsai, W.B.3
Wang, S.Y.4
Ikeda, M.A.5
Berek, J.S.6
Chen, D.J.7
Hu, M.C.8
-
33
-
-
0037007227
-
Mitochondria are morphologically and functionally heterogeneous within cells
-
Collins T.J., Berridge M.J., Lipp P., Bootman M.D. Mitochondria are morphologically and functionally heterogeneous within cells. EMBO J. 2002, 21:1616-1627.
-
(2002)
EMBO J.
, vol.21
, pp. 1616-1627
-
-
Collins, T.J.1
Berridge, M.J.2
Lipp, P.3
Bootman, M.D.4
-
34
-
-
33847752716
-
Mitochondrial function, fibre types and ageing: new insights from human muscle in vivo
-
Conley K.E., Amara C.E., Jubrias S.A., Marcinek D.J. Mitochondrial function, fibre types and ageing: new insights from human muscle in vivo. Exp. Physiol. 2007, 92:333-339.
-
(2007)
Exp. Physiol.
, vol.92
, pp. 333-339
-
-
Conley, K.E.1
Amara, C.E.2
Jubrias, S.A.3
Marcinek, D.J.4
-
36
-
-
0035943058
-
Mitochondrial enzyme-deficient hippocampal neurons and choroidal cells in AD
-
Cottrell D.A., Blakely E.L., Johnson M.A., Ince P.G., Turnbull D.M. Mitochondrial enzyme-deficient hippocampal neurons and choroidal cells in AD. Neurology 2001, 57:260-264.
-
(2001)
Neurology
, vol.57
, pp. 260-264
-
-
Cottrell, D.A.1
Blakely, E.L.2
Johnson, M.A.3
Ince, P.G.4
Turnbull, D.M.5
-
37
-
-
48149095839
-
Age-related decline in mitochondrial DNA copy number in isolated human pancreatic islets
-
Cree L.M., Patel S.K., Pyle A., Lynn S., Turnbull D.M., Chinnery P.F., Walker M. Age-related decline in mitochondrial DNA copy number in isolated human pancreatic islets. Diabetologia 2008, 51:1440-1443.
-
(2008)
Diabetologia
, vol.51
, pp. 1440-1443
-
-
Cree, L.M.1
Patel, S.K.2
Pyle, A.3
Lynn, S.4
Turnbull, D.M.5
Chinnery, P.F.6
Walker, M.7
-
38
-
-
45849099050
-
Living on a break: cellular senescence as a DNA-damage response
-
d'Adda di Fagagna F. Living on a break: cellular senescence as a DNA-damage response. Nat. Rev. Cancer 2008, 8:512-522.
-
(2008)
Nat. Rev. Cancer
, vol.8
, pp. 512-522
-
-
d'Adda di Fagagna, F.1
-
39
-
-
78049434938
-
Age-dependent cardiomyopathy in mitochondrial mutator mice is attenuated by overexpression of catalase targeted to mitochondria
-
Dai D.F., Chen T., Wanagat J., Laflamme M., Marcinek D.J., Emond M.J., Ngo C.P., Prolla T.A., Rabinovitch P.S. Age-dependent cardiomyopathy in mitochondrial mutator mice is attenuated by overexpression of catalase targeted to mitochondria. Aging Cell 2010, 9:536-544.
-
(2010)
Aging Cell
, vol.9
, pp. 536-544
-
-
Dai, D.F.1
Chen, T.2
Wanagat, J.3
Laflamme, M.4
Marcinek, D.J.5
Emond, M.J.6
Ngo, C.P.7
Prolla, T.A.8
Rabinovitch, P.S.9
-
40
-
-
84888250062
-
Recurrent tissue-specific mtDNA mutations are common in humans
-
David C.S., Chun L., Bingshan L., Zhuo S., Eric T., Hayley Boyd C., Antonis R., Tricia A.T.-W., Jason H.M., Tia M.H., Robert D.H., Jonathan L.H., Deborah G.M., Douglas P.M., Scott M.W. Recurrent tissue-specific mtDNA mutations are common in humans. PLoS Genet. 2013, 9.
-
(2013)
PLoS Genet.
, pp. 9
-
-
David, C.S.1
Chun, L.2
Bingshan, L.3
Zhuo, S.4
Eric, T.5
Hayley Boyd, C.6
Antonis, R.7
Tricia, A.T.-W.8
Jason, H.M.9
Tia, M.H.10
Robert, D.H.11
Jonathan, L.H.12
Deborah, G.M.13
Douglas, P.M.14
Scott, M.W.15
-
41
-
-
0032851615
-
Mitochondrial DNA inherited variants are associated with successful aging and longevity in humans
-
De Benedictis G., Rose G., Carrieri G., De Luca M., Falcone E., Passarino G., Bonafe M., Monti D., Baggio G., Bertolini S., Mari D., Mattace R., Franceschi C. Mitochondrial DNA inherited variants are associated with successful aging and longevity in humans. FASEB J. 1999, 13:1532-1536.
-
(1999)
FASEB J.
, vol.13
, pp. 1532-1536
-
-
De Benedictis, G.1
Rose, G.2
Carrieri, G.3
De Luca, M.4
Falcone, E.5
Passarino, G.6
Bonafe, M.7
Monti, D.8
Baggio, G.9
Bertolini, S.10
Mari, D.11
Mattace, R.12
Franceschi, C.13
-
42
-
-
24944460598
-
Shelterin: the protein complex that shapes and safeguards human telomeres
-
de Lange T. Shelterin: the protein complex that shapes and safeguards human telomeres. Genes Dev. 2005, 19:2100-2110.
-
(2005)
Genes Dev.
, vol.19
, pp. 2100-2110
-
-
de Lange, T.1
-
43
-
-
0035078395
-
Direct influence of the p53 tumor suppressor on mitochondrial biogenesis and function
-
Donahue R.J., Razmara M., Hoek J.B., Knudsen T.B. Direct influence of the p53 tumor suppressor on mitochondrial biogenesis and function. FASEB J. 2001, 15:635-644.
-
(2001)
FASEB J.
, vol.15
, pp. 635-644
-
-
Donahue, R.J.1
Razmara, M.2
Hoek, J.B.3
Knudsen, T.B.4
-
44
-
-
84874972344
-
Lamin B1 fluctuations have differential effects on cellular proliferation and senescence
-
Dreesen O., Chojnowski A., Ong P.F., Zhao T.Y., Common J.E., Lunny D., Lane E.B., Lee S.J., Vardy L.A., Stewart C.L., Colman A. Lamin B1 fluctuations have differential effects on cellular proliferation and senescence. J. Cell Biol. 2013, 200:605-617.
-
(2013)
J. Cell Biol.
, vol.200
, pp. 605-617
-
-
Dreesen, O.1
Chojnowski, A.2
Ong, P.F.3
Zhao, T.Y.4
Common, J.E.5
Lunny, D.6
Lane, E.B.7
Lee, S.J.8
Vardy, L.A.9
Stewart, C.L.10
Colman, A.11
-
45
-
-
0029878894
-
Defective repair of oxidative damage in the mitochondrial DNA of a xeroderma pigmentosum group A cell line
-
Driggers W.J., Grishko V.I., LeDoux S.P., Wilson G.L. Defective repair of oxidative damage in the mitochondrial DNA of a xeroderma pigmentosum group A cell line. Cancer Res. 1996, 56:1262-1266.
-
(1996)
Cancer Res.
, vol.56
, pp. 1262-1266
-
-
Driggers, W.J.1
Grishko, V.I.2
LeDoux, S.P.3
Wilson, G.L.4
-
46
-
-
68049115765
-
Random point mutations with major effects on protein-coding genes are the driving force behind premature aging in mtDNA mutator mice
-
Edgar D., Shabalina I., Camara Y., Wredenberg A., Calvaruso M.A., Nijtmans L., Nedergaard J., Cannon B., Larsson N.G., Trifunovic A. Random point mutations with major effects on protein-coding genes are the driving force behind premature aging in mtDNA mutator mice. Cell Metab. 2009, 10:131-138.
-
(2009)
Cell Metab.
, vol.10
, pp. 131-138
-
-
Edgar, D.1
Shabalina, I.2
Camara, Y.3
Wredenberg, A.4
Calvaruso, M.A.5
Nijtmans, L.6
Nedergaard, J.7
Cannon, B.8
Larsson, N.G.9
Trifunovic, A.10
-
47
-
-
84866363828
-
Mechanisms involved in the aging-induced vascular dysfunction
-
El Assar M., Angulo J., Vallejo S., Peiro C., Sanchez-Ferrer C.F., Rodriguez-Manas L. Mechanisms involved in the aging-induced vascular dysfunction. Front. Physiol. 2012, 3:132.
-
(2012)
Front. Physiol.
, vol.3
, pp. 132
-
-
El Assar, M.1
Angulo, J.2
Vallejo, S.3
Peiro, C.4
Sanchez-Ferrer, C.F.5
Rodriguez-Manas, L.6
-
48
-
-
0035097502
-
Random intracellular drift explains the clonal expansion of mitochondrial DNA mutations with age
-
Elson J.L., Samuels D.C., Turnbull D.M., Chinnery P.F. Random intracellular drift explains the clonal expansion of mitochondrial DNA mutations with age. Am. J. Hum. Genet. 2001, 68:802-806.
-
(2001)
Am. J. Hum. Genet.
, vol.68
, pp. 802-806
-
-
Elson, J.L.1
Samuels, D.C.2
Turnbull, D.M.3
Chinnery, P.F.4
-
49
-
-
84858153304
-
A set of miRNAs participates in the cellular senescence program in human diploid fibroblasts
-
Faraonio R., Salerno P., Passaro F., Sedia C., Iaccio A., Bellelli R., Nappi T.C., Comegna M., Romano S., Salvatore G., Santoro M., Cimino F. A set of miRNAs participates in the cellular senescence program in human diploid fibroblasts. Cell Death Differ. 2012, 19:713-721.
-
(2012)
Cell Death Differ.
, vol.19
, pp. 713-721
-
-
Faraonio, R.1
Salerno, P.2
Passaro, F.3
Sedia, C.4
Iaccio, A.5
Bellelli, R.6
Nappi, T.C.7
Comegna, M.8
Romano, S.9
Salvatore, G.10
Santoro, M.11
Cimino, F.12
-
50
-
-
47049119934
-
MicroRNA-210 modulates endothelial cell response to hypoxia and inhibits the receptor tyrosine kinase ligand Ephrin-A3
-
Fasanaro P., D'Alessandra Y., Di Stefano V., Melchionna R., Romani S., Pompilio G., Capogrossi M.C., Martelli F. MicroRNA-210 modulates endothelial cell response to hypoxia and inhibits the receptor tyrosine kinase ligand Ephrin-A3. J. Biol. Chem. 2008, 283:15878-15883.
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 15878-15883
-
-
Fasanaro, P.1
D'Alessandra, Y.2
Di Stefano, V.3
Melchionna, R.4
Romani, S.5
Pompilio, G.6
Capogrossi, M.C.7
Martelli, F.8
-
51
-
-
72049101201
-
MicroRNA: emerging therapeutic targets in acute ischemic diseases
-
Fasanaro P., Greco S., Ivan M., Capogrossi M.C., Martelli F. microRNA: emerging therapeutic targets in acute ischemic diseases. Pharmacol. Ther. 2010, 125:92-104.
-
(2010)
Pharmacol. Ther.
, vol.125
, pp. 92-104
-
-
Fasanaro, P.1
Greco, S.2
Ivan, M.3
Capogrossi, M.C.4
Martelli, F.5
-
52
-
-
0036258718
-
Ageing muscle: clonal expansions of mitochondrial DNA point mutations and deletions cause focal impairment of mitochondrial function
-
Fayet G., Jansson M., Sternberg D., Moslemi A.R., Blondy P., Lombes A., Fardeau M., Oldfors A. Ageing muscle: clonal expansions of mitochondrial DNA point mutations and deletions cause focal impairment of mitochondrial function. Neuromuscul. Disord. 2002, 12:484-493.
-
(2002)
Neuromuscul. Disord.
, vol.12
, pp. 484-493
-
-
Fayet, G.1
Jansson, M.2
Sternberg, D.3
Moslemi, A.R.4
Blondy, P.5
Lombes, A.6
Fardeau, M.7
Oldfors, A.8
-
53
-
-
34248194200
-
The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways
-
Feng Z., Hu W., de Stanchina E., Teresky A.K., Jin S., Lowe S., Levine A.J. The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways. Cancer Res. 2007, 67:3043-3053.
-
(2007)
Cancer Res.
, vol.67
, pp. 3043-3053
-
-
Feng, Z.1
Hu, W.2
de Stanchina, E.3
Teresky, A.K.4
Jin, S.5
Lowe, S.6
Levine, A.J.7
-
54
-
-
81255143302
-
MicroRNA-101 is a potent inhibitor of autophagy
-
Frankel L.B., Wen J., Lees M., Hoyer-Hansen M., Farkas T., Krogh A., Jaattela M., Lund A.H. microRNA-101 is a potent inhibitor of autophagy. EMBO J. 2011, 30:4628-4641.
-
(2011)
EMBO J.
, vol.30
, pp. 4628-4641
-
-
Frankel, L.B.1
Wen, J.2
Lees, M.3
Hoyer-Hansen, M.4
Farkas, T.5
Krogh, A.6
Jaattela, M.7
Lund, A.H.8
-
55
-
-
64749116346
-
C-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism
-
Gao P., Tchernyshyov I., Chang T.C., Lee Y.S., Kita K., Ochi T., Zeller K.I., De Marzo A.M., Van Eyk J.E., Mendell J.T., Dang C.V. c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism. Nature 2009, 458:762-765.
-
(2009)
Nature
, vol.458
, pp. 762-765
-
-
Gao, P.1
Tchernyshyov, I.2
Chang, T.C.3
Lee, Y.S.4
Kita, K.5
Ochi, T.6
Zeller, K.I.7
De Marzo, A.M.8
Van Eyk, J.E.9
Mendell, J.T.10
Dang, C.V.11
-
56
-
-
0036021375
-
Genetic analysis of tissue aging in Caenorhabditis elegans: a role for heat-shock factor and bacterial proliferation
-
Garigan D., Hsu A.L., Fraser A.G., Kamath R.S., Ahringer J., Kenyon C. Genetic analysis of tissue aging in Caenorhabditis elegans: a role for heat-shock factor and bacterial proliferation. Genetics 2002, 161:1101-1112.
-
(2002)
Genetics
, vol.161
, pp. 1101-1112
-
-
Garigan, D.1
Hsu, A.L.2
Fraser, A.G.3
Kamath, R.S.4
Ahringer, J.5
Kenyon, C.6
-
57
-
-
79957595545
-
The emerging role of telomerase reverse transcriptase in mitochondrial DNA metabolism
-
Gordon D.M., Santos J.H. The emerging role of telomerase reverse transcriptase in mitochondrial DNA metabolism. J. Nucleic Acids 2010, 2010.
-
(2010)
J. Nucleic Acids
, pp. 2010
-
-
Gordon, D.M.1
Santos, J.H.2
-
58
-
-
65949083750
-
Cytoplasmic functions of the tumour suppressor p53
-
Green D.R., Kroemer G. Cytoplasmic functions of the tumour suppressor p53. Nature 2009, 458:1127-1130.
-
(2009)
Nature
, vol.458
, pp. 1127-1130
-
-
Green, D.R.1
Kroemer, G.2
-
59
-
-
0033553455
-
Telomeres do D-loop-T-loop
-
Greider C.W. Telomeres do D-loop-T-loop. Cell 1999, 97:419-422.
-
(1999)
Cell
, vol.97
, pp. 419-422
-
-
Greider, C.W.1
-
60
-
-
84875687154
-
Identification of microRNA-mRNA functional interactions in UVB-induced senescence of human diploid fibroblasts
-
Greussing R., Hackl M., Charoentong P., Pauck A., Monteforte R., Cavinato M., Hofer E., Scheideler M., Neuhaus M., Micutkova L., Mueck C., Trajanoski Z., Grillari J., Jansen-Durr P. Identification of microRNA-mRNA functional interactions in UVB-induced senescence of human diploid fibroblasts. BMC Genomics 2013, 14:224.
-
(2013)
BMC Genomics
, vol.14
, pp. 224
-
-
Greussing, R.1
Hackl, M.2
Charoentong, P.3
Pauck, A.4
Monteforte, R.5
Cavinato, M.6
Hofer, E.7
Scheideler, M.8
Neuhaus, M.9
Micutkova, L.10
Mueck, C.11
Trajanoski, Z.12
Grillari, J.13
Jansen-Durr, P.14
-
61
-
-
0033553536
-
Mammalian telomeres end in a large duplex loop
-
Griffith J.D., Comeau L., Rosenfield S., Stansel R.M., Bianchi A., Moss H., de Lange T. Mammalian telomeres end in a large duplex loop. Cell 1999, 97:503-514.
-
(1999)
Cell
, vol.97
, pp. 503-514
-
-
Griffith, J.D.1
Comeau, L.2
Rosenfield, S.3
Stansel, R.M.4
Bianchi, A.5
Moss, H.6
de Lange, T.7
-
62
-
-
66349130192
-
Mitochondrial telomerase reverse transcriptase binds to and protects mitochondrial DNA and function from damage
-
Haendeler J., Drose S., Buchner N., Jakob S., Altschmied J., Goy C., Spyridopoulos I., Zeiher A.M., Brandt U., Dimmeler S. Mitochondrial telomerase reverse transcriptase binds to and protects mitochondrial DNA and function from damage. Arterioscler. Thromb. Vasc. Biol. 2009, 29:929-935.
-
(2009)
Arterioscler. Thromb. Vasc. Biol.
, vol.29
, pp. 929-935
-
-
Haendeler, J.1
Drose, S.2
Buchner, N.3
Jakob, S.4
Altschmied, J.5
Goy, C.6
Spyridopoulos, I.7
Zeiher, A.M.8
Brandt, U.9
Dimmeler, S.10
-
63
-
-
0038721199
-
Hydrogen peroxide triggers nuclear export of telomerase reverse transcriptase via Src kinase family-dependent phosphorylation of tyrosine 707
-
Haendeler J., Hoffmann J., Brandes R.P., Zeiher A.M., Dimmeler S. Hydrogen peroxide triggers nuclear export of telomerase reverse transcriptase via Src kinase family-dependent phosphorylation of tyrosine 707. Mol. Cell. Biol. 2003, 23:4598-4610.
-
(2003)
Mol. Cell. Biol.
, vol.23
, pp. 4598-4610
-
-
Haendeler, J.1
Hoffmann, J.2
Brandes, R.P.3
Zeiher, A.M.4
Dimmeler, S.5
-
64
-
-
1842611977
-
Antioxidants inhibit nuclear export of telomerase reverse transcriptase and delay replicative senescence of endothelial cells
-
Haendeler J., Hoffmann J., Diehl J.F., Vasa M., Spyridopoulos I., Zeiher A.M., Dimmeler S. Antioxidants inhibit nuclear export of telomerase reverse transcriptase and delay replicative senescence of endothelial cells. Circ. Res. 2004, 94:768-775.
-
(2004)
Circ. Res.
, vol.94
, pp. 768-775
-
-
Haendeler, J.1
Hoffmann, J.2
Diehl, J.F.3
Vasa, M.4
Spyridopoulos, I.5
Zeiher, A.M.6
Dimmeler, S.7
-
65
-
-
77049308856
-
Aging: a theory based on free radical and radiation chemistry
-
Harman D. Aging: a theory based on free radical and radiation chemistry. J. Gerontol. 1956, 11:298-300.
-
(1956)
J. Gerontol.
, vol.11
, pp. 298-300
-
-
Harman, D.1
-
66
-
-
0344622606
-
The serial cultivation of human diploid cell strains
-
Hayflick L., Moorhead P.S. The serial cultivation of human diploid cell strains. Exp. Cell Res. 1961, 25:585-621.
-
(1961)
Exp. Cell Res.
, vol.25
, pp. 585-621
-
-
Hayflick, L.1
Moorhead, P.S.2
-
67
-
-
18344365862
-
Induction of p21 by p53 following DNA damage inhibits both Cdk4 and Cdk2 activities
-
He G., Siddik Z.H., Huang Z., Wang R., Koomen J., Kobayashi R., Khokhar A.R., Kuang J. Induction of p21 by p53 following DNA damage inhibits both Cdk4 and Cdk2 activities. Oncogene 2005, 24:2929-2943.
-
(2005)
Oncogene
, vol.24
, pp. 2929-2943
-
-
He, G.1
Siddik, Z.H.2
Huang, Z.3
Wang, R.4
Koomen, J.5
Kobayashi, R.6
Khokhar, A.R.7
Kuang, J.8
-
68
-
-
37049010980
-
The guardian's little helper: microRNAs in the p53 tumor suppressor network
-
He X., He L., Hannon G.J. The guardian's little helper: microRNAs in the p53 tumor suppressor network. Cancer Res. 2007, 67:11099-11101.
-
(2007)
Cancer Res.
, vol.67
, pp. 11099-11101
-
-
He, X.1
He, L.2
Hannon, G.J.3
-
69
-
-
84966335197
-
MtDNA content contributes to healthy aging in Chinese: a study from nonagenarians and centenarians
-
1779.e1-1779.e4
-
He Y.-H., Lu X., Wu H., Cai W.-W., Yang L.-Q., Xu L.-Y., Sun H.-P., Kong Q.-P. MtDNA content contributes to healthy aging in Chinese: a study from nonagenarians and centenarians. Neurobiol. Aging 2014, 35:1779.e1-1779.e4.
-
(2014)
Neurobiol. Aging
, vol.35
-
-
He, Y.-H.1
Lu, X.2
Wu, H.3
Cai, W.-W.4
Yang, L.-Q.5
Xu, L.-Y.6
Sun, H.-P.7
Kong, Q.-P.8
-
70
-
-
80053124673
-
Taking a "good" look at free radicals in the aging process
-
Hekimi S., Lapointe J., Wen Y. Taking a "good" look at free radicals in the aging process. Trends Cell Biol. 2011, 21:569-576.
-
(2011)
Trends Cell Biol.
, vol.21
, pp. 569-576
-
-
Hekimi, S.1
Lapointe, J.2
Wen, Y.3
-
71
-
-
9644277218
-
Identification of a putative p53 binding sequence within the human mitochondrial genome
-
Heyne K., Mannebach S., Wuertz E., Knaup K.X., Mahyar-Roemer M., Roemer K. Identification of a putative p53 binding sequence within the human mitochondrial genome. FEBS Lett. 2004, 578:198-202.
-
(2004)
FEBS Lett.
, vol.578
, pp. 198-202
-
-
Heyne, K.1
Mannebach, S.2
Wuertz, E.3
Knaup, K.X.4
Mahyar-Roemer, M.5
Roemer, K.6
-
72
-
-
0032560817
-
Excision of mismatched nucleotides from DNA: a potential mechanism for enhancing DNA replication fidelity by the wild-type p53 protein
-
Huang P. Excision of mismatched nucleotides from DNA: a potential mechanism for enhancing DNA replication fidelity by the wild-type p53 protein. Oncogene 1998, 17:261-270.
-
(1998)
Oncogene
, vol.17
, pp. 261-270
-
-
Huang, P.1
-
73
-
-
33744912521
-
Mitochondrial and nuclear DNA-repair capacity of various brain regions in mouse is altered in an age-dependent manner
-
Imam S.Z., Karahalil B., Hogue B.A., Souza-Pinto N.C., Bohr V.A. Mitochondrial and nuclear DNA-repair capacity of various brain regions in mouse is altered in an age-dependent manner. Neurobiol. Aging 2006, 27:1129-1136.
-
(2006)
Neurobiol. Aging
, vol.27
, pp. 1129-1136
-
-
Imam, S.Z.1
Karahalil, B.2
Hogue, B.A.3
Souza-Pinto, N.C.4
Bohr, V.A.5
-
74
-
-
35548965688
-
Molecular mechanisms involved in endothelial cell aging: role of telomerase reverse transcriptase
-
Jakob S., Haendeler J. Molecular mechanisms involved in endothelial cell aging: role of telomerase reverse transcriptase. Z. Gerontol. Geriatr. 2007, 40:334-338.
-
(2007)
Z. Gerontol. Geriatr.
, vol.40
, pp. 334-338
-
-
Jakob, S.1
Haendeler, J.2
-
75
-
-
33846090789
-
Accumulation of senescent cells in mitotic tissue of aging primates
-
Jeyapalan J.C., Ferreira M., Sedivy J.M., Herbig U. Accumulation of senescent cells in mitotic tissue of aging primates. Mech. Ageing Dev. 2007, 128:36-44.
-
(2007)
Mech. Ageing Dev.
, vol.128
, pp. 36-44
-
-
Jeyapalan, J.C.1
Ferreira, M.2
Sedivy, J.M.3
Herbig, U.4
-
76
-
-
84861322460
-
Modern biological theories of aging
-
Jin K. Modern biological theories of aging. Aging Dis. 2010, 1:72-74.
-
(2010)
Aging Dis.
, vol.1
, pp. 72-74
-
-
Jin, K.1
-
77
-
-
84861161954
-
Mitochondrial variability as a source of extrinsic cellular noise
-
Johnston I.G., Gaal B., Neves R.P., Enver T., Iborra F.J., Jones N.S. Mitochondrial variability as a source of extrinsic cellular noise. PLoS Comput. Biol. 2012, 8:e1002416.
-
(2012)
PLoS Comput. Biol.
, vol.8
-
-
Johnston, I.G.1
Gaal, B.2
Neves, R.P.3
Enver, T.4
Iborra, F.J.5
Jones, N.S.6
-
78
-
-
84872574838
-
MicroRNA-22 (miR-22) overexpression is neuroprotective via general anti-apoptotic effects and may also target specific Huntington's disease-related mechanisms
-
Jovicic A., Zaldivar Jolissaint J.F., Moser R., Silva Santos Mde F., Luthi-Carter R. MicroRNA-22 (miR-22) overexpression is neuroprotective via general anti-apoptotic effects and may also target specific Huntington's disease-related mechanisms. PLoS One 2013, 8:e54222.
-
(2013)
PLoS One
, vol.8
-
-
Jovicic, A.1
Zaldivar Jolissaint, J.F.2
Moser, R.3
Silva Santos Mde, F.4
Luthi-Carter, R.5
-
79
-
-
84878011723
-
Mitochondrial CSA and CSB: protein interactions and protection from ageing associated DNA mutations
-
Kamenisch Y., Berneburg M. Mitochondrial CSA and CSB: protein interactions and protection from ageing associated DNA mutations. Mech Ageing Dev 2013, 134:270-274.
-
(2013)
Mech Ageing Dev
, vol.134
, pp. 270-274
-
-
Kamenisch, Y.1
Berneburg, M.2
-
80
-
-
77149172083
-
Proteins of nucleotide and base excision repair pathways interact in mitochondria to protect from loss of subcutaneous fat, a hallmark of aging
-
Kamenisch Y., Fousteri M., Knoch J., von Thaler A.K., Fehrenbacher B., Kato H., Becker T., Dolle M.E., Kuiper R., Majora M., Schaller M., van der Horst G.T., van Steeg H., Rocken M., Rapaport D., Krutmann J., Mullenders L.H., Berneburg M. Proteins of nucleotide and base excision repair pathways interact in mitochondria to protect from loss of subcutaneous fat, a hallmark of aging. J. Exp. Med. 2010, 207:379-390.
-
(2010)
J. Exp. Med.
, vol.207
, pp. 379-390
-
-
Kamenisch, Y.1
Fousteri, M.2
Knoch, J.3
von Thaler, A.K.4
Fehrenbacher, B.5
Kato, H.6
Becker, T.7
Dolle, M.E.8
Kuiper, R.9
Majora, M.10
Schaller, M.11
van der Horst, G.T.12
van Steeg, H.13
Rocken, M.14
Rapaport, D.15
Krutmann, J.16
Mullenders, L.H.17
Berneburg, M.18
-
81
-
-
79961194820
-
Autophagy impairment induces premature senescence in primary human fibroblasts
-
Kang H.T., Lee K.B., Kim S.Y., Choi H.R., Park S.C. Autophagy impairment induces premature senescence in primary human fibroblasts. PLoS One 2011, 6:e23367.
-
(2011)
PLoS One
, vol.6
-
-
Kang, H.T.1
Lee, K.B.2
Kim, S.Y.3
Choi, H.R.4
Park, S.C.5
-
82
-
-
0036904776
-
Base excision repair capacity in mitochondria and nuclei: tissue-specific variations
-
Karahalil B., Hogue B.A., de Souza-Pinto N.C., Bohr V.A. Base excision repair capacity in mitochondria and nuclei: tissue-specific variations. FASEB J. 2002, 16:1895-1902.
-
(2002)
FASEB J.
, vol.16
, pp. 1895-1902
-
-
Karahalil, B.1
Hogue, B.A.2
de Souza-Pinto, N.C.3
Bohr, V.A.4
-
83
-
-
36248965746
-
Mitochondrial gene expression and increased oxidative metabolism: role in increased lifespan of fat-specific insulin receptor knock-out mice
-
Katic M., Kennedy A.R., Leykin I., Norris A., McGettrick A., Gesta S., Russell S.J., Bluher M., Maratos-Flier E., Kahn C.R. Mitochondrial gene expression and increased oxidative metabolism: role in increased lifespan of fat-specific insulin receptor knock-out mice. Aging Cell 2007, 6:827-839.
-
(2007)
Aging Cell
, vol.6
, pp. 827-839
-
-
Katic, M.1
Kennedy, A.R.2
Leykin, I.3
Norris, A.4
McGettrick, A.5
Gesta, S.6
Russell, S.J.7
Bluher, M.8
Maratos-Flier, E.9
Kahn, C.R.10
-
85
-
-
84876441613
-
Mitochondrial matrix P53 sensitizes cells to oxidative stress
-
Koczor C.A., Torres R.A., Fields E.J., Boyd A., Lewis W. Mitochondrial matrix P53 sensitizes cells to oxidative stress. Mitochondrion 2013, 13:277-281.
-
(2013)
Mitochondrion
, vol.13
, pp. 277-281
-
-
Koczor, C.A.1
Torres, R.A.2
Fields, E.J.3
Boyd, A.4
Lewis, W.5
-
86
-
-
33646800306
-
Loss of autophagy in the central nervous system causes neurodegeneration in mice
-
Komatsu M., Waguri S., Chiba T., Murata S., Iwata J., Tanida I., Ueno T., Koike M., Uchiyama Y., Kominami E., Tanaka K. Loss of autophagy in the central nervous system causes neurodegeneration in mice. Nature 2006, 441:880-884.
-
(2006)
Nature
, vol.441
, pp. 880-884
-
-
Komatsu, M.1
Waguri, S.2
Chiba, T.3
Murata, S.4
Iwata, J.5
Tanida, I.6
Ueno, T.7
Koike, M.8
Uchiyama, Y.9
Kominami, E.10
Tanaka, K.11
-
87
-
-
84879985879
-
Telomere shortening in human diseases
-
Kong C.M., Lee X.W., Wang X. Telomere shortening in human diseases. FEBS J. 2013, 280:3180-3193.
-
(2013)
FEBS J.
, vol.280
, pp. 3180-3193
-
-
Kong, C.M.1
Lee, X.W.2
Wang, X.3
-
88
-
-
77955747085
-
The choice between p53-induced senescence and quiescence is determined in part by the mTOR pathway
-
Korotchkina L.G., Leontieva O.V., Bukreeva E.I., Demidenko Z.N., Gudkov A.V., Blagosklonny M.V. The choice between p53-induced senescence and quiescence is determined in part by the mTOR pathway. Aging (Albany, NY) 2010, 2:344-352.
-
(2010)
Aging (Albany, NY)
, vol.2
, pp. 344-352
-
-
Korotchkina, L.G.1
Leontieva, O.V.2
Bukreeva, E.I.3
Demidenko, Z.N.4
Gudkov, A.V.5
Blagosklonny, M.V.6
-
89
-
-
77953256244
-
A mutant telomerase defective in nuclear-cytoplasmic shuttling fails to immortalize cells and is associated with mitochondrial dysfunction
-
Kovalenko O.A., Caron M.J., Ulema P., Medrano C., Thomas A.P., Kimura M., Bonini M.G., Herbig U., Santos J.H. A mutant telomerase defective in nuclear-cytoplasmic shuttling fails to immortalize cells and is associated with mitochondrial dysfunction. Aging Cell 2010, 9:203-219.
-
(2010)
Aging Cell
, vol.9
, pp. 203-219
-
-
Kovalenko, O.A.1
Caron, M.J.2
Ulema, P.3
Medrano, C.4
Thomas, A.P.5
Kimura, M.6
Bonini, M.G.7
Herbig, U.8
Santos, J.H.9
-
91
-
-
78349257844
-
The essence of senescence
-
Kuilman T., Michaloglou C., Mooi W.J., Peeper D.S. The essence of senescence. Genes Dev. 2010, 24:2463-2479.
-
(2010)
Genes Dev.
, vol.24
, pp. 2463-2479
-
-
Kuilman, T.1
Michaloglou, C.2
Mooi, W.J.3
Peeper, D.S.4
-
92
-
-
22344456832
-
Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging
-
Kujoth G.C., Hiona A., Pugh T.D., Someya S., Panzer K., Wohlgemuth S.E., Hofer T., Seo A.Y., Sullivan R., Jobling W.A., Morrow J.D., Van Remmen H., Sedivy J.M., Yamasoba T., Tanokura M., Weindruch R., Leeuwenburgh C., Prolla T.A. Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging. Science 2005, 309:481-484.
-
(2005)
Science
, vol.309
, pp. 481-484
-
-
Kujoth, G.C.1
Hiona, A.2
Pugh, T.D.3
Someya, S.4
Panzer, K.5
Wohlgemuth, S.E.6
Hofer, T.7
Seo, A.Y.8
Sullivan, R.9
Jobling, W.A.10
Morrow, J.D.11
Van Remmen, H.12
Sedivy, J.M.13
Yamasoba, T.14
Tanokura, M.15
Weindruch, R.16
Leeuwenburgh, C.17
Prolla, T.A.18
-
93
-
-
80955180548
-
Random mtDNA mutations modulate proliferation capacity in mouse embryonic fibroblasts
-
Kukat A., Edgar D., Bratic I., Maiti P., Trifunovic A. Random mtDNA mutations modulate proliferation capacity in mouse embryonic fibroblasts. Biochem. Biophys. Res. Commun. 2011, 409:394-399.
-
(2011)
Biochem. Biophys. Res. Commun.
, vol.409
, pp. 394-399
-
-
Kukat, A.1
Edgar, D.2
Bratic, I.3
Maiti, P.4
Trifunovic, A.5
-
94
-
-
66249086606
-
P53 regulates mtDNA copy number and mitocheckpoint pathway
-
Kulawiec M., Ayyasamy V., Singh K.K. p53 regulates mtDNA copy number and mitocheckpoint pathway. J. Carcinog. 2009, 8:8.
-
(2009)
J. Carcinog.
, vol.8
, pp. 8
-
-
Kulawiec, M.1
Ayyasamy, V.2
Singh, K.K.3
-
95
-
-
44849091255
-
Nutlin-3a activates p53 to both down-regulate inhibitor of growth 2 and up-regulate mir-34a, mir-34b, and mir-34c expression, and induce senescence
-
Kumamoto K., Spillare E.A., Fujita K., Horikawa I., Yamashita T., Appella E., Nagashima M., Takenoshita S., Yokota J., Harris C.C. Nutlin-3a activates p53 to both down-regulate inhibitor of growth 2 and up-regulate mir-34a, mir-34b, and mir-34c expression, and induce senescence. Cancer Res. 2008, 68:3193-3203.
-
(2008)
Cancer Res.
, vol.68
, pp. 3193-3203
-
-
Kumamoto, K.1
Spillare, E.A.2
Fujita, K.3
Horikawa, I.4
Yamashita, T.5
Appella, E.6
Nagashima, M.7
Takenoshita, S.8
Yokota, J.9
Harris, C.C.10
-
96
-
-
84877922143
-
The role of mitochondrial DNA mutations and free radicals in disease and ageing
-
Lagouge M., Larsson N.G. The role of mitochondrial DNA mutations and free radicals in disease and ageing. J. Intern. Med. 2013, 273:529-543.
-
(2013)
J. Intern. Med.
, vol.273
, pp. 529-543
-
-
Lagouge, M.1
Larsson, N.G.2
-
97
-
-
34548617735
-
Low rates of hydrogen peroxide production by isolated heart mitochondria associate with long maximum lifespan in vertebrate homeotherms
-
Lambert A.J., Boysen H.M., Buckingham J.A., Yang T., Podlutsky A., Austad S.N., Kunz T.H., Buffenstein R., Brand M.D. Low rates of hydrogen peroxide production by isolated heart mitochondria associate with long maximum lifespan in vertebrate homeotherms. Aging Cell 2007, 6:607-618.
-
(2007)
Aging Cell
, vol.6
, pp. 607-618
-
-
Lambert, A.J.1
Boysen, H.M.2
Buckingham, J.A.3
Yang, T.4
Podlutsky, A.5
Austad, S.N.6
Kunz, T.H.7
Buffenstein, R.8
Brand, M.D.9
-
98
-
-
84862296323
-
The might of microRNA in mitochondria
-
Latronico M.V., Condorelli G. The might of microRNA in mitochondria. Circ. Res. 2012, 110:1540-1542.
-
(2012)
Circ. Res.
, vol.110
, pp. 1540-1542
-
-
Latronico, M.V.1
Condorelli, G.2
-
99
-
-
65449137587
-
Loss of p53 causes mitochondrial DNA depletion and altered mitochondrial reactive oxygen species homeostasis
-
Lebedeva M.A., Eaton J.S., Shadel G.S. Loss of p53 causes mitochondrial DNA depletion and altered mitochondrial reactive oxygen species homeostasis. Biochim. Biophys. Acta 2009, 1787:328-334.
-
(2009)
Biochim. Biophys. Acta
, vol.1787
, pp. 328-334
-
-
Lebedeva, M.A.1
Eaton, J.S.2
Shadel, G.S.3
-
100
-
-
0141843656
-
The nuclear RNase III Drosha initiates microRNA processing
-
Lee Y., Ahn C., Han J., Choi H., Kim J., Yim J., Lee J., Provost P., Radmark O., Kim S., Kim V.N. The nuclear RNase III Drosha initiates microRNA processing. Nature 2003, 425:415-419.
-
(2003)
Nature
, vol.425
, pp. 415-419
-
-
Lee, Y.1
Ahn, C.2
Han, J.3
Choi, H.4
Kim, J.5
Yim, J.6
Lee, J.7
Provost, P.8
Radmark, O.9
Kim, S.10
Kim, V.N.11
-
101
-
-
0037009364
-
MicroRNA maturation: stepwise processing and subcellular localization
-
Lee Y., Jeon K., Lee J.T., Kim S., Kim V.N. MicroRNA maturation: stepwise processing and subcellular localization. EMBO J. 2002, 21:4663-4670.
-
(2002)
EMBO J.
, vol.21
, pp. 4663-4670
-
-
Lee, Y.1
Jeon, K.2
Lee, J.T.3
Kim, S.4
Kim, V.N.5
-
102
-
-
34147193472
-
Cell biology: autophagy and cancer
-
Levine B. Cell biology: autophagy and cancer. Nature 2007, 446:745-747.
-
(2007)
Nature
, vol.446
, pp. 745-747
-
-
Levine, B.1
-
103
-
-
79954592065
-
Up-regulation of key microRNAs, and inverse down-regulation of their predicted oxidative phosphorylation target genes, during aging in mouse brain
-
Li N., Bates D.J., An J., Terry D.A., Wang E. Up-regulation of key microRNAs, and inverse down-regulation of their predicted oxidative phosphorylation target genes, during aging in mouse brain. Neurobiol. Aging 2011, 32:944-955.
-
(2011)
Neurobiol. Aging
, vol.32
, pp. 944-955
-
-
Li, N.1
Bates, D.J.2
An, J.3
Terry, D.A.4
Wang, E.5
-
104
-
-
37048999377
-
Adaptor protein LAPF recruits phosphorylated p53 to lysosomes and triggers lysosomal destabilization in apoptosis
-
Li N., Zheng Y., Chen W., Wang C., Liu X., He W., Xu H., Cao X. Adaptor protein LAPF recruits phosphorylated p53 to lysosomes and triggers lysosomal destabilization in apoptosis. Cancer Res. 2007, 67:11176-11185.
-
(2007)
Cancer Res.
, vol.67
, pp. 11176-11185
-
-
Li, N.1
Zheng, Y.2
Chen, W.3
Wang, C.4
Liu, X.5
He, W.6
Xu, H.7
Cao, X.8
-
105
-
-
84857546393
-
Control of mitochondrial activity by miRNAs
-
Li P., Jiao J., Gao G., Prabhakar B.S. Control of mitochondrial activity by miRNAs. J. Cell. Biochem. 2012, 113:1104-1110.
-
(2012)
J. Cell. Biochem.
, vol.113
, pp. 1104-1110
-
-
Li, P.1
Jiao, J.2
Gao, G.3
Prabhakar, B.S.4
-
106
-
-
0036319021
-
Generation of reactive oxygen species by the mitochondrial electron transport chain
-
Liu Y., Fiskum G., Schubert D. Generation of reactive oxygen species by the mitochondrial electron transport chain. J. Neurochem. 2002, 80:780-787.
-
(2002)
J. Neurochem.
, vol.80
, pp. 780-787
-
-
Liu, Y.1
Fiskum, G.2
Schubert, D.3
-
107
-
-
0038451396
-
POT1 as a terminal transducer of TRF1 telomere length control
-
Loayza D., De Lange T. POT1 as a terminal transducer of TRF1 telomere length control. Nature 2003, 423:1013-1018.
-
(2003)
Nature
, vol.423
, pp. 1013-1018
-
-
Loayza, D.1
De Lange, T.2
-
108
-
-
84904988972
-
In vivo levels of mitochondrial hydrogen peroxide increase with age in mtDNA mutator mice
-
Logan A., Shabalina I.G., Prime T.A., Rogatti S., Kalinovich A.V., Hartley R.C., Budd R.C., Cannon B., Murphy M.P. In vivo levels of mitochondrial hydrogen peroxide increase with age in mtDNA mutator mice. Aging Cell 2014.
-
(2014)
Aging Cell
-
-
Logan, A.1
Shabalina, I.G.2
Prime, T.A.3
Rogatti, S.4
Kalinovich, A.V.5
Hartley, R.C.6
Budd, R.C.7
Cannon, B.8
Murphy, M.P.9
-
109
-
-
79151483332
-
MicroRNA-101 downregulates Alzheimer's amyloid-beta precursor protein levels in human cell cultures and is differentially expressed
-
Long J.M., Lahiri D.K. MicroRNA-101 downregulates Alzheimer's amyloid-beta precursor protein levels in human cell cultures and is differentially expressed. Biochem. Biophys. Res. Commun. 2012, 404:889-895.
-
(2012)
Biochem. Biophys. Res. Commun.
, vol.404
, pp. 889-895
-
-
Long, J.M.1
Lahiri, D.K.2
-
110
-
-
30844438338
-
Structural basis for double-stranded RNA processing by Dicer
-
Macrae I.J., Zhou K., Li F., Repic A., Brooks A.N., Cande W.Z., Adams P.D., Doudna J.A. Structural basis for double-stranded RNA processing by Dicer. Science 2006, 311:195-198.
-
(2006)
Science
, vol.311
, pp. 195-198
-
-
Macrae, I.J.1
Zhou, K.2
Li, F.3
Repic, A.4
Brooks, A.N.5
Cande, W.Z.6
Adams, P.D.7
Doudna, J.A.8
-
111
-
-
46649098396
-
Murine microRNAs implicated in liver functions and aging process
-
Maes O.C., An J., Sarojini H., Wang E. Murine microRNAs implicated in liver functions and aging process. Mech. Ageing Dev. 2008, 129:534-541.
-
(2008)
Mech. Ageing Dev.
, vol.129
, pp. 534-541
-
-
Maes, O.C.1
An, J.2
Sarojini, H.3
Wang, E.4
-
112
-
-
84883470325
-
Oxidative stress and microRNAs in vascular diseases
-
Magenta A., Greco S., Gaetano C., Martelli F. Oxidative stress and microRNAs in vascular diseases. Int. J. Mol. Sci. 2013, 14:17319-17346.
-
(2013)
Int. J. Mol. Sci.
, vol.14
, pp. 17319-17346
-
-
Magenta, A.1
Greco, S.2
Gaetano, C.3
Martelli, F.4
-
113
-
-
70249114371
-
An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA
-
Maida Y., Yasukawa M., Furuuchi M., Lassmann T., Possemato R., Okamoto N., Kasim V., Hayashizaki Y., Hahn W.C., Masutomi K. An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA. Nature 2009, 461:230-235.
-
(2009)
Nature
, vol.461
, pp. 230-235
-
-
Maida, Y.1
Yasukawa, M.2
Furuuchi, M.3
Lassmann, T.4
Possemato, R.5
Okamoto, N.6
Kasim, V.7
Hayashizaki, Y.8
Hahn, W.C.9
Masutomi, K.10
-
114
-
-
77951243028
-
Autophagy regulation by p53
-
Maiuri M.C., Galluzzi L., Morselli E., Kepp O., Malik S.A., Kroemer G. Autophagy regulation by p53. Curr. Opin. Cell Biol. 2010, 22:181-185.
-
(2010)
Curr. Opin. Cell Biol.
, vol.22
, pp. 181-185
-
-
Maiuri, M.C.1
Galluzzi, L.2
Morselli, E.3
Kepp, O.4
Malik, S.A.5
Kroemer, G.6
-
115
-
-
80054998743
-
Meta-analysis: glutathione-S-transferase allelic variants are associated with alcoholic liver disease
-
Marcos M., Pastor I., Chamorro A.J., Ciria-Abad S., Gonzalez-Sarmiento R., Laso F.J. Meta-analysis: glutathione-S-transferase allelic variants are associated with alcoholic liver disease. Aliment. Pharmacol. Ther. 2011, 34:1159-1172.
-
(2011)
Aliment. Pharmacol. Ther.
, vol.34
, pp. 1159-1172
-
-
Marcos, M.1
Pastor, I.2
Chamorro, A.J.3
Ciria-Abad, S.4
Gonzalez-Sarmiento, R.5
Laso, F.J.6
-
116
-
-
84867089289
-
Engineering of blended nanoparticle platform for delivery of mitochondria-acting therapeutics
-
Marrache S., Dhar S. Engineering of blended nanoparticle platform for delivery of mitochondria-acting therapeutics. Proc. Nat. Acad. Sci. U.S.A. 2012, 109:16288-16293.
-
(2012)
Proc. Nat. Acad. Sci. U.S.A.
, vol.109
, pp. 16288-16293
-
-
Marrache, S.1
Dhar, S.2
-
117
-
-
2342435511
-
Stochastic variation in telomere shortening rate causes heterogeneity of human fibroblast replicative life span
-
Martin-Ruiz C., Saretzki G., Petrie J., Ladhoff J., Jeyapalan J., Wei W., Sedivy J., von Zglinicki T. Stochastic variation in telomere shortening rate causes heterogeneity of human fibroblast replicative life span. J. Biol. Chem. 2004, 279:17826-17833.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 17826-17833
-
-
Martin-Ruiz, C.1
Saretzki, G.2
Petrie, J.3
Ladhoff, J.4
Jeyapalan, J.5
Wei, W.6
Sedivy, J.7
von Zglinicki, T.8
-
118
-
-
77955173402
-
Mammalian Rap1 controls telomere function and gene expression through binding to telomeric and extratelomeric sites
-
Martinez P., Thanasoula M., Carlos A.R., Gomez-Lopez G., Tejera A.M., Schoeftner S., Dominguez O., Pisano D.G., Tarsounas M., Blasco M.A. Mammalian Rap1 controls telomere function and gene expression through binding to telomeric and extratelomeric sites. Nat. Cell Biol. 2010, 12:768-780.
-
(2010)
Nat. Cell Biol.
, vol.12
, pp. 768-780
-
-
Martinez, P.1
Thanasoula, M.2
Carlos, A.R.3
Gomez-Lopez, G.4
Tejera, A.M.5
Schoeftner, S.6
Dominguez, O.7
Pisano, D.G.8
Tarsounas, M.9
Blasco, M.A.10
-
119
-
-
20444371017
-
The telomerase reverse transcriptase regulates chromatin state and DNA damage responses
-
Masutomi K., Possemato R., Wong J.M., Currier J.L., Tothova Z., Manola J.B., Ganesan S., Lansdorp P.M., Collins K., Hahn W.C. The telomerase reverse transcriptase regulates chromatin state and DNA damage responses. Proc. Nat. Acad. Sci. U.S.A. 2005, 102:8222-8227.
-
(2005)
Proc. Nat. Acad. Sci. U.S.A.
, vol.102
, pp. 8222-8227
-
-
Masutomi, K.1
Possemato, R.2
Wong, J.M.3
Currier, J.L.4
Tothova, Z.5
Manola, J.B.6
Ganesan, S.7
Lansdorp, P.M.8
Collins, K.9
Hahn, W.C.10
-
120
-
-
33745149291
-
P53 regulates mitochondrial respiration
-
Matoba S., Kang J.G., Patino W.D., Wragg A., Boehm M., Gavrilova O., Hurley P.J., Bunz F., Hwang P.M. p53 regulates mitochondrial respiration. Science 2006, 312:1650-1653.
-
(2006)
Science
, vol.312
, pp. 1650-1653
-
-
Matoba, S.1
Kang, J.G.2
Patino, W.D.3
Wragg, A.4
Boehm, M.5
Gavrilova, O.6
Hurley, P.J.7
Bunz, F.8
Hwang, P.M.9
-
121
-
-
80052007901
-
The human mitochondrial transcriptome
-
Mercer T.R., Neph S., Dinger M.E., Crawford J., Smith M.A., Shearwood A.M., Haugen E., Bracken C.P., Rackham O., Stamatoyannopoulos J.A., Filipovska A., Mattick J.S. The human mitochondrial transcriptome. Cell 2011, 146:645-658.
-
(2011)
Cell
, vol.146
, pp. 645-658
-
-
Mercer, T.R.1
Neph, S.2
Dinger, M.E.3
Crawford, J.4
Smith, M.A.5
Shearwood, A.M.6
Haugen, E.7
Bracken, C.P.8
Rackham, O.9
Stamatoyannopoulos, J.A.10
Filipovska, A.11
Mattick, J.S.12
-
122
-
-
84859857694
-
VHL-regulated MiR-204 suppresses tumor growth through inhibition of LC3B-mediated autophagy in renal clear cell carcinoma
-
Mikhaylova O., Stratton Y., Hall D., Kellner E., Ehmer B., Drew A.F., Gallo C.A., Plas D.R., Biesiada J., Meller J., Czyzyk-Krzeska M.F. VHL-regulated MiR-204 suppresses tumor growth through inhibition of LC3B-mediated autophagy in renal clear cell carcinoma. Cancer Cell 2012, 21:532-546.
-
(2012)
Cancer Cell
, vol.21
, pp. 532-546
-
-
Mikhaylova, O.1
Stratton, Y.2
Hall, D.3
Kellner, E.4
Ehmer, B.5
Drew, A.F.6
Gallo, C.A.7
Plas, D.R.8
Biesiada, J.9
Meller, J.10
Czyzyk-Krzeska, M.F.11
-
123
-
-
33846121333
-
Vascular cell senescence: contribution to atherosclerosis
-
Minamino T., Komuro I. Vascular cell senescence: contribution to atherosclerosis. Circ. Res. 2007, 100:15-26.
-
(2007)
Circ. Res.
, vol.100
, pp. 15-26
-
-
Minamino, T.1
Komuro, I.2
-
124
-
-
53649086181
-
Mutant p53 protein localized in the cytoplasm inhibits autophagy
-
Morselli E., Tasdemir E., Maiuri M.C., Galluzzi L., Kepp O., Criollo A., Vicencio J.M., Soussi T., Kroemer G. Mutant p53 protein localized in the cytoplasm inhibits autophagy. Cell Cycle 2008, 7:3056-3061.
-
(2008)
Cell Cycle
, vol.7
, pp. 3056-3061
-
-
Morselli, E.1
Tasdemir, E.2
Maiuri, M.C.3
Galluzzi, L.4
Kepp, O.5
Criollo, A.6
Vicencio, J.M.7
Soussi, T.8
Kroemer, G.9
-
126
-
-
0024366601
-
Cytochrome-c-oxidase deficient cardiomyocytes in the human heart-an age-related phenomenon. A histochemical ultracytochemical study
-
Muller-Hocker J. Cytochrome-c-oxidase deficient cardiomyocytes in the human heart-an age-related phenomenon. A histochemical ultracytochemical study. Am. J. Pathol. 1989, 134:1167-1173.
-
(1989)
Am. J. Pathol.
, vol.134
, pp. 1167-1173
-
-
Muller-Hocker, J.1
-
127
-
-
0025673968
-
Cytochrome c oxidase deficient fibres in the limb muscle and diaphragm of man without muscular disease: an age-related alteration
-
Muller-Hocker J. Cytochrome c oxidase deficient fibres in the limb muscle and diaphragm of man without muscular disease: an age-related alteration. J. Neurol. Sci. 1990, 100:14-21.
-
(1990)
J. Neurol. Sci.
, vol.100
, pp. 14-21
-
-
Muller-Hocker, J.1
-
128
-
-
0030604728
-
P53 Protein exhibits 3'-to-5' exonuclease activity
-
Mummenbrauer T., Janus F., Muller B., Wiesmuller L., Deppert W., Grosse F. p53 Protein exhibits 3'-to-5' exonuclease activity. Cell 1996, 85:1089-1099.
-
(1996)
Cell
, vol.85
, pp. 1089-1099
-
-
Mummenbrauer, T.1
Janus, F.2
Muller, B.3
Wiesmuller, L.4
Deppert, W.5
Grosse, F.6
-
129
-
-
58249093939
-
How mitochondria produce reactive oxygen species
-
Murphy M.P. How mitochondria produce reactive oxygen species. Biochem. J. 2009, 417:1-13.
-
(2009)
Biochem. J.
, vol.417
, pp. 1-13
-
-
Murphy, M.P.1
-
130
-
-
33847059997
-
The mitochondrial energy transduction system and the aging process
-
Navarro A., Boveris A. The mitochondrial energy transduction system and the aging process. Am. J. Physiol. Cell Physiol. 2007, 292:C670-C686.
-
(2007)
Am. J. Physiol. Cell Physiol.
, vol.292
-
-
Navarro, A.1
Boveris, A.2
-
131
-
-
84871302192
-
Senescent cells: a novel therapeutic target for aging and age-related diseases
-
Naylor R.M., Baker D.J., van Deursen J.M. Senescent cells: a novel therapeutic target for aging and age-related diseases. Clin. Pharmacol. Ther. 2012, 93:105-116.
-
(2012)
Clin. Pharmacol. Ther.
, vol.93
, pp. 105-116
-
-
Naylor, R.M.1
Baker, D.J.2
van Deursen, J.M.3
-
132
-
-
79955698235
-
Accumulating mitochondrial DNA mutations drive premature hematopoietic aging phenotypes distinct from physiological stem cell aging
-
Norddahl G.L., Pronk C.J., Wahlestedt M., Sten G., Nygren J.M., Ugale A., Sigvardsson M., Bryder D. Accumulating mitochondrial DNA mutations drive premature hematopoietic aging phenotypes distinct from physiological stem cell aging. Cell Stem Cell 2011, 8:499-510.
-
(2011)
Cell Stem Cell
, vol.8
, pp. 499-510
-
-
Norddahl, G.L.1
Pronk, C.J.2
Wahlestedt, M.3
Sten, G.4
Nygren, J.M.5
Ugale, A.6
Sigvardsson, M.7
Bryder, D.8
-
133
-
-
70849126417
-
Telomeric armor: the layers of end protection
-
Oganesian L., Karlseder J. Telomeric armor: the layers of end protection. J. Cell Sci. 2009, 122:4013-4025.
-
(2009)
J. Cell Sci.
, vol.122
, pp. 4013-4025
-
-
Oganesian, L.1
Karlseder, J.2
-
134
-
-
84885228743
-
MiR-146a as marker of senescence-associated pro-inflammatory status in cells involved in vascular remodelling
-
Olivieri F., Lazzarini R., Recchioni R., Marcheselli F., Rippo M.R., Di Nuzzo S., Albertini M.C., Graciotti L., Babini L., Mariotti S., Spada G., Abbatecola A.M., Antonicelli R., Franceschi C., Procopio A.D. MiR-146a as marker of senescence-associated pro-inflammatory status in cells involved in vascular remodelling. Age (Dordr) 2012, 35:1157-1172.
-
(2012)
Age (Dordr)
, vol.35
, pp. 1157-1172
-
-
Olivieri, F.1
Lazzarini, R.2
Recchioni, R.3
Marcheselli, F.4
Rippo, M.R.5
Di Nuzzo, S.6
Albertini, M.C.7
Graciotti, L.8
Babini, L.9
Mariotti, S.10
Spada, G.11
Abbatecola, A.M.12
Antonicelli, R.13
Franceschi, C.14
Procopio, A.D.15
-
135
-
-
46249125488
-
How shelterin protects mammalian telomeres
-
Palm W., de Lange T. How shelterin protects mammalian telomeres. Annu. Rev. Genet. 2008, 42:301-334.
-
(2008)
Annu. Rev. Genet.
, vol.42
, pp. 301-334
-
-
Palm, W.1
de Lange, T.2
-
136
-
-
34249028642
-
Mitochondrial dysfunction accounts for the stochastic heterogeneity in telomere-dependent senescence
-
Passos J.F., Saretzki G., Ahmed S., Nelson G., Richter T., Peters H., Wappler I., Birket M.J., Harold G., Schaeuble K., Birch-Machin M.A., Kirkwood T.B., von Zglinicki T. Mitochondrial dysfunction accounts for the stochastic heterogeneity in telomere-dependent senescence. PLoS Biol. 2007, 5:e110.
-
(2007)
PLoS Biol.
, vol.5
-
-
Passos, J.F.1
Saretzki, G.2
Ahmed, S.3
Nelson, G.4
Richter, T.5
Peters, H.6
Wappler, I.7
Birket, M.J.8
Harold, G.9
Schaeuble, K.10
Birch-Machin, M.A.11
Kirkwood, T.B.12
von Zglinicki, T.13
-
137
-
-
52049089147
-
Mitochondrial dysfunction in rat brain with aging Involvement of complex I, reactive oxygen species and cardiolipin
-
Petrosillo G., Matera M., Casanova G., Ruggiero F.M., Paradies G. Mitochondrial dysfunction in rat brain with aging Involvement of complex I, reactive oxygen species and cardiolipin. Neurochem. Int. 2008, 53:126-131.
-
(2008)
Neurochem. Int.
, vol.53
, pp. 126-131
-
-
Petrosillo, G.1
Matera, M.2
Casanova, G.3
Ruggiero, F.M.4
Paradies, G.5
-
138
-
-
84878650485
-
Epigenetic modification of liver mitochondrial DNA is associated with histological severity of nonalcoholic fatty liver disease
-
Pirola C.J., Fernandez Gianotti T., Burgueno A.L., Rey-Funes M., Loidl C.F., Mallardi P., San Martino J., Castano G.O., Sookoian S. Epigenetic modification of liver mitochondrial DNA is associated with histological severity of nonalcoholic fatty liver disease. Gut 2012.
-
(2012)
Gut
-
-
Pirola, C.J.1
Fernandez Gianotti, T.2
Burgueno, A.L.3
Rey-Funes, M.4
Loidl, C.F.5
Mallardi, P.6
San Martino, J.7
Castano, G.O.8
Sookoian, S.9
-
139
-
-
34447118849
-
P53R2-dependent ribonucleotide reduction provides deoxyribonucleotides in quiescent human fibroblasts in the absence of induced DNA damage
-
Pontarin G., Ferraro P., Hakansson P., Thelander L., Reichard P., Bianchi V. p53R2-dependent ribonucleotide reduction provides deoxyribonucleotides in quiescent human fibroblasts in the absence of induced DNA damage. J. Biol. Chem. 2007, 282:16820-16828.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 16820-16828
-
-
Pontarin, G.1
Ferraro, P.2
Hakansson, P.3
Thelander, L.4
Reichard, P.5
Bianchi, V.6
-
140
-
-
79951678403
-
MiR-210 is overexpressed in late stages of lung cancer and mediates mitochondrial alterations associated with modulation of HIF-1 activity
-
Puissegur M.P., Mazure N.M., Bertero T., Pradelli L., Grosso S., Robbe-Sermesant K., Maurin T., Lebrigand K., Cardinaud B., Hofman V., Fourre S., Magnone V., Ricci J.E., Pouyssegur J., Gounon P., Hofman P., Barbry P., Mari B. miR-210 is overexpressed in late stages of lung cancer and mediates mitochondrial alterations associated with modulation of HIF-1 activity. Cell Death Differ. 2011, 18:465-478.
-
(2011)
Cell Death Differ.
, vol.18
, pp. 465-478
-
-
Puissegur, M.P.1
Mazure, N.M.2
Bertero, T.3
Pradelli, L.4
Grosso, S.5
Robbe-Sermesant, K.6
Maurin, T.7
Lebrigand, K.8
Cardinaud, B.9
Hofman, V.10
Fourre, S.11
Magnone, V.12
Ricci, J.E.13
Pouyssegur, J.14
Gounon, P.15
Hofman, P.16
Barbry, P.17
Mari, B.18
-
141
-
-
81755161589
-
Long noncoding RNAs are generated from the mitochondrial genome and regulated by nuclear-encoded proteins
-
Rackham O., Shearwood A.M., Mercer T.R., Davies S.M., Mattick J.S., Filipovska A. Long noncoding RNAs are generated from the mitochondrial genome and regulated by nuclear-encoded proteins. RNA 2011, 17:2085-2093.
-
(2011)
RNA
, vol.17
, pp. 2085-2093
-
-
Rackham, O.1
Shearwood, A.M.2
Mercer, T.R.3
Davies, S.M.4
Mattick, J.S.5
Filipovska, A.6
-
142
-
-
84901209263
-
The co-occurrence of mtDNA mutations on different oxidative phosphorylation subunits, not detected by haplogroup analysis, affects human longevity and is population specific
-
Raule N., Sevini F., Li S., Barbieri A., Tallaro F., Lomartire L., Vianello D., Montesanto A., Moilanen J.S., Bezrukov V., Blanche H., Hervonen A., Christensen K., Deiana L., Gonos E.S., Kirkwood T.B., Kristensen P., Leon A., Pelicci P.G., Poulain M., Rea I.M., Remacle J., Robine J.M., Schreiber S., Sikora E., Eline Slagboom P., Spazzafumo L., Antonietta Stazi M., Toussaint O., Vaupel J.W., Rose G., Majamaa K., Perola M., Johnson T.E., Bolund L., Yang H., Passarino G., Franceschi C. The co-occurrence of mtDNA mutations on different oxidative phosphorylation subunits, not detected by haplogroup analysis, affects human longevity and is population specific. Aging Cell 2013.
-
(2013)
Aging Cell
-
-
Raule, N.1
Sevini, F.2
Li, S.3
Barbieri, A.4
Tallaro, F.5
Lomartire, L.6
Vianello, D.7
Montesanto, A.8
Moilanen, J.S.9
Bezrukov, V.10
Blanche, H.11
Hervonen, A.12
Christensen, K.13
Deiana, L.14
Gonos, E.S.15
Kirkwood, T.B.16
Kristensen, P.17
Leon, A.18
Pelicci, P.G.19
Poulain, M.20
Rea, I.M.21
Remacle, J.22
Robine, J.M.23
Schreiber, S.24
Sikora, E.25
Eline Slagboom, P.26
Spazzafumo, L.27
Antonietta Stazi, M.28
Toussaint, O.29
Vaupel, J.W.30
Rose, G.31
Majamaa, K.32
Perola, M.33
Johnson, T.E.34
Bolund, L.35
Yang, H.36
Passarino, G.37
Franceschi, C.38
more..
-
143
-
-
79959350253
-
Extending life span by increasing oxidative stress
-
Ristow M., Schmeisser S. Extending life span by increasing oxidative stress. Free Radical Biol. Med. 2011, 51:327-336.
-
(2011)
Free Radical Biol. Med.
, vol.51
, pp. 327-336
-
-
Ristow, M.1
Schmeisser, S.2
-
144
-
-
84878692183
-
The mitochondrial genome encodes abundant small noncoding RNAs
-
Ro S., Ma H.Y., Park C., Ortogero N., Song R., Hennig G.W., Zheng H., Lin Y.M., Moro L., Hsieh J.T., Yan W. The mitochondrial genome encodes abundant small noncoding RNAs. Cell Res. 2013, 23:759-774.
-
(2013)
Cell Res.
, vol.23
, pp. 759-774
-
-
Ro, S.1
Ma, H.Y.2
Park, C.3
Ortogero, N.4
Song, R.5
Hennig, G.W.6
Zheng, H.7
Lin, Y.M.8
Moro, L.9
Hsieh, J.T.10
Yan, W.11
-
145
-
-
79951812916
-
Telomere dysfunction induces metabolic and mitochondrial compromise
-
Sahin E., Colla S., Liesa M., Moslehi J., Muller F.L., Guo M., Cooper M., Kotton D., Fabian A.J., Walkey C., Maser R.S., Tonon G., Foerster F., Xiong R., Wang Y.A., Shukla S.A., Jaskelioff M., Martin E.S., Heffernan T.P., Protopopov A., Ivanova E., Mahoney J.E., Kost-Alimova M., Perry S.R., Bronson R., Liao R., Mulligan R., Shirihai O.S., Chin L., DePinho R.A. Telomere dysfunction induces metabolic and mitochondrial compromise. Nature 2011, 470:359-365.
-
(2011)
Nature
, vol.470
, pp. 359-365
-
-
Sahin, E.1
Colla, S.2
Liesa, M.3
Moslehi, J.4
Muller, F.L.5
Guo, M.6
Cooper, M.7
Kotton, D.8
Fabian, A.J.9
Walkey, C.10
Maser, R.S.11
Tonon, G.12
Foerster, F.13
Xiong, R.14
Wang, Y.A.15
Shukla, S.A.16
Jaskelioff, M.17
Martin, E.S.18
Heffernan, T.P.19
Protopopov, A.20
Ivanova, E.21
Mahoney, J.E.22
Kost-Alimova, M.23
Perry, S.R.24
Bronson, R.25
Liao, R.26
Mulligan, R.27
Shirihai, O.S.28
Chin, L.29
DePinho, R.A.30
more..
-
146
-
-
0037066695
-
ATM mediates phosphorylation at multiple p53 sites, including Ser(46), in response to ionizing radiation
-
Saito S., Goodarzi A.A., Higashimoto Y., Noda Y., Lees-Miller S.P., Appella E., Anderson C.W. ATM mediates phosphorylation at multiple p53 sites, including Ser(46), in response to ionizing radiation. J. Biol. Chem. 2002, 277:12491-12494.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 12491-12494
-
-
Saito, S.1
Goodarzi, A.A.2
Higashimoto, Y.3
Noda, Y.4
Lees-Miller, S.P.5
Appella, E.6
Anderson, C.W.7
-
147
-
-
84880746018
-
Acute exercise induces tumour suppressor protein p53 translocation to the mitochondria and promotes a p53-Tfam-mitochondrial DNA complex in skeletal muscle
-
Saleem A., Hood D.A. Acute exercise induces tumour suppressor protein p53 translocation to the mitochondria and promotes a p53-Tfam-mitochondrial DNA complex in skeletal muscle. J. Physiol. 2013, 591:3625-3636.
-
(2013)
J. Physiol.
, vol.591
, pp. 3625-3636
-
-
Saleem, A.1
Hood, D.A.2
-
148
-
-
13844272923
-
Mitochondrial hTERT exacerbates free-radical-mediated mtDNA damage
-
Santos J.H., Meyer J.N., Skorvaga M., Annab L.A., Van Houten B. Mitochondrial hTERT exacerbates free-radical-mediated mtDNA damage. Aging Cell 2004, 3:399-411.
-
(2004)
Aging Cell
, vol.3
, pp. 399-411
-
-
Santos, J.H.1
Meyer, J.N.2
Skorvaga, M.3
Annab, L.A.4
Van Houten, B.5
-
149
-
-
33744745014
-
Mitochondrial localization of telomerase as a determinant for hydrogen peroxide-induced mitochondrial DNA damage and apoptosis
-
Santos J.H., Meyer J.N., Van Houten B. Mitochondrial localization of telomerase as a determinant for hydrogen peroxide-induced mitochondrial DNA damage and apoptosis. Hum. Mol. Genet. 2006, 15:1757-1768.
-
(2006)
Hum. Mol. Genet.
, vol.15
, pp. 1757-1768
-
-
Santos, J.H.1
Meyer, J.N.2
Van Houten, B.3
-
150
-
-
67650627734
-
Telomerase, mitochondria and oxidative stress
-
Saretzki G. Telomerase, mitochondria and oxidative stress. Exp. Gerontol. 2009, 44:485-492.
-
(2009)
Exp. Gerontol.
, vol.44
, pp. 485-492
-
-
Saretzki, G.1
-
151
-
-
23944516520
-
Conditional telomerase induction causes proliferation of hair follicle stem cells
-
Sarin K.Y., Cheung P., Gilison D., Lee E., Tennen R.I., Wang E., Artandi M.K., Oro A.E., Artandi S.E. Conditional telomerase induction causes proliferation of hair follicle stem cells. Nature 2005, 436:1048-1052.
-
(2005)
Nature
, vol.436
, pp. 1048-1052
-
-
Sarin, K.Y.1
Cheung, P.2
Gilison, D.3
Lee, E.4
Tennen, R.I.5
Wang, E.6
Artandi, M.K.7
Oro, A.E.8
Artandi, S.E.9
-
152
-
-
0037036115
-
Nuclear activators and coactivators in mammalian mitochondrial biogenesis
-
Scarpulla R.C. Nuclear activators and coactivators in mammalian mitochondrial biogenesis. Biochim. Biophys. Acta 2002, 1576:1-14.
-
(2002)
Biochim. Biophys. Acta
, vol.1576
, pp. 1-14
-
-
Scarpulla, R.C.1
-
153
-
-
42049114034
-
Transcriptional paradigms in mammalian mitochondrial biogenesis and function
-
Scarpulla R.C. Transcriptional paradigms in mammalian mitochondrial biogenesis and function. Physiol. Rev. 2008, 88:611-638.
-
(2008)
Physiol. Rev.
, vol.88
, pp. 611-638
-
-
Scarpulla, R.C.1
-
154
-
-
79957960940
-
Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network
-
Scarpulla R.C. Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network. Biochim. Biophys. Acta 2011, 1813:1269-1278.
-
(2011)
Biochim. Biophys. Acta
, vol.1813
, pp. 1269-1278
-
-
Scarpulla, R.C.1
-
155
-
-
21144434217
-
Extension of murine life span by overexpression of catalase targeted to mitochondria
-
Schriner S.E., Linford N.J., Martin G.M., Treuting P., Ogburn C.E., Emond M., Coskun P.E., Ladiges W., Wolf N., Van Remmen H., Wallace D.C., Rabinovitch P.S. Extension of murine life span by overexpression of catalase targeted to mitochondria. Science 2005, 308:1909-1911.
-
(2005)
Science
, vol.308
, pp. 1909-1911
-
-
Schriner, S.E.1
Linford, N.J.2
Martin, G.M.3
Treuting, P.4
Ogburn, C.E.5
Emond, M.6
Coskun, P.E.7
Ladiges, W.8
Wolf, N.9
Van Remmen, H.10
Wallace, D.C.11
Rabinovitch, P.S.12
-
157
-
-
84855905939
-
Human telomerase acts as a hTR-independent reverse transcriptase in mitochondria
-
Sharma N.K., Reyes A., Green P., Caron M.J., Bonini M.G., Gordon D.M., Holt I.J., Santos J.H. Human telomerase acts as a hTR-independent reverse transcriptase in mitochondria. Nucleic Acids Res. 2012, 40:712-725.
-
(2012)
Nucleic Acids Res.
, vol.40
, pp. 712-725
-
-
Sharma, N.K.1
Reyes, A.2
Green, P.3
Caron, M.J.4
Bonini, M.G.5
Gordon, D.M.6
Holt, I.J.7
Santos, J.H.8
-
159
-
-
0000133469
-
Defining cellular senescence in IMR-90 cells: a flow cytometric analysis
-
Sherwood S.W., Rush D., Ellsworth J.L., Schimke R.T. Defining cellular senescence in IMR-90 cells: a flow cytometric analysis. Proc. Nat. Acad. Sci. U.S.A. 1988, 85:9086-9090.
-
(1988)
Proc. Nat. Acad. Sci. U.S.A.
, vol.85
, pp. 9086-9090
-
-
Sherwood, S.W.1
Rush, D.2
Ellsworth, J.L.3
Schimke, R.T.4
-
160
-
-
0025981359
-
Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG
-
Shibutani S., Takeshita M., Grollman A.P. Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG. Nature 1991, 349:431-434.
-
(1991)
Nature
, vol.349
, pp. 431-434
-
-
Shibutani, S.1
Takeshita, M.2
Grollman, A.P.3
-
161
-
-
79952749156
-
DNA methyltransferase 1, cytosine methylation, and cytosine hydroxymethylation in mammalian mitochondria
-
Shock L.S., Thakkar P.V., Peterson E.J., Moran R.G., Taylor S.M. DNA methyltransferase 1, cytosine methylation, and cytosine hydroxymethylation in mammalian mitochondria. Proc. Nat. Acad. Sci. U.S.A. 2011, 108:3630-3635.
-
(2011)
Proc. Nat. Acad. Sci. U.S.A.
, vol.108
, pp. 3630-3635
-
-
Shock, L.S.1
Thakkar, P.V.2
Peterson, E.J.3
Moran, R.G.4
Taylor, S.M.5
-
162
-
-
79960147671
-
The human TTAGGG repeat factors 1 and 2 bind to a subset of interstitial telomeric sequences and satellite repeats
-
Simonet T., Zaragosi L.E., Philippe C., Lebrigand K., Schouteden C., Augereau A., Bauwens S., Ye J., Santagostino M., Giulotto E., Magdinier F., Horard B., Barbry P., Waldmann R., Gilson E. The human TTAGGG repeat factors 1 and 2 bind to a subset of interstitial telomeric sequences and satellite repeats. Cell Res. 2011, 21:1028-1038.
-
(2011)
Cell Res.
, vol.21
, pp. 1028-1038
-
-
Simonet, T.1
Zaragosi, L.E.2
Philippe, C.3
Lebrigand, K.4
Schouteden, C.5
Augereau, A.6
Bauwens, S.7
Ye, J.8
Santagostino, M.9
Giulotto, E.10
Magdinier, F.11
Horard, B.12
Barbry, P.13
Waldmann, R.14
Gilson, E.15
-
163
-
-
84872251777
-
Mitochondrial telomerase protects cancer cells from nuclear DNA damage and apoptosis
-
Singhapol C., Pal D., Czapiewski R., Porika M., Nelson G., Saretzki G.C. Mitochondrial telomerase protects cancer cells from nuclear DNA damage and apoptosis. PLoS One 2013, 8:e52989.
-
(2013)
PLoS One
, vol.8
-
-
Singhapol, C.1
Pal, D.2
Czapiewski, R.3
Porika, M.4
Nelson, G.5
Saretzki, G.C.6
-
164
-
-
33751009381
-
Regulation of AIF expression by p53
-
Stambolsky P., Weisz L., Shats I., Klein Y., Goldfinger N., Oren M., Rotter V. Regulation of AIF expression by p53. Cell Death Differ. 2006, 13:2140-2149.
-
(2006)
Cell Death Differ.
, vol.13
, pp. 2140-2149
-
-
Stambolsky, P.1
Weisz, L.2
Shats, I.3
Klein, Y.4
Goldfinger, N.5
Oren, M.6
Rotter, V.7
-
165
-
-
72949115497
-
Trichothiodystrophy: from basic mechanisms to clinical implications
-
Stefanini M., Botta E., Lanzafame M., Orioli D. Trichothiodystrophy: from basic mechanisms to clinical implications. DNA Repair (Amst) 2010, 9:2-10.
-
(2010)
DNA Repair (Amst)
, vol.9
, pp. 2-10
-
-
Stefanini, M.1
Botta, E.2
Lanzafame, M.3
Orioli, D.4
-
166
-
-
0027182560
-
Changes in skeletal muscle, heart and liver mitochondrial electron transport activities in rats and dogs of various ages
-
Sugiyama S., Takasawa M., Hayakawa M., Ozawa T. Changes in skeletal muscle, heart and liver mitochondrial electron transport activities in rats and dogs of various ages. Biochem. Mol. Biol. Int. 1993, 30:937-944.
-
(1993)
Biochem. Mol. Biol. Int.
, vol.30
, pp. 937-944
-
-
Sugiyama, S.1
Takasawa, M.2
Hayakawa, M.3
Ozawa, T.4
-
167
-
-
84874267510
-
High-resolution enzymatic mapping of genomic 5-hydroxymethylcytosine in mouse embryonic stem cells
-
Sun Z., Jolyon T., Borgaro J.G., Liu Y., Yu L., Guan S., Wang H., Sun D., Cheng X., Zhu Z., Pradhan S., Zheng Y. High-resolution enzymatic mapping of genomic 5-hydroxymethylcytosine in mouse embryonic stem cells. Cell Rep. 2013, 3:567-576.
-
(2013)
Cell Rep.
, vol.3
, pp. 567-576
-
-
Sun, Z.1
Jolyon, T.2
Borgaro, J.G.3
Liu, Y.4
Yu, L.5
Guan, S.6
Wang, H.7
Sun, D.8
Cheng, X.9
Zhu, Z.10
Pradhan, S.11
Zheng, Y.12
-
168
-
-
0034738386
-
Mitochondrial genotype associated with longevity and its inhibitory effect on mutagenesis
-
Tanaka M., Gong J., Zhang J., Yamada Y., Borgeld H.J., Yagi K. Mitochondrial genotype associated with longevity and its inhibitory effect on mutagenesis. Mech. Ageing Dev. 2000, 116:65-76.
-
(2000)
Mech. Ageing Dev.
, vol.116
, pp. 65-76
-
-
Tanaka, M.1
Gong, J.2
Zhang, J.3
Yamada, Y.4
Borgeld, H.J.5
Yagi, K.6
-
169
-
-
0032539447
-
Mitochondrial genotype associated with longevity
-
Tanaka M., Gong J.S., Zhang J., Yoneda M., Yagi K. Mitochondrial genotype associated with longevity. Lancet 1998, 351:185-186.
-
(1998)
Lancet
, vol.351
, pp. 185-186
-
-
Tanaka, M.1
Gong, J.S.2
Zhang, J.3
Yoneda, M.4
Yagi, K.5
-
170
-
-
34250868124
-
Differential regulation of microRNAs by p53 revealed by massively parallel sequencing: miR-34a is a p53 target that induces apoptosis and G1-arrest
-
Tarasov V., Jung P., Verdoodt B., Lodygin D., Epanchintsev A., Menssen A., Meister G., Hermeking H. Differential regulation of microRNAs by p53 revealed by massively parallel sequencing: miR-34a is a p53 target that induces apoptosis and G1-arrest. Cell Cycle 2007, 6:1586-1593.
-
(2007)
Cell Cycle
, vol.6
, pp. 1586-1593
-
-
Tarasov, V.1
Jung, P.2
Verdoodt, B.3
Lodygin, D.4
Epanchintsev, A.5
Menssen, A.6
Meister, G.7
Hermeking, H.8
-
171
-
-
44649141966
-
Regulation of autophagy by cytoplasmic p53
-
Tasdemir E., Maiuri M.C., Galluzzi L., Vitale I., Djavaheri-Mergny M., D'Amelio M., Criollo A., Morselli E., Zhu C., Harper F., Nannmark U., Samara C., Pinton P., Vicencio J.M., Carnuccio R., Moll U.M., Madeo F., Paterlini-Brechot P., Rizzuto R., Szabadkai G., Pierron G., Blomgren K., Tavernarakis N., Codogno P., Cecconi F., Kroemer G. Regulation of autophagy by cytoplasmic p53. Nat. Cell Biol. 2008, 10:676-687.
-
(2008)
Nat. Cell Biol.
, vol.10
, pp. 676-687
-
-
Tasdemir, E.1
Maiuri, M.C.2
Galluzzi, L.3
Vitale, I.4
Djavaheri-Mergny, M.5
D'Amelio, M.6
Criollo, A.7
Morselli, E.8
Zhu, C.9
Harper, F.10
Nannmark, U.11
Samara, C.12
Pinton, P.13
Vicencio, J.M.14
Carnuccio, R.15
Moll, U.M.16
Madeo, F.17
Paterlini-Brechot, P.18
Rizzuto, R.19
Szabadkai, G.20
Pierron, G.21
Blomgren, K.22
Tavernarakis, N.23
Codogno, P.24
Cecconi, F.25
Kroemer, G.26
more..
-
172
-
-
34848868157
-
Tumor-suppressive miR-34a induces senescence-like growth arrest through modulation of the E2F pathway in human colon cancer cells
-
Tazawa H., Tsuchiya N., Izumiya M., Nakagama H. Tumor-suppressive miR-34a induces senescence-like growth arrest through modulation of the E2F pathway in human colon cancer cells. Proc. Nat. Acad. Sci. U.S.A. 2007, 104:15472-15477.
-
(2007)
Proc. Nat. Acad. Sci. U.S.A.
, vol.104
, pp. 15472-15477
-
-
Tazawa, H.1
Tsuchiya, N.2
Izumiya, M.3
Nakagama, H.4
-
173
-
-
75349112375
-
Mitochondrial turnover and aging of long-lived postmitotic cells: the mitochondrial-lysosomal axis theory of aging
-
Terman A., Kurz T., Navratil M., Arriaga E.A., Brunk U.T. Mitochondrial turnover and aging of long-lived postmitotic cells: the mitochondrial-lysosomal axis theory of aging. Antioxid. Redox Signal. 2010, 12:503-535.
-
(2010)
Antioxid. Redox Signal.
, vol.12
, pp. 503-535
-
-
Terman, A.1
Kurz, T.2
Navratil, M.3
Arriaga, E.A.4
Brunk, U.T.5
-
174
-
-
0034622645
-
Disruption of the microsomal glutathione S-transferase-like gene reduces life span of Drosophila melanogaster
-
Toba G., Aigaki T. Disruption of the microsomal glutathione S-transferase-like gene reduces life span of Drosophila melanogaster. Gene 2000, 253:179-187.
-
(2000)
Gene
, vol.253
, pp. 179-187
-
-
Toba, G.1
Aigaki, T.2
-
175
-
-
2642580016
-
Premature ageing in mice expressing defective mitochondrial DNA polymerase
-
Trifunovic A., Wredenberg A., Falkenberg M., Spelbrink J.N., Rovio A.T., Bruder C.E., Bohlooly Y.M., Gidlof S., Oldfors A., Wibom R., Tornell J., Jacobs H.T., Larsson N.G. Premature ageing in mice expressing defective mitochondrial DNA polymerase. Nature 2004, 429:417-423.
-
(2004)
Nature
, vol.429
, pp. 417-423
-
-
Trifunovic, A.1
Wredenberg, A.2
Falkenberg, M.3
Spelbrink, J.N.4
Rovio, A.T.5
Bruder, C.E.6
Bohlooly, Y.M.7
Gidlof, S.8
Oldfors, A.9
Wibom, R.10
Tornell, J.11
Jacobs, H.T.12
Larsson, N.G.13
-
176
-
-
29144486726
-
Mutant mitochondrial helicase Twinkle causes multiple mtDNA deletions and a late-onset mitochondrial disease in mice
-
Tyynismaa H., Mjosund K.P., Wanrooij S., Lappalainen I., Ylikallio E., Jalanko A., Spelbrink J.N., Paetau A., Suomalainen A. Mutant mitochondrial helicase Twinkle causes multiple mtDNA deletions and a late-onset mitochondrial disease in mice. Proc. Nat. Acad. Sci. U.S.A. 2005, 102:17687-17692.
-
(2005)
Proc. Nat. Acad. Sci. U.S.A.
, vol.102
, pp. 17687-17692
-
-
Tyynismaa, H.1
Mjosund, K.P.2
Wanrooij, S.3
Lappalainen, I.4
Ylikallio, E.5
Jalanko, A.6
Spelbrink, J.N.7
Paetau, A.8
Suomalainen, A.9
-
177
-
-
84888198135
-
Insulin, IGF-1 and longevity
-
van Heemst D. Insulin, IGF-1 and longevity. Aging Dis. 2010, 1:147-157.
-
(2010)
Aging Dis.
, vol.1
, pp. 147-157
-
-
van Heemst, D.1
-
178
-
-
34047116291
-
Mitochondrial point mutations do not limit the natural lifespan of mice
-
Vermulst M., Bielas J.H., Kujoth G.C., Ladiges W.C., Rabinovitch P.S., Prolla T.A., Loeb L.A. Mitochondrial point mutations do not limit the natural lifespan of mice. Nat. Genet. 2007, 39:540-543.
-
(2007)
Nat. Genet.
, vol.39
, pp. 540-543
-
-
Vermulst, M.1
Bielas, J.H.2
Kujoth, G.C.3
Ladiges, W.C.4
Rabinovitch, P.S.5
Prolla, T.A.6
Loeb, L.A.7
-
179
-
-
41349087783
-
DNA deletions and clonal mutations drive premature aging in mitochondrial mutator mice
-
Vermulst M., Wanagat J., Kujoth G.C., Bielas J.H., Rabinovitch P.S., Prolla T.A., Loeb L.A. DNA deletions and clonal mutations drive premature aging in mitochondrial mutator mice. Nat. Genet. 2008, 40:392-394.
-
(2008)
Nat. Genet.
, vol.40
, pp. 392-394
-
-
Vermulst, M.1
Wanagat, J.2
Kujoth, G.C.3
Bielas, J.H.4
Rabinovitch, P.S.5
Prolla, T.A.6
Loeb, L.A.7
-
180
-
-
84863011496
-
Transmitochondrial cybrids: tools for functional studies of mutant mitochondria
-
Vithayathil S.A., Ma Y., Kaipparettu B.A. Transmitochondrial cybrids: tools for functional studies of mutant mitochondria. Methods Mol. Biol. 2012, 837:219-230.
-
(2012)
Methods Mol. Biol.
, vol.837
, pp. 219-230
-
-
Vithayathil, S.A.1
Ma, Y.2
Kaipparettu, B.A.3
-
181
-
-
84881587735
-
Oxidative stress response elicited by mitochondrial dysfunction: implication in the pathophysiology of aging
-
Wang C.H., Wu S.B., Wu Y.T., Wei Y.H. Oxidative stress response elicited by mitochondrial dysfunction: implication in the pathophysiology of aging. Exp. Biol. Med. (Maywood) 2013, 238:450-460.
-
(2013)
Exp. Biol. Med. (Maywood)
, vol.238
, pp. 450-460
-
-
Wang, C.H.1
Wu, S.B.2
Wu, Y.T.3
Wei, Y.H.4
-
182
-
-
0032565577
-
Mutagenicity and repair of oxidative DNA damage: insights from studies using defined lesions
-
Wang D., Kreutzer D.A., Essigmann J.M. Mutagenicity and repair of oxidative DNA damage: insights from studies using defined lesions. Mutat. Res. 1998, 400:99-115.
-
(1998)
Mutat. Res.
, vol.400
, pp. 99-115
-
-
Wang, D.1
Kreutzer, D.A.2
Essigmann, J.M.3
-
183
-
-
77953811054
-
The human mitochondrial replication fork in health and disease
-
Wanrooij S., Falkenberg M. The human mitochondrial replication fork in health and disease. Biochim. Biophys. Acta 2010, 1797:1378-1388.
-
(2010)
Biochim. Biophys. Acta
, vol.1797
, pp. 1378-1388
-
-
Wanrooij, S.1
Falkenberg, M.2
-
184
-
-
64949161526
-
Respiratory function decline and DNA mutation in mitochondria, oxidative stress and altered gene expression during aging
-
Wei Y.H., Wu S.B., Ma Y.S., Lee H.C. Respiratory function decline and DNA mutation in mitochondria, oxidative stress and altered gene expression during aging. Chang Gung Med. J. 2009, 32:113-132.
-
(2009)
Chang Gung Med. J.
, vol.32
, pp. 113-132
-
-
Wei, Y.H.1
Wu, S.B.2
Ma, Y.S.3
Lee, H.C.4
-
185
-
-
0030659644
-
Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT
-
Weinrich S.L., Pruzan R., Ma L., Ouellette M., Tesmer V.M., Holt S.E., Bodnar A.G., Lichtsteiner S., Kim N.W., Trager J.B., Taylor R.D., Carlos R., Andrews W.H., Wright W.E., Shay J.W., Harley C.B., Morin G.B. Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT. Nat. Genet. 1997, 17:498-502.
-
(1997)
Nat. Genet.
, vol.17
, pp. 498-502
-
-
Weinrich, S.L.1
Pruzan, R.2
Ma, L.3
Ouellette, M.4
Tesmer, V.M.5
Holt, S.E.6
Bodnar, A.G.7
Lichtsteiner, S.8
Kim, N.W.9
Trager, J.B.10
Taylor, R.D.11
Carlos, R.12
Andrews, W.H.13
Wright, W.E.14
Shay, J.W.15
Harley, C.B.16
Morin, G.B.17
-
186
-
-
0033538473
-
Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1
-
Wu Z., Puigserver P., Andersson U., Zhang C., Adelmant G., Mootha V., Troy A., Cinti S., Lowell B., Scarpulla R.C., Spiegelman B.M. Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1. Cell 1999, 98:115-124.
-
(1999)
Cell
, vol.98
, pp. 115-124
-
-
Wu, Z.1
Puigserver, P.2
Andersson, U.3
Zhang, C.4
Adelmant, G.5
Mootha, V.6
Troy, A.7
Cinti, S.8
Lowell, B.9
Scarpulla, R.C.10
Spiegelman, B.M.11
-
187
-
-
79959973301
-
MiR-204 regulates cardiomyocyte autophagy induced by ischemia-reperfusion through LC3-II
-
Xiao J., Zhu X., He B., Zhang Y., Kang B., Wang Z., Ni X. MiR-204 regulates cardiomyocyte autophagy induced by ischemia-reperfusion through LC3-II. J. Biomed. Sci. 2011, 18:35.
-
(2011)
J. Biomed. Sci.
, vol.18
, pp. 35
-
-
Xiao, J.1
Zhu, X.2
He, B.3
Zhang, Y.4
Kang, B.5
Wang, Z.6
Ni, X.7
-
188
-
-
0141763944
-
Senescence-enhanced oxidative stress is associated with deficiency of mitochondrial cytochrome c oxidase in vascular endothelial cells
-
Xin M.G., Zhang J., Block E.R., Patel J.M. Senescence-enhanced oxidative stress is associated with deficiency of mitochondrial cytochrome c oxidase in vascular endothelial cells. Mech. Ageing Dev. 2003, 124:911-919.
-
(2003)
Mech. Ageing Dev.
, vol.124
, pp. 911-919
-
-
Xin, M.G.1
Zhang, J.2
Block, E.R.3
Patel, J.M.4
-
189
-
-
79960112520
-
Human telomeric proteins occupy selective interstitial sites
-
Yang D., Xiong Y., Kim H., He Q., Li Y., Chen R., Songyang Z. Human telomeric proteins occupy selective interstitial sites. Cell Res. 2011, 21:1013-1027.
-
(2011)
Cell Res.
, vol.21
, pp. 1013-1027
-
-
Yang, D.1
Xiong, Y.2
Kim, H.3
He, Q.4
Li, Y.5
Chen, R.6
Songyang, Z.7
-
190
-
-
84872616169
-
MiR-34 modulates Caenorhabditis elegans lifespan via repressing the autophagy gene atg9
-
Yang J., Chen D., He Y., Melendez A., Feng Z., Hong Q., Bai X., Li Q., Cai G., Wang J., Chen X. MiR-34 modulates Caenorhabditis elegans lifespan via repressing the autophagy gene atg9. Age (Dordr) 2011, 35:11-22.
-
(2011)
Age (Dordr)
, vol.35
, pp. 11-22
-
-
Yang, J.1
Chen, D.2
He, Y.3
Melendez, A.4
Feng, Z.5
Hong, Q.6
Bai, X.7
Li, Q.8
Cai, G.9
Wang, J.10
Chen, X.11
-
191
-
-
84886264092
-
Possible formation of mitochondrial-RNA containing chimeric or trimeric RNA implies a post-transcriptional and post-splicing mechanism for RNA fusion
-
Yang W., Wu J.M., Bi A.D., Ou-Yang Y.C., Shen H.H., Chirn G.W., Zhou J.H., Weiss E., Holman E.P., Liao D.J. Possible formation of mitochondrial-RNA containing chimeric or trimeric RNA implies a post-transcriptional and post-splicing mechanism for RNA fusion. PLoS One 2013, 8:e77016.
-
(2013)
PLoS One
, vol.8
-
-
Yang, W.1
Wu, J.M.2
Bi, A.D.3
Ou-Yang, Y.C.4
Shen, H.H.5
Chirn, G.W.6
Zhou, J.H.7
Weiss, E.8
Holman, E.P.9
Liao, D.J.10
-
192
-
-
84874515942
-
Accumulation of mtDNA variations in human single CD34+ cells from maternally related individuals: effects of aging and family genetic background
-
Yao Y.G., Kajigaya S., Feng X., Samsel L., McCoy J.P., Torelli G., Young N.S. Accumulation of mtDNA variations in human single CD34+ cells from maternally related individuals: effects of aging and family genetic background. Stem Cell Res. 2013, 10:361-370.
-
(2013)
Stem Cell Res.
, vol.10
, pp. 361-370
-
-
Yao, Y.G.1
Kajigaya, S.2
Feng, X.3
Samsel, L.4
McCoy, J.P.5
Torelli, G.6
Young, N.S.7
-
193
-
-
3142679378
-
POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex
-
Ye J.Z., Hockemeyer D., Krutchinsky A.N., Loayza D., Hooper S.M., Chait B.T., de Lange T. POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex. Genes Dev. 2004, 18:1649-1654.
-
(2004)
Genes Dev.
, vol.18
, pp. 1649-1654
-
-
Ye, J.Z.1
Hockemeyer, D.2
Krutchinsky, A.N.3
Loayza, D.4
Hooper, S.M.5
Chait, B.T.6
de Lange, T.7
-
194
-
-
0024980878
-
Liver mitochondrial respiratory functions decline with age
-
Yen T.C., Chen Y.S., King K.L., Yeh S.H., Wei Y.H. Liver mitochondrial respiratory functions decline with age. Biochem. Biophys. Res. Commun. 1989, 165:944-1003.
-
(1989)
Biochem. Biophys. Res. Commun.
, vol.165
, pp. 944-1003
-
-
Yen, T.C.1
Chen, Y.S.2
King, K.L.3
Yeh, S.H.4
Wei, Y.H.5
-
195
-
-
0038418297
-
P53 physically interacts with mitochondrial transcription factor A and differentially regulates binding to damaged DNA
-
Yoshida Y., Izumi H., Torigoe T., Ishiguchi H., Itoh H., Kang D., Kohno K. P53 physically interacts with mitochondrial transcription factor A and differentially regulates binding to damaged DNA. Cancer Res. 2003, 63:3729-3734.
-
(2003)
Cancer Res.
, vol.63
, pp. 3729-3734
-
-
Yoshida, Y.1
Izumi, H.2
Torigoe, T.3
Ishiguchi, H.4
Itoh, H.5
Kang, D.6
Kohno, K.7
-
196
-
-
64349123107
-
Autophagy mediates the mitotic senescence transition
-
Young A.R., Narita M., Ferreira M., Kirschner K., Sadaie M., Darot J.F., Tavare S., Arakawa S., Shimizu S., Watt F.M. Autophagy mediates the mitotic senescence transition. Genes Dev. 2009, 23:798-803.
-
(2009)
Genes Dev.
, vol.23
, pp. 798-803
-
-
Young, A.R.1
Narita, M.2
Ferreira, M.3
Kirschner, K.4
Sadaie, M.5
Darot, J.F.6
Tavare, S.7
Arakawa, S.8
Shimizu, S.9
Watt, F.M.10
-
197
-
-
84861203685
-
Gene delivery to mitochondria by targeting modified adenoassociated virus suppresses Leber's hereditary optic neuropathy in a mouse model
-
Yu H., Koilkonda R.D., Chou T.H., Porciatti V., Ozdemir S.S., Chiodo V., Boye S.L., Boye S.E., Hauswirth W.W., Lewin A.S., Guy J. Gene delivery to mitochondria by targeting modified adenoassociated virus suppresses Leber's hereditary optic neuropathy in a mouse model. Proc. Nat. Acad. Sci. U.S.A. 2012, 109:E1238-E1247.
-
(2012)
Proc. Nat. Acad. Sci. U.S.A.
, vol.109
-
-
Yu, H.1
Koilkonda, R.D.2
Chou, T.H.3
Porciatti, V.4
Ozdemir, S.S.5
Chiodo, V.6
Boye, S.L.7
Boye, S.E.8
Hauswirth, W.W.9
Lewin, A.S.10
Guy, J.11
-
198
-
-
77953457652
-
MicroRNA-34a induces endothelial progenitor cell senescence and impedes its angiogenesis via suppressing silent information regulator 1
-
Zhao T., Li J., Chen A.F. MicroRNA-34a induces endothelial progenitor cell senescence and impedes its angiogenesis via suppressing silent information regulator 1. Am. J. Physiol. Endocrinol. Metab. 2010, 299:E110-E116.
-
(2010)
Am. J. Physiol. Endocrinol. Metab.
, vol.299
-
-
Zhao, T.1
Li, J.2
Chen, A.F.3
-
199
-
-
34247251276
-
Single- and double-stranded DNA: building a trigger of ATR-mediated DNA damage response
-
Zou L. Single- and double-stranded DNA: building a trigger of ATR-mediated DNA damage response. Genes Dev. 2007, 21:879-885.
-
(2007)
Genes Dev.
, vol.21
, pp. 879-885
-
-
Zou, L.1
|