Loss of p53 causes mitochondrial DNA depletion and altered mitochondrial reactive oxygen species homeostasis

Biochimica et Biophysica Acta - Bioenergetics

Volumn 1787, Issue 5, 2009, Pages 328-334

  Lebedeva, Maria A ^a   Eaton, Jana S ^a,b   Shadel, Gerald S ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b EMORY UNIVERSITY   (United States)

Author keywords

Cancer; Mitochondrial transcription factor A; mtDNA depletion; p53; p53R2; Reactive oxygen species

Indexed keywords

HYDROGEN PEROXIDE; MESSENGER RNA; MITOCHONDRIAL DNA; MITOCHONDRIAL TRANSCRIPTION FACTOR A; PROTEIN P53; REACTIVE OXYGEN METABOLITE; RIBONUCLEOTIDE REDUCTASE; SUPEROXIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CANCER CELL; CELL STRESS; CELL TRANSFORMATION; GENE DISRUPTION; HUMAN; HUMAN CELL; MITOCHONDRIAL DNA DEPLETION; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEPLETION; TUMOR SUPPRESSOR GENE; WARBURG EFFECT;

ANIMALS; DNA PRIMERS; DNA, MITOCHONDRIAL; FIBROBLASTS; GENE DELETION; HOMEOSTASIS; HUMANS; MEMBRANE POTENTIALS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MITOCHONDRIA; OXIDATIVE PHOSPHORYLATION; POLYMERASE CHAIN REACTION; REACTIVE OXYGEN SPECIES; RNA, MESSENGER; TRANSCRIPTION, GENETIC; TUMOR SUPPRESSOR PROTEIN P53;

MAMMALIA;

EID: 65449137587     PISSN: 00052728     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbabio.2009.01.004     Document Type: Article

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