Mitochondrial telomerase reverse transcriptase binds to and protects mitochondrial DNA and function from damage

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 29, Issue 6, 2009, Pages 929-935

  Haendeler, Judith ^a,c   Dröse, Stefan ^b   Büchner, Nicole ^c   Jakob, Sascha ^c   Altschmied, Joachim ^c   Goy, Christine ^a   Spyridopoulos, Ioakim ^a   Zeiher, Andreas M ^a   Brandt, Ulrich ^b   Dimmeler, Stefanie ^a  

^a Department of Internal Medicine III ^*  (Germany)

^b GOETHE UNIVERSITY   (Germany)

^c HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

Aging; Apoptosis; Mitochondrial DNA; Mitochondrial functions; Reactive oxygen species; Telomerase reverse transcriptase

Indexed keywords

ETHIDIUM BROMIDE; HYDROGEN PEROXIDE; MITOCHONDRIAL DNA; REACTIVE OXYGEN METABOLITE; SHORT HAIRPIN RNA; TELOMERASE REVERSE TRANSCRIPTASE; ETHIDIUM; SMALL INTERFERING RNA; TELOMERASE; TERT PROTEIN, HUMAN; TERT PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; DNA DAMAGE; EMBRYO; ENZYME ACTIVITY; EXTRACELLULAR MATRIX; HEART MITOCHONDRION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LUNG FIBROBLAST; MITOCHONDRION; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA BINDING; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RADIOSENSITIVITY; RESPIRATORY CHAIN; RNA INTERFERENCE; ULTRAVIOLET B RADIATION; WILD TYPE; ANIMAL; CELL CULTURE; DRUG EFFECT; ELECTRON TRANSPORT; ENDOTHELIUM CELL; ENZYMOLOGY; FIBROBLAST; GENETIC TRANSFECTION; GENETICS; LUNG; METABOLISM; MOUSE MUTANT; PATHOLOGY; PROTEIN BINDING; RADIATION EXPOSURE; ULTRAVIOLET RADIATION;

ANIMALS; APOPTOSIS; CELLS, CULTURED; DNA DAMAGE; DNA, MITOCHONDRIAL; ELECTRON TRANSPORT; ENDOTHELIAL CELLS; ETHIDIUM; FIBROBLASTS; HUMANS; HYDROGEN PEROXIDE; LUNG; MICE; MICE, KNOCKOUT; MITOCHONDRIA; MITOCHONDRIA, HEART; OXIDATIVE STRESS; PROTEIN BINDING; REACTIVE OXYGEN SPECIES; RNA INTERFERENCE; RNA, SMALL INTERFERING; TELOMERASE; TRANSFECTION; ULTRAVIOLET RAYS;

EID: 66349130192     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/ATVBAHA.109.185546     Document Type: Article

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