-
1
-
-
43149087522
-
Telomerase does not counteract telomere shortening but protects mitochondrial function under oxidative stress
-
Ahmed S., Passos J.F., Birket M.J., Beckmann T., Brings S., Peters H., Birch-Machin MA., von Zglinicki T., and Saretzki G. Telomerase does not counteract telomere shortening but protects mitochondrial function under oxidative stress. J. Cell Sci. 17 (2008) 1046-1053
-
(2008)
J. Cell Sci.
, vol.17
, pp. 1046-1053
-
-
Ahmed, S.1
Passos, J.F.2
Birket, M.J.3
Beckmann, T.4
Brings, S.5
Peters, H.6
Birch-Machin, MA.7
von Zglinicki, T.8
Saretzki, G.9
-
2
-
-
1542512436
-
TNFalpha induces rapid activation and nuclear translocation of telomerase in human lymphocytes
-
Akiyama M., Yamada O., Hideshima T., Yanagisawa T., Yokoi K., Fujisawa K., Eto Y., Yamada H., and Anderson K.C. TNFalpha induces rapid activation and nuclear translocation of telomerase in human lymphocytes. Biochem. Biophys. Res. Commun. 316 (2004) 528-532
-
(2004)
Biochem. Biophys. Res. Commun.
, vol.316
, pp. 528-532
-
-
Akiyama, M.1
Yamada, O.2
Hideshima, T.3
Yanagisawa, T.4
Yokoi, K.5
Fujisawa, K.6
Eto, Y.7
Yamada, H.8
Anderson, K.C.9
-
3
-
-
0037480961
-
Telomerase is required to slow telomere shortening and extend replicative lifespan of HSCs during serial transplantation
-
Allsopp R.C., Morin G.B., DePinho R., Harley C.B., and Weissman I.L. Telomerase is required to slow telomere shortening and extend replicative lifespan of HSCs during serial transplantation. Blood 102 (2003) 517-520
-
(2003)
Blood
, vol.102
, pp. 517-520
-
-
Allsopp, R.C.1
Morin, G.B.2
DePinho, R.3
Harley, C.B.4
Weissman, I.L.5
-
4
-
-
16444384725
-
Overexpression of telomerase confers growth advantage, stress resistance and enhanced differentiation of ES cells towards the haematopoietic lineage
-
Armstrong L., Saretzki G., Evans J., Hole N., von Zglinicki T., and Lako M. Overexpression of telomerase confers growth advantage, stress resistance and enhanced differentiation of ES cells towards the haematopoietic lineage. Stem Cells 23 (2005) 516-529
-
(2005)
Stem Cells
, vol.23
, pp. 516-529
-
-
Armstrong, L.1
Saretzki, G.2
Evans, J.3
Hole, N.4
von Zglinicki, T.5
Lako, M.6
-
5
-
-
33746591648
-
Genes and pathways downstream of telomerase in melanoma metastasis
-
Bagheri S., Nosrati M., Li S., Fong S., Torabian S., Rangel J., Moore D.H., Federman S., Laposa R.R., Baehner F.L., Sagebiel R.W., Cleaver J.E., Haqq C., Debs R.J., Blackburn E.H., and Kashani-Sabet M. Genes and pathways downstream of telomerase in melanoma metastasis. Proc. Natl. Acad. Sci. USA 103 30 (2006) 11306-11311
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, Issue.30
, pp. 11306-11311
-
-
Bagheri, S.1
Nosrati, M.2
Li, S.3
Fong, S.4
Torabian, S.5
Rangel, J.6
Moore, D.H.7
Federman, S.8
Laposa, R.R.9
Baehner, F.L.10
Sagebiel, R.W.11
Cleaver, J.E.12
Haqq, C.13
Debs, R.J.14
Blackburn, E.H.15
Kashani-Sabet, M.16
-
6
-
-
0010045614
-
Extension of life-span by introduction of telomerase into normal human cells
-
Bodnar A.G., Ouellette M., Frolkis M., Holt S.E., Chiu C.P., Morin G.B., Harley C.B., Shay J.W., Lichtsteiner S., and Wright W.E. Extension of life-span by introduction of telomerase into normal human cells. Science 279 (1998) 349-352
-
(1998)
Science
, vol.279
, pp. 349-352
-
-
Bodnar, A.G.1
Ouellette, M.2
Frolkis, M.3
Holt, S.E.4
Chiu, C.P.5
Morin, G.B.6
Harley, C.B.7
Shay, J.W.8
Lichtsteiner, S.9
Wright, W.E.10
-
7
-
-
34548667973
-
Telomere length, stem cells and aging
-
Blasco M.A. Telomere length, stem cells and aging. Nat. Chem. Biol. 3 10 (2007) 640-649
-
(2007)
Nat. Chem. Biol.
, vol.3
, Issue.10
, pp. 640-649
-
-
Blasco, M.A.1
-
8
-
-
0036905921
-
Amyloid beta-peptide (1-42)-induced oxidative stress and neurotoxicity: implications for neurodegeneration in Alzheimer's disease brain. A review
-
Butterfield D.A. Amyloid beta-peptide (1-42)-induced oxidative stress and neurotoxicity: implications for neurodegeneration in Alzheimer's disease brain. A review. Free Radic. Res. 36 12 (2002) 1307-1313
-
(2002)
Free Radic. Res.
, vol.36
, Issue.12
, pp. 1307-1313
-
-
Butterfield, D.A.1
-
9
-
-
85047697807
-
TERT regulates cell survival independent of telomerase enzymatic activity
-
Cao Y., Li H., Deb S., and Liu J.P. TERT regulates cell survival independent of telomerase enzymatic activity. Oncogene 21 20 (2002) 3130-3138
-
(2002)
Oncogene
, vol.21
, Issue.20
, pp. 3130-3138
-
-
Cao, Y.1
Li, H.2
Deb, S.3
Liu, J.P.4
-
10
-
-
38949156672
-
TERT promotes epithelial proliferation through transcriptional control of a Myc- and Wnt-related developmental program
-
Choi J., Southworth L.K., Sarin K.Y., Venteicher A.S., Ma W., Chang W., Cheung P., Jun S., Artandi M.K., Shah N., Kim S.K., and Artandi S.E. TERT promotes epithelial proliferation through transcriptional control of a Myc- and Wnt-related developmental program. PLoS Genet. 1 (2008) e10
-
(2008)
PLoS Genet.
, vol.1
-
-
Choi, J.1
Southworth, L.K.2
Sarin, K.Y.3
Venteicher, A.S.4
Ma, W.5
Chang, W.6
Cheung, P.7
Jun, S.8
Artandi, M.K.9
Shah, N.10
Kim, S.K.11
Artandi, S.E.12
-
11
-
-
0037125201
-
Stress-induced premature senescence in BJ and hTERT-BJ1 human foreskin fibroblasts
-
de Magalhães J.P., Chainiaux F., Remacle J., and Toussaint O. Stress-induced premature senescence in BJ and hTERT-BJ1 human foreskin fibroblasts. FEBS Lett. 523 1-3 (2002) 157-162
-
(2002)
FEBS Lett.
, vol.523
, Issue.1-3
, pp. 157-162
-
-
de Magalhães, J.P.1
Chainiaux, F.2
Remacle, J.3
Toussaint, O.4
-
12
-
-
27344446189
-
Involvement of hTERT in apoptosis induced by interference with Bcl-2 expression and function
-
Del Bufalo D., Rizzo A., Trisciuoglio D., Cardinali G., Torrisi M.R., Zangemeister-Wittke U., Zupi G., and Biroccio A. Involvement of hTERT in apoptosis induced by interference with Bcl-2 expression and function. Cell Death Differ. 12 (2005) 1429-1438
-
(2005)
Cell Death Differ.
, vol.12
, pp. 1429-1438
-
-
Del Bufalo, D.1
Rizzo, A.2
Trisciuoglio, D.3
Cardinali, G.4
Torrisi, M.R.5
Zangemeister-Wittke, U.6
Zupi, G.7
Biroccio, A.8
-
13
-
-
0036363033
-
Import of nuclear encoded RNAs into yeast and human mitochondria: experimental approaches and possible biomedical applications
-
Entelis N., Kolesnikova O., Kazakova H., Brandina I., Kamenski P., Martin R.P., and Tarassov I. Import of nuclear encoded RNAs into yeast and human mitochondria: experimental approaches and possible biomedical applications. Genet. Eng. (N. Y.) 24 (2002) 191-213
-
(2002)
Genet. Eng. (N. Y.)
, vol.24
, pp. 191-213
-
-
Entelis, N.1
Kolesnikova, O.2
Kazakova, H.3
Brandina, I.4
Kamenski, P.5
Martin, R.P.6
Tarassov, I.7
-
14
-
-
10344229954
-
Accelerated telomere shortening in response to life stress
-
Epel E.S., Blackburn E.H., Lin J., Dhabhar F.S., Adler N.E., Morrow J.D., and Cawthon R.M. Accelerated telomere shortening in response to life stress. Proc. Natl. Acad. Sci. USA 101 (2004) 17312-17315
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 17312-17315
-
-
Epel, E.S.1
Blackburn, E.H.2
Lin, J.3
Dhabhar, F.S.4
Adler, N.E.5
Morrow, J.D.6
Cawthon, R.M.7
-
15
-
-
40349085766
-
The longest telomeres: a general signature of adult stem cell compartments
-
Flores I., Canela A., Vera E., Tejera A., Cotsarelis G., and Blasco M.A. The longest telomeres: a general signature of adult stem cell compartments. Genes Dev. 5 (2008) 654-667
-
(2008)
Genes Dev.
, vol.5
, pp. 654-667
-
-
Flores, I.1
Canela, A.2
Vera, E.3
Tejera, A.4
Cotsarelis, G.5
Blasco, M.A.6
-
16
-
-
0034122088
-
The catalytic subunit of telomerase is expressed in developing brain neurons and serves a cell survival-promoting function
-
Fu W., Killen M., Culmsee C., Dhar S., Pandita T.K., and Mattson M.P. The catalytic subunit of telomerase is expressed in developing brain neurons and serves a cell survival-promoting function. J. Mol. Neurosci. 14 (2000) 3-15
-
(2000)
J. Mol. Neurosci.
, vol.14
, pp. 3-15
-
-
Fu, W.1
Killen, M.2
Culmsee, C.3
Dhar, S.4
Pandita, T.K.5
Mattson, M.P.6
-
17
-
-
0037064011
-
Expression of human telomerase (hTERT) does not prevent stress-induced senescence in normal human fibroblasts but protects the cells from stress-induced apoptosis and necrosis
-
Gorbunova V., Seluanov A., and Pereira-Smith O.M. Expression of human telomerase (hTERT) does not prevent stress-induced senescence in normal human fibroblasts but protects the cells from stress-induced apoptosis and necrosis. J. Biol. Chem. 277 41 (2002) 38540-38549
-
(2002)
J. Biol. Chem.
, vol.277
, Issue.41
, pp. 38540-38549
-
-
Gorbunova, V.1
Seluanov, A.2
Pereira-Smith, O.M.3
-
18
-
-
33646126516
-
Novel roles for telomerase in aging
-
Geserick C., and Blasco M.A. Novel roles for telomerase in aging. Mech. Ageing Dev. 127 6 (2006) 579-583
-
(2006)
Mech. Ageing Dev.
, vol.127
, Issue.6
, pp. 579-583
-
-
Geserick, C.1
Blasco, M.A.2
-
19
-
-
77049308856
-
Aging: a theory based on free radical and radiation chemistry
-
Harman D. Aging: a theory based on free radical and radiation chemistry. J. Gerontol. 11 (1956) 298-300
-
(1956)
J. Gerontol.
, vol.11
, pp. 298-300
-
-
Harman, D.1
-
20
-
-
0015319592
-
The biologic clock: the mitochondria?
-
Harman D. The biologic clock: the mitochondria?. J. Am. Geriatr. Soc. 20 4 (1972) 145-147
-
(1972)
J. Am. Geriatr. Soc.
, vol.20
, Issue.4
, pp. 145-147
-
-
Harman, D.1
-
21
-
-
66349130192
-
Mitochondrial telomerase reverse transcriptase binds to and protects mitochondrial DNA and function from damage
-
Haendeler J., Dröse S., Büchner N., Jakob S., Altschmied J., Goy C., Spyridopoulos I., Zeiher A.M., Brandt U., and Dimmeler S. Mitochondrial telomerase reverse transcriptase binds to and protects mitochondrial DNA and function from damage. Arterioscler. Thromb. Vasc. Biol. 29 6 (2009) 929-935
-
(2009)
Arterioscler. Thromb. Vasc. Biol.
, vol.29
, Issue.6
, pp. 929-935
-
-
Haendeler, J.1
Dröse, S.2
Büchner, N.3
Jakob, S.4
Altschmied, J.5
Goy, C.6
Spyridopoulos, I.7
Zeiher, A.M.8
Brandt, U.9
Dimmeler, S.10
-
22
-
-
0038721199
-
Hydrogen peroxide triggers nuclear export of telomerase reverse transcriptase via Src kinase family-dependent phosphorylation of tyrosine 707
-
Haendeler J., Hoffmann J., Brandes R.P., Zeiher A.M., and Dimmeler S. Hydrogen peroxide triggers nuclear export of telomerase reverse transcriptase via Src kinase family-dependent phosphorylation of tyrosine 707. Mol. Cell. Biol. 23 13 (2003) 4598-4610
-
(2003)
Mol. Cell. Biol.
, vol.23
, Issue.13
, pp. 4598-4610
-
-
Haendeler, J.1
Hoffmann, J.2
Brandes, R.P.3
Zeiher, A.M.4
Dimmeler, S.5
-
23
-
-
1842611977
-
Antioxidants inhibit nuclear export of telomerase reverse transcriptase and delay replicative senescence of endothelial cells
-
Haendeler J., Hoffmann J., Diehl J.F., Vasa M., Spyridopoulos I., Zeiher A.M., and Dimmeler S. Antioxidants inhibit nuclear export of telomerase reverse transcriptase and delay replicative senescence of endothelial cells. Circ. Res. 94 6 (2004) 768-775
-
(2004)
Circ. Res.
, vol.94
, Issue.6
, pp. 768-775
-
-
Haendeler, J.1
Hoffmann, J.2
Diehl, J.F.3
Vasa, M.4
Spyridopoulos, I.5
Zeiher, A.M.6
Dimmeler, S.7
-
24
-
-
0033455559
-
Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death
-
Herbert B., Pitts A.E., Baker S.I., Hamilton S.E., Wright W.E., Shay J.W., and Corey D.R. Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death. Proc. Natl. Acad. Sci. USA 96 (1999) 14276-14281
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 14276-14281
-
-
Herbert, B.1
Pitts, A.E.2
Baker, S.I.3
Hamilton, S.E.4
Wright, W.E.5
Shay, J.W.6
Corey, D.R.7
-
25
-
-
35548965688
-
Molecular mechanisms involved in endothelial cell aging: role of telomerase reverse transcriptase
-
Jakob S., and Haendeler J. Molecular mechanisms involved in endothelial cell aging: role of telomerase reverse transcriptase. Z. Gerontol. Geriatr. 40 (2007) 334-338
-
(2007)
Z. Gerontol. Geriatr.
, vol.40
, pp. 334-338
-
-
Jakob, S.1
Haendeler, J.2
-
26
-
-
62349116477
-
The mitochondrial theory of aging: insight from transgenic and knockout mouse models
-
Jang Y.C., and Remmen V.H. The mitochondrial theory of aging: insight from transgenic and knockout mouse models. Exp. Gerontol. 44 4 (2009) 256-260
-
(2009)
Exp. Gerontol.
, vol.44
, Issue.4
, pp. 256-260
-
-
Jang, Y.C.1
Remmen, V.H.2
-
27
-
-
10744219690
-
Ectopic expression of the catalytic subunit of telomerase protects against brain injury resulting from ischemia and NMDA-induced neurotoxicity
-
Kang H.J., Choi Y.S., Hong S.B., Kim K.W., Woo R.S., Won S.J., Kim E.J., Jeon H.K., Jo S.Y., Kim T.K., Bachoo R., Reynolds I.J., Gwag B.J., and Lee H.W. Ectopic expression of the catalytic subunit of telomerase protects against brain injury resulting from ischemia and NMDA-induced neurotoxicity. J. Neurosci. 24 (2004) 1280-1287
-
(2004)
J. Neurosci.
, vol.24
, pp. 1280-1287
-
-
Kang, H.J.1
Choi, Y.S.2
Hong, S.B.3
Kim, K.W.4
Woo, R.S.5
Won, S.J.6
Kim, E.J.7
Jeon, H.K.8
Jo, S.Y.9
Kim, T.K.10
Bachoo, R.11
Reynolds, I.J.12
Gwag, B.J.13
Lee, H.W.14
-
28
-
-
0032566005
-
Targeted therapy of human malignant glioma in a mouse model by 2-5A antisense directed against telomerase RNA
-
Kondo S., Kondo Y., Li G., Silverman R.H., and Cowell J.K. Targeted therapy of human malignant glioma in a mouse model by 2-5A antisense directed against telomerase RNA. Oncogene 16 (1998) 3323-3330
-
(1998)
Oncogene
, vol.16
, pp. 3323-3330
-
-
Kondo, S.1
Kondo, Y.2
Li, G.3
Silverman, R.H.4
Cowell, J.K.5
-
29
-
-
0032580369
-
Inhibition of telomerase increases the susceptibility of human malignant glioblastoma cells to cisplatin-induced apoptosis
-
Kondo Y., Kondo S., Tanaka Y., Haqqi T., Barna B.P., and Cowell J.K. Inhibition of telomerase increases the susceptibility of human malignant glioblastoma cells to cisplatin-induced apoptosis. Oncogene 16 (1998) 2243-2248
-
(1998)
Oncogene
, vol.16
, pp. 2243-2248
-
-
Kondo, Y.1
Kondo, S.2
Tanaka, Y.3
Haqqi, T.4
Barna, B.P.5
Cowell, J.K.6
-
31
-
-
54449091329
-
Early mitochondrial dysfunction in long-lived Mclk1+/- mice
-
Lapointe J., and Hekimi S. Early mitochondrial dysfunction in long-lived Mclk1+/- mice. J. Biol. Chem. 283 38 (2008) 26217-26227
-
(2008)
J. Biol. Chem.
, vol.283
, Issue.38
, pp. 26217-26227
-
-
Lapointe, J.1
Hekimi, S.2
-
32
-
-
45949096290
-
TERT promotes cellular and organismal survival independently of telomerase activity
-
Lee L., Sung Y.H., Cheong C., Choi Y.S., Jeon H.K., Sun W., Hahn W.C., Ishikawa F., and Lee H.W. TERT promotes cellular and organismal survival independently of telomerase activity. Oncogene 7 (2008) 3754-3760
-
(2008)
Oncogene
, vol.7
, pp. 3754-3760
-
-
Lee, L.1
Sung, Y.H.2
Cheong, C.3
Choi, Y.S.4
Jeon, H.K.5
Sun, W.6
Hahn, W.C.7
Ishikawa, F.8
Lee, H.W.9
-
33
-
-
21244502260
-
Cellular and gene expression responses involved in the rapid growth inhibition of human cancer cells by RNA interference-mediated depletion of telomerase RNA
-
Li S., Crothers J., Haqq C.M., and Blackburn E.H. Cellular and gene expression responses involved in the rapid growth inhibition of human cancer cells by RNA interference-mediated depletion of telomerase RNA. J. Biol. Chem. 280 (2005) 23709-23717
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 23709-23717
-
-
Li, S.1
Crothers, J.2
Haqq, C.M.3
Blackburn, E.H.4
-
34
-
-
0035871710
-
Cutting edge: telomerase activation in human T lymphocytes does not require increase in telomerase reverse transcriptase (hTERT) protein but is associated with hTERT phosphorylation and nuclear translocation
-
Liu K., Hodes R.J., and Weng N.P. Cutting edge: telomerase activation in human T lymphocytes does not require increase in telomerase reverse transcriptase (hTERT) protein but is associated with hTERT phosphorylation and nuclear translocation. J. Immunol. 166 (2001) 4826-4830
-
(2001)
J. Immunol.
, vol.166
, pp. 4826-4830
-
-
Liu, K.1
Hodes, R.J.2
Weng, N.P.3
-
35
-
-
0035300424
-
Ribozyme cleavage of telomerase mRNA sensitizes breast epithelial cells to inhibitors of topoisomerase
-
Ludwig A., Saretzki G., Holm P.S., Tiemann F., Lorenz M., Emrich T., Harley C.B., and von Zglinicki T. Ribozyme cleavage of telomerase mRNA sensitizes breast epithelial cells to inhibitors of topoisomerase. Cancer Res. 61 (2001) 3053-3061
-
(2001)
Cancer Res.
, vol.61
, pp. 3053-3061
-
-
Ludwig, A.1
Saretzki, G.2
Holm, P.S.3
Tiemann, F.4
Lorenz, M.5
Emrich, T.6
Harley, C.B.7
von Zglinicki, T.8
-
36
-
-
33646152108
-
Mitochondria are a direct site of A beta accumulation in Alzheimer's disease neurons: implications for free radical generation and oxidative damage in disease progression
-
Manczak M., Anekonda T.S., Henson E., Park B.S., Quinn J., and Reddy P.H. Mitochondria are a direct site of A beta accumulation in Alzheimer's disease neurons: implications for free radical generation and oxidative damage in disease progression. Hum. Mol. Genet. 15 (2006) 1437-1449
-
(2006)
Hum. Mol. Genet.
, vol.15
, pp. 1437-1449
-
-
Manczak, M.1
Anekonda, T.S.2
Henson, E.3
Park, B.S.4
Quinn, J.5
Reddy, P.H.6
-
37
-
-
33847276654
-
Monoubiquitylation promotes mitochondrial p53 translocation
-
Marchenko N.D., Wolff S., Erster S., Becker K., and Moll U.M. Monoubiquitylation promotes mitochondrial p53 translocation. EMBO J. 26 4 (2007) 923-934
-
(2007)
EMBO J.
, vol.26
, Issue.4
, pp. 923-934
-
-
Marchenko, N.D.1
Wolff, S.2
Erster, S.3
Becker, K.4
Moll, U.M.5
-
38
-
-
58949094552
-
Telomeres acquire embryonic stem cell characteristics in induced pluripotent stem cells
-
Marion R.M., Strati K., Li H., Tejera A., Schoeftner S., Ortega S., Serrano M., and Blasco M.A. Telomeres acquire embryonic stem cell characteristics in induced pluripotent stem cells. Cell Stem Cell 4 2 (2009) 141-154
-
(2009)
Cell Stem Cell
, vol.4
, Issue.2
, pp. 141-154
-
-
Marion, R.M.1
Strati, K.2
Li, H.3
Tejera, A.4
Schoeftner, S.5
Ortega, S.6
Serrano, M.7
Blasco, M.A.8
-
39
-
-
33746828140
-
Telomere length predicts poststroke mortality, dementia, and cognitive decline
-
Martin-Ruiz C., Dickinson H.O., Keys B., Rowan E., Kenny R.A., and von Zglinicki T. Telomere length predicts poststroke mortality, dementia, and cognitive decline. Ann. Neurol. 60 (2006) 174-180
-
(2006)
Ann. Neurol.
, vol.60
, pp. 174-180
-
-
Martin-Ruiz, C.1
Dickinson, H.O.2
Keys, B.3
Rowan, E.4
Kenny, R.A.5
von Zglinicki, T.6
-
40
-
-
33746851957
-
HTERT: a novel endogenous inhibitor of the mitochondrial cell death pathway
-
Massard C., Zermati Y., Pauleau A.L., Larochette N., Metivier D., Sabatier L., Kroemer G., and Soria J.C. HTERT: a novel endogenous inhibitor of the mitochondrial cell death pathway. Oncogene 25 (2006) 4505-4514
-
(2006)
Oncogene
, vol.25
, pp. 4505-4514
-
-
Massard, C.1
Zermati, Y.2
Pauleau, A.L.3
Larochette, N.4
Metivier, D.5
Sabatier, L.6
Kroemer, G.7
Soria, J.C.8
-
41
-
-
20444371017
-
The telomerase reverse transcriptase regulates chromatin state and DNA damage responses
-
Masutomi K., Possemato R., Wong J.M., Currier J.L., Tothova Z., Manola J.B., Ganesan S., Lansdorp P.M., Collins K., and Hahn W.C. The telomerase reverse transcriptase regulates chromatin state and DNA damage responses. Proc. Natl. Acad. Sci. USA 102 (2005) 8222-8227
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 8222-8227
-
-
Masutomi, K.1
Possemato, R.2
Wong, J.M.3
Currier, J.L.4
Tothova, Z.5
Manola, J.B.6
Ganesan, S.7
Lansdorp, P.M.8
Collins, K.9
Hahn, W.C.10
-
42
-
-
0019160038
-
Mitochondrial role in cell aging
-
Miquel J., Economos A.C., Fleming J., and Johnson Jr. J.E. Mitochondrial role in cell aging. Exp. Gerontol. 15 6 (1980) 575-591
-
(1980)
Exp. Gerontol.
, vol.15
, Issue.6
, pp. 575-591
-
-
Miquel, J.1
Economos, A.C.2
Fleming, J.3
Johnson Jr., J.E.4
-
43
-
-
54349098423
-
Increased telomerase activity and comprehensive lifestyle changes: a pilot study
-
Ornish D., Lin J., Daubenmier J., Weidner G., Epel E., Kemp C., Magbanua M.J., Marlin R., Yglecias L., Carroll P.R., and Blackburn E.H. Increased telomerase activity and comprehensive lifestyle changes: a pilot study. Lancet Oncol. 9 (2008) 1048-1057
-
(2008)
Lancet Oncol.
, vol.9
, pp. 1048-1057
-
-
Ornish, D.1
Lin, J.2
Daubenmier, J.3
Weidner, G.4
Epel, E.5
Kemp, C.6
Magbanua, M.J.7
Marlin, R.8
Yglecias, L.9
Carroll, P.R.10
Blackburn, E.H.11
-
44
-
-
34249028642
-
Mitochondrial dysfunction accounts for the stochastic heterogeneity in telomere-dependent replicative senescence
-
Passos J.F., Saretzki G., Ahmed S., Nelson G., Richter T., Peters H., Wappler I., Birket M., Harold G., Schaeuble K., Birch-Machin M.A., Kirkwood T.B.L., and von Zglinicki T. Mitochondrial dysfunction accounts for the stochastic heterogeneity in telomere-dependent replicative senescence. PLoS Biol. 5 (2007) 1138-1151
-
(2007)
PLoS Biol.
, vol.5
, pp. 1138-1151
-
-
Passos, J.F.1
Saretzki, G.2
Ahmed, S.3
Nelson, G.4
Richter, T.5
Peters, H.6
Wappler, I.7
Birket, M.8
Harold, G.9
Schaeuble, K.10
Birch-Machin, M.A.11
Kirkwood, T.B.L.12
von Zglinicki, T.13
-
45
-
-
34250193219
-
The loss of telomerase activity in highly differentiated CD8 + CD28 - CD27 - T cells is associated with decreased Akt (Ser473) phosphorylation
-
Plunkett F., Franzese O., Finney H.M., Fletcher J.M., Belaramani L.L., Salmon M., Dokal I., Webster D., Lawson A.D., and Akbar A.N. The loss of telomerase activity in highly differentiated CD8 + CD28 - CD27 - T cells is associated with decreased Akt (Ser473) phosphorylation. J. Immunol. 178 (2007) 7710-7719
-
(2007)
J. Immunol.
, vol.178
, pp. 7710-7719
-
-
Plunkett, F.1
Franzese, O.2
Finney, H.M.3
Fletcher, J.M.4
Belaramani, L.L.5
Salmon, M.6
Dokal, I.7
Webster, D.8
Lawson, A.D.9
Akbar, A.N.10
-
46
-
-
56049115567
-
Telomerase levels in schizophrenia: a preliminary study
-
Porton B., Delisi L.E., Bertisch H.C., Ji F., Gordon D., Li P., Benedict M.M., Greenberg W.M., and Kao H.T. Telomerase levels in schizophrenia: a preliminary study. Schizophr. Res. 106 (2008) 242-247
-
(2008)
Schizophr. Res.
, vol.106
, pp. 242-247
-
-
Porton, B.1
Delisi, L.E.2
Bertisch, H.C.3
Ji, F.4
Gordon, D.5
Li, P.6
Benedict, M.M.7
Greenberg, W.M.8
Kao, H.T.9
-
47
-
-
3042822263
-
Telomere length mediates the effects of telomerase on the cellular response to genotoxic stress
-
Rubio M.A., Davalos A.R., and Campisi J. Telomere length mediates the effects of telomerase on the cellular response to genotoxic stress. Exp. Cell Res. 298 1 (2004) 17-27
-
(2004)
Exp. Cell Res.
, vol.298
, Issue.1
, pp. 17-27
-
-
Rubio, M.A.1
Davalos, A.R.2
Campisi, J.3
-
48
-
-
13844272923
-
Mitochondrial hTERT exacerbates free-radical-mediated mtDNA damage
-
Santos J.H., Meyer J.N., Skorvaga M., Annab L.A., and Van Houten B. Mitochondrial hTERT exacerbates free-radical-mediated mtDNA damage. Aging Cell 3 (2004) 399-411
-
(2004)
Aging Cell
, vol.3
, pp. 399-411
-
-
Santos, J.H.1
Meyer, J.N.2
Skorvaga, M.3
Annab, L.A.4
Van Houten, B.5
-
49
-
-
33744745014
-
Mitochondrial localization of telomerase as a determinant for hydrogen peroxide-induced mitochondrial DNA damage and apoptosis
-
Santos J.H., Meyer J.N., and Van Houten B. Mitochondrial localization of telomerase as a determinant for hydrogen peroxide-induced mitochondrial DNA damage and apoptosis. Hum. Mol. Genet. 15 11 (2006) 1757-1768
-
(2006)
Hum. Mol. Genet.
, vol.15
, Issue.11
, pp. 1757-1768
-
-
Santos, J.H.1
Meyer, J.N.2
Van Houten, B.3
-
50
-
-
0034775290
-
Ribozyme-mediated telomerase inhibition induces immediate cell loss but not telomere shortening in ovarian cancer cells
-
Saretzki G., Ludwig A., von Zglinicki T., and Runnebaum I.B. Ribozyme-mediated telomerase inhibition induces immediate cell loss but not telomere shortening in ovarian cancer cells. Cancer Gene Ther. 8 (2001) 827-834
-
(2001)
Cancer Gene Ther.
, vol.8
, pp. 827-834
-
-
Saretzki, G.1
Ludwig, A.2
von Zglinicki, T.3
Runnebaum, I.B.4
-
51
-
-
0041419866
-
MitoQ counteracts telomere shortening and elongates lifespan of fibroblasts under mild oxidative stress
-
Saretzki G., Murphy M.P., and von Zglinicki T. MitoQ counteracts telomere shortening and elongates lifespan of fibroblasts under mild oxidative stress. Aging Cell 141 (2003) 143
-
(2003)
Aging Cell
, vol.141
, pp. 143
-
-
Saretzki, G.1
Murphy, M.P.2
von Zglinicki, T.3
-
52
-
-
40949088547
-
Down-regulation of multiple stress defence mechanisms during differentiation of human embryonic stem cells
-
Saretzki G., Walter T., Atkinson S., Passos J.F., Bareth B., Keith W.N., Stewart R., Hoare S., Stojkovic M., Armstrong L., von Zglinicki T., and Lako M. Down-regulation of multiple stress defence mechanisms during differentiation of human embryonic stem cells. Stem Cells 26 (2008) 455-465
-
(2008)
Stem Cells
, vol.26
, pp. 455-465
-
-
Saretzki, G.1
Walter, T.2
Atkinson, S.3
Passos, J.F.4
Bareth, B.5
Keith, W.N.6
Stewart, R.7
Hoare, S.8
Stojkovic, M.9
Armstrong, L.10
von Zglinicki, T.11
Lako, M.12
-
53
-
-
23944516520
-
Conditional telomerase induction causes proliferation of hair follicle stem cells
-
Sarin K.Y., Cheung P., Gilison D., Lee E., Tennen R.I., Wang E., Artandi M.K., Oro A.E., and Artandi S.E. Conditional telomerase induction causes proliferation of hair follicle stem cells. Nature 436 (2005) 1048-1052
-
(2005)
Nature
, vol.436
, pp. 1048-1052
-
-
Sarin, K.Y.1
Cheung, P.2
Gilison, D.3
Lee, E.4
Tennen, R.I.5
Wang, E.6
Artandi, M.K.7
Oro, A.E.8
Artandi, S.E.9
-
54
-
-
0038199601
-
The role of mitochondrial oxidative stress in aging
-
Sastre J., Pallardó F.V., and Viña J. The role of mitochondrial oxidative stress in aging. Free Radic. Biol. Med. 35 1 (2003) 1-8
-
(2003)
Free Radic. Biol. Med.
, vol.35
, Issue.1
, pp. 1-8
-
-
Sastre, J.1
Pallardó, F.V.2
Viña, J.3
-
55
-
-
33644959683
-
Mitochondrial respiration and reactive oxygen species in mitochondrial aging mutants
-
Sedensky M.M., and Morgan P.G. Mitochondrial respiration and reactive oxygen species in mitochondrial aging mutants. Exp. Gerontol. 41 3 (2006) 237-245
-
(2006)
Exp. Gerontol.
, vol.41
, Issue.3
, pp. 237-245
-
-
Sedensky, M.M.1
Morgan, P.G.2
-
56
-
-
0034212582
-
Involvement of 14-3-3 proteins in nuclear localization of telomerase
-
Seimiya H., Sawada H., Muramatsu Y., Shimizu M., Ohko K., Yamane K., and Tsuruo T. Involvement of 14-3-3 proteins in nuclear localization of telomerase. EMBO J. 19 11 (2000) 2652-2661
-
(2000)
EMBO J.
, vol.19
, Issue.11
, pp. 2652-2661
-
-
Seimiya, H.1
Sawada, H.2
Muramatsu, Y.3
Shimizu, M.4
Ohko, K.5
Yamane, K.6
Tsuruo, T.7
-
57
-
-
0037470062
-
Extracellular superoxide dismutase is a major antioxidant in human fibroblasts and slows down telomere shortening
-
Serra V., von Zglinicki T., Lorenz M., and Saretzki G. Extracellular superoxide dismutase is a major antioxidant in human fibroblasts and slows down telomere shortening. J. Biol. Chem. 278 (2003) 6824-6830
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 6824-6830
-
-
Serra, V.1
von Zglinicki, T.2
Lorenz, M.3
Saretzki, G.4
-
58
-
-
0037427086
-
HTERT associates with human telomeres and enhances genomic stability and DNA repair
-
Sharma G.G., Gupta A., Wang H., Scherthan H., Dhar S., Gandhi V., Iliakis G., Shay J.W., Young C.S., and Pandita T.K. HTERT associates with human telomeres and enhances genomic stability and DNA repair. Oncogene 22 (2003) 131-146
-
(2003)
Oncogene
, vol.22
, pp. 131-146
-
-
Sharma, G.G.1
Gupta, A.2
Wang, H.3
Scherthan, H.4
Dhar, S.5
Gandhi, V.6
Iliakis, G.7
Shay, J.W.8
Young, C.S.9
Pandita, T.K.10
-
59
-
-
0038056347
-
Telomerase modulates expression of growth-controlling genes and enhances cell proliferation
-
Smith L.L., Coller H.A., and Roberts J.M. Telomerase modulates expression of growth-controlling genes and enhances cell proliferation. Nat. Cell Biol. 5 (2003) 474-479
-
(2003)
Nat. Cell Biol.
, vol.5
, pp. 474-479
-
-
Smith, L.L.1
Coller, H.A.2
Roberts, J.M.3
-
60
-
-
18644373013
-
Telomerase contributes to tumorigenesis by a telomere length-independent mechanism
-
Stewart S.A., Hahn W.C., O'Connor B.F., Banner E.N., Lundberg A.S., Modha P., Mizuno H., Brooks M.W., Fleming M., Zimonjic D.B., Popescu N.C., and Weinberg R.A. Telomerase contributes to tumorigenesis by a telomere length-independent mechanism. Proc. Natl. Acad. Sci. USA 99 (2002) 12606-12611
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 12606-12611
-
-
Stewart, S.A.1
Hahn, W.C.2
O'Connor, B.F.3
Banner, E.N.4
Lundberg, A.S.5
Modha, P.6
Mizuno, H.7
Brooks, M.W.8
Fleming, M.9
Zimonjic, D.B.10
Popescu, N.C.11
Weinberg, R.A.12
-
61
-
-
55449122193
-
Telomerase reverse transcriptase delays aging in cancer-resistant mice
-
Tomás-Loba A., Flores I., Fernández-Marcos P.J., Cayuela M.L., Maraver A., Tejera A., Borrás C., Matheu A., Klatt P., Flores J.M., Viña J., Serrano M., and Blasco M.A. Telomerase reverse transcriptase delays aging in cancer-resistant mice. Cell 135 4 (2008) 609-622
-
(2008)
Cell
, vol.135
, Issue.4
, pp. 609-622
-
-
Tomás-Loba, A.1
Flores, I.2
Fernández-Marcos, P.J.3
Cayuela, M.L.4
Maraver, A.5
Tejera, A.6
Borrás, C.7
Matheu, A.8
Klatt, P.9
Flores, J.M.10
Viña, J.11
Serrano, M.12
Blasco, M.A.13
-
62
-
-
2642580016
-
Premature ageing in mice expressing defective mitochondrial DNA polymerase
-
Trifunovic A., Wredenberg A., Falkenberg M., Spelbrink J.N., Rovio A.T., Bruder C.E., Bohlooly Y.M., Gidlöf S., Oldfors A., Wibom R., Törnell J., Jacobs H.T., and Larsson N.G. Premature ageing in mice expressing defective mitochondrial DNA polymerase. Nature 429 (2004) 417-423
-
(2004)
Nature
, vol.429
, pp. 417-423
-
-
Trifunovic, A.1
Wredenberg, A.2
Falkenberg, M.3
Spelbrink, J.N.4
Rovio, A.T.5
Bruder, C.E.6
Bohlooly, Y.M.7
Gidlöf, S.8
Oldfors, A.9
Wibom, R.10
Törnell, J.11
Jacobs, H.T.12
Larsson, N.G.13
-
63
-
-
0034988397
-
Oxidative damage to mitochondria and aging
-
Van Remmen H., and Richardson A. Oxidative damage to mitochondria and aging. Exp. Gerontol. 36 7 (2001) 957-968
-
(2001)
Exp. Gerontol.
, vol.36
, Issue.7
, pp. 957-968
-
-
Van Remmen, H.1
Richardson, A.2
-
64
-
-
0029127226
-
Mild hyperoxia shortens telomeres and inhibits proliferation of fibroblasts: a model for senescence?
-
von Zglinicki T., Saretzki G., Docke W., and Lotze C. Mild hyperoxia shortens telomeres and inhibits proliferation of fibroblasts: a model for senescence?. Exp. Cell Res. 220 (1995) 186-193
-
(1995)
Exp. Cell Res.
, vol.220
, pp. 186-193
-
-
von Zglinicki, T.1
Saretzki, G.2
Docke, W.3
Lotze, C.4
-
65
-
-
0033747604
-
Short telomeres in patients with vascular dementia: an indicator of low antioxidative capacity and a possible risk factor?
-
von Zglinicki T., Serra V., Lorenz M., Saretzki G., Lenzen-Grossimlighaus R., Gessner R., Risch A., and Steinhagen-Thiessen E. Short telomeres in patients with vascular dementia: an indicator of low antioxidative capacity and a possible risk factor?. Lab. Invest. 80 (2000) 1739-1747
-
(2000)
Lab. Invest.
, vol.80
, pp. 1739-1747
-
-
von Zglinicki, T.1
Serra, V.2
Lorenz, M.3
Saretzki, G.4
Lenzen-Grossimlighaus, R.5
Gessner, R.6
Risch, A.7
Steinhagen-Thiessen, E.8
-
66
-
-
0036711651
-
Subnuclear shuttling of human telomerase induced by transformation and DNA damage
-
Wong J.M., Kusdra L., and Collins K. Subnuclear shuttling of human telomerase induced by transformation and DNA damage. Nat. Cell Biol. 4 9 (2002) 731-736
-
(2002)
Nat. Cell Biol.
, vol.4
, Issue.9
, pp. 731-736
-
-
Wong, J.M.1
Kusdra, L.2
Collins, K.3
-
67
-
-
2942548982
-
Immunohistochemical localization of hTERT protein in human tissues
-
Yan P., Benhattar J., Seelentag W., Stehle J.C., and Bosman F.T. Immunohistochemical localization of hTERT protein in human tissues. Histochem. Cell Biol. 121 (2004) 391-397
-
(2004)
Histochem. Cell Biol.
, vol.121
, pp. 391-397
-
-
Yan, P.1
Benhattar, J.2
Seelentag, W.3
Stehle, J.C.4
Bosman, F.T.5
-
68
-
-
49249111098
-
A key role for telomerase reverse transcriptase unit (TERT) in modulating human ESC proliferation, cell cycle dynamics and in vitro differentiation
-
Yang C., Pryzborski S., Cooke M.J., Zhang X., Stewart R., Atkinson S., Saretzki G., Armstrong L., and Lako M. A key role for telomerase reverse transcriptase unit (TERT) in modulating human ESC proliferation, cell cycle dynamics and in vitro differentiation. Stem Cells 26 (2008) 850-863
-
(2008)
Stem Cells
, vol.26
, pp. 850-863
-
-
Yang, C.1
Pryzborski, S.2
Cooke, M.J.3
Zhang, X.4
Stewart, R.5
Atkinson, S.6
Saretzki, G.7
Armstrong, L.8
Lako, M.9
-
69
-
-
0037390962
-
Mendoza M, Mattson MP TERT suppresses apoptosis at a premitochondrial step by a mechanism requiring reverse transcriptase activity and 14-3-3 protein-binding ability
-
Zhang P., Chan S.L., and Fu W. Mendoza M, Mattson MP TERT suppresses apoptosis at a premitochondrial step by a mechanism requiring reverse transcriptase activity and 14-3-3 protein-binding ability. FASEB J. 17 (2003) 767-769
-
(2003)
FASEB J.
, vol.17
, pp. 767-769
-
-
Zhang, P.1
Chan, S.L.2
Fu, W.3
-
70
-
-
0034086553
-
The catalytic subunit of telomerase protects neurons against amyloid beta-peptide-induced apoptosis
-
Zhu H., Fu W., and Mattson M.P. The catalytic subunit of telomerase protects neurons against amyloid beta-peptide-induced apoptosis. J. Neurochem. 75 (2000) 117-124
-
(2000)
J. Neurochem.
, vol.75
, pp. 117-124
-
-
Zhu, H.1
Fu, W.2
Mattson, M.P.3
|