메뉴 건너뛰기




Volumn 46, Issue 3, 2014, Pages 261-282

Phase 0 and phase III transport in various organs: Combined concept of phases in xenobiotic transport and metabolism

Author keywords

ABC transporters; BCRP; Blood tissue barrier; Drug transport; MDR1; Metabolism transport interplay; MRP2; Phase0

Indexed keywords

ABC TRANSPORTER; BREAST CANCER RESISTANCE PROTEIN; DRUG CARRIER; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 2; MULTIDRUG RESISTANCE PROTEIN; ORGANIC CATION TRANSPORTER; XENOBIOTIC AGENT; CARRIER PROTEIN;

EID: 84905496565     PISSN: 03602532     EISSN: 10979883     Source Type: Journal    
DOI: 10.3109/03602532.2014.882353     Document Type: Review
Times cited : (89)

References (320)
  • 1
    • 80053538365 scopus 로고    scopus 로고
    • Breast cancer resistance protein and P-glycoprotein in brain cancer: Two gatekeepers team up
    • Agarwal S, Hartz AM, Elmquist WF, Bauer B. (2011). Breast cancer resistance protein and P-glycoprotein in brain cancer: Two gatekeepers team up. Curr Pharm Des 17:2793-2802.
    • (2011) Curr Pharm des , vol.17 , pp. 2793-2802
    • Agarwal, S.1    Hartz, A.M.2    Elmquist, W.F.3    Bauer, B.4
  • 2
    • 33846678695 scopus 로고    scopus 로고
    • The ABCA subfamily-gene and protein structures, functions and associated hereditary diseases
    • Albrecht C, Viturro E. (2007). The ABCA subfamily-gene and protein structures, functions and associated hereditary diseases. Pflugers Arch 453:581-589.
    • (2007) Pflugers Arch , vol.453 , pp. 581-589
    • Albrecht, C.1    Viturro, E.2
  • 3
    • 0032404092 scopus 로고    scopus 로고
    • A human placenta-specific ATP-binding cassette gene (ABCP) on chromosome 4q22 that is involved in multidrug resistance
    • Allikmets R, Schriml LM, Hutchinson A, et al. (1998). A human placenta-specific ATP-binding cassette gene (ABCP) on chromosome 4q22 that is involved in multidrug resistance. Cancer Res 58: 5337-5339.
    • (1998) Cancer Res , vol.58 , pp. 5337-5339
    • Allikmets, R.1    Schriml, L.M.2    Hutchinson, A.3
  • 4
    • 0028948839 scopus 로고
    • A theoretical basis for a biopharmaceutic drug classification: The correlation of in vitro drug product dissolution and in vivo bioavailability
    • Amidon GL, Lennernas H, Shah VP, Crison JR. (1995). A theoretical basis for a biopharmaceutic drug classification: The correlation of in vitro drug product dissolution and in vivo bioavailability. Pharm Res 12:413-420.
    • (1995) Pharm Res , vol.12 , pp. 413-420
    • Amidon, G.L.1    Lennernas, H.2    Shah, V.P.3    Crison, J.R.4
  • 5
    • 77949909138 scopus 로고    scopus 로고
    • The human carnitine transporter SLC22A16 mediates high affinity uptake of the anticancer polyamine analogue bleomycin-A5
    • Aouida M, Poulin R, Ramotar D. (2010). The human carnitine transporter SLC22A16 mediates high affinity uptake of the anticancer polyamine analogue bleomycin-A5. J Biol Chem 285:6275-6284.
    • (2010) J Biol Chem , vol.285 , pp. 6275-6284
    • Aouida, M.1    Poulin, R.2    Ramotar, D.3
  • 6
    • 30844460667 scopus 로고    scopus 로고
    • OSTalpha-OSTbeta: A major basolateral bile acid and steroid transporter in human intestinal, renal, and biliary epithelia
    • Ballatori N, Christian WV, Lee JY, et al. (2005). OSTalpha-OSTbeta: A major basolateral bile acid and steroid transporter in human intestinal, renal, and biliary epithelia. Hepatology 42:1270-1279.
    • (2005) Hepatology , vol.42 , pp. 1270-1279
    • Ballatori, N.1    Christian, W.V.2    Lee, J.Y.3
  • 7
    • 51149089559 scopus 로고    scopus 로고
    • Ostalpha-Ostbeta is required for bile acid and conjugated steroid disposition in the intestine, kidney, and liver
    • Ballatori N, Fang F, Christian WV, et al. (2008). Ostalpha-Ostbeta is required for bile acid and conjugated steroid disposition in the intestine, kidney, and liver. Am J Physiol Gastrointest Liver Physiol 295:G179-G186.
    • (2008) Am J Physiol Gastrointest Liver Physiol , vol.295
    • Ballatori, N.1    Fang, F.2    Christian, W.V.3
  • 8
    • 84875125374 scopus 로고    scopus 로고
    • The heteromeric organic solute transporter, OSTalpha-OSTbeta/SLC51: A transporter for steroid-derived molecules
    • Ballatori N, Christian WV, Wheeler SG, Hammond CL. (2013). The heteromeric organic solute transporter, OSTalpha-OSTbeta/SLC51: A transporter for steroid-derived molecules. Mol Aspects Med 34: 683-692.
    • (2013) Mol Aspects Med , vol.34 , pp. 683-692
    • Ballatori, N.1    Christian, W.V.2    Wheeler, S.G.3    Hammond, C.L.4
  • 9
    • 0036080556 scopus 로고    scopus 로고
    • Prostaglandin transporter PGT is expressed in cell types that synthesize and release prostanoids
    • Bao Y, Pucci ML, Chan BS, et al. (2002). Prostaglandin transporter PGT is expressed in cell types that synthesize and release prostanoids. Am J Physiol Renal Physiol 282:F1103-F1110.
    • (2002) Am J Physiol Renal Physiol , vol.282
    • Bao, Y.1    Pucci, M.L.2    Chan, B.S.3
  • 10
    • 41549158741 scopus 로고    scopus 로고
    • Assembly and channel opening in a bacterial drug efflux machine
    • Bavro VN, Pietras Z, Furnham N, et al. (2008). Assembly and channel opening in a bacterial drug efflux machine. Mol Cell 30: 114-121.
    • (2008) Mol Cell , vol.30 , pp. 114-121
    • Bavro, V.N.1    Pietras, Z.2    Furnham, N.3
  • 11
    • 0033020785 scopus 로고    scopus 로고
    • MOAT-E (ARA) is a full-length MRP/cMOAT subfamily transporter expressed in kidney and liver
    • Belinsky MG, Kruh GD. (1999). MOAT-E (ARA) is a full-length MRP/cMOAT subfamily transporter expressed in kidney and liver. Br J Cancer 80:1342-1349.
    • (1999) Br J Cancer , vol.80 , pp. 1342-1349
    • Belinsky, M.G.1    Kruh, G.D.2
  • 12
    • 2442719906 scopus 로고    scopus 로고
    • Unmasking the dynamic interplay between efflux transporters and metabolic enzymes
    • Benet LZ, Cummins CL, Wu CY (2004). Unmasking the dynamic interplay between efflux transporters and metabolic enzymes. Int J Pharm 277:3-9.
    • (2004) Int J Pharm , vol.277 , pp. 3-9
    • Benet, L.Z.1    Cummins, C.L.2    Wu, C.Y.3
  • 13
    • 71949106600 scopus 로고    scopus 로고
    • The drug transporter-metabolism alliance: Uncovering and defining the interplay
    • Benet LZ. (2009). The drug transporter-metabolism alliance: Uncovering and defining the interplay. Mol Pharm 6:1631-1643.
    • (2009) Mol Pharm , vol.6 , pp. 1631-1643
    • Benet, L.Z.1
  • 14
    • 77955921793 scopus 로고    scopus 로고
    • The FDA should eliminate the ambiguities in the current BCS biowaiver guidance and make public the drugs for which BCS biowaivers have been granted
    • Benet LZ, Larregieu CA. (2010). The FDA should eliminate the ambiguities in the current BCS biowaiver guidance and make public the drugs for which BCS biowaivers have been granted. Clin Pharmacol Ther 88:405-407.
    • (2010) Clin Pharmacol Ther , vol.88 , pp. 405-407
    • Benet, L.Z.1    Larregieu, C.A.2
  • 16
    • 84876817977 scopus 로고    scopus 로고
    • P-glycoprotein inhibition as a therapeutic approach for overcoming multidrug resistance in cancer: Current status and future perspectives
    • Binkhathlan Z, Lavasanifar A. (2013). P-glycoprotein inhibition as a therapeutic approach for overcoming multidrug resistance in cancer: Current status and future perspectives. Curr Cancer Drug Targets 13: 326-346.
    • (2013) Curr Cancer Drug Targets , vol.13 , pp. 326-346
    • Binkhathlan, Z.1    Lavasanifar, A.2
  • 17
    • 33751578245 scopus 로고    scopus 로고
    • Expression profiles of 50 xenobiotic transporter genes in humans and pre-clinical species: A resource for investigations into drug disposition
    • Bleasby K, Castle JC, Roberts CJ, et al. (2006). Expression profiles of 50 xenobiotic transporter genes in humans and pre-clinical species: A resource for investigations into drug disposition. Xenobiotica 36: 963-988.
    • (2006) Xenobiotica , vol.36 , pp. 963-988
    • Bleasby, K.1    Castle, J.C.2    Roberts, C.J.3
  • 18
    • 0036074018 scopus 로고    scopus 로고
    • Mammalian ABC transporters in health and disease
    • Borst P, Oude Elferink RP. (2002). Mammalian ABC transporters in health and disease. Annu Rev Biochem 71:537-592.
    • (2002) Annu Rev Biochem , vol.71 , pp. 537-592
    • Borst, P.1    Oude Elferink, R.P.2
  • 19
    • 42549117180 scopus 로고    scopus 로고
    • Pharmaceutical and pharmacological importance of peptide transporters
    • Brandsch M, Knutter I, Bosse-Doenecke E. (2008). Pharmaceutical and pharmacological importance of peptide transporters. J Pharm Pharmacol 60:543-585.
    • (2008) J Pharm Pharmacol , vol.60 , pp. 543-585
    • Brandsch, M.1    Knutter, I.2    Bosse-Doenecke, E.3
  • 20
    • 68149161029 scopus 로고    scopus 로고
    • Transport of drugs by proton-coupled peptide transporters: Pearls and pitfalls
    • Brandsch M. (2009). Transport of drugs by proton-coupled peptide transporters: Pearls and pitfalls. Expert Opin Drug Metab Toxicol 5: 887-905.
    • (2009) Expert Opin Drug Metab Toxicol , vol.5 , pp. 887-905
    • Brandsch, M.1
  • 21
  • 22
    • 84864705133 scopus 로고    scopus 로고
    • QSAR modeling and data mining link torsades de pointes risk to the interplay of extent of metabolism, active transport, and hERG liability
    • Broccatelli F, Mannhold R, Moriconi A, et al. (2012). QSAR modeling and data mining link torsades de pointes risk to the interplay of extent of metabolism, active transport, and hERG liability. Mol Pharm 9: 2290-2301.
    • (2012) Mol Pharm , vol.9 , pp. 2290-2301
    • Broccatelli, F.1    Mannhold, R.2    Moriconi, A.3
  • 23
    • 84960962793 scopus 로고
    • Some physico-chemical factors in drug action
    • Brodie BB, Hogben CA. (1957). Some physico-chemical factors in drug action. J Pharm Pharmacol 9:345-380.
    • (1957) J Pharm Pharmacol , vol.9 , pp. 345-380
    • Brodie, B.B.1    Hogben, C.A.2
  • 24
    • 0005416810 scopus 로고
    • Physico-chemical factors in drug absorption
    • Binns TB, ed Edingburgh: Livingstone
    • Brodie BB. (1964). Physico-chemical factors in drug absorption. In: Binns TB, ed. Absorption and Distribution of Drugs. Edingburgh: Livingstone, 16-48.
    • (1964) Absorption and Distribution of Drugs , pp. 16-48
    • Brodie, B.B.1
  • 25
    • 0038728565 scopus 로고    scopus 로고
    • Transport of organic anions across the basolateral membrane of proximal tubule cells
    • Burckhardt BC, Burckhardt G. (2003). Transport of organic anions across the basolateral membrane of proximal tubule cells. Rev Physiol Biochem Pharmacol 146:95-158.
    • (2003) Rev Physiol Biochem Pharmacol , vol.146 , pp. 95-158
    • Burckhardt, B.C.1    Burckhardt, G.2
  • 26
    • 78649665012 scopus 로고    scopus 로고
    • In vitro and in vivo evidence of the importance of organic anion transporters (OATs) in drug therapy
    • Burckhardt G, Burckhardt BC. (2011). In vitro and in vivo evidence of the importance of organic anion transporters (OATs) in drug therapy. Handb Exp Pharmacol 201:29-104.
    • (2011) Handb Exp Pharmacol , vol.201 , pp. 29-104
    • Burckhardt, G.1    Burckhardt, B.C.2
  • 27
    • 84865578333 scopus 로고    scopus 로고
    • Drug transport by Organic Anion Transporters (OATs)
    • Burckhardt G. (2012). Drug transport by Organic Anion Transporters (OATs). Pharmacol Ther 136:106-130.
    • (2012) Pharmacol Ther , vol.136 , pp. 106-130
    • Burckhardt, G.1
  • 28
    • 0040761368 scopus 로고    scopus 로고
    • CDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMrp, reveals a novel conjugate export pump deficient in hyperbilir-ubinemic mutant rats
    • Büchler MJ, Brom M, Kartenbeck J, et al. (1996). cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMrp, reveals a novel conjugate export pump deficient in hyperbilir-ubinemic mutant rats. J Biol Chem 271:15091-15098.
    • (1996) J Biol Chem , vol.271 , pp. 15091-15098
    • Büchler, M.J.1    Brom, M.2    Kartenbeck, J.3
  • 29
    • 84857691265 scopus 로고    scopus 로고
    • Transporters that translocate nucleosides and structural similar drugs: Structural requirements for substrate recognition
    • Cano-Soldado P, Pastor-Anglada M. (2012). Transporters that translocate nucleosides and structural similar drugs: Structural requirements for substrate recognition. Med Res Rev 32:428-457.
    • (2012) Med Res Rev , vol.32 , pp. 428-457
    • Cano-Soldado, P.1    Pastor-Anglada, M.2
  • 30
    • 78649647827 scopus 로고    scopus 로고
    • P-glycoprotein: Tissue distribution, substrates, and functional consequences of genetic variations
    • Cascorbi I. (2011). P-glycoprotein: Tissue distribution, substrates, and functional consequences of genetic variations. Handb Exp Pharmacol 201:261-283.
    • (2011) Handb Exp Pharmacol , vol.201 , pp. 261-283
    • Cascorbi, I.1
  • 31
    • 84859937789 scopus 로고    scopus 로고
    • Elevated hepatic multidrug resistance-associated protein 3/ATP-binding cassette subfamily C 3 expression in human obstructive cholestasis is mediated through tumor necrosis factor alpha and c-Jun NH2-terminal kinase/stress- activated protein kinase-signaling pathway
    • Chai J, He Y, Cai SY, et al. (2012). Elevated hepatic multidrug resistance-associated protein 3/ATP-binding cassette subfamily C 3 expression in human obstructive cholestasis is mediated through tumor necrosis factor alpha and c-Jun NH2-terminal kinase/stress-activated protein kinase-signaling pathway. Hepatology 55: 1485-1494.
    • (2012) Hepatology , vol.55 , pp. 1485-1494
    • Chai, J.1    He, Y.2    Cai, S.Y.3
  • 32
    • 0022972654 scopus 로고
    • Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells
    • Chen CJ, Chin JE, Ueda K, et al. (1986). Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells. Cell 47: 381-389.
    • (1986) Cell , vol.47 , pp. 381-389
    • Chen, C.J.1    Chin, J.E.2    Ueda, K.3
  • 33
    • 79959906965 scopus 로고    scopus 로고
    • The BCS, BDDCS, and regulatory guidances
    • Chen ML, Amidon GL, Benet LZ, et al. (2011). The BCS, BDDCS, and regulatory guidances. Pharm Res 28:1774-1778.
    • (2011) Pharm Res , vol.28 , pp. 1774-1778
    • Chen, M.L.1    Amidon, G.L.2    Benet, L.Z.3
  • 34
    • 56149118632 scopus 로고    scopus 로고
    • Organic cation transporters and their pharmacokinetic and pharmacodynamic consequences
    • Choi MK, Song IS. (2008). Organic cation transporters and their pharmacokinetic and pharmacodynamic consequences. Drug Metab Pharmacokinet 23:243-253.
    • (2008) Drug Metab Pharmacokinet , vol.23 , pp. 243-253
    • Choi, M.K.1    Song, I.S.2
  • 35
    • 33645868291 scopus 로고    scopus 로고
    • Characterization of mice lacking the multidrug resistance protein MRP2 (ABCC2)
    • Chu XY, Strauss JR, Mariano MA, et al. (2006). Characterization of mice lacking the multidrug resistance protein MRP2 (ABCC2). J Pharmacol Exp Ther 317:579-589.
    • (2006) J Pharmacol Exp Ther , vol.317 , pp. 579-589
    • Chu, X.Y.1    Strauss, J.R.2    Mariano, M.A.3
  • 36
    • 48749099279 scopus 로고    scopus 로고
    • Organic cation transporters
    • Ciarimboli G. (2008). Organic cation transporters. Xenobiotica 38: 936-971.
    • (2008) Xenobiotica , vol.38 , pp. 936-971
    • Ciarimboli, G.1
  • 37
    • 0027095653 scopus 로고
    • Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line
    • Cole SP, Bhardwaj G, Gerlach JH, et al. (1992). Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line. Science 258:1650-1654.
    • (1992) Science , vol.258 , pp. 1650-1654
    • Cole, S.P.1    Bhardwaj, G.2    Gerlach, J.H.3
  • 38
    • 66549099938 scopus 로고    scopus 로고
    • Coordinate regulation of metabolic enzymes and transporters by nuclear transcription factors in human liver disease
    • Congiu M, Mashford ML, Slavin JL, Desmond PV. (2009). Coordinate regulation of metabolic enzymes and transporters by nuclear transcription factors in human liver disease. J Gastroenterol Hepatol 24:1038-1044.
    • (2009) J Gastroenterol Hepatol , vol.24 , pp. 1038-1044
    • Congiu, M.1    Mashford, M.L.2    Slavin, J.L.3    Desmond, P.V.4
  • 39
    • 0000712439 scopus 로고
    • Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites
    • Cordon-Cardo C, O'Brien JP, Casals D, et al. (1989). Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites. Proc Natl Acad Sci USA 86: 695-698.
    • (1989) Proc Natl Acad Sci USA , vol.86 , pp. 695-698
    • Cordon-Cardo, C.1    O'Brien, J.P.2    Casals, D.3
  • 40
    • 0025071180 scopus 로고
    • Expression of the multidrug resistance gene product (P-glycoprotein) in human normal and tumor tissues
    • Cordon-Cardo C, O'Brien JP, Boccia J, et al. (1990). Expression of the multidrug resistance gene product (P-glycoprotein) in human normal and tumor tissues. J Histochem Cytochem 38:1277-1287.
    • (1990) J Histochem Cytochem , vol.38 , pp. 1277-1287
    • Cordon-Cardo, C.1    O'Brien, J.P.2    Boccia, J.3
  • 41
    • 0035197725 scopus 로고    scopus 로고
    • Interindividual variability in acetaminophen glucuronidation by human liver microsomes: Identification of relevant acetaminophen UDP- glucuronosyltransferase isoforms
    • Court MH, Duan SX, von Moltke LL, et al. (2001). Interindividual variability in acetaminophen glucuronidation by human liver microsomes: Identification of relevant acetaminophen UDP-glucuronosyltransferase isoforms. J Pharmacol Exp Ther 299: 998-1006.
    • (2001) J Pharmacol Exp Ther , vol.299 , pp. 998-1006
    • Court, M.H.1    Duan, S.X.2    Von Moltke, L.L.3
  • 42
    • 33645112753 scopus 로고
    • Studies on the mechanism of the intestinal active transport of sugars
    • Crane RK, Krane SM. (1959). Studies on the mechanism of the intestinal active transport of sugars. Biochim Biophys Acta 31:397-401.
    • (1959) Biochim Biophys Acta , vol.31 , pp. 397-401
    • Crane, R.K.1    Krane, S.M.2
  • 43
    • 0013800748 scopus 로고
    • +-dependent transport in the intestine and other animal tissues
    • +-dependent transport in the intestine and other animal tissues. Fed Proc 24:1000-1006.
    • (1965) Fed Proc , vol.24 , pp. 1000-1006
    • Crane, R.K.1
  • 44
    • 0017439356 scopus 로고
    • The gradient hypothesis and other models of carrier-mediated active transport
    • Crane RK. (1977). The gradient hypothesis and other models of carrier-mediated active transport. Rev Physiol Biochem Pharmacol 78: 99-159.
    • (1977) Rev Physiol Biochem Pharmacol , vol.78 , pp. 99-159
    • Crane, R.K.1
  • 45
    • 0345299165 scopus 로고    scopus 로고
    • Drug resistance and ATP-dependent conjugate transport mediated by the apical multidrug resistance protein, MRP2, permanently expressed in human and canine cells
    • Cui Y, König J, Buchholz JK, et al. (1999). Drug resistance and ATP-dependent conjugate transport mediated by the apical multidrug resistance protein, MRP2, permanently expressed in human and canine cells. Mol Pharmacol 55:929-937.
    • (1999) Mol Pharmacol , vol.55 , pp. 929-937
    • Cui, Y.1    König, J.2    Buchholz, J.K.3
  • 46
    • 0036881095 scopus 로고    scopus 로고
    • Sex-related differences in the clearance of cytochrome P450 3A4 substrates may be caused by P-glycoprotein
    • Cummins CL, Wu CY, Benet LZ. (2002). Sex-related differences in the clearance of cytochrome P450 3A4 substrates may be caused by P-glycoprotein. Clin Pharmacol Ther 72:474-489.
    • (2002) Clin Pharmacol Ther , vol.72 , pp. 474-489
    • Cummins, C.L.1    Wu, C.Y.2    Benet, L.Z.3
  • 47
    • 0037382316 scopus 로고    scopus 로고
    • In vivo modulation of intestinal CYP3A metabolism by P-glycoprotein: Studies using the rat single-pass intestinal perfusion model
    • Cummins CL, Salphati L, Reid MJ, Benet LZ. (2003). In vivo modulation of intestinal CYP3A metabolism by P-glycoprotein: Studies using the rat single-pass intestinal perfusion model. J Pharmacol Exp Ther 305:306-314.
    • (2003) J Pharmacol Exp Ther , vol.305 , pp. 306-314
    • Cummins, C.L.1    Salphati, L.2    Reid, M.J.3    Benet, L.Z.4
  • 49
    • 56749151204 scopus 로고    scopus 로고
    • ABC transporters, cytochromes P450 and their main transcription factors: Expression at the human blood-brain barrier
    • Dauchy S, Dutheil F, Weaver RJ, et al. (2008). ABC transporters, cytochromes P450 and their main transcription factors: expression at the human blood-brain barrier. J Neurochem 107:1518-1528.
    • (2008) J Neurochem , vol.107 , pp. 1518-1528
    • Dauchy, S.1    Dutheil, F.2    Weaver, R.J.3
  • 50
    • 0034953105 scopus 로고    scopus 로고
    • The human ATP-binding cassette (ABC) transporter superfamily
    • Dean M, Hamon Y, Chimini G. (2001). The human ATP-binding cassette (ABC) transporter superfamily. J Lipid Res 42:1007-1017.
    • (2001) J Lipid Res , vol.42 , pp. 1007-1017
    • Dean, M.1    Hamon, Y.2    Chimini, G.3
  • 51
    • 80053555632 scopus 로고    scopus 로고
    • Interplay of drug metabolizing CYP450 enzymes and ABC transporters in the blood-brain barrier
    • Declèves X, Jacob A, Yousif S, et al. (2011). Interplay of drug metabolizing CYP450 enzymes and ABC transporters in the blood-brain barrier. Curr Drug Metab 12:732-741.
    • (2011) Curr Drug Metab , vol.12 , pp. 732-741
    • Declèves, X.1    Jacob, A.2    Yousif, S.3
  • 52
    • 0031887288 scopus 로고    scopus 로고
    • P glycoprotein: A new mechanism to control drug-induced nephrotoxicity
    • del Moral RG, Olmo A, Aguilar M, O'Valle F. (1998). P glycoprotein: A new mechanism to control drug-induced nephrotoxicity. Exp Nephrol 6:89-97.
    • (1998) Exp Nephrol , vol.6 , pp. 89-97
    • Del Moral, R.G.1    Olmo, A.2    Aguilar, M.3    O'Valle, F.4
  • 53
    • 0035034532 scopus 로고    scopus 로고
    • Increased bioavailability of the food-derived carcinogen 2-amino-1-methyl-6-phenylimidazo[4, 5-b]pyridine in MRP2-deficient rats
    • Dietrich CG, de Waart DR, Ottenhoff R, et al. (2001). Increased bioavailability of the food-derived carcinogen 2-amino-1-methyl-6- phenylimidazo[4, 5-b]pyridine in MRP2-deficient rats. Mol Pharmacol 59:974-980.
    • (2001) Mol Pharmacol , vol.59 , pp. 974-980
    • Dietrich, C.G.1    De Waart, D.R.2    Ottenhoff, R.3
  • 54
    • 0034928631 scopus 로고    scopus 로고
    • Up-regulation of basolateral multidrug resistance protein 3 (Mrp3) in cholestatic rat liver
    • Donner MG, Keppler D. (2001). Up-regulation of basolateral multidrug resistance protein 3 (Mrp3) in cholestatic rat liver. Hepatology 34: 351-359.
    • (2001) Hepatology , vol.34 , pp. 351-359
    • Donner, M.G.1    Keppler, D.2
  • 55
    • 19944425121 scopus 로고    scopus 로고
    • The impact of P-glycoprotein on the disposition of drugs targeted for indications of the central nervous system: Evaluation using the MDR1A/1B knockout mouse model
    • Doran A, Obach RS, Smith BJ, et al. (2005). The impact of P-glycoprotein on the disposition of drugs targeted for indications of the central nervous system: evaluation using the MDR1A/1B knockout mouse model. Drug Metab Dispos 33:165-174.
    • (2005) Drug Metab Dispos , vol.33 , pp. 165-174
    • Doran, A.1    Obach, R.S.2    Smith, B.J.3
  • 56
    • 13044249156 scopus 로고    scopus 로고
    • A multidrug resistance transporter from human MCF-7 breast cancer cells
    • Doyle LA, Yang W, Abruzzo LV, et al. (1998). A multidrug resistance transporter from human MCF-7 breast cancer cells. Proc Natl Acad Sci USA 95:15665-15670.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 15665-15670
    • Doyle, L.A.1    Yang, W.2    Abruzzo, L.V.3
  • 57
    • 51049095076 scopus 로고    scopus 로고
    • The effect of chronic renal failure on drug metabolism and transport
    • Dreisbach AW, Lertora JJ. (2008). The effect of chronic renal failure on drug metabolism and transport. Expert Opin Drug Metab Toxicol 4: 1065-1074.
    • (2008) Expert Opin Drug Metab Toxicol , vol.4 , pp. 1065-1074
    • Dreisbach, A.W.1    Lertora, J.J.2
  • 58
    • 0034520267 scopus 로고    scopus 로고
    • St John's Wort induces intestinal P-glycoprotein/MDR1 and intestinal and hepatic CYP3A4
    • Dürr D, Stieger B, Kullak-Ublick GA, et al. (2000). St John's Wort induces intestinal P-glycoprotein/MDR1 and intestinal and hepatic CYP3A4. Clin Pharmacol Ther 68:598-604.
    • (2000) Clin Pharmacol Ther , vol.68 , pp. 598-604
    • Dürr, D.1    Stieger, B.2    Kullak-Ublick, G.A.3
  • 59
    • 79551694176 scopus 로고    scopus 로고
    • Drug transporters and imatinib treatment: Implications for clinical practice
    • Eechoute K, Sparreboom A, Burger H, et al. (2011). Drug transporters and imatinib treatment: implications for clinical practice. Clin Cancer Res 17:406-415.
    • (2011) Clin Cancer Res , vol.17 , pp. 406-415
    • Eechoute, K.1    Sparreboom, A.2    Burger, H.3
  • 60
    • 0037427379 scopus 로고    scopus 로고
    • Characterisation of the brain multidrug resistance protein (BMDP/ABCG2/BCRP) expressed at the blood-brain barrier
    • Eisenblätter T, Hüwel S, Galla HJ. (2003). Characterisation of the brain multidrug resistance protein (BMDP/ABCG2/BCRP) expressed at the blood-brain barrier. Brain Res 971:221-231.
    • (2003) Brain Res , vol.971 , pp. 221-231
    • Eisenblätter, T.1    Hüwel, S.2    Galla, H.J.3
  • 62
    • 77950959714 scopus 로고    scopus 로고
    • Chronic myeloid leukemia CD34+ cells have reduced uptake of imatinib due to low OCT-1 activity
    • Engler JR, Frede A, Saunders VA, et al. (2010). Chronic myeloid leukemia CD34+ cells have reduced uptake of imatinib due to low OCT-1 activity. Leukemia 24:765-770.
    • (2010) Leukemia , vol.24 , pp. 765-770
    • Engler, J.R.1    Frede, A.2    Saunders, V.A.3
  • 63
    • 0037184037 scopus 로고    scopus 로고
    • Molecular identification of a novel carnitine transporter specific to human testis. Insights into the mechanism of carnitine recognition
    • Enomoto A, Wempe MF, Tsuchida H, et al. (2002). Molecular identification of a novel carnitine transporter specific to human testis. Insights into the mechanism of carnitine recognition. J Biol Chem 277:36262-36271.
    • (2002) J Biol Chem , vol.277 , pp. 36262-36271
    • Enomoto, A.1    Wempe, M.F.2    Tsuchida, H.3
  • 64
    • 0036188407 scopus 로고    scopus 로고
    • St John's Wort supplements endanger the success of organ transplantation
    • Ernst E. (2002). St John's Wort supplements endanger the success of organ transplantation. Arch Surg 137:316-319.
    • (2002) Arch Surg , vol.137 , pp. 316-319
    • Ernst, E.1
  • 65
    • 75149114141 scopus 로고    scopus 로고
    • Multidrug efflux pumps: Substrate selection in ATP-binding cassette multidrug efflux pumps-first come, first served?
    • Ernst R, Kueppers P, Stindt J, et al. (2010). Multidrug efflux pumps: Substrate selection in ATP-binding cassette multidrug efflux pumps-first come, first served? FEBS J 277:540-549.
    • (2010) FEBS J , vol.277 , pp. 540-549
    • Ernst, R.1    Kueppers, P.2    Stindt, J.3
  • 66
    • 0001308329 scopus 로고    scopus 로고
    • Drug export activity of the human canalicular multispecific organic anion transporter in polarized kidney MDCK cells expressing cMOAT (MRP2) cDNA
    • Evers R, Kool M, van Deemter DL, et al. (1998). Drug export activity of the human canalicular multispecific organic anion transporter in polarized kidney MDCK cells expressing cMOAT (MRP2) cDNA. J Clin Invest 101:1310-1319.
    • (1998) J Clin Invest , vol.101 , pp. 1310-1319
    • Evers, R.1    Kool, M.2    Van Deemter, D.L.3
  • 67
    • 78751481403 scopus 로고    scopus 로고
    • Influence of efflux transporters on drug metabolism: Theoretical approach for bioavailability and clearance prediction
    • Fagiolino P, Vàzquez M, Eiraldi R, et al. (2011). Influence of efflux transporters on drug metabolism: theoretical approach for bioavailability and clearance prediction. Clin Pharmacokinet 50: 75-80.
    • (2011) Clin Pharmacokinet , vol.50 , pp. 75-80
    • Fagiolino, P.1    Vàzquez, M.2    Eiraldi, R.3
  • 68
    • 84876230615 scopus 로고    scopus 로고
    • Phase i and II metabolism and MRP2-mediated export of bosentan in a MDCKII-OATP1B1-CYP3A4-UGT1A1-MRP2 quadruple-transfected cell line
    • Fahrmayr C, König J, Auge D, et al. (2013). Phase I and II metabolism and MRP2-mediated export of bosentan in a MDCKII-OATP1B1-CYP3A4- UGT1A1-MRP2 quadruple-transfected cell line. Br J Pharmacol 169:21-33.
    • (2013) Br J Pharmacol , vol.169 , pp. 21-33
    • Fahrmayr, C.1    König, J.2    Auge, D.3
  • 69
    • 38149047597 scopus 로고    scopus 로고
    • Ketoconazole and the modulation of multidrug resistance-mediated transport in Caco-2 and MDCKII-MDR1 drug transport models
    • Fan Y, Rodriguez-Proteau R. (2008). Ketoconazole and the modulation of multidrug resistance-mediated transport in Caco-2 and MDCKII-MDR1 drug transport models. Xenobiotica 38:107-129.
    • (2008) Xenobiotica , vol.38 , pp. 107-129
    • Fan, Y.1    Rodriguez-Proteau, R.2
  • 71
    • 0344514098 scopus 로고    scopus 로고
    • Characterization of the transport of the bicyclic peptide phalloidin by human hepatic transport proteins
    • Fehrenbach T, Cui Y, Faulstich H, Keppler D. (2003). Characterization of the transport of the bicyclic peptide phalloidin by human hepatic transport proteins. Naunyn Schmiedebergs Arch Pharmacol 368: 415-420.
    • (2003) Naunyn Schmiedebergs Arch Pharmacol , vol.368 , pp. 415-420
    • Fehrenbach, T.1    Cui, Y.2    Faulstich, H.3    Keppler, D.4
  • 72
    • 33645930969 scopus 로고    scopus 로고
    • Localization of the ABCG2 mitoxantrone resistance-associated protein in normal tissues
    • Fetsch PA, Abati A, Litman T, et al. (2006). Localization of the ABCG2 mitoxantrone resistance-associated protein in normal tissues. Cancer Lett 235:84-92.
    • (2006) Cancer Lett , vol.235 , pp. 84-92
    • Fetsch, P.A.1    Abati, A.2    Litman, T.3
  • 74
    • 3242785620 scopus 로고    scopus 로고
    • Importance of P-glycoprotein at blood-tissue barriers
    • Fromm MF. (2004). Importance of P-glycoprotein at blood-tissue barriers. Trends Pharmacol Sci 25:423-429.
    • (2004) Trends Pharmacol Sci , vol.25 , pp. 423-429
    • Fromm, M.F.1
  • 75
    • 76749168084 scopus 로고    scopus 로고
    • Tyrosine kinase inhibitor enhances the bioavailability of oral irinotecan in pediatric patients with refractory solid tumors
    • Furman WL, Navid F, Daw NC, et al. (2009). Tyrosine kinase inhibitor enhances the bioavailability of oral irinotecan in pediatric patients with refractory solid tumors. J Clin Oncol 27:4599-4604.
    • (2009) J Clin Oncol , vol.27 , pp. 4599-4604
    • Furman, W.L.1    Navid, F.2    Daw, N.C.3
  • 76
    • 0021025978 scopus 로고
    • Role of pH gradient and membrane potential in dipeptide transport in intestinal and renal brush-border membrane vesicles from the rabbit. Studies with L-carnosine and glycyl-L-proline
    • Ganapathy V, Leibach FH. (1983). Role of pH gradient and membrane potential in dipeptide transport in intestinal and renal brush-border membrane vesicles from the rabbit. Studies with L-carnosine and glycyl-L-proline. J Biol Chem 258:14189-14192.
    • (1983) J Biol Chem , vol.258 , pp. 14189-14192
    • Ganapathy, V.1    Leibach, F.H.2
  • 77
    • 34548489866 scopus 로고    scopus 로고
    • In vivo relevance of Mrp2-mediated biliary excretion of the Amanita mushroom toxin demethyl-phalloin
    • Gavrilova O, Geyer J, Petzinger E. (2007). In vivo relevance of Mrp2-mediated biliary excretion of the Amanita mushroom toxin demethyl-phalloin. Biochim Biophys Acta 1768:2070-2077.
    • (2007) Biochim Biophys Acta , vol.1768 , pp. 2070-2077
    • Gavrilova, O.1    Geyer, J.2    Petzinger, E.3
  • 78
    • 0029790347 scopus 로고    scopus 로고
    • Inhibition and kinetics of cytochrome P4503A activity in microsomes from rat, human, and cDNA-expressed human cytochrome P450
    • Ghosal A, Satoh H, Thomas PE, et al. (1996). Inhibition and kinetics of cytochrome P4503A activity in microsomes from rat, human, and cDNA-expressed human cytochrome P450. Drug Metab Dispos 24: 940-947.
    • (1996) Drug Metab Dispos , vol.24 , pp. 940-947
    • Ghosal, A.1    Satoh, H.2    Thomas, P.E.3
  • 80
    • 7544246185 scopus 로고
    • Metabolism of drugs and other foreign compounds by enzymatic mechanisms
    • Gillette JR. (1963). Metabolism of drugs and other foreign compounds by enzymatic mechanisms. Prog Drug Res 6:11-73.
    • (1963) Prog Drug Res , vol.6 , pp. 11-73
    • Gillette, J.R.1
  • 81
    • 78649661850 scopus 로고    scopus 로고
    • Importance of P-glycoprotein for drug-drug interactions
    • Glaeser H. (2011). Importance of P-glycoprotein for drug-drug interactions. Handb Exp Pharmacol 201:285-297.
    • (2011) Handb Exp Pharmacol , vol.201 , pp. 285-297
    • Glaeser, H.1
  • 82
    • 0029123393 scopus 로고
    • The effects of ketoconazole on the intestinal metabolism and bioavailability of cyclosporine
    • Gomez DY, Wacher VJ, Tomlanovich SJ, et al. (1995). The effects of ketoconazole on the intestinal metabolism and bioavailability of cyclosporine. Clin Pharmacol Ther 58:15-19.
    • (1995) Clin Pharmacol Ther , vol.58 , pp. 15-19
    • Gomez, D.Y.1    Wacher, V.J.2    Tomlanovich, S.J.3
  • 83
    • 0036792072 scopus 로고    scopus 로고
    • Identification of OCT6 as a novel organic cation transporter preferentially expressed in hematopoietic cells and leukemias
    • Gong S, Lu X, Xu Y, et al. (2002). Identification of OCT6 as a novel organic cation transporter preferentially expressed in hematopoietic cells and leukemias. Exp Hematol 30:1162-1169.
    • (2002) Exp Hematol , vol.30 , pp. 1162-1169
    • Gong, S.1    Lu, X.2    Xu, Y.3
  • 84
    • 44649134627 scopus 로고    scopus 로고
    • Pharmacogenomics of MRP transporters (ABCC1-5) and BCRP (ABCG2)
    • Gradhand U, Kim RB. (2008). Pharmacogenomics of MRP transporters (ABCC1-5) and BCRP (ABCG2). Drug Metab Rev 40:317-354.
    • (2008) Drug Metab Rev , vol.40 , pp. 317-354
    • Gradhand, U.1    Kim, R.B.2
  • 85
    • 38349090221 scopus 로고    scopus 로고
    • Variability in human hepatic MRP4 expression: Influence of cholestasis and genotype
    • Gradhand U, Lang T, Schaeffeler E, et al. (2008). Variability in human hepatic MRP4 expression: influence of cholestasis and genotype. Pharmacogenomics J 8:42-52.
    • (2008) Pharmacogenomics J , vol.8 , pp. 42-52
    • Gradhand, U.1    Lang, T.2    Schaeffeler, E.3
  • 86
    • 79959267428 scopus 로고    scopus 로고
    • Breed distribution of the nt230(del4) MDR1 mutation in dogs
    • Gramer I, Leidolf R, Döring B, et al. (2011). Breed distribution of the nt230(del4) MDR1 mutation in dogs. Vet J 189:67-71.
    • (2011) Vet J , vol.189 , pp. 67-71
    • Gramer, I.1    Leidolf, R.2    Döring, B.3
  • 88
    • 0028063302 scopus 로고
    • Drug excretion mediated by a new prototype of polyspecific transporter
    • Gründemann D, Gorboulev V, Gambaryan S, et al. (1994). Drug excretion mediated by a new prototype of polyspecific transporter. Nature 372:549-552.
    • (1994) Nature , vol.372 , pp. 549-552
    • Gründemann, D.1    Gorboulev, V.2    Gambaryan, S.3
  • 90
    • 0343772220 scopus 로고
    • Human cytochrome P450 enzymes and chemical carcinogenesis
    • Jeffrey EH, ed Boca Raton: CRC Press
    • Guengerich FP, Shimada T. (1993). Human cytochrome P450 enzymes and chemical carcinogenesis. In: Jeffrey EH, ed. Human Drug Metabolism: From Molecular Biology to Man. Boca Raton: CRC Press, 5-12.
    • (1993) Human Drug Metabolism: From Molecular Biology to Man , pp. 5-12
    • Guengerich, F.P.1    Shimada, T.2
  • 91
    • 0042531890 scopus 로고    scopus 로고
    • MRP8, ATP-binding cassette C11 (ABCC11), is a cyclic nucleotide efflux pump and a resistance factor for fluoropyrimidines 2, 3-dideoxycytidine and 9-(2-phosphonylmethoxyethyl)adenine
    • Guo Y, Kotova E, Chen ZS, et al. (2003). MRP8, ATP-binding cassette C11 (ABCC11), is a cyclic nucleotide efflux pump and a resistance factor for fluoropyrimidines 2, 3-dideoxycytidine and 9-(2-phosphonylmethoxyethyl)adenine. J Biol Chem 278:29509-29514.
    • (2003) J Biol Chem , vol.278 , pp. 29509-29514
    • Guo, Y.1    Kotova, E.2    Chen, Z.S.3
  • 92
    • 1242272736 scopus 로고    scopus 로고
    • Organic anion transporting polypeptides of the OATP/SLC21 family: Phylogenetic classification as OATP/SLCO superfamily, new nomenclature and molecular/functional properties
    • Hagenbuch B, Meier PJ. (2004). Organic anion transporting polypeptides of the OATP/SLC21 family: Phylogenetic classification as OATP/SLCO superfamily, new nomenclature and molecular/functional properties. Pflugers Arch 447:653-665.
    • (2004) Pflugers Arch , vol.447 , pp. 653-665
    • Hagenbuch, B.1    Meier, P.J.2
  • 93
    • 34249981138 scopus 로고    scopus 로고
    • Cellular entry of thyroid hormones by organic anion transporting polypeptides
    • Hagenbuch B. (2007). Cellular entry of thyroid hormones by organic anion transporting polypeptides. Best Pract Res Clin Endocrinol Metab 21:209-221.
    • (2007) Best Pract Res Clin Endocrinol Metab , vol.21 , pp. 209-221
    • Hagenbuch, B.1
  • 94
    • 84875163715 scopus 로고    scopus 로고
    • The SLCO (former SLC21) superfam-ily of transporters
    • Hagenbuch B, Stieger B. (2013). The SLCO (former SLC21) superfam-ily of transporters. Mol Aspects Med 34:396-412.
    • (2013) Mol Aspects Med , vol.34 , pp. 396-412
    • Hagenbuch, B.1    Stieger, B.2
  • 95
    • 0036022593 scopus 로고    scopus 로고
    • Expression and pharmacological profile of the human organic cation transporters hOCT1, hOCT2 and hOCT3
    • Hayer-Zillgen M, Brüss M, Bönisch H. (2002). Expression and pharmacological profile of the human organic cation transporters hOCT1, hOCT2 and hOCT3. Br J Pharmacol 136:829-836.
    • (2002) Br J Pharmacol , vol.136 , pp. 829-836
    • Hayer-Zillgen, M.1    Brüss, M.2    Bönisch, H.3
  • 96
    • 1242340323 scopus 로고    scopus 로고
    • The ABCs of solute carriers: Physiological, pathological and therapeutic implications of human membrane transport proteins
    • Hediger MA, Romero MF, Peng JB, et al. (2004). The ABCs of solute carriers: Physiological, pathological and therapeutic implications of human membrane transport proteins. Pflugers Arch 447: 465-468.
    • (2004) Pflugers Arch , vol.447 , pp. 465-468
    • Hediger, M.A.1    Romero, M.F.2    Peng, J.B.3
  • 97
    • 84875123211 scopus 로고    scopus 로고
    • The ABCs of membrane transporters in health and disease (SLC series): Introduction
    • Hediger MA, Clemencon B, Burrier RE, Bruford EA. (2013). The ABCs of membrane transporters in health and disease (SLC series): Introduction. Mol Aspects Med 34:95-107.
    • (2013) Mol Aspects Med , vol.34 , pp. 95-107
    • Hediger, M.A.1    Clemencon, B.2    Burrier, R.E.3    Bruford, E.A.4
  • 98
    • 0026621245 scopus 로고
    • ABC transporters: From microorganisms to man
    • Higgins CF. (1992). ABC transporters: from microorganisms to man. Annu Rev Cell Biol 8:67-113.
    • (1992) Annu Rev Cell Biol , vol.8 , pp. 67-113
    • Higgins, C.F.1
  • 99
    • 0031160951 scopus 로고    scopus 로고
    • Structure of the multidrug resistance P-glycoprotein
    • Higgins CF, Callaghan R, Linton KJ, et al. (1997). Structure of the multidrug resistance P-glycoprotein. Semin Cancer Biol 8:135-142.
    • (1997) Semin Cancer Biol , vol.8 , pp. 135-142
    • Higgins, C.F.1    Callaghan, R.2    Linton, K.J.3
  • 100
    • 3042838743 scopus 로고    scopus 로고
    • Structure of the periplasmic component of a bacterial drug efflux pump
    • Higgins MK, Bokma E, Koronakis E, et al. (2004). Structure of the periplasmic component of a bacterial drug efflux pump. Proc Natl Acad Sci USA 101:9994-9999.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 9994-9999
    • Higgins, M.K.1    Bokma, E.2    Koronakis, E.3
  • 101
    • 22944458539 scopus 로고    scopus 로고
    • Bile salt export pump (BSEP/ABCB11) can transport a nonbile acid substrate, pravastatin
    • Hirano M, Maeda K, Hayashi H, et al. (2005). Bile salt export pump (BSEP/ABCB11) can transport a nonbile acid substrate, pravastatin. J Pharmacol Exp Ther 314:876-882.
    • (2005) J Pharmacol Exp Ther , vol.314 , pp. 876-882
    • Hirano, M.1    Maeda, K.2    Hayashi, H.3
  • 102
    • 63849295015 scopus 로고    scopus 로고
    • The enterohepatic circulation of bile acids in mammals: Form and functions
    • Hofmann AF. (2009). The enterohepatic circulation of bile acids in mammals: Form and functions. Front Biosci 14:2584-2598.
    • (2009) Front Biosci , vol.14 , pp. 2584-2598
    • Hofmann, A.F.1
  • 104
    • 0033152212 scopus 로고    scopus 로고
    • Antifolate resistance mediated by the multidrug resistance proteins MRP1 and MRP2
    • Hooijberg JH, Broxterman HJ, Kool M, et al. (1999). Antifolate resistance mediated by the multidrug resistance proteins MRP1 and MRP2. Cancer Res 59:2532-2535.
    • (1999) Cancer Res , vol.59 , pp. 2532-2535
    • Hooijberg, J.H.1    Broxterman, H.J.2    Kool, M.3
  • 105
    • 79956157982 scopus 로고    scopus 로고
    • Contribution of Abcc10 (Mrp7) to in vivo paclitaxel resistance as assessed in Abcc10(-/-) mice
    • Hopper-Borge EA, Churchill T, Paulose C, et al. (2011). Contribution of Abcc10 (Mrp7) to in vivo paclitaxel resistance as assessed in Abcc10(-/-) mice. Cancer Res 71:3649-3657.
    • (2011) Cancer Res , vol.71 , pp. 3649-3657
    • Hopper-Borge, E.A.1    Churchill, T.2    Paulose, C.3
  • 106
    • 0007630205 scopus 로고
    • ATP-dependent transport of vinblastine in vesicles from human multidrug-resistant cells
    • Horio M, Gottesman MM, Pastan I. (1988). ATP-dependent transport of vinblastine in vesicles from human multidrug-resistant cells. Proc Natl Acad Sci USA 85:3580-3584.
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 3580-3584
    • Horio, M.1    Gottesman, M.M.2    Pastan, I.3
  • 107
    • 0032919287 scopus 로고    scopus 로고
    • Molecular cloning and functional expression of a multispecific organic anion transporter from human kidney
    • Hosoyamada M, Sekine T, Kanai Y, Endou H. (1999). Molecular cloning and functional expression of a multispecific organic anion transporter from human kidney. Am J Physiol 276:F122-F128.
    • (1999) Am J Physiol , vol.276
    • Hosoyamada, M.1    Sekine, T.2    Kanai, Y.3    Endou, H.4
  • 108
    • 33947396419 scopus 로고    scopus 로고
    • Pharmacogenetics/genomics of membrane transporters in cancer chemotherapy
    • Huang Y. (2007). Pharmacogenetics/genomics of membrane transporters in cancer chemotherapy. Cancer Metastasis Rev 26:183-201.
    • (2007) Cancer Metastasis Rev , vol.26 , pp. 183-201
    • Huang, Y.1
  • 109
    • 37549068911 scopus 로고    scopus 로고
    • The breast cancer resistance protein transporter ABCG2 is expressed in the human kidney proximal tubule apical membrane
    • Huls M, Brown CD, Windass AS, et al. (2008). The breast cancer resistance protein transporter ABCG2 is expressed in the human kidney proximal tubule apical membrane. Kidney Int 73:220-225.
    • (2008) Kidney Int , vol.73 , pp. 220-225
    • Huls, M.1    Brown, C.D.2    Windass, A.S.3
  • 110
    • 3242723840 scopus 로고    scopus 로고
    • The MDR1 (ABCB1) gene polymorphism and its clinical implications
    • Ieiri I, Takane H, Otsubo K. (2004). The MDR1 (ABCB1) gene polymorphism and its clinical implications. Clin Pharmacokinet 43: 553-576.
    • (2004) Clin Pharmacokinet , vol.43 , pp. 553-576
    • Ieiri, I.1    Takane, H.2    Otsubo, K.3
  • 111
    • 0026459859 scopus 로고
    • The ATP-dependent glutathione S-conjugate export pump
    • Ishikawa T. (1992). The ATP-dependent glutathione S-conjugate export pump. Trends Biochem Sci 17:463-468.
    • (1992) Trends Biochem Sci , vol.17 , pp. 463-468
    • Ishikawa, T.1
  • 112
    • 0347136014 scopus 로고    scopus 로고
    • The genetic polymorphism of drug transporters: Functional analysis approaches
    • Ishikawa T, Tsuji A, Inui K, et al. (2004). The genetic polymorphism of drug transporters: Functional analysis approaches. Pharmacogenomics 5:67-99.
    • (2004) Pharmacogenomics , vol.5 , pp. 67-99
    • Ishikawa, T.1    Tsuji, A.2    Inui, K.3
  • 113
    • 77649273238 scopus 로고    scopus 로고
    • Emerging new technologies in pharmacogenomics: Rapid SNP detection, molecular dynamic simulation, and QSAR analysis methods to validate clinically important genetic variants of human ABC Transporter ABCB1 (P-gp/MDR1)
    • Ishikawa T, Sakurai A, Hirano H, et al. (2010). Emerging new technologies in pharmacogenomics: rapid SNP detection, molecular dynamic simulation, and QSAR analysis methods to validate clinically important genetic variants of human ABC Transporter ABCB1 (P-gp/MDR1). Pharmacol Ther 126:69-81.
    • (2010) Pharmacol Ther , vol.126 , pp. 69-81
    • Ishikawa, T.1    Sakurai, A.2    Hirano, H.3
  • 114
    • 42949168885 scopus 로고    scopus 로고
    • 6-mercaptopurine and 9-(2-phosphonyl-methoxyethyl) adenine (PMEA) transport altered by two missense mutations in the drug transporter gene ABCC4
    • Janke D, Mehralivand S, Strand D, et al. (2008). 6-mercaptopurine and 9-(2-phosphonyl-methoxyethyl) adenine (PMEA) transport altered by two missense mutations in the drug transporter gene ABCC4. Hum Mutat 29:659-669.
    • (2008) Hum Mutat , vol.29 , pp. 659-669
    • Janke, D.1    Mehralivand, S.2    Strand, D.3
  • 115
    • 0021804301 scopus 로고
    • Hereditary chronic conjugated hyperbilirubinemia in mutant rats caused by defective hepatic anion transport
    • Jansen PL, Peters WH, Lamers WH. (1985). Hereditary chronic conjugated hyperbilirubinemia in mutant rats caused by defective hepatic anion transport. Hepatology 5:573-579.
    • (1985) Hepatology , vol.5 , pp. 573-579
    • Jansen, P.L.1    Peters, W.H.2    Lamers, W.H.3
  • 116
    • 0030668526 scopus 로고    scopus 로고
    • ATP-dependent transport of bilirubin glucuronides by the multidrug resistance protein MRP1 and its hepatocyte canalicular isoform MRP2
    • Jedlitschky G, Leier I, Buchholz U, et al. (1997). ATP-dependent transport of bilirubin glucuronides by the multidrug resistance protein MRP1 and its hepatocyte canalicular isoform MRP2. Biochem J 327: 305-310.
    • (1997) Biochem J , vol.327 , pp. 305-310
    • Jedlitschky, G.1    Leier, I.2    Buchholz, U.3
  • 117
    • 33846418041 scopus 로고    scopus 로고
    • Structure and function of the MRP2 (ABCC2) protein and its role in drug disposition
    • Jedlitschky G, Hoffmann U, Kroemer HK. (2006). Structure and function of the MRP2 (ABCC2) protein and its role in drug disposition. Expert Opin Drug Metab Toxicol 2:351-366.
    • (2006) Expert Opin Drug Metab Toxicol , vol.2 , pp. 351-366
    • Jedlitschky, G.1    Hoffmann, U.2    Kroemer, H.K.3
  • 118
    • 77954358310 scopus 로고    scopus 로고
    • ABCC2/Abcc2: A multispecific transporter with dominant excretory functions
    • Jemnitz K, Heredi-Szabo K, Janossy J, et al. (2010). ABCC2/Abcc2: A multispecific transporter with dominant excretory functions. Drug Metab Rev 42:402-436.
    • (2010) Drug Metab Rev , vol.42 , pp. 402-436
    • Jemnitz, K.1    Heredi-Szabo, K.2    Janossy, J.3
  • 119
    • 0035675648 scopus 로고    scopus 로고
    • The impact of P-glycoprotein efflux on enterocyte residence time and enterocyte-based metabolism of verapamil
    • Johnson BM, Charman WN, Porter CJ. (2001). The impact of P-glycoprotein efflux on enterocyte residence time and enterocyte-based metabolism of verapamil. J Pharm Pharmacol 53:1611-1619.
    • (2001) J Pharm Pharmacol , vol.53 , pp. 1611-1619
    • Johnson, B.M.1    Charman, W.N.2    Porter, C.J.3
  • 120
    • 14644409841 scopus 로고    scopus 로고
    • The breast cancer resistance protein BCRP (ABCG2) concentrates drugs and carcinogenic xenotoxins into milk
    • Jonker JW, Merino G, Musters S, et al. (2005). The breast cancer resistance protein BCRP (ABCG2) concentrates drugs and carcinogenic xenotoxins into milk. Nat Med 11:127-129.
    • (2005) Nat Med , vol.11 , pp. 127-129
    • Jonker, J.W.1    Merino, G.2    Musters, S.3
  • 121
    • 33645830172 scopus 로고
    • A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants
    • Juliano RL, Ling V. (1976). A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants. Biochim Biophys Acta 455:152-162.
    • (1976) Biochim Biophys Acta , vol.455 , pp. 152-162
    • Juliano, R.L.1    Ling, V.2
  • 122
    • 84905465521 scopus 로고    scopus 로고
    • ABC transporters: A smart example of molecular machineries
    • Ponte-Sucre A, ed Norfolk, UK: Caister Academic Press
    • Jumpertz T, Holland IB, Schmitt L. (2009). ABC transporters: A smart example of molecular machineries. In: Ponte-Sucre A, ed. ABC Transporters in Microorganisms. Norfolk, UK: Caister Academic Press, 1-35.
    • (2009) ABC Transporters in Microorganisms , pp. 1-35
    • Jumpertz, T.1    Holland, I.B.2    Schmitt, L.3
  • 123
    • 0032769284 scopus 로고    scopus 로고
    • Transport of monoglucuronosyl and bisglucuronosyl bilirubin by recombinant human and rat multi-drug resistance protein 2
    • Kamisako T, Leier I, Cui Y, et al. (1999). Transport of monoglucuronosyl and bisglucuronosyl bilirubin by recombinant human and rat multi-drug resistance protein 2. Hepatology 30:485-490.
    • (1999) Hepatology , vol.30 , pp. 485-490
    • Kamisako, T.1    Leier, I.2    Cui, Y.3
  • 125
    • 78649678134 scopus 로고    scopus 로고
    • Multidrug resistance proteins (MRPs, ABCCs): Importance for pathophysiology and drug therapy
    • Keppler D. (2011). Multidrug resistance proteins (MRPs, ABCCs): importance for pathophysiology and drug therapy. Handb Exp Pharmacol 201:299-323.
    • (2011) Handb Exp Pharmacol , vol.201 , pp. 299-323
    • Keppler, D.1
  • 126
    • 0032518290 scopus 로고    scopus 로고
    • The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors
    • Kim RB, Fromm MF, Wandel C, et al. (1998). The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors. J Clin Invest 101:289-294.
    • (1998) J Clin Invest , vol.101 , pp. 289-294
    • Kim, R.B.1    Fromm, M.F.2    Wandel, C.3
  • 127
    • 0032907322 scopus 로고    scopus 로고
    • Interrelationship between substrates and inhibitors of human CYP3A and P-glycoprotein
    • Kim RB, Wandel C, Leake B, et al. (1999). Interrelationship between substrates and inhibitors of human CYP3A and P-glycoprotein. Pharm Res 16:408-414.
    • (1999) Pharm Res , vol.16 , pp. 408-414
    • Kim, R.B.1    Wandel, C.2    Leake, B.3
  • 128
    • 34547734539 scopus 로고    scopus 로고
    • Mechanism of multidrug recognition by MDR1/ABCB1
    • Kimura Y, Morita SY, Matsuo M, Ueda K. (2007). Mechanism of multidrug recognition by MDR1/ABCB1. Cancer Sci 98:1303-1310.
    • (2007) Cancer Sci , vol.98 , pp. 1303-1310
    • Kimura, Y.1    Morita, S.Y.2    Matsuo, M.3    Ueda, K.4
  • 129
    • 77949398878 scopus 로고    scopus 로고
    • Xenobiotic, bile acid, and cholesterol transporters: Function and regulation
    • Klaassen CD, Aleksunes LM. (2010). Xenobiotic, bile acid, and cholesterol transporters: function and regulation. Pharmacol Rev 62: 1-96.
    • (2010) Pharmacol Rev , vol.62 , pp. 1-96
    • Klaassen, C.D.1    Aleksunes, L.M.2
  • 130
    • 12944286618 scopus 로고    scopus 로고
    • ABCG1 (ABC8), the human homolog of the Drosophila white gene, is a regulator of macrophage cholesterol and phospholipid transport
    • Klucken J, Büchler C, Orsó E, et al. (2000). ABCG1 (ABC8), the human homolog of the Drosophila white gene, is a regulator of macrophage cholesterol and phospholipid transport. Proc Natl Acad Sci USA 97: 817-822.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 817-822
    • Klucken, J.1    Büchler, C.2    Orsó, E.3
  • 131
    • 3042569768 scopus 로고    scopus 로고
    • Polyspecific organic cation transporters: Their functions and interactions with drugs
    • Koepsell H. (2004). Polyspecific organic cation transporters: Their functions and interactions with drugs. Trends Pharmacol Sci 25: 375-381.
    • (2004) Trends Pharmacol Sci , vol.25 , pp. 375-381
    • Koepsell, H.1
  • 132
    • 34249943356 scopus 로고    scopus 로고
    • Polyspecific organic cation transporters: Structure, function, physiological roles, and biopharma-ceutical implications
    • Koepsell H, Lips K, Volk C. (2007). Polyspecific organic cation transporters: Structure, function, physiological roles, and biopharma-ceutical implications. Pharm Res 24:1227-1251.
    • (2007) Pharm Res , vol.24 , pp. 1227-1251
    • Koepsell, H.1    Lips, K.2    Volk, C.3
  • 133
    • 84875181483 scopus 로고    scopus 로고
    • The SLC22 family with transporters of organic cations, anions and zwitterions
    • Koepsell H. (2013). The SLC22 family with transporters of organic cations, anions and zwitterions. Mol Aspects Med 34:413-435.
    • (2013) Mol Aspects Med , vol.34 , pp. 413-435
    • Koepsell, H.1
  • 134
    • 0032746479 scopus 로고    scopus 로고
    • Genetic epidemiology of the carnitine transporter OCTN2 gene in a Japanese population and phenotypic characterization in Japanese pedigrees with primary systemic carnitine deficiency
    • Koizumi A, Nozaki J, Ohura T, et al. (1999). Genetic epidemiology of the carnitine transporter OCTN2 gene in a Japanese population and phenotypic characterization in Japanese pedigrees with primary systemic carnitine deficiency. Hum Mol Genet 8:2247-2254.
    • (1999) Hum Mol Genet , vol.8 , pp. 2247-2254
    • Koizumi, A.1    Nozaki, J.2    Ohura, T.3
  • 135
    • 0030437929 scopus 로고    scopus 로고
    • Uptake of the mycotoxin ochratoxin A in liver cells occurs via the cloned organic anion transporting polypeptide
    • Kontaxi M, Eckardt U, Hagenbuch B, et al. (1996). Uptake of the mycotoxin ochratoxin A in liver cells occurs via the cloned organic anion transporting polypeptide. J Pharmacol Exp Ther 279: 1507-1513.
    • (1996) J Pharmacol Exp Ther , vol.279 , pp. 1507-1513
    • Kontaxi, M.1    Eckardt, U.2    Hagenbuch, B.3
  • 136
    • 51849173007 scopus 로고
    • Symposium on membrane transport and metabolism
    • Kotyk A. (1961). Symposium on membrane transport and metabolism. Folia Microbiol 6:141-143.
    • (1961) Folia Microbiol , vol.6 , pp. 141-143
    • Kotyk, A.1
  • 137
    • 0344927562 scopus 로고    scopus 로고
    • Conjugate export pumps of the multidrug resistance protein (MRP) family: Localization, substrate specificity, and MRP2-mediated drug resistance
    • König J, Nies AT, Cui Y, et al. (1999). Conjugate export pumps of the multidrug resistance protein (MRP) family: localization, substrate specificity, and MRP2-mediated drug resistance. Biochim Biophys Acta 1461:377-394.
    • (1999) Biochim Biophys Acta , vol.1461 , pp. 377-394
    • König, J.1    Nies, A.T.2    Cui, Y.3
  • 138
    • 78649656801 scopus 로고    scopus 로고
    • Uptake transporters of the human OATP family: Molecular characteristics, substrates, their role in drug-drug interactions, and functional consequences of polymorphisms
    • König J. (2011). Uptake transporters of the human OATP family: Molecular characteristics, substrates, their role in drug-drug interactions, and functional consequences of polymorphisms. Handb Exp Pharmacol 201:1-28.
    • (2011) Handb Exp Pharmacol , vol.201 , pp. 1-28
    • König, J.1
  • 139
    • 84878359254 scopus 로고    scopus 로고
    • Transporters and drug-drug interactions: Important determinants of drug disposition and effects
    • König J, Müller F, Fromm MF. (2013). Transporters and drug-drug interactions: Important determinants of drug disposition and effects. Pharmacol Rev 65:944-966.
    • (2013) Pharmacol Rev , vol.65 , pp. 944-966
    • König, J.1    Müller, F.2    Fromm, M.F.3
  • 140
    • 77952497062 scopus 로고    scopus 로고
    • The prostaglandin transporter OATP2A1 is expressed in human ocular tissues and transports the antiglaucoma prostanoid latanoprost
    • Kraft ME, Glaeser H, Mandery K, et al. (2010). The prostaglandin transporter OATP2A1 is expressed in human ocular tissues and transports the antiglaucoma prostanoid latanoprost. Invest Ophthalmol Vis Sci 51:2504-2511.
    • (2010) Invest Ophthalmol Vis Sci , vol.51 , pp. 2504-2511
    • Kraft, M.E.1    Glaeser, H.2    Mandery, K.3
  • 141
    • 0345724724 scopus 로고    scopus 로고
    • The MRP family of drug efflux pumps
    • Kruh GD, Belinsky MG. (2003). The MRP family of drug efflux pumps. Oncogene 22:7537-7552.
    • (2003) Oncogene , vol.22 , pp. 7537-7552
    • Kruh, G.D.1    Belinsky, M.G.2
  • 142
    • 0036644903 scopus 로고    scopus 로고
    • Increased oral bioavailability of topotecan in combination with the breast cancer resistance protein and P-glycoprotein inhibitor GF120918
    • Kruijtzer CM, Beijnen JH, Rosing H, et al. (2002). Increased oral bioavailability of topotecan in combination with the breast cancer resistance protein and P-glycoprotein inhibitor GF120918. J Clin Oncol 20:2943-2950.
    • (2002) J Clin Oncol , vol.20 , pp. 2943-2950
    • Kruijtzer, C.M.1    Beijnen, J.H.2    Rosing, H.3
  • 143
    • 0346100571 scopus 로고    scopus 로고
    • Enterohepatic bile salt transporters in normal physiology and liver disease
    • Kullak-Ublick GA, Stieger B, Meier PJ. (2004). Enterohepatic bile salt transporters in normal physiology and liver disease. Gastroenterology 126:322-342.
    • (2004) Gastroenterology , vol.126 , pp. 322-342
    • Kullak-Ublick, G.A.1    Stieger, B.2    Meier, P.J.3
  • 144
    • 34250686621 scopus 로고    scopus 로고
    • A phase I, randomized, open-label, parallel-cohort, dose-finding study of elacridar (GF120918) and oral topotecan in cancer patients
    • Kuppens IE, Witteveen EO, Jewell RC, et al. (2007). A phase I, randomized, open-label, parallel-cohort, dose-finding study of elacridar (GF120918) and oral topotecan in cancer patients. Clin Cancer Res 13:3276-3285.
    • (2007) Clin Cancer Res , vol.13 , pp. 3276-3285
    • Kuppens, I.E.1    Witteveen, E.O.2    Jewell, R.C.3
  • 145
    • 77956235037 scopus 로고    scopus 로고
    • Preclinical and clinical evidence for the collaborative transport and renal secretion of an oxazolidinone antibiotic by organic anion transporter 3 (OAT3/SLC22A8) and multidrug and toxin extrusion protein 1 (MATE1/SLC47A1)
    • Lai Y, Sampson KE, Balogh LM, et al. (2010). Preclinical and clinical evidence for the collaborative transport and renal secretion of an oxazolidinone antibiotic by organic anion transporter 3 (OAT3/SLC22A8) and multidrug and toxin extrusion protein 1 (MATE1/SLC47A1). J Pharmacol Exp Ther 334:936-944.
    • (2010) J Pharmacol Exp Ther , vol.334 , pp. 936-944
    • Lai, Y.1    Sampson, K.E.2    Balogh, L.M.3
  • 146
    • 84862076531 scopus 로고    scopus 로고
    • Impact of drug transporter pharmacogenomics on pharmacokinetic and pharmacodynamic variability-considerations for drug development
    • Lai Y, Varma M, Feng B, et al. (2012). Impact of drug transporter pharmacogenomics on pharmacokinetic and pharmacodynamic variability- considerations for drug development. Expert Opin Drug Metab Toxicol 8:723-743.
    • (2012) Expert Opin Drug Metab Toxicol , vol.8 , pp. 723-743
    • Lai, Y.1    Varma, M.2    Feng, B.3
  • 147
    • 33746089203 scopus 로고    scopus 로고
    • In vitro and in vivo correlation of hepatic transporter effects on erythromycin metabolism: Characterizing the importance of transporter-enzyme interplay
    • Lam JL, Okochi H, Huang Y, Benet LZ. (2006). In vitro and in vivo correlation of hepatic transporter effects on erythromycin metabolism: characterizing the importance of transporter-enzyme interplay. Drug Metab Dispos 34:1336-1344.
    • (2006) Drug Metab Dispos , vol.34 , pp. 1336-1344
    • Lam, J.L.1    Okochi, H.2    Huang, Y.3    Benet, L.Z.4
  • 148
    • 0037474487 scopus 로고    scopus 로고
    • A third human carnitine/organic cation transporter (OCTN3) as a candidate for the 5q31 Crohn's disease locus (IBD5)
    • Lamhonwah AM, Skaug J, Scherer SW, Tein I. (2003). A third human carnitine/organic cation transporter (OCTN3) as a candidate for the 5q31 Crohn's disease locus (IBD5). Biochem Biophys Res Commun 301:98-101.
    • (2003) Biochem Biophys Res Commun , vol.301 , pp. 98-101
    • Lamhonwah, A.M.1    Skaug, J.2    Scherer, S.W.3    Tein, I.4
  • 149
    • 27844515602 scopus 로고    scopus 로고
    • OCTN3 is a mammalian peroxisomal membrane carnitine transporter
    • Lamhonwah AM, Ackerley CA, Tilups A, et al. (2005). OCTN3 is a mammalian peroxisomal membrane carnitine transporter. Biochem Biophys Res Commun 338:1966-1972.
    • (2005) Biochem Biophys Res Commun , vol.338 , pp. 1966-1972
    • Lamhonwah, A.M.1    Ackerley, C.A.2    Tilups, A.3
  • 150
    • 1342302110 scopus 로고    scopus 로고
    • Ex situ inhibition of hepatic uptake and efflux significantly changes metabolism: Hepatic enzyme-transporter interplay
    • Lau YY, Wu CY, Okochi H, Benet LZ. (2004). Ex situ inhibition of hepatic uptake and efflux significantly changes metabolism: Hepatic enzyme-transporter interplay. J Pharmacol Exp Ther 308:1040-1045.
    • (2004) J Pharmacol Exp Ther , vol.308 , pp. 1040-1045
    • Lau, Y.Y.1    Wu, C.Y.2    Okochi, H.3    Benet, L.Z.4
  • 151
    • 70450121903 scopus 로고    scopus 로고
    • Organic cation transporters: Physiology, toxicology and special focus on ethidium as a novel substrate
    • Lee WK, Wolff NA, Thévenod F. (2009a). Organic cation transporters: Physiology, toxicology and special focus on ethidium as a novel substrate. Curr Drug Metab 10:617-631.
    • (2009) Curr Drug Metab , vol.10 , pp. 617-631
    • Lee, W.K.1    Wolff, N.A.2    Thévenod, F.3
  • 152
    • 66449087083 scopus 로고    scopus 로고
    • Organic cation transporters OCT1, 2, and 3 mediate high-affinity transport of the mutagenic vital dye ethidium in the kidney proximal tubule
    • Lee WK, Reichold M, Edemir B, et al. (2009b). Organic cation transporters OCT1, 2, and 3 mediate high-affinity transport of the mutagenic vital dye ethidium in the kidney proximal tubule. Am J Physiol Renal Physiol 296:F1504-F1513.
    • (2009) Am J Physiol Renal Physiol , vol.296
    • Lee, W.K.1    Reichold, M.2    Edemir, B.3
  • 153
    • 0006526775 scopus 로고
    • The present state of the carrier hypothesis
    • Bronner F, Kleinzeller A, ed London: Academic Press
    • LeFevre PG. (1975). The present state of the carrier hypothesis. In: Bronner F, Kleinzeller A, ed. Current Topics in Membranes and Transport. London: Academic Press, 109-215.
    • (1975) Current Topics in Membranes and Transport , pp. 109-215
    • Lefevre, P.G.1
  • 154
    • 0028347079 scopus 로고
    • Characterization of the ATP-dependent leukotriene C4 export carrier in mastocytoma cells
    • Leier I, Jedlitschky G, Buchholz U, Keppler D. (1994a). Characterization of the ATP-dependent leukotriene C4 export carrier in mastocytoma cells. Eur J Biochem 220:599-606.
    • (1994) Eur J Biochem , vol.220 , pp. 599-606
    • Leier, I.1    Jedlitschky, G.2    Buchholz, U.3    Keppler, D.4
  • 155
    • 0027984511 scopus 로고
    • The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates
    • Leier I, Jedlitschky G, Buchholz U, et al. (1994b). The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates. J Biol Chem 269:27807-27810.
    • (1994) J Biol Chem , vol.269 , pp. 27807-27810
    • Leier, I.1    Jedlitschky, G.2    Buchholz, U.3
  • 156
    • 0034083906 scopus 로고    scopus 로고
    • ATP-dependent para-aminohippurate transport by apical multidrug resistance protein MRP2
    • Leier I, Hummel-Eisenbeiss J, Cui Y, Keppler D. (2000). ATP-dependent para-aminohippurate transport by apical multidrug resistance protein MRP2. Kidney Int 57:1636-1642.
    • (2000) Kidney Int , vol.57 , pp. 1636-1642
    • Leier, I.1    Hummel-Eisenbeiss, J.2    Cui, Y.3    Keppler, D.4
  • 157
    • 14744272833 scopus 로고    scopus 로고
    • The use of biopharmaceutic classification of drugs in drug discovery and development: Current status and future extension
    • Lennernäs H, Abrahamsson B. (2005). The use of biopharmaceutic classification of drugs in drug discovery and development: current status and future extension. J Pharm Pharmacol 57:273-285.
    • (2005) J Pharm Pharmacol , vol.57 , pp. 273-285
    • Lennernäs, H.1    Abrahamsson, B.2
  • 158
    • 65249143403 scopus 로고    scopus 로고
    • Mechanisms of pH-gradient driven transport mediated by organic anion polypeptide transporters
    • Leuthold S, Hagenbuch B, Mohebbi N, et al. (2009). Mechanisms of pH-gradient driven transport mediated by organic anion polypeptide transporters. Am J Physiol Cell Physiol 296:C570-C582.
    • (2009) Am J Physiol Cell Physiol , vol.296
    • Leuthold, S.1    Hagenbuch, B.2    Mohebbi, N.3
  • 159
    • 0032568838 scopus 로고    scopus 로고
    • Identification of glutathione as a driving force and leukotriene C4 as a substrate for oatp1, the hepatic sinusoidal organic solute transporter
    • Li L, Lee TK, Meier PJ, Ballatori N. (1998). Identification of glutathione as a driving force and leukotriene C4 as a substrate for oatp1, the hepatic sinusoidal organic solute transporter. J Biol Chem 273: 16184-16191.
    • (1998) J Biol Chem , vol.273 , pp. 16184-16191
    • Li, L.1    Lee, T.K.2    Meier, P.J.3    Ballatori, N.4
  • 160
    • 0033943874 scopus 로고    scopus 로고
    • Oatp2 mediates bidirectional organic solute transport: A role for intracellular glutathione
    • Li L, Meier PJ, Ballatori N. (2000). Oatp2 mediates bidirectional organic solute transport: A role for intracellular glutathione. Mol Pharmacol 58:335-340.
    • (2000) Mol Pharmacol , vol.58 , pp. 335-340
    • Li, L.1    Meier, P.J.2    Ballatori, N.3
  • 161
    • 84861916495 scopus 로고    scopus 로고
    • The role of ABC and SLC transporters in the pharmacokinetics of dietary and herbal phytochemicals and their interactions with xenobiotics
    • Li Y, Lu J, Paxton JW. (2012). The role of ABC and SLC transporters in the pharmacokinetics of dietary and herbal phytochemicals and their interactions with xenobiotics. Curr Drug Metab 13:624-639.
    • (2012) Curr Drug Metab , vol.13 , pp. 624-639
    • Li, Y.1    Lu, J.2    Paxton, J.W.3
  • 162
    • 0034081847 scopus 로고    scopus 로고
    • The multidrug-resistant phenotype associated with overexpression of the new ABC half-transporter, MXR (ABCG2)
    • Litman T, Brangi M, Hudson E, et al. (2000). The multidrug-resistant phenotype associated with overexpression of the new ABC half-transporter, MXR (ABCG2). J Cell Sci 113 (Pt 11):2011-2021.
    • (2000) J Cell Sci , vol.113 , Issue.PART 11 , pp. 2011-2021
    • Litman, T.1    Brangi, M.2    Hudson, E.3
  • 163
    • 84864380891 scopus 로고    scopus 로고
    • Substrate recognition and processing by a Walker B mutant of the human mitochondrial AAA+ protein CLPX
    • Lowth BR, Kirstein-Miles J, Saiyed T, et al. (2012). Substrate recognition and processing by a Walker B mutant of the human mitochondrial AAA+ protein CLPX. J Struct Biol 179:193-201.
    • (2012) J Struct Biol , vol.179 , pp. 193-201
    • Lowth, B.R.1    Kirstein-Miles, J.2    Saiyed, T.3
  • 164
    • 0343527392 scopus 로고    scopus 로고
    • Modern bioavailability, bioequiva-lence and biopharmaceutics classification system. New scientific approaches to international regulatory standards
    • Löbenberg R, Amidon GL. (2000). Modern bioavailability, bioequiva-lence and biopharmaceutics classification system. New scientific approaches to international regulatory standards. Eur J Pharm Biopharm 50:3-12.
    • (2000) Eur J Pharm Biopharm , vol.50 , pp. 3-12
    • Löbenberg, R.1    Amidon, G.L.2
  • 165
    • 80053506403 scopus 로고    scopus 로고
    • Do ATP-binding cassette transporters cause pharmacoresistance in epilepsy? Problems and approaches in determining which antiepileptic drugs are affected
    • Löscher W, Luna-Tortos C, Römermann K, Fedrowitz M. (2011). Do ATP-binding cassette transporters cause pharmacoresistance in epilepsy? Problems and approaches in determining which antiepileptic drugs are affected. Curr Pharm Des 17:2808-2828.
    • (2011) Curr Pharm des , vol.17 , pp. 2808-2828
    • Löscher, W.1    Luna-Tortos, C.2    Römermann, K.3    Fedrowitz, M.4
  • 166
    • 0035987895 scopus 로고    scopus 로고
    • CYP3A4 induction by drugs: Correlation between a pregnane X receptor reporter gene assay and CYP3A4 expression in human hepatocytes
    • Luo G, Cunningham M, Kim S, et al. (2002). CYP3A4 induction by drugs: Correlation between a pregnane X receptor reporter gene assay and CYP3A4 expression in human hepatocytes. Drug Metab Dispos 30:795-804.
    • (2002) Drug Metab Dispos , vol.30 , pp. 795-804
    • Luo, G.1    Cunningham, M.2    Kim, S.3
  • 167
    • 33751228701 scopus 로고    scopus 로고
    • Effect of ketoconazole and rifampicin on the pharmacokinetics of ranitidine in healthy human volunteers: A possible role of P-glycoprotein
    • Machavaram KK, Gundu J, Yamsani MR. (2006). Effect of ketoconazole and rifampicin on the pharmacokinetics of ranitidine in healthy human volunteers: A possible role of P-glycoprotein. Drug Metab Drug Interact 22:47-65.
    • (2006) Drug Metab Drug Interact , vol.22 , pp. 47-65
    • Machavaram, K.K.1    Gundu, J.2    Yamsani, M.R.3
  • 168
    • 33750349856 scopus 로고    scopus 로고
    • The ATP-binding cassette transporter ABCA2 as a mediator of intracellular trafficking
    • Mack JT, Beljanski V, Tew KD, Townsend DM. (2006). The ATP-binding cassette transporter ABCA2 as a mediator of intracellular trafficking. Biomed Pharmacother 60:587-592.
    • (2006) Biomed Pharmacother , vol.60 , pp. 587-592
    • Mack, J.T.1    Beljanski, V.2    Tew, K.D.3    Townsend, D.M.4
  • 169
    • 33846028781 scopus 로고    scopus 로고
    • The ABCA2 transporter: Intracellular roles in trafficking and metabolism of LDL-derived cholesterol and sterol-related compounds
    • Mack JT, Townsend DM, Beljanski V, Tew KD. (2007). The ABCA2 transporter: Intracellular roles in trafficking and metabolism of LDL-derived cholesterol and sterol-related compounds. Curr Drug Metab 8:47-57.
    • (2007) Curr Drug Metab , vol.8 , pp. 47-57
    • Mack, J.T.1    Townsend, D.M.2    Beljanski, V.3    Tew, K.D.4
  • 170
    • 34547104864 scopus 로고    scopus 로고
    • Human organic anion transporter 1B1 and 1B3 function as bidirectional carriers and do not mediate GSH-bile acid cotransport
    • Mahagita C, Grassl SM, Piyachaturawat P, Ballatori N. (2007). Human organic anion transporter 1B1 and 1B3 function as bidirectional carriers and do not mediate GSH-bile acid cotransport. Am J Physiol Gastrointest Liver Physiol 293:G271-G278.
    • (2007) Am J Physiol Gastrointest Liver Physiol , vol.293
    • Mahagita, C.1    Grassl, S.M.2    Piyachaturawat, P.3    Ballatori, N.4
  • 171
    • 0035870289 scopus 로고    scopus 로고
    • Subcellular localization and distribution of the breast cancer resistance protein transporter in normal human tissues
    • Maliepaard M, Scheffer GL, Faneyte IF, et al. (2001). Subcellular localization and distribution of the breast cancer resistance protein transporter in normal human tissues. Cancer Res 61:3458-3464.
    • (2001) Cancer Res , vol.61 , pp. 3458-3464
    • Maliepaard, M.1    Scheffer, G.L.2    Faneyte, I.F.3
  • 172
    • 76749159821 scopus 로고    scopus 로고
    • Influence of cyclooxygenase inhibitors on the function of the prostaglandin transporter organic anion-transporting polypeptide 2A1 expressed in human gastroduodenal mucosa
    • Mandery K, Bujok K, Schmidt I, et al. (2010). Influence of cyclooxygenase inhibitors on the function of the prostaglandin transporter organic anion-transporting polypeptide 2A1 expressed in human gastroduodenal mucosa. J Pharmacol Exp Ther 332: 345-351.
    • (2010) J Pharmacol Exp Ther , vol.332 , pp. 345-351
    • Mandery, K.1    Bujok, K.2    Schmidt, I.3
  • 173
    • 27644480743 scopus 로고    scopus 로고
    • Role of the breast cancer resistance protein (ABCG2) in drug transport
    • Mao Q, Unadkat JD. (2005). Role of the breast cancer resistance protein (ABCG2) in drug transport. AAPS J 7:E118-E133.
    • (2005) AAPS J , vol.7
    • Mao, Q.1    Unadkat, J.D.2
  • 174
    • 0029894447 scopus 로고    scopus 로고
    • MDR1/P-glycoprotein in haematological neoplasms
    • Marie JP, Zhou DC, Gurbuxani S, et al. (1996). MDR1/P-glycoprotein in haematological neoplasms. Eur J Cancer 32A:1034-1038.
    • (1996) Eur J Cancer , vol.32 A , pp. 1034-1038
    • Marie, J.P.1    Zhou, D.C.2    Gurbuxani, S.3
  • 175
    • 0033862765 scopus 로고    scopus 로고
    • Communication between multiple drug binding sites on P-glycoprotein
    • Martin C, Berridge G, Higgins CF, et al. (2000). Communication between multiple drug binding sites on P-glycoprotein. Mol Pharmacol 58:624-632.
    • (2000) Mol Pharmacol , vol.58 , pp. 624-632
    • Martin, C.1    Berridge, G.2    Higgins, C.F.3
  • 176
    • 47349109041 scopus 로고    scopus 로고
    • The pharmacogenomics of P-glycoprotein and its role in veterinary medicine
    • Martinez M, Modric S, Sharkey M, et al. (2008). The pharmacogenomics of P-glycoprotein and its role in veterinary medicine. J Vet Pharmacol Ther 31:285-300.
    • (2008) J Vet Pharmacol Ther , vol.31 , pp. 285-300
    • Martinez, M.1    Modric, S.2    Sharkey, M.3
  • 177
    • 1642523162 scopus 로고    scopus 로고
    • Polymorphisms in human MDR1 (P-glycoprotein): Recent advances and clinical relevance
    • Marzolini C, Paus E, Buclin T, Kim RB. (2004). Polymorphisms in human MDR1 (P-glycoprotein): Recent advances and clinical relevance. Clin Pharmacol Ther 75:13-33.
    • (2004) Clin Pharmacol Ther , vol.75 , pp. 13-33
    • Marzolini, C.1    Paus, E.2    Buclin, T.3    Kim, R.B.4
  • 178
    • 33746548445 scopus 로고    scopus 로고
    • +/organic cation antiporter, kidney-specific multidrug and toxin extrusion 2
    • +/organic cation antiporter, kidney-specific multidrug and toxin extrusion 2. J Am Soc Nephrol 17:2127-2135.
    • (2006) J Am Soc Nephrol , vol.17 , pp. 2127-2135
    • Masuda, S.1    Terada, T.2    Yonezawa, A.3
  • 179
    • 61449246570 scopus 로고    scopus 로고
    • The inhibition of human multidrug and toxin extrusion 1 is involved in the drug-drug interaction caused by cimetidine
    • Matsushima S, Maeda K, Inoue K, et al. (2009). The inhibition of human multidrug and toxin extrusion 1 is involved in the drug-drug interaction caused by cimetidine. Drug Metab Dispos 37:555-559.
    • (2009) Drug Metab Dispos , vol.37 , pp. 555-559
    • Matsushima, S.1    Maeda, K.2    Inoue, K.3
  • 180
    • 0035164622 scopus 로고    scopus 로고
    • Ivermectin sensitivity in collies is associated with a deletion mutation of the mdr1 gene
    • Mealey KL, Bentjen SA, Gay JM, Cantor GH. (2001). Ivermectin sensitivity in collies is associated with a deletion mutation of the mdr1 gene.
    • (2001) Pharmacogenetics , vol.11 , pp. 727-733
    • Mealey, K.L.1    Bentjen, S.A.2    Gay, J.M.3    Cantor, G.H.4
  • 181
    • 55249113858 scopus 로고    scopus 로고
    • Canine ABCB1 and macrocyclic lactones: Heartworm prevention and pharmacogenetics
    • Mealey KL. (2008). Canine ABCB1 and macrocyclic lactones: Heartworm prevention and pharmacogenetics. Vet Parasitol 158: 215-222.
    • (2008) Vet Parasitol , vol.158 , pp. 215-222
    • Mealey, K.L.1
  • 182
    • 3042550238 scopus 로고    scopus 로고
    • Identification of phalloidin uptake systems of rat and human liver
    • Meier-Abt F, Faulstich H, Hagenbuch B. (2004). Identification of phalloidin uptake systems of rat and human liver. Biochim Biophys Acta 1664:64-69.
    • (2004) Biochim Biophys Acta , vol.1664 , pp. 64-69
    • Meier-Abt, F.1    Faulstich, H.2    Hagenbuch, B.3
  • 183
    • 33745901941 scopus 로고    scopus 로고
    • Interindividual variability of canalicular ATP-binding-cassette (ABC)-transporter expression in human liver
    • Meier Y, Pauli-Magnus C, Zanger UM, et al. (2006). Interindividual variability of canalicular ATP-binding-cassette (ABC)-transporter expression in human liver. Hepatology 44:62-74.
    • (2006) Hepatology , vol.44 , pp. 62-74
    • Meier, Y.1    Pauli-Magnus, C.2    Zanger, U.M.3
  • 184
    • 78649648616 scopus 로고    scopus 로고
    • In vitro and in vivo evidence for the importance of breast cancer resistance protein transporters (BCRP/MXR/ABCP/ABCG2)
    • Meyer zu Schwabedissen HE, Kroemer HK. (2011). In vitro and in vivo evidence for the importance of breast cancer resistance protein transporters (BCRP/MXR/ABCP/ABCG2). Handb Exp Pharmacol 201:325-371.
    • (2011) Handb Exp Pharmacol , vol.201 , pp. 325-371
    • Meyer Zu Schwabedissen, H.E.1    Kroemer, H.K.2
  • 185
    • 77950852256 scopus 로고    scopus 로고
    • Human multidrug and toxin extrusion 1 (MATE1/SLC47A1) transporter: Functional characterization, interaction with OCT2 (SLC22A2), and single nucleotide polymorphisms
    • Meyer zu Schwabedissen HE, Verstuyft C, Kroemer HK, et al. (2010) Human multidrug and toxin extrusion 1 (MATE1/SLC47A1) transporter: functional characterization, interaction with OCT2 (SLC22A2), and single nucleotide polymorphisms. Am J Physiol Renal Physiol 298: F997-F1005.
    • (2010) Am J Physiol Renal Physiol , vol.298
    • Meyer Zu Schwabedissen, H.E.1    Verstuyft, C.2    Kroemer, H.K.3
  • 186
    • 0000053197 scopus 로고
    • The character of a new mutant in rats with hyperbilirubinuria syndrome
    • Mikami T, Nozaki Y, Tagaya O, et al. (1986). The character of a new mutant in rats with hyperbilirubinuria syndrome. Cong Anom 26: 250-251.
    • (1986) Cong Anom , vol.26 , pp. 250-251
    • Mikami, T.1    Nozaki, Y.2    Tagaya, O.3
  • 187
    • 12144288563 scopus 로고    scopus 로고
    • Isolation and characterization of a digoxin transporter and its rat homologue expressed in the kidney
    • Mikkaichi T, Suzuki T, Onogawa T, et al. (2004). Isolation and characterization of a digoxin transporter and its rat homologue expressed in the kidney. Proc Natl Acad Sci USA 101:3569-3574.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 3569-3574
    • Mikkaichi, T.1    Suzuki, T.2    Onogawa, T.3
  • 188
    • 80053530180 scopus 로고    scopus 로고
    • Vectorial transport of fexofenadine across Caco-2 cells: Involvement of apical uptake and basolateral efflux transporters
    • Ming X, Knight BM, Thakker DR. (2011). Vectorial transport of fexofenadine across Caco-2 cells: Involvement of apical uptake and basolateral efflux transporters. Mol Pharm 8:1677-1686.
    • (2011) Mol Pharm , vol.8 , pp. 1677-1686
    • Ming, X.1    Knight, B.M.2    Thakker, D.R.3
  • 189
    • 0032895533 scopus 로고    scopus 로고
    • Molecular cloning of cDNAs which are highly overexpressed in mitoxantrone-resistant cells: Demonstration of homology to ABC transport genes
    • Miyake K, Mickley L, Litman T, et al. (1999). Molecular cloning of cDNAs which are highly overexpressed in mitoxantrone-resistant cells: Demonstration of homology to ABC transport genes. Cancer Res 59:8-13.
    • (1999) Cancer Res , vol.59 , pp. 8-13
    • Miyake, K.1    Mickley, L.2    Litman, T.3
  • 190
    • 84859727401 scopus 로고    scopus 로고
    • Human ABCG2: Structure, function, and its role in multidrug resistance
    • Mo W, Zhang JT. (2012). Human ABCG2: Structure, function, and its role in multidrug resistance. Int J Biochem Mol Biol 3:1-27.
    • (2012) Int J Biochem Mol Biol , vol.3 , pp. 1-27
    • Mo, W.1    Zhang, J.T.2
  • 191
    • 38749091688 scopus 로고    scopus 로고
    • Regulation of drug-metabolizing enzymes and transporters in infection, inflammation, and cancer
    • Morgan ET, Goralski KB, Piquette-Miller M, et al. (2008). Regulation of drug-metabolizing enzymes and transporters in infection, inflammation, and cancer. Drug Metab Dispos 36:205-216.
    • (2008) Drug Metab Dispos , vol.36 , pp. 205-216
    • Morgan, E.T.1    Goralski, K.B.2    Piquette-Miller, M.3
  • 192
    • 0030772953 scopus 로고    scopus 로고
    • Kidney-specific expression of a novel mouse organic cation transporter-like protein
    • Mori K, Ogawa Y, Ebihara K, et al. (1997). Kidney-specific expression of a novel mouse organic cation transporter-like protein. FEBS Lett 417:371-374.
    • (1997) FEBS Lett , vol.417 , pp. 371-374
    • Mori, K.1    Ogawa, Y.2    Ebihara, K.3
  • 193
    • 84875174656 scopus 로고    scopus 로고
    • Multidrug and toxin extrusion family SLC47: Physiological, pharmacokinetic and toxicokinetic importance of MATE1 and MATE2-K
    • Motohashi H, Inui K. (2013). Multidrug and toxin extrusion family SLC47: Physiological, pharmacokinetic and toxicokinetic importance of MATE1 and MATE2-K. Mol Aspects Med 34:661-668.
    • (2013) Mol Aspects Med , vol.34 , pp. 661-668
    • Motohashi, H.1    Inui, K.2
  • 194
    • 0142010611 scopus 로고    scopus 로고
    • P-glycoprotein increases from proximal to distal regions of human small intestine
    • Mouly S, Paine MF. (2003). P-glycoprotein increases from proximal to distal regions of human small intestine. Pharm Res 20:1595-1599.
    • (2003) Pharm Res , vol.20 , pp. 1595-1599
    • Mouly, S.1    Paine, M.F.2
  • 195
    • 74249102458 scopus 로고    scopus 로고
    • Regulation of drug metabolism and transporters
    • Muntané J. (2009). Regulation of drug metabolism and transporters. Curr Drug Metab 10:932-945.
    • (2009) Curr Drug Metab , vol.10 , pp. 932-945
    • Muntané, J.1
  • 196
    • 27744454598 scopus 로고    scopus 로고
    • Drug specificity and intestinal membrane localization of human organic cation transporters (OCT)
    • Müller J, Lips KS, Metzner L, et al. (2005). Drug specificity and intestinal membrane localization of human organic cation transporters (OCT). Biochem Pharmacol 70:1851-1860.
    • (2005) Biochem Pharmacol , vol.70 , pp. 1851-1860
    • Müller, J.1    Lips, K.S.2    Metzner, L.3
  • 197
    • 0029937429 scopus 로고    scopus 로고
    • Secretion of organic anions by hepatocytes: Involvement of homologues of the multidrug resistance protein
    • Müller M, Roelofsen H, Jansen PL. (1996). Secretion of organic anions by hepatocytes: Involvement of homologues of the multidrug resistance protein. Semin Liver Dis 16:211-220.
    • (1996) Semin Liver Dis , vol.16 , pp. 211-220
    • Müller, M.1    Roelofsen, H.2    Jansen, P.L.3
  • 198
    • 77649135512 scopus 로고    scopus 로고
    • Drug interactions with HMG-CoA reductase inhibitors (statins): The importance of CYP enzymes, transporters and pharmacogenetics
    • Neuvonen PJ. (2010). Drug interactions with HMG-CoA reductase inhibitors (statins): The importance of CYP enzymes, transporters and pharmacogenetics. Curr Opin Investig Drugs 11:323-332.
    • (2010) Curr Opin Investig Drugs , vol.11 , pp. 323-332
    • Neuvonen, P.J.1
  • 199
    • 79953803082 scopus 로고    scopus 로고
    • ATP-binding cassette efflux transporters in human placenta
    • Ni Z, Mao Q. (2011). ATP-binding cassette efflux transporters in human placenta. Curr Pharm Biotechnol 12:674-685.
    • (2011) Curr Pharm Biotechnol , vol.12 , pp. 674-685
    • Ni, Z.1    Mao, Q.2
  • 200
    • 33750319402 scopus 로고    scopus 로고
    • Association of genetic polymorphism in ABCC2 with hepatic multidrug resistance-associated protein 2 expression and pravastatin pharmacokinetics
    • Niemi M, Arnold KA, Backman JT, et al. (2006). Association of genetic polymorphism in ABCC2 with hepatic multidrug resistance-associated protein 2 expression and pravastatin pharmacokinetics. Pharmacogenet Genom 16:801-808.
    • (2006) Pharmacogenet Genom , vol.16 , pp. 801-808
    • Niemi, M.1    Arnold, K.A.2    Backman, J.T.3
  • 201
    • 79953901458 scopus 로고    scopus 로고
    • Organic anion transporting polypeptide 1B1: A genetically polymorphic transporter of major importance for hepatic drug uptake
    • Niemi M, Pasanen MK, Neuvonen PJ. (2011). Organic anion transporting polypeptide 1B1: A genetically polymorphic transporter of major importance for hepatic drug uptake. Pharmacol Rev 63:157-181.
    • (2011) Pharmacol Rev , vol.63 , pp. 157-181
    • Niemi, M.1    Pasanen, M.K.2    Neuvonen, P.J.3
  • 202
    • 6344265573 scopus 로고    scopus 로고
    • Expression and immunolocalization of the multidrug resistance proteins, MRP1-MRP6 (ABCC1-ABCC6), in human brain
    • Nies AT, Jedlitschky G, König J, et al. (2004). Expression and immunolocalization of the multidrug resistance proteins, MRP1-MRP6 (ABCC1-ABCC6), in human brain. Neuroscience 129: 349-360.
    • (2004) Neuroscience , vol.129 , pp. 349-360
    • Nies, A.T.1    Jedlitschky, G.2    König, J.3
  • 203
    • 33846706434 scopus 로고    scopus 로고
    • The apical conjugate efflux pump ABCC2 (MRP2)
    • Nies AT, Keppler D. (2007). The apical conjugate efflux pump ABCC2 (MRP2). Pflugers Arch 453:643-659.
    • (2007) Pflugers Arch , vol.453 , pp. 643-659
    • Nies, A.T.1    Keppler, D.2
  • 204
    • 45949102855 scopus 로고    scopus 로고
    • Interplay of conjugating enzymes with OATP uptake transporters and ABCC/MRP efflux pumps in the elimination of drugs
    • Nies AT, Schwab M, Keppler D. (2008). Interplay of conjugating enzymes with OATP uptake transporters and ABCC/MRP efflux pumps in the elimination of drugs. Expert Opin Drug Metab Toxicol 4:545-568.
    • (2008) Expert Opin Drug Metab Toxicol , vol.4 , pp. 545-568
    • Nies, A.T.1    Schwab, M.2    Keppler, D.3
  • 205
    • 78649646556 scopus 로고    scopus 로고
    • Organic cation transporters (OCTs, MATEs), in vitro and in vivo evidence for the importance in drug therapy
    • Nies AT, Koepsell H, Damme K, Schwab M. (2011). Organic cation transporters (OCTs, MATEs), in vitro and in vivo evidence for the importance in drug therapy. Handb Exp Pharmacol 201: 105-167.
    • (2011) Handb Exp Pharmacol , vol.201 , pp. 105-167
    • Nies, A.T.1    Koepsell, H.2    Damme, K.3    Schwab, M.4
  • 206
    • 84867419830 scopus 로고    scopus 로고
    • Overcoming tumor multidrug resistance using drugs able to evade P-glycoprotein or to exploit its expression
    • Nobili S, Landini I, Mazzei T, Mini E. (2012). Overcoming tumor multidrug resistance using drugs able to evade P-glycoprotein or to exploit its expression. Med Res Rev 32:1220-1262.
    • (2012) Med Res Rev , vol.32 , pp. 1220-1262
    • Nobili, S.1    Landini, I.2    Mazzei, T.3    Mini, E.4
  • 207
    • 84855869661 scopus 로고    scopus 로고
    • The expression and function of organic anion transporting polypeptides in normal tissues and in cancer
    • Obaidat A, Roth M, Hagenbuch B. (2012). The expression and function of organic anion transporting polypeptides in normal tissues and in cancer. Annu Rev Pharmacol Toxicol 52:135-151.
    • (2012) Annu Rev Pharmacol Toxicol , vol.52 , pp. 135-151
    • Obaidat, A.1    Roth, M.2    Hagenbuch, B.3
  • 208
    • 33747606815 scopus 로고    scopus 로고
    • Disposition and sterol-lowering effect of ezetimibe in multidrug resistance-associated protein 2-deficient rats
    • Oswald S, Westrup S, Grube M, et al. (2006). Disposition and sterol-lowering effect of ezetimibe in multidrug resistance-associated protein 2-deficient rats. J Pharmacol Exp Ther 318:1293-1299.
    • (2006) J Pharmacol Exp Ther , vol.318 , pp. 1293-1299
    • Oswald, S.1    Westrup, S.2    Grube, M.3
  • 209
    • 29144523534 scopus 로고    scopus 로고
    • A human transporter protein that mediates the final excretion step for toxic organic cations
    • Otsuka M, MatsumotoT, Morimoto R, et al. (2005). A human transporter protein that mediates the final excretion step for toxic organic cations. Proc Natl Acad Sci USA 102:17923-17928.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 17923-17928
    • Otsuka, M.1    Matsumotot Morimoto, R.2
  • 210
    • 0027480216 scopus 로고
    • Accumulation of organic anion in intracellular vesicles of cultured rat hepatocytes is mediated by the canalicular multispecific organic anion transporter
    • Oude Elferink RP, Bakker CT, Roelofsen H, et al. (1993). Accumulation of organic anion in intracellular vesicles of cultured rat hepatocytes is mediated by the canalicular multispecific organic anion transporter. Hepatology 17:434-444.
    • (1993) Hepatology , vol.17 , pp. 434-444
    • Oude Elferink, R.P.1    Bakker, C.T.2    Roelofsen, H.3
  • 211
    • 33747352798 scopus 로고    scopus 로고
    • MDR-and CYP3A4-mediated drug-drug interactions
    • Pal D, Mitra AK. (2006). MDR-and CYP3A4-mediated drug-drug interactions. J Neuroimmune Pharmacol 1:323-339.
    • (2006) J Neuroimmune Pharmacol , vol.1 , pp. 323-339
    • Pal, D.1    Mitra, A.K.2
  • 212
    • 0028308901 scopus 로고
    • Multidrug resistance in cancer chemotherapy
    • Patel NH, Rothenberg ML. (1994). Multidrug resistance in cancer chemotherapy. Invest New Drugs 12:1-13.
    • (1994) Invest New Drugs , vol.12 , pp. 1-13
    • Patel, N.H.1    Rothenberg, M.L.2
  • 213
    • 0023323838 scopus 로고
    • Clinical observations in collies given ivermectin orally
    • Paul AJ, Tranquilli WJ, Seward RL, et al. (1987). Clinical observations in collies given ivermectin orally. Am J Vet Res 48:684-685.
    • (1987) Am J Vet Res , vol.48 , pp. 684-685
    • Paul, A.J.1    Tranquilli, W.J.2    Seward, R.L.3
  • 214
    • 0029981430 scopus 로고    scopus 로고
    • Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene
    • Paulusma CC, Bosma PJ, Zaman GJ, et al. (1996). Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene. Science 271:1126-1128.
    • (1996) Science , vol.271 , pp. 1126-1128
    • Paulusma, C.C.1    Bosma, P.J.2    Zaman, G.J.3
  • 215
    • 0030994468 scopus 로고    scopus 로고
    • A mutation in the human canalicular multispecific organic anion transporter gene causes the Dubin-Johnson syndrome
    • Paulusma CC, Kool M, Bosma PJ, et al. (1997). A mutation in the human canalicular multispecific organic anion transporter gene causes the Dubin-Johnson syndrome. Hepatology 25:1539-1542.
    • (1997) Hepatology , vol.25 , pp. 1539-1542
    • Paulusma, C.C.1    Kool, M.2    Bosma, P.J.3
  • 216
    • 0040276377 scopus 로고
    • Occurence of a multispecific transporter for the hepatocellular accumulation of bile acids and various cyclopeptides
    • Paumgartner G, Stiehl A, Gerok W, ed Lancaster: MTP-Press
    • Petzinger E, Ziegler K, Frimmer M. (1987). Occurence of a multispecific transporter for the hepatocellular accumulation of bile acids and various cyclopeptides. In: Paumgartner G, Stiehl A, Gerok W, ed. Bile Acids and the Liver. Lancaster: MTP-Press, 111-124.
    • (1987) Bile Acids and the Liver , pp. 111-124
    • Petzinger, E.1    Ziegler, K.2    Frimmer, M.3
  • 217
    • 0030000642 scopus 로고    scopus 로고
    • What we have learned about bumetanide and the concept of multispecific bile acid/drug transporters from the liver
    • Petzinger E, Blumrich M, Brühl B, et al. (1996). What we have learned about bumetanide and the concept of multispecific bile acid/drug transporters from the liver. J Hepatol 24:42-46.
    • (1996) J Hepatol , vol.24 , pp. 42-46
    • Petzinger, E.1    Blumrich, M.2    Brühl, B.3
  • 219
    • 33947323721 scopus 로고    scopus 로고
    • New strategies to address drug-drug interactions involving OATPs
    • Poirier A, Funk C, Lave T, Noe J. (2007). New strategies to address drug-drug interactions involving OATPs. Curr Opin Drug Discov Devel 10:74-83.
    • (2007) Curr Opin Drug Discov Devel , vol.10 , pp. 74-83
    • Poirier, A.1    Funk, C.2    Lave, T.3    Noe, J.4
  • 220
    • 76749087401 scopus 로고    scopus 로고
    • Regulation of BCRP (ABCG2) and P-glycoprotein (ABCB1) by cytokines in a model of the human blood-brain barrier
    • Poller B, Drewe J, Krahenbuhl S, et al. (2010). Regulation of BCRP (ABCG2) and P-glycoprotein (ABCB1) by cytokines in a model of the human blood-brain barrier. Cell Mol Neurobiol 30: 63-70.
    • (2010) Cell Mol Neurobiol , vol.30 , pp. 63-70
    • Poller, B.1    Drewe, J.2    Krahenbuhl, S.3
  • 222
    • 84890663852 scopus 로고    scopus 로고
    • Interindividual variability in hepatic oatps and P-glycoprotein (ABCB1) protein expression: Quantification by LC-MS/MS and influence of genotype, age and sex
    • Prasad B, Evers R, Gupta A, et al. (2014). Interindividual variability in hepatic oatps and P-glycoprotein (ABCB1) protein expression: Quantification by LC-MS/MS and influence of genotype, age and sex. Drug Metab Dispos 42:78-88.
    • (2014) Drug Metab Dispos , vol.42 , pp. 78-88
    • Prasad, B.1    Evers, R.2    Gupta, A.3
  • 224
    • 55449113709 scopus 로고    scopus 로고
    • Comparative analyses of fundamental differences in membrane transport capabilities in prokaryotes and eukaryotes
    • Ren Q, Paulsen IT. (2005). Comparative analyses of fundamental differences in membrane transport capabilities in prokaryotes and eukaryotes. PLoS Comput Biol 1:e27.
    • (2005) PLoS Comput Biol , vol.1
    • Ren, Q.1    Paulsen, I.T.2
  • 225
    • 0030712175 scopus 로고    scopus 로고
    • Sudden neonatal death in carnitine transporter deficiency
    • Rinaldo P, Stanley CA, Hsu BY, et al. (1997). Sudden neonatal death in carnitine transporter deficiency. J Pediatr 131:304-305.
    • (1997) J Pediatr , vol.131 , pp. 304-305
    • Rinaldo, P.1    Stanley, C.A.2    Hsu, B.Y.3
  • 226
    • 0034705145 scopus 로고    scopus 로고
    • Pseudoxanthoma elasticum: Mutations in the MRP6 gene encoding a transmembrane ATP-binding cassette (ABC) transporter
    • Ringpfeil F, Lebwohl MG, Christiano AM, Uitto J. (2000). Pseudoxanthoma elasticum: Mutations in the MRP6 gene encoding a transmembrane ATP-binding cassette (ABC) transporter. Proc Natl Acad Sci USA 97:6001-6006.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 6001-6006
    • Ringpfeil, F.1    Lebwohl, M.G.2    Christiano, A.M.3    Uitto, J.4
  • 227
    • 0021797892 scopus 로고
    • Amplification of P-glycoprotein genes in multidrug-resistant mammalian cell lines
    • Riordan JR, Deuchars K, Kartner N, et al. (1985). Amplification of P-glycoprotein genes in multidrug-resistant mammalian cell lines. Nature 316:817-819.
    • (1985) Nature , vol.316 , pp. 817-819
    • Riordan, J.R.1    Deuchars, K.2    Kartner, N.3
  • 228
    • 0035293717 scopus 로고    scopus 로고
    • The transporter associated with antigen processing (TAP): Structural integrity, expression, function, and its clinical relevance
    • Ritz U, Seliger B. (2001). The transporter associated with antigen processing (TAP): Structural integrity, expression, function, and its clinical relevance. Mol Med 7:149-158.
    • (2001) Mol Med , vol.7 , pp. 149-158
    • Ritz, U.1    Seliger, B.2
  • 229
    • 33847139479 scopus 로고    scopus 로고
    • Organic anion transporters of the SLC22 family: Biopharmaceutical, physiological, and pathological roles
    • Rizwan AN, Burckhardt G. (2007). Organic anion transporters of the SLC22 family: Biopharmaceutical, physiological, and pathological roles. Pharm Res 24:450-470.
    • (2007) Pharm Res , vol.24 , pp. 450-470
    • Rizwan, A.N.1    Burckhardt, G.2
  • 231
    • 0000598335 scopus 로고
    • Isolation of human mdr DNA sequences amplified in multidrug-resistant KB carcinoma cells
    • Roninson IB, Chin JE, Choi KG, et al. (1986). Isolation of human mdr DNA sequences amplified in multidrug-resistant KB carcinoma cells. Proc Natl Acad Sci USA 83:4538-4542.
    • (1986) Proc Natl Acad Sci USA , vol.83 , pp. 4538-4542
    • Roninson, I.B.1    Chin, J.E.2    Choi, K.G.3
  • 232
    • 0037424343 scopus 로고    scopus 로고
    • Three-dimensional structures of the mammalian multidrug resistance P-glycoprotein demonstrate major conformational changes in the transmembrane domains upon nucleotide binding
    • Rosenberg MF, Kamis AB, Callaghan R, et al. (2003). Three-dimensional structures of the mammalian multidrug resistance P-glycoprotein demonstrate major conformational changes in the transmembrane domains upon nucleotide binding. J Biol Chem 278: 8294-8299.
    • (2003) J Biol Chem , vol.278 , pp. 8294-8299
    • Rosenberg, M.F.1    Kamis, A.B.2    Callaghan, R.3
  • 233
    • 84857092984 scopus 로고    scopus 로고
    • OATPs, OATs and OCTs: The organic anion and cation transporters of the SLCO and SLC22A gene superfamilies
    • Roth M, Obaidat A, Hagenbuch B. (2012). OATPs, OATs and OCTs: The organic anion and cation transporters of the SLCO and SLC22A gene superfamilies. Br J Pharmacol 165:1260-1287.
    • (2012) Br J Pharmacol , vol.165 , pp. 1260-1287
    • Roth, M.1    Obaidat, A.2    Hagenbuch, B.3
  • 234
    • 0037462462 scopus 로고    scopus 로고
    • MDR1-deficient genotype in Collie dogs hypersensitive to the P-glycoprotein substrate ivermectin
    • Roulet A, Puel O, Gesta S, et al. (2003). MDR1-deficient genotype in Collie dogs hypersensitive to the P-glycoprotein substrate ivermectin. Eur J Pharmacol 460:85-91.
    • (2003) Eur J Pharmacol , vol.460 , pp. 85-91
    • Roulet, A.1    Puel, O.2    Gesta, S.3
  • 235
    • 84867578454 scopus 로고    scopus 로고
    • Endothelin receptor antagonists for the treatment of pulmonary artery hypertension
    • Rubin LJ. (2012). Endothelin receptor antagonists for the treatment of pulmonary artery hypertension. Life Sci 91:517-521.
    • (2012) Life Sci , vol.91 , pp. 517-521
    • Rubin, L.J.1
  • 236
    • 48749131090 scopus 로고    scopus 로고
    • Peptide transporters and their roles in physiological processes and drug disposition
    • Rubio-Aliaga I, Daniel H. (2008). Peptide transporters and their roles in physiological processes and drug disposition. Xenobiotica 38: 1022-1042.
    • (2008) Xenobiotica , vol.38 , pp. 1022-1042
    • Rubio-Aliaga, I.1    Daniel, H.2
  • 237
    • 0034671544 scopus 로고    scopus 로고
    • Identification of basic residues involved in drug export function of human multidrug resistance-associated protein 2
    • Ryu S, Kawabe T, Nada S, Yamaguchi A. (2000). Identification of basic residues involved in drug export function of human multidrug resistance-associated protein 2. J Biol Chem 275: 39617-39624.
    • (2000) J Biol Chem , vol.275 , pp. 39617-39624
    • Ryu, S.1    Kawabe, T.2    Nada, S.3    Yamaguchi, A.4
  • 238
    • 33845365814 scopus 로고    scopus 로고
    • Factors influencing the magnitude and clinical significance of drug interactions between azole antifungals and select immunosuppressants
    • Saad AH, DePestel DD, Carver PL. (2006). Factors influencing the magnitude and clinical significance of drug interactions between azole antifungals and select immunosuppressants. Pharmacotherapy 26: 1730-1744.
    • (2006) Pharmacotherapy , vol.26 , pp. 1730-1744
    • Saad, A.H.1    Depestel, D.D.2    Carver, P.L.3
  • 239
    • 33644873454 scopus 로고    scopus 로고
    • TCDB: The Transporter Classification Database for membrane transport protein analyses and information
    • Saier Jr MH, Tran CV, Barabote RD. (2006). TCDB: The Transporter Classification Database for membrane transport protein analyses and information. Nucleic Acids Res 34:D181-D186.
    • (2006) Nucleic Acids Res , vol.34
    • Saier Jr., M.H.1    Tran, C.V.2    Barabote, R.D.3
  • 240
    • 58149202169 scopus 로고    scopus 로고
    • The Transporter Classification Database: Recent advances
    • Saier Jr MH, Yen MR, Noto K, et al. (2009). The Transporter Classification Database: recent advances. Nucleic Acids Res 37: D274-D278.
    • (2009) Nucleic Acids Res , vol.37
    • Saier Jr., M.H.1    Yen, M.R.2    Noto, K.3
  • 241
    • 21344446092 scopus 로고    scopus 로고
    • The impact of pharmacologic and genetic knockout of P-glycoprotein on nelfinavir levels in the brain and other tissues in mice
    • Salama NN, Kelly EJ, Bui T, Ho RJ. (2005). The impact of pharmacologic and genetic knockout of P-glycoprotein on nelfinavir levels in the brain and other tissues in mice. J Pharm Sci 94: 1216-1225.
    • (2005) J Pharm Sci , vol.94 , pp. 1216-1225
    • Salama, N.N.1    Kelly, E.J.2    Bui, T.3    Ho, R.J.4
  • 242
    • 0035985610 scopus 로고    scopus 로고
    • Expression of multidrug resistance-associated protein 2 (MRP2) in normal human tissues and carcinomas using tissue microarrays
    • Sandusky GE, Mintze KS, Pratt SE, Dantzig AH. (2002). Expression of multidrug resistance-associated protein 2 (MRP2) in normal human tissues and carcinomas using tissue microarrays. Histopathology 41: 65-74.
    • (2002) Histopathology , vol.41 , pp. 65-74
    • Sandusky, G.E.1    Mintze, K.S.2    Pratt, S.E.3    Dantzig, A.H.4
  • 243
    • 0030724010 scopus 로고    scopus 로고
    • Organic anion transporting polypeptide mediates organic anion/HCO^ exchange
    • Satlin LM, Amin V, Wolkoff AW. (1997). Organic anion transporting polypeptide mediates organic anion/HCO^ exchange. J Biol Chem 272:26340-26345.
    • (1997) J Biol Chem , vol.272 , pp. 26340-26345
    • Satlin, L.M.1    Amin, V.2    Wolkoff, A.W.3
  • 244
    • 0028229150 scopus 로고
    • Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs
    • Schinkel AH, Smit JJ, van Tellingen O, et al. (1994). Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs. Cell 77:491-502.
    • (1994) Cell , vol.77 , pp. 491-502
    • Schinkel, A.H.1    Smit, J.J.2    Van Tellingen, O.3
  • 245
    • 0028825399 scopus 로고
    • Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A
    • Schinkel AH, Wagenaar E, van Deemter L, et al. (1995). Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A. J Clin Invest 96:1698-1705.
    • (1995) J Clin Invest , vol.96 , pp. 1698-1705
    • Schinkel, A.H.1    Wagenaar, E.2    Van Deemter, L.3
  • 246
    • 33646587050 scopus 로고    scopus 로고
    • The intracellular antigen transport machinery TAP in adaptive immunity and virus escape mechanisms
    • Scholz C, Tampe R. (2005). The intracellular antigen transport machinery TAP in adaptive immunity and virus escape mechanisms. J Bioenerg Biomembr 37:509-515.
    • (2005) J Bioenerg Biomembr , vol.37 , pp. 509-515
    • Scholz, C.1    Tampe, R.2
  • 248
    • 0030855487 scopus 로고    scopus 로고
    • Expression cloning and characterization of a novel multispecific organic anion transporter
    • Sekine T, Watanabe N, HosoyamadaM, et al. (1997). Expression cloning and characterization of a novel multispecific organic anion transporter. J Biol Chem 272:18526-18529.
    • (1997) J Biol Chem , vol.272 , pp. 18526-18529
    • Sekine, T.1    Hosoyamadam, W.N.2
  • 249
    • 0041344702 scopus 로고    scopus 로고
    • Functional complementation between a novel mammalian polygenic transport complex and an evolutionarily ancient organic solute transporter, OSTalpha-OSTbeta
    • Seward DJ, Koh AS, Boyer JL, Ballatori N. (2003). Functional complementation between a novel mammalian polygenic transport complex and an evolutionarily ancient organic solute transporter, OSTalpha-OSTbeta. J Biol Chem 278:27473-27482.
    • (2003) J Biol Chem , vol.278 , pp. 27473-27482
    • Seward, D.J.1    Koh, A.S.2    Boyer, J.L.3    Ballatori, N.4
  • 250
    • 0020824908 scopus 로고
    • Reactions in dogs given ivermectin
    • Seward RL. (1983). Reactions in dogs given ivermectin. J Am Vet Med Assoc 183:493.
    • (1983) J Am Vet Med Assoc , vol.183 , pp. 493
    • Seward, R.L.1
  • 251
    • 0033083015 scopus 로고    scopus 로고
    • Stimulation of P-glycoprotein-mediated drug transport by prazosin and progesterone. Evidence for a third drug-binding site
    • Shapiro AB, Fox K, Lam P, Ling V. (1999). Stimulation of P-glycoprotein-mediated drug transport by prazosin and progesterone. Evidence for a third drug-binding site. Eur J Biochem 259:841-850.
    • (1999) Eur J Biochem , vol.259 , pp. 841-850
    • Shapiro, A.B.1    Fox, K.2    Lam, P.3    Ling, V.4
  • 252
    • 33748042671 scopus 로고    scopus 로고
    • Pharmacokinetic and pharmacodynamic alterations of 3-hydroxy-3- methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors: Drug-drug interactions and interindividual differences in transporter and metabolic enzyme functions
    • Shitara Y, Sugiyama Y (2006). Pharmacokinetic and pharmacodynamic alterations of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors: Drug-drug interactions and interindividual differences in transporter and metabolic enzyme functions. Pharmacol Ther 112:71-105.
    • (2006) Pharmacol Ther , vol.112 , pp. 71-105
    • Shitara, Y.1    Sugiyama, Y.2
  • 253
    • 0028098101 scopus 로고
    • Ketoconazole effectively reverses multidrug resistance in highly resistant KB cells
    • Siegsmund MJ, Cardarelli C, Aksentijevich I, et al. (1994). Ketoconazole effectively reverses multidrug resistance in highly resistant KB cells. J Urol 151:485-491.
    • (1994) J Urol , vol.151 , pp. 485-491
    • Siegsmund, M.J.1    Cardarelli, C.2    Aksentijevich, I.3
  • 254
    • 33947429086 scopus 로고    scopus 로고
    • Intestinal expression of cytochrome P450 enzymes and ABC transporters and carbamazepine and phenytoin disposition
    • Simon C, Stieger B, Kullak-Ublick GA, et al. (2007). Intestinal expression of cytochrome P450 enzymes and ABC transporters and carbamazepine and phenytoin disposition. Acta Neurol Scand 115: 232-242.
    • (2007) Acta Neurol Scand , vol.115 , pp. 232-242
    • Simon, C.1    Stieger, B.2    Kullak-Ublick, G.A.3
  • 255
    • 12144269640 scopus 로고    scopus 로고
    • Contribution of multidrug resistance protein 2 (MRP2/ABCC2) to the renal excretion of p-aminohippurate (PAH) and identification of MRP4 (ABCC4) as a novel PAH transporter
    • Smeets PH, Van Aubel RA, Wouterse AC, et al. (2004). Contribution of multidrug resistance protein 2 (MRP2/ABCC2) to the renal excretion of p-aminohippurate (PAH) and identification of MRP4 (ABCC4) as a novel PAH transporter. J Am Soc Nephrol 15:2828-2835.
    • (2004) J Am Soc Nephrol , vol.15 , pp. 2828-2835
    • Smeets, P.H.1    Van Aubel, R.A.2    Wouterse, A.C.3
  • 256
    • 0034604707 scopus 로고    scopus 로고
    • MDR3 P-glycoprotein, a phosphatidylcholine translocase, transports several cytotoxic drugs and directly interacts with drugs as judged by interference with nucleotide trapping
    • Smith AJ, van Helfoort HA, van Meer MG, et al. (2000). MDR3 P-glycoprotein, a phosphatidylcholine translocase, transports several cytotoxic drugs and directly interacts with drugs as judged by interference with nucleotide trapping. J Biol Chem 275:23530-23539.
    • (2000) J Biol Chem , vol.275 , pp. 23530-23539
    • Smith, A.J.1    Van Helfoort, H.A.2    Van Meer, M.G.3
  • 257
    • 84873329542 scopus 로고    scopus 로고
    • Proton-coupled oligopeptide transporter family SLC15: Physiological, pharmacological and pathological implications
    • Smith DE, Clemencon B, Hediger MA. (2013). Proton-coupled oligopeptide transporter family SLC15: Physiological, pharmacological and pathological implications. Mol Aspects Med 34:323-336.
    • (2013) Mol Aspects Med , vol.34 , pp. 323-336
    • Smith, D.E.1    Clemencon, B.2    Hediger, M.A.3
  • 258
    • 0343275558 scopus 로고
    • Studies in detoxication. 22. The metabolism of phenacetin (p-ethoxyacetanilide) in the rabbit and a further observation on acetanilide metabolism
    • Smith JN, Williams RT (1949a). Studies in detoxication. 22. The metabolism of phenacetin (p-ethoxyacetanilide) in the rabbit and a further observation on acetanilide metabolism. Biochem J 44: 239-242.
    • (1949) Biochem J , vol.44 , pp. 239-242
    • Smith, J.N.1    Williams, R.T.2
  • 259
    • 0343161490 scopus 로고
    • Studies in detoxication. 23. The fate of aniline in the rabbit
    • Smith JN, Williams RT. (1949b). Studies in detoxication. 23. The fate of aniline in the rabbit. Biochem J 44:242-250.
    • (1949) Biochem J , vol.44 , pp. 242-250
    • Smith, J.N.1    Williams, R.T.2
  • 260
    • 0000613560 scopus 로고
    • Studies in detoxication. 24. The metabolism of p-phenetidine (p-ethoxyaniline) with some observations on the anisidines (methoxyanilines)
    • Smith JN, Williams RT. (1949c). Studies in detoxication. 24. The metabolism of p-phenetidine (p-ethoxyaniline) with some observations on the anisidines (methoxyanilines). Biochem J 44:250-255.
    • (1949) Biochem J , vol.44 , pp. 250-255
    • Smith, J.N.1    Williams, R.T.2
  • 261
    • 79957629733 scopus 로고    scopus 로고
    • Pharmacogenetics of drug transporters in the enterohepatic circulation
    • Stieger B, Meier PJ. (2011). Pharmacogenetics of drug transporters in the enterohepatic circulation. Pharmacogenomics 12:611-631.
    • (2011) Pharmacogenomics , vol.12 , pp. 611-631
    • Stieger, B.1    Meier, P.J.2
  • 262
    • 33644756715 scopus 로고    scopus 로고
    • Improving the in vitro prediction of in vivo central nervous system penetration: Integrating permeability, P-glycoprotein efflux, and free fractions in blood and brain
    • Summerfield SG, Stevens AJ, Cutler L, et al. (2006). Improving the in vitro prediction of in vivo central nervous system penetration: integrating permeability, P-glycoprotein efflux, and free fractions in blood and brain. J Pharmacol Exp Ther 316:1282-1290.
    • (2006) J Pharmacol Exp Ther , vol.316 , pp. 1282-1290
    • Summerfield, S.G.1    Stevens, A.J.2    Cutler, L.3
  • 263
    • 0033739725 scopus 로고    scopus 로고
    • Role of metabolic enzymes and efflux transporters in the absorption of drugs from the small intestine
    • Suzuki H, Sugiyama Y. (2000). Role of metabolic enzymes and efflux transporters in the absorption of drugs from the small intestine. Eur J Pharm Sci 12:3-12.
    • (2000) Eur J Pharm Sci , vol.12 , pp. 3-12
    • Suzuki, H.1    Sugiyama, Y.2
  • 264
    • 0037131880 scopus 로고    scopus 로고
    • Single nucleotide polymorphisms in multidrug resistance associated protein 2 (MRP2/ABCC2): Its impact on drug disposition
    • Suzuki H, Sugiyama Y. (2002). Single nucleotide polymorphisms in multidrug resistance associated protein 2 (MRP2/ABCC2): Its impact on drug disposition. Adv Drug Deliv Rev 54:1311-1331.
    • (2002) Adv Drug Deliv Rev , vol.54 , pp. 1311-1331
    • Suzuki, H.1    Sugiyama, Y.2
  • 265
    • 0038265441 scopus 로고    scopus 로고
    • ABCG2 transports sulfated conjugates of steroids and xenobiotics
    • Suzuki M, Suzuki H, Sugimoto Y, Sugiyama Y. (2003). ABCG2 transports sulfated conjugates of steroids and xenobiotics. J Biol Chem 278:22644-22649.
    • (2003) J Biol Chem , vol.278 , pp. 22644-22649
    • Suzuki, M.1    Suzuki, H.2    Sugimoto, Y.3    Sugiyama, Y.4
  • 267
    • 0031434178 scopus 로고    scopus 로고
    • Cloning and characterization of a novel human pH-dependent organic cation transporter, OCTN1
    • Tamai I, Yabuuchi H, Nezu J, et al. (1997). Cloning and characterization of a novel human pH-dependent organic cation transporter, OCTN1. FEBS Lett 419:107-111.
    • (1997) FEBS Lett , vol.419 , pp. 107-111
    • Tamai, I.1    Yabuuchi, H.2    Nezu, J.3
  • 268
    • 0032493741 scopus 로고    scopus 로고
    • Molecular and functional identification of sodium ion-dependent, high affinity human carnitine transporter OCTN2
    • Tamai I, Ohashi R, Nezu J, et al. (1998). Molecular and functional identification of sodium ion-dependent, high affinity human carnitine transporter OCTN2. J Biol Chem 273:20378-20382.
    • (1998) J Biol Chem , vol.273 , pp. 20378-20382
    • Tamai, I.1    Ohashi, R.2    Nezu, J.3
  • 269
    • 0034704135 scopus 로고    scopus 로고
    • Molecular and functional characterization of organic cation/carnitine transporter family in mice
    • Tamai I, Ohashi R, Nezu JI, et al. (2000). Molecular and functional characterization of organic cation/carnitine transporter family in mice. J Biol Chem 275:40064-40072.
    • (2000) J Biol Chem , vol.275 , pp. 40064-40072
    • Tamai, I.1    Ohashi, R.2    Nezu, J.I.3
  • 270
    • 84872688669 scopus 로고    scopus 로고
    • Pharmacological and pathophysiological roles of carnitine/organic cation transporters (OCTNs: SLC22A4, SLC22A5 and Slc22a21)
    • Tamai I. (2013). Pharmacological and pathophysiological roles of carnitine/organic cation transporters (OCTNs: SLC22A4, SLC22A5 and Slc22a21). Biopharm Drug Dispos 34:29-44.
    • (2013) Biopharm Drug Dispos , vol.34 , pp. 29-44
    • Tamai, I.1
  • 271
    • 9544233652 scopus 로고    scopus 로고
    • A human canalicular multispecific organic anion transporter (cMOAT) gene is over-expressed in cisplatin-resistant human cancer cell lines with decreased drug accumulation
    • Taniguchi K, Wada M, Kohno K, et al. (1996). A human canalicular multispecific organic anion transporter (cMOAT) gene is over-expressed in cisplatin-resistant human cancer cell lines with decreased drug accumulation. Cancer Res 56:4124-4129.
    • (1996) Cancer Res , vol.56 , pp. 4124-4129
    • Taniguchi, K.1    Wada, M.2    Kohno, K.3
  • 272
    • 34250005960 scopus 로고    scopus 로고
    • Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters
    • Tanihara Y, Masuda S, Sato T, et al. (2007). Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters. Biochem Pharmacol 74:359-371.
    • (2007) Biochem Pharmacol , vol.74 , pp. 359-371
    • Tanihara, Y.1    Masuda, S.2    Sato, T.3
  • 273
    • 0023447098 scopus 로고
    • Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues
    • Thiebaut F, Tsuruo T, Hamada H, et al. (1987). Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues. Proc Natl Acad Sci USA 84:7735-7738.
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 7735-7738
    • Thiebaut, F.1    Tsuruo, T.2    Hamada, H.3
  • 274
    • 37549000177 scopus 로고    scopus 로고
    • Multidrug resistance-associated protein 2 is primarily responsible for the biliary excretion of fexofenadine in mice
    • Tian X, Zamek-Gliszczynski MJ, Li J, et al. (2008). Multidrug resistance-associated protein 2 is primarily responsible for the biliary excretion of fexofenadine in mice. Drug Metab Dispos 36:61-64.
    • (2008) Drug Metab Dispos , vol.36 , pp. 61-64
    • Tian, X.1    Zamek-Gliszczynski, M.J.2    Li, J.3
  • 275
    • 78649657340 scopus 로고    scopus 로고
    • Molecular mechanisms of drug transporter regulation
    • Tirona RG. (2011). Molecular mechanisms of drug transporter regulation. Handb Exp Pharmacol 201:373-402.
    • (2011) Handb Exp Pharmacol , vol.201 , pp. 373-402
    • Tirona, R.G.1
  • 276
    • 0024669363 scopus 로고
    • Ivermectin plasma concentrations in collies sensitive to ivermectin-induced toxicosis
    • Tranquilli WJ, Paul AJ, Seward RL. (1989). Ivermectin plasma concentrations in collies sensitive to ivermectin-induced toxicosis. Am J Vet Res 50:769-770.
    • (1989) Am J Vet Res , vol.50 , pp. 769-770
    • Tranquilli, W.J.1    Paul, A.J.2    Seward, R.L.3
  • 277
    • 79959375990 scopus 로고    scopus 로고
    • Genetically polymorphic OCT1: Another piece in the puzzle of the variable pharmacokinetics and pharmacodynamics of the opioidergic drug tramadol
    • Tzvetkov MV, Saadatmand AR, Lötsch J, et al. (2011). Genetically polymorphic OCT1: Another piece in the puzzle of the variable pharmacokinetics and pharmacodynamics of the opioidergic drug tramadol. Clin Pharmacol Ther 90:143-150.
    • (2011) Clin Pharmacol Ther , vol.90 , pp. 143-150
    • Tzvetkov, M.V.1    Saadatmand, A.R.2    Lötsch, J.3
  • 278
    • 84856233573 scopus 로고    scopus 로고
    • Effects of OCT1 polymorphisms on the cellular uptake, plasma concentrations and efficacy of the 5-HT(3) antagonists tropisetron and ondansetron
    • Tzvetkov MV, Saadatmand AR, Bokelmann K, et al. (2012). Effects of OCT1 polymorphisms on the cellular uptake, plasma concentrations and efficacy of the 5-HT(3) antagonists tropisetron and ondansetron. Pharmacogenomics J 12:22-29.
    • (2012) Pharmacogenomics J , vol.12 , pp. 22-29
    • Tzvetkov, M.V.1    Saadatmand, A.R.2    Bokelmann, K.3
  • 279
    • 0023153149 scopus 로고
    • The human multidrug resistance (mdr1) gene. CDNA cloning and transcription initiation
    • Ueda K, Clark DP, Chen CJ, et al. (1987a). The human multidrug resistance (mdr1) gene. cDNA cloning and transcription initiation. J Biol Chem 262:505-508.
    • (1987) J Biol Chem , vol.262 , pp. 505-508
    • Ueda, K.1    Clark, D.P.2    Chen, C.J.3
  • 280
    • 0008632564 scopus 로고
    • Expression of a full-length cDNA for the human "mDR1" gene confers resistance to colchicine, doxorubicin, and vinblastine
    • Ueda K, Cardarelli C, Gottesman MM, Pastan I. (1987b). Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastine. Proc Natl Acad Sci USA 84: 3004-3008.
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 3004-3008
    • Ueda, K.1    Cardarelli, C.2    Gottesman, M.M.3    Pastan, I.4
  • 281
    • 40849104960 scopus 로고    scopus 로고
    • Induction of metabolism and transport in human intestine: Validation of precision-cut slices as a tool to study induction of drug metabolism in human intestine in vitro
    • van de Kerkhof EG, de Graaf IA, Ungell AL, Groothuis GM. (2008). Induction of metabolism and transport in human intestine: Validation of precision-cut slices as a tool to study induction of drug metabolism in human intestine in vitro. Drug Metab Dispos 36:604-613.
    • (2008) Drug Metab Dispos , vol.36 , pp. 604-613
    • Van De Kerkhof, E.G.1    De Graaf, I.A.2    Ungell, A.L.3    Groothuis, G.M.4
  • 282
    • 30344444454 scopus 로고    scopus 로고
    • The function of breast cancer resistance protein in epithelial barriers, stem cells and milk secretion of drugs and xenotoxins
    • van Herwaarden AE, Schinkel AH. (2006). The function of breast cancer resistance protein in epithelial barriers, stem cells and milk secretion of drugs and xenotoxins. Trends Pharmacol Sci 27:10-16.
    • (2006) Trends Pharmacol Sci , vol.27 , pp. 10-16
    • Van Herwaarden, A.E.1    Schinkel, A.H.2
  • 283
    • 29744441900 scopus 로고    scopus 로고
    • Breast cancer resistance protein (Bcrp1/Abcg2) reduces systemic exposure of the dietary carcinogens aflatoxin B1, IQ and Trp-P-1 but also mediates their secretion into breast milk
    • van Herwaarden AE, Wagenaar E, Karnekamp B, et al. (2006). Breast cancer resistance protein (Bcrp1/Abcg2) reduces systemic exposure of the dietary carcinogens aflatoxin B1, IQ and Trp-P-1 but also mediates their secretion into breast milk. Carcinogenesis 27:123-130.
    • (2006) Carcinogenesis , vol.27 , pp. 123-130
    • Van Herwaarden, A.E.1    Wagenaar, E.2    Karnekamp, B.3
  • 284
    • 71549157438 scopus 로고    scopus 로고
    • Absence of both cytochrome P450 3A and P-glycoprotein dramatically increases docetaxel oral bioavailability and risk of intestinal toxicity
    • van Waterschoot RA, Lagas JS, Wagenaar E, et al. (2009). Absence of both cytochrome P450 3A and P-glycoprotein dramatically increases docetaxel oral bioavailability and risk of intestinal toxicity. Cancer Res 69:8996-9002.
    • (2009) Cancer Res , vol.69 , pp. 8996-9002
    • Van Waterschoot, R.A.1    Lagas, J.S.2    Wagenaar, E.3
  • 285
    • 79955783384 scopus 로고    scopus 로고
    • A critical analysis of the interplay between cytochrome P450 3A and P-glycoprotein: Recent insights from knockout and transgenic mice
    • van Waterschoot RA, Schinkel AH. (2011). A critical analysis of the interplay between cytochrome P450 3A and P-glycoprotein: Recent insights from knockout and transgenic mice. Pharmacol Rev 63: 390-410.
    • (2011) Pharmacol Rev , vol.63 , pp. 390-410
    • Van Waterschoot, R.A.1    Schinkel, A.H.2
  • 286
    • 70350053125 scopus 로고    scopus 로고
    • Drug transporters in the human blood-placental barrier
    • Vähäkangas K, Myllynen P. (2009). Drug transporters in the human blood-placental barrier. Br J Pharmacol 158:665-678.
    • (2009) Br J Pharmacol , vol.158 , pp. 665-678
    • Vähäkangas, K.1    Myllynen, P.2
  • 287
    • 84867572006 scopus 로고    scopus 로고
    • Clinical pharmacokinetics and drug-drug interactions of endothelin receptor antagonists in pulmonary arterial hypertension
    • Venitz J, Zack J, Gillies H, et al. (2012). Clinical pharmacokinetics and drug-drug interactions of endothelin receptor antagonists in pulmonary arterial hypertension. J Clin Pharmacol 52:1784-1805.
    • (2012) J Clin Pharmacol , vol.52 , pp. 1784-1805
    • Venitz, J.1    Zack, J.2    Gillies, H.3
  • 288
    • 33745236689 scopus 로고    scopus 로고
    • Carcinogen and anticancer drug transport by Mrp2 in vivo: Studies using Mrp2 (Abcc2) knockout mice
    • Vlaming ML, Mohrmann K, Wagenaar E, et al. (2006). Carcinogen and anticancer drug transport by Mrp2 in vivo: Studies using Mrp2 (Abcc2) knockout mice. J Pharmacol Exp Ther 318:319-327.
    • (2006) J Pharmacol Exp Ther , vol.318 , pp. 319-327
    • Vlaming, M.L.1    Mohrmann, K.2    Wagenaar, E.3
  • 289
    • 0029028792 scopus 로고
    • Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: Implications for drug delivery and activity in cancer chemotherapy
    • Wacher VJ, Wu CY, Benet LZ. (1995). Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: implications for drug delivery and activity in cancer chemotherapy. Mol Carcinog 13:129-134.
    • (1995) Mol Carcinog , vol.13 , pp. 129-134
    • Wacher, V.J.1    Wu, C.Y.2    Benet, L.Z.3
  • 290
    • 0031765907 scopus 로고    scopus 로고
    • Role of P-glycoprotein and cytochrome P450 3A in limiting oral absorption of peptides and peptidomimetics
    • Wacher VJ, Silverman JA, Zhang Y, Benet LZ. (1998). Role of P-glycoprotein and cytochrome P450 3A in limiting oral absorption of peptides and peptidomimetics. J Pharm Sci 87:1322-1330.
    • (1998) J Pharm Sci , vol.87 , pp. 1322-1330
    • Wacher, V.J.1    Silverman, J.A.2    Zhang, Y.3    Benet, L.Z.4
  • 291
    • 0035290059 scopus 로고    scopus 로고
    • Active secretion and enterocytic drug metabolism barriers to drug absorption
    • Wacher VJ, Salphati L, Benet LZ. (2001). Active secretion and enterocytic drug metabolism barriers to drug absorption. Adv Drug Deliv Rev 46:89-102.
    • (2001) Adv Drug Deliv Rev , vol.46 , pp. 89-102
    • Wacher, V.J.1    Salphati, L.2    Benet, L.Z.3
  • 292
    • 0001607723 scopus 로고
    • Distantly related sequences in the alpha-and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold
    • Walker JE, Saraste M, Runswick MJ, Gay NJ. (1982). Distantly related sequences in the alpha-and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold. EMBO J 1:945-951.
    • (1982) EMBO J , vol.1 , pp. 945-951
    • Walker, J.E.1    Saraste, M.2    Runswick, M.J.3    Gay, N.J.4
  • 293
    • 0345411341 scopus 로고    scopus 로고
    • P-glycoprotein and cytochrome P-450 3A inhibition: Dissociation of inhibitory potencies
    • Wandel C, Kim RB, Kajiji S, et al. (1999). P-glycoprotein and cytochrome P-450 3A inhibition: Dissociation of inhibitory potencies. Cancer Res 59:3944-3948.
    • (1999) Cancer Res , vol.59 , pp. 3944-3948
    • Wandel, C.1    Kim, R.B.2    Kajiji, S.3
  • 294
    • 0036135397 scopus 로고    scopus 로고
    • Interaction of common azole antifungals with P glycoprotein
    • Wang EJ, Lew K, Casciano CN, et al. (2002). Interaction of common azole antifungals with P glycoprotein. Antimicrob Agents Chemother 46:160-165.
    • (2002) Antimicrob Agents Chemother , vol.46 , pp. 160-165
    • Wang, E.J.1    Lew, K.2    Casciano, C.N.3
  • 295
    • 38349193809 scopus 로고    scopus 로고
    • Expression of the uptake drug transporter hOCT1 is an important clinical determinant of the response to imatinib in chronic myeloid leukemia
    • Wang L, Giannoudis A, Lane S, et al. (2008a). Expression of the uptake drug transporter hOCT1 is an important clinical determinant of the response to imatinib in chronic myeloid leukemia. Clin Pharmacol Ther 83:258-264.
    • (2008) Clin Pharmacol Ther , vol.83 , pp. 258-264
    • Wang, L.1    Giannoudis, A.2    Lane, S.3
  • 296
    • 0033515017 scopus 로고    scopus 로고
    • Mutations in the organic cation/carnitine transporter OCTN2 in primary carnitine deficiency
    • Wang Y, Ye J, Ganapathy V, Longo N. (1999). Mutations in the organic cation/carnitine transporter OCTN2 in primary carnitine deficiency. Proc Natl Acad Sci USA 96:2356-2360.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 2356-2360
    • Wang, Y.1    Ye, J.2    Ganapathy, V.3    Longo, N.4
  • 297
    • 53049095113 scopus 로고    scopus 로고
    • OCT2 polymorphisms and in-vivo renal functional consequence: Studies with metformin and cimetidine
    • Wang ZJ, Yin OQ, Tomlinson B, Chow MS. (2008b). OCT2 polymorphisms and in-vivo renal functional consequence: Studies with metformin and cimetidine. Pharmacogenet Genomics 18:637-645.
    • (2008) Pharmacogenet Genomics , vol.18 , pp. 637-645
    • Wang, Z.J.1    Yin, O.Q.2    Tomlinson, B.3    Chow, M.S.4
  • 298
    • 65049090941 scopus 로고    scopus 로고
    • Comparative gene expression profiles of ABC transporters in brain microvessel endo-thelial cells and brain in five species including human
    • Warren MS, Zerangue N, Woodford K, et al. (2009). Comparative gene expression profiles of ABC transporters in brain microvessel endo-thelial cells and brain in five species including human. Pharmacol Res 59:404-413.
    • (2009) Pharmacol Res , vol.59 , pp. 404-413
    • Warren, M.S.1    Zerangue, N.2    Woodford, K.3
  • 299
    • 0342762062 scopus 로고    scopus 로고
    • The barrier function of CYP3A4 and P-glycoprotein in the small bowel
    • Watkins PB. (1997). The barrier function of CYP3A4 and P-glycoprotein in the small bowel. Adv Drug Deliv Rev 27:161-170.
    • (1997) Adv Drug Deliv Rev , vol.27 , pp. 161-170
    • Watkins, P.B.1
  • 302
    • 17644380257 scopus 로고    scopus 로고
    • Predicting drug disposition via application of BCS: Transport/absorption/ elimination interplay and development of a biopharmaceutics drug disposition classification system
    • Wu CY, Benet LZ. (2005). Predicting drug disposition via application of BCS: Transport/absorption/elimination interplay and development of a biopharmaceutics drug disposition classification system. Pharm Res 22:11-23.
    • (2005) Pharm Res , vol.22 , pp. 11-23
    • Wu, C.Y.1    Benet, L.Z.2
  • 303
    • 9144251609 scopus 로고    scopus 로고
    • ABC transporter ABCA3 is expressed in acute myeloid leukemia blast cells and participates in vesicular transport
    • Wulf GG, Modlich S, Inagaki N, et al. (2004). ABC transporter ABCA3 is expressed in acute myeloid leukemia blast cells and participates in vesicular transport. Hematologica 89:1395-7.
    • (2004) Hematologica , vol.89 , pp. 1395-1397
    • Wulf, G.G.1    Modlich, S.2    Inagaki, N.3
  • 304
    • 23344450788 scopus 로고    scopus 로고
    • Induction of phase I, II and III drug metabolism/transport by xenobiotics
    • Xu C, Li CY, Kong AN. (2005). Induction of phase I, II and III drug metabolism/transport by xenobiotics. Arch Pharm Res 28:249-268.
    • (2005) Arch Pharm Res , vol.28 , pp. 249-268
    • Xu, C.1    Li, C.Y.2    Kong, A.N.3
  • 305
    • 2442520293 scopus 로고    scopus 로고
    • Characterization of oligomeric human half-ABC transporter ATP-binding cassette G2
    • Xu J, Liu Y, Yang Y, et al. (2004). Characterization of oligomeric human half-ABC transporter ATP-binding cassette G2. J Biol Chem 279: 19781-19789.
    • (2004) J Biol Chem , vol.279 , pp. 19781-19789
    • Xu, J.1    Liu, Y.2    Yang, Y.3
  • 306
    • 0038730731 scopus 로고    scopus 로고
    • Characterization of organic cation/carnitine transporter family in human sperm
    • Xuan W, Lamhonwah AM, Librach C, et al. (2003). Characterization of organic cation/carnitine transporter family in human sperm. Biochem Biophys Res Commun 306:121-128.
    • (2003) Biochem Biophys Res Commun , vol.306 , pp. 121-128
    • Xuan, W.1    Lamhonwah, A.M.2    Librach, C.3
  • 307
    • 0029149374 scopus 로고
    • A new mutant rat with hyperbilirubinuria (hyb)
    • Yamazaki K, Mikami T, Hosokawa S, et al. (1995). A new mutant rat with hyperbilirubinuria (hyb). J Hered 86:314-317.
    • (1995) J Hered , vol.86 , pp. 314-317
    • Yamazaki, K.1    Mikami, T.2    Hosokawa, S.3
  • 308
    • 0036784516 scopus 로고    scopus 로고
    • Interaction of cytochrome P450 3A inhibitors with P-glycoprotein
    • Yasuda K, Lan LB, Sanglard D, et al. (2002). Interaction of cytochrome P450 3A inhibitors with P-glycoprotein. J Pharmacol Exp Ther 303: 323-332.
    • (2002) J Pharmacol Exp Ther , vol.303 , pp. 323-332
    • Yasuda, K.1    Lan, L.B.2    Sanglard, D.3
  • 309
    • 81355124801 scopus 로고    scopus 로고
    • Importance of the multidrug and toxin extrusion MATE/SLC47A family to pharmacokinetics, pharmaco-dynamics/toxicodynamics and pharmacogenomics
    • Yonezawa A, Inui K. (2011). Importance of the multidrug and toxin extrusion MATE/SLC47A family to pharmacokinetics, pharmaco-dynamics/ toxicodynamics and pharmacogenomics. Br J Pharmacol 164:1817-1825.
    • (2011) Br J Pharmacol , vol.164 , pp. 1817-1825
    • Yonezawa, A.1    Inui, K.2
  • 310
    • 84875191343 scopus 로고    scopus 로고
    • The human concentrative and equilibrative nucleoside transporter families, SLC28 and SLC29
    • Young JD, Yao SY, Baldwin JM, et al. (2013). The human concentrative and equilibrative nucleoside transporter families, SLC28 and SLC29. Mol Aspects Med 34:529-547.
    • (2013) Mol Aspects Med , vol.34 , pp. 529-547
    • Young, J.D.1    Yao, S.Y.2    Baldwin, J.M.3
  • 311
  • 312
    • 48749084803 scopus 로고    scopus 로고
    • A regulatory viewpoint on transporter-based drug interactions
    • Zhang L, Zhang YD, Strong JM, et al. (2008). A regulatory viewpoint on transporter-based drug interactions. Xenobiotica 38:709-724.
    • (2008) Xenobiotica , vol.38 , pp. 709-724
    • Zhang, L.1    Zhang, Y.D.2    Strong, J.M.3
  • 313
    • 0035054725 scopus 로고    scopus 로고
    • The gut as a barrier to drug absorption: Combined role of cytochrome P450 3A and P-glycoprotein
    • Zhang Y, Benet LZ. (2001). The gut as a barrier to drug absorption: Combined role of cytochrome P450 3A and P-glycoprotein. Clin Pharmacokinet 40:159-168.
    • (2001) Clin Pharmacokinet , vol.40 , pp. 159-168
    • Zhang, Y.1    Benet, L.Z.2
  • 314
    • 47349094025 scopus 로고    scopus 로고
    • An update on clinical drug interactions with the herbal antidepressant St. John's wort
    • Zhou SF, Lai X. (2008). An update on clinical drug interactions with the herbal antidepressant St. John's wort. Curr Drug Metab 9: 394-409.
    • (2008) Curr Drug Metab , vol.9 , pp. 394-409
    • Zhou, S.F.1    Lai, X.2
  • 315
    • 47349110179 scopus 로고    scopus 로고
    • Structure, function and regulation of P-glycoprotein and its clinical relevance in drug disposition
    • Zhou SF. (2008). Structure, function and regulation of P-glycoprotein and its clinical relevance in drug disposition. Xenobiotica 38: 802-832.
    • (2008) Xenobiotica , vol.38 , pp. 802-832
    • Zhou, S.F.1
  • 316
    • 0021855165 scopus 로고
    • Modified somatostatins as inhibitors of a multispecific transport system for bile acids and phallotoxins in isolated hepatocytes
    • Ziegler K, Frimmer M, Kessler H, et al. (1985). Modified somatostatins as inhibitors of a multispecific transport system for bile acids and phallotoxins in isolated hepatocytes. Biochim Biophys Acta 845: 86-93.
    • (1985) Biochim Biophys Acta , vol.845 , pp. 86-93
    • Ziegler, K.1    Frimmer, M.2    Kessler, H.3
  • 317
    • 0024359410 scopus 로고
    • +-dependent taurocholate uptake in basolateral (sinusoidal) rat liver plasma membrane vesicles
    • +-dependent taurocholate uptake in basolateral (sinusoidal) rat liver plasma membrane vesicles. J Pharmacol Exp Ther 250: 301-308.
    • (1989) J Pharmacol Exp Ther , vol.250 , pp. 301-308
    • Zimmerli, B.1    Valantinas, J.2    Meier, P.J.3
  • 318
    • 0027361042 scopus 로고
    • Dubin-Johnson and Rotor syndromes: Molecular basis and pathogenesis
    • Zimniak P. (1993). Dubin-Johnson and Rotor syndromes: molecular basis and pathogenesis. Semin Liver Dis 13:248-260.
    • (1993) Semin Liver Dis , vol.13 , pp. 248-260
    • Zimniak, P.1
  • 320
    • 79956326438 scopus 로고    scopus 로고
    • Transporter-mediated drug uptake and efflux: Important determinants of adverse drug reactions
    • Zolk O, Fromm MF. (2011). Transporter-mediated drug uptake and efflux: important determinants of adverse drug reactions. Clin Pharmacol Ther 89:798-805.
    • (2011) Clin Pharmacol Ther , vol.89 , pp. 798-805
    • Zolk, O.1    Fromm, M.F.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.