Excision of nucleoside analogs in mitochondria by p53 protein

AIDS

Volumn 23, Issue 7, 2009, Pages 779-788

  Bakhanashvili, Mary ^a,b   Grinberg, Shai ^a   Bonda, Elad ^a   Rahav, Galia ^a  

^a SHEBA MEDICAL CENTER   (Israel)

^b BAR ILAN UNIVERSITY   (Israel)

Author keywords

3 5' exonuclease; Dna polymerase ; Mitochondrial dna; Nucleoside analogs; P53

Indexed keywords

ADENOSINE TRIPHOSPHATE; CELL EXTRACT; CYTARABINE; CYTIDINE TRIPHOSPHATE; CYTOCHROME C; DEOXYGUANOSINE TRIPHOSPHATE; DNA DIRECTED DNA POLYMERASE GAMMA; DOUBLE STRANDED DNA; EXONUCLEASE; GLUTATHIONE TRANSFERASE; MITOCHONDRIAL DNA; MUTANT PROTEIN; NUCLEOSIDE ANALOG; NUCLEOTIDE; PROTEIN P53; RECOMBINANT PROTEIN; THYMIDINE TRIPHOSPHATE; DNA DIRECTED DNA POLYMERASE; NUCLEOSIDE; PRIMER DNA; PROTEINASE K; VIRUS DNA;

ARTICLE; CARCINOMA CELL; CELL STRESS; COLON CARCINOMA; CONTROLLED STUDY; CYTOPLASM; EXCISION REPAIR; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IONIZING RADIATION; LARGE CELL CARCINOMA; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PROTEIN PURIFICATION; UPREGULATION; WILD TYPE; CELL CULTURE; DNA DAMAGE; GENETICS; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; METABOLISM; TUMOR CELL LINE; WESTERN BLOTTING;

BLOTTING, WESTERN; CARCINOMA, LARGE CELL; CELL LINE, TUMOR; CELLS, CULTURED; DNA DAMAGE; DNA PRIMERS; DNA, MITOCHONDRIAL; DNA, VIRAL; DNA-DIRECTED DNA POLYMERASE; ENDOPEPTIDASE K; HIV INFECTIONS; HIV-1; HUMANS; NUCLEOSIDES; TUMOR SUPPRESSOR PROTEIN P53;

EID: 67649647889     PISSN: 02699370     EISSN: 14735571     Source Type: Journal    
DOI: 10.1097/QAD.0b013e328329c74e     Document Type: Article

References (40)

1. Lewis W, Day BJ, Copeland WC. Mitochondrial toxicity of NRTI antiviral drugs: an integrated cellular perspective. NatRev 2003;2:812-822.
2. Feng JY, Murakami E, Zorca SM, Johnson AA, Kohnson KA, Schinazi RF, et al. Relationship between antiviral activity and host toxicity: comparison of the incorporation efficiencies of 2',3'-dideoxy-5-fluoro-3'- thiacytidine-triphosphate analogs by human immunodeficiency virus type1 reverse transcriptase and human mitochondrial DNA polymerase. Antimicrob Agents Chemother 2004;48:1300-1306.
3. Brinkman K, Smeitink JA, Romijn JA, Reiss P. Mitochondrial toxicity induced by nucleoside-analogue reverse transcriptase inhibitors is a key factor in the pathogenesis of antiretroviral- therapy related. Lancet 1999;354:1112-1115.
4. Martin AM, Hammond E, Nolan D, PaceC, Den BoerM, Taylor L, et al. Accumulation of mitochondrial DNA mutations in human immunodeficiency virus-infected patients treated with nucleoside analogue reverse transcriptase inhibitors. Am J Hum Genet 2003;72:549-560.
5. Lewis W, Copeland WC, Day BJ. Mitochondrial DNA depletion, oxidative stress and mutations: mechanism ofdysfunction from nucleoside reverse transcriptase inhibitors. Lab Invest 2001;81:777-790.
6. Kaguni LS. DNA polymerase g, the mitochondrial replicase. Ann Rev Biochem 2004; 73:293-320.
7. Kunkel T, Sonu A. Exonucleolytic proofreading enhances the fidelity of DNA synthesis by chick embryo DNA polymerase gamma. J Biol Chem 1988;263:4450-4459.
8. Johnson A, Johnson K. Fidelity of nucleotide incorporation by human mitochondrial DNA polymerase. J Biol Chem 2001; 276:38090- 38106.
9. Johnson A, Johnson K. Exonuclease proofreading by human mitochondrial DNA polymerase. J Biol Chem 2001; 276:38097-38107.
10. Feng JY, Johnson AA, Kohnson KA, Anderson KA. Insights into the molecular mechanism of mitochondrial toxicity by AIDS drugs. J Biol Chem 2001; 276:23832-23837.
11. Johnson AA, Ray AS, HanesJ, SuoZ, ColacinoJM, Anderson KS, Johnson KA. Toxicity of antiviral nucleoside analogs and the human mitochondrial DNA polymerase. J Biol Chem 2001;276:40847-40857.
12. Lim SE, Copeland WC. Differential incorporation and removal of antiviral deoxynucleotides by human DNA polymerase g.J Biol Chem 2001; 276:23616-23623.
13. Zhou Y, Achanta G, Pelicano H, Gandhi V, PlunkettW, Huang P. Action of (E)-2' deoxy-2'-(fluoromethylene) cytidine on DNA metabolism: incorporation, excision, and cellular response. Mol Pharmacol 2002; 61 :222-229.
14. Pellicano H, Kuchanova M, Cheng Y. Excision of fβ-D- and fβ-L- nucleotide analogs from DNA by the human cytosolic 3'-to 5' exonuclease. Mol Pharmacol 2000; 57:1051-1055.
15. PrivesC, Hall PA. Thep 53 pathway.JPathol1999; 187:112-126.
16. Albrechtsen N, Dornreiter I, Grosse F, Kim E, Wiesmuller L, Deppert W. Maintenance of genomic integrity by p53: complementary roles for activated p53. Oncogene 1999; 18:7708-7717.
17. MummenbrauerT, Janus F, Muller B, Wiesmuller B, Deppert W, Gross F. p53 protein exhibits 3 ' -to 5 ' exonuclease activity. Cell 1996;85:1089-1099.
18. Huang P. Excision of mismatched nucleotides from DNA: a potential mechanism for enhancing DNA replication fidelity by the wild-type p53 protein. Oncogene 1998; 17:261-270.
19. Bakhanashvili M. Exonucleolytic proofreading by p53 protein. Eur J Biochem 2001; 268:2047-2054.
20. Bakhanashvili M. p53 enhances the fidelity of DNA synthesis by human immunodeficiency virus type 1 reverse transcriptase. Oncogene 2001;20:7635-7644.
21. Melle C, Nasheuer H. Physical and functional interactions of the tumor suppressor protein p53 and DNA polymerase a- primase. Nucleic Acids Res 2002;30:1493-1499.
22. Bakhanashvili M, Novitsky E, Lilling G, Rahav G. p53 in cytoplasm may enhance the accuracy of DNA synthesis by human immunodeficiency virus type 1 reverse transcriptase. Oncogene 2004; 23:6890-6899.
23. Feng L, Achanta G, Pelicano H, Zhang W, Plunkett W, Huang P. Role of p53 in cellular response to anticancer nucleoside analog-induced DNA damage. Int J MolMed 2000;5:597-604.
24. Bakhanashvili M, Novitsky E, Rubinstein E, Levy I, Rahav G. Excision of nucleoside analogs from DNA by p53 protein, a potential cellular mechanism of resistance to inhibitors of human immunodeficiency virus type 1 reverse transcriptase. Antimicrob Agents Chemother 2005;49:1576-1579.
25. Marchenko ND, Zaika A, Moll UM. Death signal-induced localization of p53 protein to mitochondria. A potential role in apoptotic signaling. J Biol Chem 2000;275:16202-16212.
26. Sansome C, Zaika C, Marchenko ND, Moll F UM. Hypoxia death stimulus induces transcolation of p53 protein to mitochondria. Detection by immunofluorescence on whole cells. FEBS Lett 2001;488:110-115.
27. Chen D, Yu Z, Zhu Z, Lopez CD. The p53 pathway promotes efficient mitochondrial DNA base excision repair in colorectal cancer cells. Cancer Res 2006; 66:3485-3494.
28. Achanta G, Sasaki R, Feng L, CarewJS, Lu W, Pelicano H, etal. Novel role of p53 in maintaining mitochondrial genetic stability through interaction with DNA pol g. EMBO J 2005; 24:3482-3492.
29. Yoshida Y, Izumi H, Torigoe T, Ishiguchi H, Yoshida T, Itoh H, et al. P53 physically interacts with mitochondrial transcription factor A and differentially regulates binding to damaged DNA. Cancer Res 2003; 63:3729-3734.
30. de Souza-Pinto NC, Harris CC, Bohr VA. p53 functions in the incorporation step in DNA base excision repair in mouse liver mitochondria. Oncogene 2004; 23:6559-6568.
31. Bakhanashvili1 M, Grinberg S, Bonda E, Simon AJ, Moshitch- Moshkovitz S, Rahav G. p53 in mitochondria enhances the accuracy of DNA synthesis. Cell Death Differ 2008;15:1865- 1874; 10.1038/cdd.2008.122.
32. Lilling G, Novitsky E, Sidi Y, Bakhanashvili M. p53-associated 3-5 exonuclease activity in nuclear and cytoplasmic com partments of cells. Oncogene 2003; 22:233-245.
33. Shevelev IV, Hubscher U. The 3-5 exonucleases. Nat Rev 2002; 3:1-12.
34. Kunkel T. Exonucleolytic proofreading. Cell 1988;53:837-840.
35. Bakhanashvili M, Gedelovich R, GrinbergS, Rahav G. Exonucleolytic degradation of RNA by the tumor suppression protein p53 in cytoplasm. J Mol Med 2008;86:75-88.
36. Essmann F, Pohlmann S, Gillissen P, Daniel PT, Schulze-Osthoff K, Janicke RU. Irradiation-induced translocation of p53 to mitochondria in the absence of apoptosis. J Biol Chem 2005;280:37169-37177.
37. Goodman MF, Fygenson DK. DNA polymerase fidelity: from genetics toward a biochemical understanding. Genetics 1998; 148:1475-1482.
38. Mahyar-Roemer M, Fritzsche C, Wagner S, Laue M, Roemer K. Mitochondrial p53 levels parallel total p53 levels independent of stress response in human colorectal carcinoma and glio- blastoma cells. Oncogene 2004; 23:6226-6236.
39. Katz R, Skalka AM. Generation of diversity in retroviruses. Ann Rev Genet 1990; 24:409-445.
40. Genini D, Sheeter D, Rought S, Zaunders JJ, Susin SA, Kroemer G, et al. HIV induces lymphocyte apoptosis by a p53-initiated, mitochondrial-mediated mechanism. FASEB J 2001; 15:5-6.