Random mtDNA mutations modulate proliferation capacity in mouse embryonic fibroblasts

Biochemical and Biophysical Research Communications

Volumn 409, Issue 3, 2011, Pages 394-399

  Kukat, Alexandra ^a,b   Edgar, Daniel ^a   Bratic, Ivana ^a,b   Maiti, Priyanka ^b   Trifunovic, Aleksandra ^a,b  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UNIVERSITY HOSPITAL OF COLOGNE   (Germany)

Author keywords

Aerobic glycolysis; Cellular senescence; MEFs; MtDNA mutator

Indexed keywords

ADENOSINE TRIPHOSPHATE; MITOCHONDRIAL DNA; OXYGEN; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ARTICLE; CELL AGING; CELL DIVISION; CELL PROLIFERATION; FIBROBLAST; GENE MUTATION; GLYCOLYSIS; IN VITRO STUDY; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; WILD TYPE;

ANIMALS; CELL AGING; CELL PROLIFERATION; CELLS, CULTURED; DNA, MITOCHONDRIAL; EMBRYO, MAMMALIAN; FIBROBLASTS; GLYCOLYSIS; MICE; MITOCHONDRIA;

MUS;

EID: 80955180548     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2011.04.145     Document Type: Article

References (26)

1. Campisi J. Cellular senescence: putting the paradoxes in perspective. Curr. Opin. Genet. Dev. 2011, 21:107-112.
2. Shamblott M.J., Axelman J., Littlefield J.W., Blumenthal P.D., Huggins G.R., Cui Y., Cheng L., Gearhart J.D. Human embryonic germ cell derivatives express a broad range of developmentally distinct markers and proliferate extensively in vitro. Proc. Natl Acad. Sci. USA 2001, 98:113-118.
3. Reddel R.R. The role of senescence and immortalization in carcinogenesis. Carcinogenesis 2000, 21:477-484.
4. Campisi J. Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbours. Cell 2005, 120:513-522.
5. Coppe J.P., Patil C.K., Rodier F., Sun Y., Munoz D.P., Goldstein J., Nelson P.S., Desprez P.Y., Campisi J. Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor. PLoS Biol. 2008, 6:2853-2868.
6. Blasco M.A. Telomere length stem cells and aging. Nat. Chem. Biol. 2007, 3:640-649.
7. Sherr C.J., DePinho R.A. Cellular senescence: mitotic clock or culture shock?. Cell 2000, 102:407-410.
8. Loo D.T., Fuquay J.I., Rawson C.L., Barnes D.W. Extended culture of mouse embryo cells without senescence: inhibition by serum. Science 1987, 236:200-202.
9. Parrinello S., Samper E., Krtolica A., Goldstein J., Melov S., Campisi J. Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts. Nat. Cell Biol. 2003, 5:741-747.
10. Harvey D.M., Levine A.J. p53 Alteration is a common event in the spontaneous immortalization of primary BALB/c murine embryo fibroblasts. Genes Dev. 1991, 5:2375-2385.
11. Serrano M., Lin A.W., McCurrach M.E., Beach D., Lowe S.W. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 1997, 88:593-602.
12. Trifunovic A., Wredenberg A., Falkenberg M., Spelbrink J.N., Rovio A.T., Bruder C.E., Bohlooly Y.M., Gidlof S., Oldfors A., Wibom R., Tornell J., Jacobs H.T., Larsson N.G. Premature ageing in mice expressing defective mitochondrial DNA polymerase. Nature 2004, 429:417-423.
13. Trifunovic A., Hansson A., Wredenberg A., Rovio A.T., Dufour E., Khvorostov I., Spelbrink J.N., Wibom R., Jacobs H.T., Larsson N.G. Somatic mtDNA mutations cause aging phenotypes without affecting reactive oxygen species production. Proc. Natl Acad. Sci. USA 2005, 102:17993-17998.
14. Meek R.L., Bowman P.D., Daniel C.W. Establishment of mouse embryo cells in vitro. Relationship of DNA synthesis, senescence and malignant transformation. Exp. Cell Res. 1977, 107:277-284.
15. Dimri G.P., Lee X., Basile G., Acosta M., Scott G., Roskelley C., Medrano E.E., Linskens M., Rubelj I., Pereira-Smith O., et al. A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc. Natl Acad. Sci. USA 1995, 92:9363-9367.
16. Polla B.S., Kantengwa S., Francois D., Salvioli S., Franceschi C., Marsac C., Cossarizza A. Mitochondria are selective targets for the protective effects of heat shock against oxidative injury. Proc. Natl Acad. Sci. USA 1996, 93:6458-6463.
17. Halliwell B. Oxidative stress in cell culture: an under-appreciated problem?. FEBS Lett. 2003, 540:3-6.
18. Chen J.H., Hales C.N., Ozanne S.E. DNA damage cellular senescence and organismal ageing: causal or correlative?. Nucleic Acids Res. 2007, 35:7417-7428.
19. Martien S., Abbadie C. Acquisition of oxidative DNA damage during senescence: the first step toward carcinogenesis?. Ann. N. Y. Acad. Sci. 2007, 1119:51-63.
20. Todaro G.J., Green H. Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines. J. Cell Biol. 1963, 17:299-313.
21. Schieke S.M., Ma M., Cao L., McCoy J.P., Liu C., Hensel N.F., Barrett A.J., Boehm M., Finkel T. Mitochondrial metabolism modulates differentiation and teratoma formation capacity in mouse embryonic stem cells. J. Biol. Chem. 2008, 283:28506-28512.
22. Lee H.C., Yin P.H., Chi C.W., Wei Y.H. Increase in mitochondrial mass in human fibroblasts under oxidative stress and during replicative cell senescence. J. Biomed. Sci. 2002, 9:517-526.
23. Whibley C., Odell A.F., Nedelko T., Balaburski G., Murphy M., Liu Z., Stevens L., Walker J.H., Routledge M., Hollstein M. Wild-type and Hupki (human p53 knock-in) murine embryonic fibroblasts: p53/ARF pathway disruption in spontaneous escape from senescence. J. Biol. Chem. 2010, 285:11326-11335.
24. Kondoh H., Lleonart M.E., Gil J., Wang J., Degan P., Peters G., Martinez D., Carnero A., Beach D. Glycolytic enzymes can modulate cellular life span. Cancer Res. 2005, 65:177-185.
25. Kondoh H., Lleonart M.E., Bernard D., Gil J. Protection from oxidative stress by enhanced glycolysis; a possible mechanism of cellular immortalization. Histol. Histopathol. 2007, 22:85-90.
26. Schulz T.J., Thierbach R., Voigt A., Drewes G., Mietzner B., Steinberg P., Pfeiffer A.F., Ristow M. Induction of oxidative metabolism by mitochondrial frataxin inhibits cancer growth: Otto Warburg revisited. J. Biol. Chem. 2006, 281:977-981.