Mitochondria are morphologically and functionally heterogeneous within cells

EMBO Journal

Volumn 21, Issue 7, 2002, Pages 1616-1627

  Collins, Tony J ^a   Berridge, Michael J ^a   Lipp, Peter ^a   Bootman, Martin D ^a,b  

^a BABRAHAM INSTITUTE   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Calcium; FRAP; Membrane potential; Mitochondria; Permeability transition

Indexed keywords

CALCEIN; HYDROPEROXIDE;

ARTICLE; ASTROCYTE; BLEACHING; CALCIUM SIGNALING; CELL AGGREGATION; CELL FUNCTION; CELL MEMBRANE PERMEABILITY; CELL SIZE; CELL STRUCTURE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOSOL; DEPOLARIZATION; FLUORESCENCE; HUMAN; HUMAN CELL; LIVER CELL; MEMBRANE POTENTIAL; MITOCHONDRION; NERVE CELL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANIMALS; CELLS, CULTURED; CERCOPITHECUS AETHIOPS; COS CELLS; ENDOTHELIUM, VASCULAR; HELA CELLS; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MITOCHONDRIA; SWINE;

EID: 0037007227     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/21.7.1616     Document Type: Article

References (52)

1. Coupling membranes as energy-transmitting cables. 1. Filamentous mitochondria in fibroblasts and mitochondrial clusters in cardiomyocytes
2. 2+ network
3. Are there distinct subcellular populations of mitochondria in rainbow trout red muscle?
4. 2+ stores
5. Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization
6. The structure of rat liver mitochondria: A reevaluation
7. Spontaneous changes in mitochondrial membrane potential in cultured neurons
8. Mitochondrial membrane potential in living cells
9. 2+ signals
10. The mitochondrial permeability transition pore and its role in cell death
11. Electrical coupling and plasticity of the mitochondrial network
12. Transient mitochondrial depolarizations reflect focal sarcoplasmic reticular calcium release in single rat cardiomyocytes
13. Intracellular ATP levels determine cell death fate by apoptosis or necrosis
14. Intracellular fluorescent probe concentrations by confocal microscopy
15. The role of Dynamin-Related Protein 1, a mediator of mitochondrial fission, in apoptosis
16. The coordinate release of cytochrome c during apoptosis is rapid, complete and kinetically invariant
17. Transport of calcium by mitochondria
18. Mechanisms by which mitochondria transport calcium
19. Decoding of cytosolic calcium oscillations in the mitochondria
20. Mitochondrial depolarization accompanies cytochrome c release during apoptosis in PC6 cells
21. Mitochondrion of yeast: Ultrastructural evidence for one giant, branched organelle per cell
22. Mitochondrial regulation of store-operated calcium signaling in T lymphocytes
23. Fluctuations in mitochondrial membrane potential caused by repetitive gating of the permeability transition pore
24. Imaging the permeability pore transition in single mitochondria
25. Mitochondrial calcium spiking-a transduction mechanism-based on calcium-induced permeability transition involved in cell calcium signaling
26. Two mitochondrial populations in the heart: Are subsarcolemmal mitochondria the primary target of mitochondrial K-ATP channel opener action?
27. Synchronization of calcium waves by mitochondrial substrates in Xenopus laevis oocytes
28. Regulation of mitochondrial ATP synthesis by calcium: Evidence for a long-term metabolic priming
29. Intracellular adenosine triphosphate (ATP) concentration: A switch in the decision between apoptosis and necrosis
30. Characterisation of oxidative phosphorylation in skeletal muscle mitochondria subpopulations in pig: A study using top-down elasticity analysis
31. Evaluation of fluorescent dyes for the detection of mitochondrial membrane potential changes in cultured cardiomyocytes
32. 2+ entry through basal membrane patch
33. Monitoring mitochondrial function in single cells
34. The effect of chemicals and radiations within the cell: An ultrastructural and micrurgical study using Amoeba proteus as a single-cell model
35. Perinuclear, perigranular and sub-plasmalemmal mitochondria have distinct functions in the regulation of cellular calcium transport
36. Transient and long-lasting openings of the mitochondrial permeability transition pore can be monitored directly in intact cells by changes in mitochondrial calcein fluorescence
37. J-aggregate formation of a carbocyanine as a quantitative fluorescent indicator of membrane-potential
38. Mitochondrial-membrane potential monitored by JC-1 dye
39. 2+ transients in HT29 cells
40. 3-sensitive channels that are sensed by neighboring mitochondria
41. 2+ responses
42. 2+ release: An intimate connection
43. 2+ with recombinant targeted aequorin-significance for the regulation of pyruvate-dehydrogenase activity
44. 6(3) or rhodamine 123, is a reliable fluorescent probe to assess Δψ changes in intact cells: Implications for studies on mitochondrial functionality during apoptosis
45. Measurement of mitochondrial membrane potential using fluorescent rhodamine derivatives
46. An electron microscope study of changes in mitochondria of flight muscle of ageing houseflies (Musca domestica)
47. Mitochondrial filaments and cluster as intracellular power transmitting cables
48. A critical evaluation of in situ measurement of mitochondrial electrical potentials in single hepatocytes
49. Cytochrome c maintains mitochondrial transmembrane potential and ATP generation after outer mitochondrial membrane permeabilization during the apoptotic process
50. Glucagon effects on the membrane-potential and calcium-uptake rate of rat-liver mitochondria
51. Reactive oxygen species (ROS)-induced ROS release: A new phenomenon accompanying induction of the mitochondrial permeability transition in cardiac myocytes