An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA

Nature

Volumn 461, Issue 7261, 2009, Pages 230-235

  Maida, Yoshiko ^a   Yasukawa, Mami ^a   Furuuchi, Miho ^a   Lassmann, Timo ^b   Possemato, Richard ^c   Okamoto, Naoko ^a   Kasim, Vivi ^a   Hayashizaki, Yoshihide ^b   Hahn, William C ^c,d   Masutomi, Kenkichi ^a,e  

^a NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

^b RIKEN YOKOHAMA INSTITUTE   (Japan)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^e JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

DICER; DOUBLE STRANDED RNA; GENE PRODUCT; PROTEIN RMRP; RIBONUCLEOPROTEIN; RNA DIRECTED RNA POLYMERASE; SMALL INTERFERING RNA; TELOMERASE; TELOMERASE REVERSE TRANSCRIPTASE; UNCLASSIFIED DRUG;

CATALYSIS; CYTOLOGY; ENZYME ACTIVITY; GENE EXPRESSION; MAMMAL; MUTATION; PHYSIOLOGY; PROTEIN; RNA; SENESCENCE;

ARTICLE; CARTILAGE HAIR HYPOPLASIA SYNDROME; COMPLEX FORMATION; CONTROLLED STUDY; GENE; GENE MUTATION; HOMEOSTASIS; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN RNA BINDING; RMRP GENE; RNA PROCESSING; SYNDROME; TELOMERE;

CELL LINE; ENDORIBONUCLEASES; GENE EXPRESSION REGULATION; HELA CELLS; HUMANS; PROTEIN BINDING; RIBONUCLEASE III; RIBONUCLEOPROTEINS; RNA REPLICASE; RNA, DOUBLE-STRANDED; RNA, SMALL INTERFERING; RNA, UNTRANSLATED; TELOMERASE;

MAMMALIA;

EID: 70249114371     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature08283     Document Type: Article

References (44)

1. Cohen, S. B. et al. Protein composition of catalytically active human telomerase from immortal cells. Science 315, 1850-1853 (2007).
2. 2. Fu, D. & Collins, K. Purification of human telomerase complexes identifies factors Involved in telomerase biogenesis and telomere length regulation. Mol. Cell 28, 773-785 (2007). (Pubitemid 350217053)
3. Venteicher, A. S., Meng, Z., Mason, P, J., Veenstra, T. D. & Artandi, S. E. Identification of ATPases pontin and reptln as telomerase components essential for holoenzyme assembly. Cell 132, 945-971 (2008).
4. Venteicher, A. S. et al. A human telomerase holoenzyme protein required for Cajal body localization and telomere synthesis. Science 323, 644-648 (2009).
5. Weinrich, S. L. et al. Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunlt hTRT. Nature Genet 17, 498-502 (1997).
6. Chan, S. W. & Blackburn, E. H. New ways not to make ends meet: telomerase, DNA damage proteins and heterochromatln. Oncogene 21, 553-563 (2002).
7. Liu, J. M. & Ellis, S. R. Ribosomes and marrow failure: coincidental association or molecular paradigm? Blood 107, 4583-4588 (2006).
8. Calado, R. T. & Young, N. S. Telomere maintenance and human bone marrow failure. Blood 111, 4446-4455 (2008).
9. 9. Gonzalez-Suarez. E. et al. Increased epidermal tumors and Increased skin wound healing in transgenic mice overexpressing the catalytic subunlt of telomerase, mTERT, in basal keratlnocytes. EMBO J. 20, 2619-2630 (2001). (Pubitemid 32938547)
10. Artandi. S. E. et al. Constitutive telomerase expression promotes mammary carcinomas in aging mice. Proc. Natl Acad. Sci. USA 99, 8191-8196 (2002).
11. Masutoml, K. et al. The telomerase reverse transcriptase regulates chromatin state and DNA damage responses. Proc. Natl Acad. Sci. USA 102, 8222-8227 (2005).
12. Sarin, K. Y. et al. Conditional telomerase induction causes proliferation of hair follicle stem cells. Nature 436, 1048-1052 (2005).
13. Lee, J. et al. TERT promotes cellular and organismal survival Independently of telomerase activity. Oncogene 27, 3754-3760 (2008).
14. 14. Tollervey, D. & Kiss, T. Function and synthesis of small nucleolar RNAs. Curr. Opin. Cell Biol. 9, 337-342 (1997). (Pubitemid 27263174)
15. 15. Ridanpaa, M. et al. Mutations in the RNA component of RNase MRP cause a pleiotrope human disease, cartilage-hair hypoplasia. Cell 104, 195-203 (2001). (Pubitemid 32174836)
16. 16. Moriarty. T. J., Huard, S., Dupuis, S, & Autexler, C. Functional multimerization of human telomerase requires an RNA interaction domain in the N terminus of the catalytic subunit. Mol. Cell. Biol. 22, 1253-1265 (2002). (Pubitemid 34094860)
17. Lue, N. F. et al. Telomerase can act as a template- and RNA-independent terminal transferase. Proc. Natl Acad. Sci. USA 102, 9778-9783 (2005).
18. Nakamura, T. M. et al. Telomerase catalytic subunit homologs from fission yeast and human. Science 277, 955-959 (1997).
19. Mourrain, P. et al. Arabidopsis SGS2 and SGS3 genes are required for posttranscriptional gene silencing and natural virus resistance. Cell 101, 533-542 (2000).
20. 20. Smardon, A. et al. EGO-1 is related to RNA-directed RNA polymerase and functions In germ-line development and RNA Interference In C. elegans. Curr. Biol. 10, 169-178 (2000). (Pubitemid 30146781)
21. 21. Lipardl, C., Wei. Q. & Paterson, B, M. RNAi as random degradative PCR: siRNA primers convert mRNA into dsRNAs that are degraded to generate new siRNAs. Cell 107, 297-307 (2001). (Pubitemid 33049974)
22. Sljen, T. et al. On the role of RNA amplification in dsRNA-triggered gene silencing. Cell 107, 465-476 (2001).
23. Makeyev, E. V. & Bamford, D. H. Cellular RNA-dependent RNA polymerase involved in posttranscriptional gene silencing has two distinct activity modes. Mol. Cell 10, 1417-1427(2002).
24. Semler, B. L. & Wimmer, E. Molecular Biology of Picomaviruses 255-267 (American Society for Microbiology. 2002).
25. Behrens, S. E., Tomei, L. & De Francesco, R. Identification and properties of the RNA-dependent RNA polymerase of hepatitis C virus. EMSO J. 15, 12-22 (1996).
26. Suglyama, T., Cam. H., Verdel, A., Moazed. D. & Grewal, S. I. RNA-dependent RNA polymerase is an essential component of a self-enforcing loop coupling heterochromatin assembly to siRN A production. Proc. Natl Acad. Sci. USA 102, 152-157 (2005).
27. 27. Masutomi, K. et al. Telomerase maintains telomere structure In normal human cells. Cell 114, 241-253 (2003). (Pubitemid 36936917)
28. Ford, L. P. et al. Telomerase can Inhibit the recombination-based pathway of telomere maintenance in human cells. J. Biol. Chem. 276, 32198-32203 (2001).
29. 29. Pascale, E., Clmino Reale, G. & D'Ambroslo, E. Tumor cells fall to trans-induce telomerase in human umbilical vein endothelial cell cultures, Cancer Res, 64, 7702-7705 (2004). (Pubitemid 39446900)
30. 30. Won, J., Chang, S., Oh, S. & Kim, T. K. Small-molecule-based identification of dynamic assembly of E2F-pocket protein-hlstone deacetylase complex for telomerase regulation In human cells, Proc. Natl Acad. Sci. USA 101, 11328-11333 (2004). (Pubitemid 39038346)
31. Almeida, R. & Allshire, R. C. RNA silencing and genome regulation. Trends Cell Biol. 15, 251-258 (2005).
32. 32. Schwarz, D. S., Hutvagner, G., Haley, B. & Zamore, P, D. Evidence that siRNAs function as guides, not primers, In the Drosophlla and human RNAi pathways. MoI. Cell 10, 537-548 (2002). (Pubitemid 35284172)
33. 2- "-dependent endonuclease, Curr. Biol. 14, 787-791 (2004).
34. Vagin, V. V. et al. A distinct small RNA pathway silences selfish genetic elements in the germline. Science 313, 320-324 (2006).
35. Nishlkura, K. A. short primer on RNAi: RNA-dlrected RNA polymerase acts as a key catalyst. Cell 107, 415-418 (2001).
36. 36. Aoki, K., Moriguchi, H., Yoshioka, T., Okawa, K. & Tabara. H. In vitro analyses of the production and activity of secondary small Interfering RNAs In C. elegans. EMBO J. 26, 5007-5019 (2007). (Pubitemid 350261276)
37. Gillis, A. J., Schuller, A. P. & Skordalakes, E. Structure of the Tribolium castaneum telomerase catalytic subunlt TERT. Nature 455, 633-637 (2008).
38. Salgado, P. S. et al. The structure of an RNAi polymerase links RNA silencing and transcription. PLoS Biol. 4, e434 (2006).
39. Tarn, O. H. et al. Pseudogene-derlved small interfering RNAs regulate gene expression In mouse oocytes. Nature 453, 534-538 (2008).
40. 40. Watanabe. T., et al. Endogenous siRNAs from naturally formed dsRNAs regulate transcripts In mouse oocytes. Nature 453, 539-543 (2008). (Pubitemid 351733315)
41. Babiarz, J. E., Ruby, J. G., Wang, Y., Bartel, D. P. & Bleiloch, R. Mouse ES cells express endogenous shRNAs, siRNAs, and other Microprocessor- independent, Dicer-dependent small RNAs. Genes Dev. 22, 2773-2785 (2008).
42. 42. Yang, N. & Kazazlan. H. H. Jr. L1 retrotranspositlon is suppressed by endogenously encoded small interfering RNAs in human cultured cells. Nature Struct. MoI. Biol. 13, 763-771(2006). (Pubitemid 44338769)
43. Guggenheim, R., Somech, R., Grunebaum, E., Atkinson, A. & Roifman, C. M. Bone marrow transplantation for cartilage-hair-hypoplasla. Bone Marrow Transplant 38, 751-756(2006).
44. 44. Choi, J. et al. TERT promotes epithelial proliferation through transcriptional control of a Myc- and Wnt-related developmental program. PLoS Genet. 4, e10 (2008). (Pubitemid 351230880)