Gene delivery to mitochondria by targeting modified adenoassociated virus suppresses Leber's hereditary optic neuropathy in a mouse model

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 20, 2012, Pages

  Yu, Hong ^a   Koilkonda, Rajeshwari D ^a   Chou, Tsung Han ^a   Porciatti, Vittorio ^a   Ozdemir, Sacide S ^a   Chiodo, Vince ^b   Boye, Sanford L ^b   Boye, Shannon E ^b   Hauswirth, William W ^b   Lewin, Alfred S ^b   Guy, John ^a,b  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; MITOCHONDRIAL DNA; PROTEIN VP2; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE);

ADENO ASSOCIATED VIRUS; AGING; ARTICLE; CONTROLLED STUDY; EMBRYO; GENE DELETION; GENE DELIVERY SYSTEM; GENE INSERTION; GENE MUTATION; HUMAN; HUMAN CELL; LEBER HEREDITARY OPTIC NEUROPATHY; MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; VIRUS CAPSID;

ANIMALS; CAPSID PROTEINS; DEPENDOVIRUS; GENE THERAPY; GENE TRANSFER TECHNIQUES; HUMANS; IMMUNOBLOTTING; MICE; MITOCHONDRIA; NADH DEHYDROGENASE; OLIGONUCLEOTIDES; OPTIC ATROPHY, HEREDITARY, LEBER; PLASMIDS; POINT MUTATION; RETINA; TRANSFECTION;

MIRIDAE; RODENTIA;

EID: 84861203685     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1119577109     Document Type: Article

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