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Volumn 46, Issue 1-3, 2001, Pages 89-102

Active secretion and enterocytic drug metabolism barriers to drug absorption

Author keywords

Active transport; Bioavailability; Cytochrome P450 3A; Intestine; Metabolism; P glycoprotein

Indexed keywords

DRUG; GLYCOPROTEIN P;

EID: 0035290059     PISSN: 0169409X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-409X(00)00126-5     Document Type: Article
Times cited : (233)

References (90)
  • 1
    • 85047692219 scopus 로고
    • Novel formulation strategies for improving oral bioavailability of drugs with poor membrane permeation or presystemic metabolism
    • Aungst, B.J. (1993) Novel formulation strategies for improving oral bioavailability of drugs with poor membrane permeation or presystemic metabolism. J. Pharm. Sci. 82, 979-987.
    • (1993) J. Pharm. Sci. , vol.82 , pp. 979-987
    • Aungst, B.J.1
  • 2
    • 0025057187 scopus 로고
    • Metabolism of drugs and other xenobiotics in the gut lumen and wall
    • Ilett, K.F., Tee, L.B.G., Reeves, P.T. and Minchin, R.F. (1990) Metabolism of drugs and other xenobiotics in the gut lumen and wall. Pharmacol. Ther. 46, 67-93.
    • (1990) Pharmacol. Ther. , vol.46 , pp. 67-93
    • Ilett, K.F.1    Tee, L.B.G.2    Reeves, P.T.3    Minchin, R.F.4
  • 3
    • 0027366792 scopus 로고
    • Individual variation in first-pass metabolism
    • Tam, Y.K. (1993) Individual variation in first-pass metabolism. Clin. Pharmacokinet. 25, 300-328.
    • (1993) Clin. Pharmacokinet. , vol.25 , pp. 300-328
    • Tam, Y.K.1
  • 4
    • 0028054999 scopus 로고
    • Extrahepatic metabolism of drugs in humans
    • Krishna, D.R. and Klotz, U. (1994) Extrahepatic metabolism of drugs in humans. Clin. Pharmacokinet. 26, 144-160.
    • (1994) Clin. Pharmacokinet. , vol.26 , pp. 144-160
    • Krishna, D.R.1    Klotz, U.2
  • 5
    • 0023422908 scopus 로고
    • First-pass metabolism by gastrointestinal mucosa
    • Back, D.J. and Rogers, S.M. (1987) First-pass metabolism by gastrointestinal mucosa. Aliment. Pharmacol. Ther. 1, 339-357.
    • (1987) Aliment. Pharmacol. Ther. , vol.1 , pp. 339-357
    • Back, D.J.1    Rogers, S.M.2
  • 6
    • 0025344378 scopus 로고
    • Cytochrome P450 isoenzymes, epoxide hydrolase and glutathione transferases in rat and human hepatic and extrahepatic tissues
    • de Waziers, PH., Cugnenc, PH., Yang, C.S., Leroux, J.-P. and Beaune, RH. (1990) Cytochrome P450 isoenzymes, epoxide hydrolase and glutathione transferases in rat and human hepatic and extrahepatic tissues. J. Pharmacol. Exp. Ther. 253, 387-394.
    • (1990) J. Pharmacol. Exp. Ther. , vol.253 , pp. 387-394
    • De Waziers, P.H.1    Cugnenc, P.H.2    Yang, C.S.3    Leroux, J.-P.4    Beaune, R.H.5
  • 7
    • 0029028792 scopus 로고
    • Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: Implications for drug delivery and activity in cancer chemotherapy
    • Wacher, V.J., Wu, C.-Y. and Benet L.Z. (1995) Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: implications for drug delivery and activity in cancer chemotherapy. Mol. Carcinog. 13, 129-134.
    • (1995) Mol. Carcinog. , vol.13 , pp. 129-134
    • Wacher, V.J.1    Wu, C.-Y.2    Benet, L.Z.3
  • 8
    • 0028071759 scopus 로고
    • Non-invasive tests of CYP3A enzymes
    • Watkins, P.B. (1994) Non-invasive tests of CYP3A enzymes. Pharmacogenetics 4, 171-184.
    • (1994) Pharmacogenetics , vol.4 , pp. 171-184
    • Watkins, P.B.1
  • 9
    • 0023588109 scopus 로고
    • Identification of glucocorticoid-inducible cytochromes P-450 in the intestinal mucosa of rats and man
    • Watkins, RB., Wrighton, S.A., Schuetz, E.G. and Guzelian, P.S. (1987) Identification of glucocorticoid-inducible cytochromes P-450 in the intestinal mucosa of rats and man. J. Clin. Invest. 80, 1029-1036.
    • (1987) J. Clin. Invest. , vol.80 , pp. 1029-1036
    • Watkins, R.B.1    Wrighton, S.A.2    Schuetz, E.G.3    Guzelian, P.S.4
  • 10
    • 0023898817 scopus 로고
    • The immunocytochemical localisation and distribution of cytochrome P-450 in normal human hepatic and extrahepatic tissues with a monoclonal antibody to human cytochrome P-450
    • Murray, G.I., Barnes, T.S., Sewell, H.F., Ewen, S.W.B., Melvin, W.T. and Burke, M.D. (1988) The immunocytochemical localisation and distribution of cytochrome P-450 in normal human hepatic and extrahepatic tissues with a monoclonal antibody to human cytochrome P-450. Br. J. Pharmacol. 25, 465-475.
    • (1988) Br. J. Pharmacol. , vol.25 , pp. 465-475
    • Murray, G.I.1    Barnes, T.S.2    Sewell, H.F.3    Ewen, S.W.B.4    Melvin, W.T.5    Burke, M.D.6
  • 11
    • 0024604149 scopus 로고
    • Cytochromes P-450 in the intestinal mucosa of man
    • Peters, W.H.M. and Kremers, P.G. (1989) Cytochromes P-450 in the intestinal mucosa of man. Biochem. Pharmacol. 38, 1535-1538.
    • (1989) Biochem. Pharmacol. , vol.38 , pp. 1535-1538
    • Peters, W.H.M.1    Kremers, P.G.2
  • 12
    • 0026464616 scopus 로고
    • Identification of rifampin-inducible P450IIIA4 (CYP3A4) in human small bowel enterocytes
    • Kolars, J.C., Schmiedlin-Ren, R, Schuetz, J.D., Fang, C. and Watkins, P.B. (1992) Identification of rifampin-inducible P450IIIA4 (CYP3A4) in human small bowel enterocytes. J. Clin. Invest. 90, 1871-1888.
    • (1992) J. Clin. Invest. , vol.90 , pp. 1871-1888
    • Kolars, J.C.1    Schmiedlin-Ren, R.2    Schuetz, J.D.3    Fang, C.4    Watkins, P.B.5
  • 15
    • 0028237729 scopus 로고
    • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: Studies with liver microsomes of 30 Japanese and 30 caucasians
    • Shimada, T., Yamazaki, H., Mimura, M., Inui, Y. and Guengerich, F.P. (1994) Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 caucasians. J. Pharmacol. Exp. Ther. 270, 414-423.
    • (1994) J. Pharmacol. Exp. Ther. , vol.270 , pp. 414-423
    • Shimada, T.1    Yamazaki, H.2    Mimura, M.3    Inui, Y.4    Guengerich, F.P.5
  • 16
    • 0014373873 scopus 로고
    • Normal distribution of cardiac output in the unanesthetized, restrained rhesus monkey
    • Forsyth, R.P., Nies, A.S., Wyler, F., Neutze, J. and Melmon, K.L. (1968) Normal distribution of cardiac output in the unanesthetized, restrained rhesus monkey. J. Appl. Physiol. 25, 736-741.
    • (1968) J. Appl. Physiol. , vol.25 , pp. 736-741
    • Forsyth, R.P.1    Nies, A.S.2    Wyler, F.3    Neutze, J.4    Melmon, K.L.5
  • 17
    • 0030002504 scopus 로고    scopus 로고
    • Intestinal drug metabolism and antitransport processes: A potential paradigm shift in oral drug delivery
    • Benet, L.Z., Wu, C.-Y., Hebert, M.F. and Wacher, V.J. (1996) Intestinal drug metabolism and antitransport processes: A potential paradigm shift in oral drug delivery. J. Control. Rel. 39, 139-143.
    • (1996) J. Control. Rel. , vol.39 , pp. 139-143
    • Benet, L.Z.1    Wu, C.-Y.2    Hebert, M.F.3    Wacher, V.J.4
  • 18
    • 0029013159 scopus 로고
    • P-glycoprotein and pharmacokinetics
    • Levêque, D. and Jehl, F. (1995) P-glycoprotein and pharmacokinetics. Anticancer Res. 15, 331-336.
    • (1995) Anticancer Res. , vol.15 , pp. 331-336
    • Levêque, D.1    Jehl, F.2
  • 20
    • 0026782943 scopus 로고
    • Induction of cytochrome P4501A genes by omeprazole in the human alimentary tract
    • McDonnell, W.M., Scheiman, J.M. and Traber, P.G. (1992) Induction of cytochrome P4501A genes by omeprazole in the human alimentary tract. Gastroenterology 103, 1509-1516.
    • (1992) Gastroenterology , vol.103 , pp. 1509-1516
    • McDonnell, W.M.1    Scheiman, J.M.2    Traber, P.G.3
  • 21
    • 0028558737 scopus 로고
    • Induction of cytochrome P4501A by smoking or omeprazole in comparison with UDP-glucuronosyltransferase in biopsies of human duodenal mucosa
    • Buchthal, J., Grund, K.E., Buchmann, A., Schrenk, D., Beaune, P. and Bock, K.W. (1995) Induction of cytochrome P4501A by smoking or omeprazole in comparison with UDP-glucuronosyltransferase in biopsies of human duodenal mucosa. Eur. J. Clin. Pharmacol. 47, 431-435.
    • (1995) Eur. J. Clin. Pharmacol. , vol.47 , pp. 431-435
    • Buchthal, J.1    Grund, K.E.2    Buchmann, A.3    Schrenk, D.4    Beaune, P.5    Bock, K.W.6
  • 22
    • 0028113492 scopus 로고
    • Interpatient heterogeneity in expression of CYP3A4 and CYP3A5 in small bowel. Lack of prediction by the erythromycin breath test
    • Lown, K.S., Kolars, J.C., Thummel, K.E., Barnett, J.L., Kunze, K.L., Wrighton, S.A. and Watkins, P.B. (1994) Interpatient heterogeneity in expression of CYP3A4 and CYP3A5 in small bowel. Lack of prediction by the erythromycin breath test. Drug Metab. Dispos. 22, 947-955.
    • (1994) Drug Metab. Dispos. , vol.22 , pp. 947-955
    • Lown, K.S.1    Kolars, J.C.2    Thummel, K.E.3    Barnett, J.L.4    Kunze, K.L.5    Wrighton, S.A.6    Watkins, P.B.7
  • 23
    • 0024400702 scopus 로고
    • Identification of a polymorphically expressed member of the human cytochrome P-450III family
    • Wrighton, S.A., Ring, B.J., Watkins, P.B. and Vandenbranden, M. (1989) Identification of a polymorphically expressed member of the human cytochrome P-450III family. Mol. Pharmacol. 36, 97-105.
    • (1989) Mol. Pharmacol. , vol.36 , pp. 97-105
    • Wrighton, S.A.1    Ring, B.J.2    Watkins, P.B.3    Vandenbranden, M.4
  • 25
    • 0027427551 scopus 로고
    • Regulation of human liver cytochromes P-450 in family 3A in primary and continuous culture of human hepatocytes
    • Schuetz, E.G., Schuetz, J.D., Strom, S.C., Thompson, M.T., Fisher, R.A., Molowa, D.T., Li, D. and Guzelian, P.S. (1993) Regulation of human liver cytochromes P-450 in family 3A in primary and continuous culture of human hepatocytes. Hepatology 18, 1254-1262.
    • (1993) Hepatology , vol.18 , pp. 1254-1262
    • Schuetz, E.G.1    Schuetz, J.D.2    Strom, S.C.3    Thompson, M.T.4    Fisher, R.A.5    Molowa, D.T.6    Li, D.7    Guzelian, P.S.8
  • 27
    • 0028234586 scopus 로고
    • Regioselective biotransformation of midazolam by members of the cytochrome P450 3A (CYP3A) subfamily
    • Gorski, J.C., Hall, S.D., Jones, D.R., Vandenbranden, M. and Wrighton, S.A. (1994) Regioselective biotransformation of midazolam by members of the cytochrome P450 3A (CYP3A) subfamily. Biochem. Pharmacol. 47, 1643-1653.
    • (1994) Biochem. Pharmacol. , vol.47 , pp. 1643-1653
    • Gorski, J.C.1    Hall, S.D.2    Jones, D.R.3    Vandenbranden, M.4    Wrighton, S.A.5
  • 32
    • 0028945124 scopus 로고
    • Influence of nutrients and other dietary materials on cytochrome P-450 enzymes
    • Guengerich, F.P. (1995) Influence of nutrients and other dietary materials on cytochrome P-450 enzymes. Am. J. Clin. Nutr. 61 (suppl), 651S-658S.
    • (1995) Am. J. Clin. Nutr. , vol.61 , Issue.SUPPL.
    • Guengerich, F.P.1
  • 34
    • 0028920836 scopus 로고
    • Single dose pharmacokinetics of sumatriptan in healthy volunteers
    • Lacey, L.F., Hussey, E.K. and Fowler, RA. (1995) Single dose pharmacokinetics of sumatriptan in healthy volunteers. Eur. J. Clin. Pharmacol. 47, 543-548.
    • (1995) Eur. J. Clin. Pharmacol. , vol.47 , pp. 543-548
    • Lacey, L.F.1    Hussey, E.K.2    Fowler, R.A.3
  • 35
    • 0027369881 scopus 로고
    • Pharmacokinetics of oral decongestants
    • Kanfer, I., Dowse, R. and Vuma, V. (1993) Pharmacokinetics of oral decongestants. Pharmacotherapy 13, 116S-128S.
    • (1993) Pharmacotherapy , vol.13
    • Kanfer, I.1    Dowse, R.2    Vuma, V.3
  • 36
    • 0017704386 scopus 로고
    • Metabolism of flurazepam by the small intestine
    • Mahon, W.A., Inaba, T. and Stone, R.M. (1977) Metabolism of flurazepam by the small intestine. Clin. Pharmacol. Ther. 22, 228-233.
    • (1977) Clin. Pharmacol. Ther. , vol.22 , pp. 228-233
    • Mahon, W.A.1    Inaba, T.2    Stone, R.M.3
  • 37
    • 0025719746 scopus 로고
    • First-pass metabolism of cyclosporine by the gut
    • Kolars, J.C., Awni, W.M., Merion, R.M. and Watkins, P.B. (1991) First-pass metabolism of cyclosporine by the gut. Lancet 338, 1488-1490.
    • (1991) Lancet , vol.338 , pp. 1488-1490
    • Kolars, J.C.1    Awni, W.M.2    Merion, R.M.3    Watkins, P.B.4
  • 39
    • 0026457407 scopus 로고
    • Bioavailability of cyclosporine with concomitant rifampin administration is markedly less than predicted by hepatic enzyme induction
    • Hebert, M.F., Roberts, J.P., Prueksaritanont, T. and Benet, L.Z. (1992) Bioavailability of cyclosporine with concomitant rifampin administration is markedly less than predicted by hepatic enzyme induction. Clin. Pharmacol. Ther. 52, 453-457.
    • (1992) Clin. Pharmacol. Ther. , vol.52 , pp. 453-457
    • Hebert, M.F.1    Roberts, J.P.2    Prueksaritanont, T.3    Benet, L.Z.4
  • 40
    • 0029123393 scopus 로고
    • The effects of ketoconazole on the intestinal metabolism and bioavailability of cyclosporine
    • Gomez, D.Y., Wacher, V.J., Tomlanovich, S.J., Hebert, M.F. and Benet, L.Z. (1995) The effects of ketoconazole on the intestinal metabolism and bioavailability of cyclosporine. Clin. Pharmacol. Ther. 58, 15-19.
    • (1995) Clin. Pharmacol. Ther. , vol.58 , pp. 15-19
    • Gomez, D.Y.1    Wacher, V.J.2    Tomlanovich, S.J.3    Hebert, M.F.4    Benet, L.Z.5
  • 43
    • 0025337223 scopus 로고
    • Effect of food on the pharmacokinetics of cyclosporine in healthy subjects following oral and intravenous administration
    • Gupta, S.K., Manfro, R.C., Tomlanovich, S.J., Gambertoglio, J.G., Garovoy, M.R. and Benet, L.Z. (1990) Effect of food on the pharmacokinetics of cyclosporine in healthy subjects following oral and intravenous administration. J. Clin. Pharmacol. 30, 643-653.
    • (1990) J. Clin. Pharmacol. , vol.30 , pp. 643-653
    • Gupta, S.K.1    Manfro, R.C.2    Tomlanovich, S.J.3    Gambertoglio, J.G.4    Garovoy, M.R.5    Benet, L.Z.6
  • 44
    • 0026685806 scopus 로고
    • Improved oral bioavailability of propanolol in healthy human volunteers using a liver bypass drug delivery system containing oleic acid
    • Barnwell, S.G., Laudanski, T., Story, M.J., Mallinson, C.B., Harris, R.J., Cole, S.K., Keating, M. and Attwood, D. (1992) Improved oral bioavailability of propanolol in healthy human volunteers using a liver bypass drug delivery system containing oleic acid. Int. J. Pharm. 88, 423-432.
    • (1992) Int. J. Pharm. , vol.88 , pp. 423-432
    • Barnwell, S.G.1    Laudanski, T.2    Story, M.J.3    Mallinson, C.B.4    Harris, R.J.5    Cole, S.K.6    Keating, M.7    Attwood, D.8
  • 45
    • 0029055363 scopus 로고
    • Disposition of intravenous and oral cyclosporine after administration with grapefruit juice
    • Ducharme, M.R, Warbasse, L.H. and Edwards, D.J. (1995) Disposition of intravenous and oral cyclosporine after administration with grapefruit juice. Clin. Pharmacol. Ther. 57, 485-491.
    • (1995) Clin. Pharmacol. Ther. , vol.57 , pp. 485-491
    • Ducharme, M.R.1    Warbasse, L.H.2    Edwards, D.J.3
  • 47
    • 0026099498 scopus 로고
    • Interaction of citrus juices with felodipine and nifedipine
    • Bailey, D.G., Spence, J.D., Munoz, C. and Arnold, J.M.O. (1991) Interaction of citrus juices with felodipine and nifedipine. Lancet 337, 268-269.
    • (1991) Lancet , vol.337 , pp. 268-269
    • Bailey, D.G.1    Spence, J.D.2    Munoz, C.3    Arnold, J.M.O.4
  • 48
    • 0026544204 scopus 로고
    • Acute effects of drinking grapefruit juice on the pharmacokinetics and dynamics of felodipine -and its potential clinical relevance
    • Edgar, B., Bailey, D., Bergstrand, R., Johnsson, G. and Regårdh, C.G. (1992) Acute effects of drinking grapefruit juice on the pharmacokinetics and dynamics of felodipine -and its potential clinical relevance. Eur. J. Clin. Pharmacol. 42, 313-317.
    • (1992) Eur. J. Clin. Pharmacol. , vol.42 , pp. 313-317
    • Edgar, B.1    Bailey, D.2    Bergstrand, R.3    Johnsson, G.4    Regårdh, C.G.5
  • 49
    • 0027155665 scopus 로고
    • Grapefruit juice-felodipine interaction: Mechanism, predictability and effect of naringin
    • Bailey, D.G., Arnold, J.M.O., Strong, H.A., Munoz, C. and Spence, J.D. (1993) Grapefruit juice-felodipine interaction: mechanism, predictability and effect of naringin. Clin. Pharmacol. Ther. 53, 637-642.
    • (1993) Clin. Pharmacol. Ther. , vol.53 , pp. 637-642
    • Bailey, D.G.1    Arnold, J.M.O.2    Strong, H.A.3    Munoz, C.4    Spence, J.D.5
  • 50
    • 0029143160 scopus 로고
    • Grapefruit juice-felodipine interaction: Reproducibility and characterization with the extended release drug formulation
    • Bailey, D.G., Arnold, J.M.O., Bend, J.R., Tran, L.T. and Spence, J.D. (1995) Grapefruit juice-felodipine interaction: reproducibility and characterization with the extended release drug formulation. Br. J. Clin. Pharmacol. 40, 135-140.
    • (1995) Br. J. Clin. Pharmacol. , vol.40 , pp. 135-140
    • Bailey, D.G.1    Arnold, J.M.O.2    Bend, J.R.3    Tran, L.T.4    Spence, J.D.5
  • 51
    • 0027496441 scopus 로고
    • Quercetin, an in vitro inhibitor of CYP3A, does not contribute to the interaction between nifedipine and grapefruit juice
    • Rashid, J., McKinstry, C., Renwick, A.G., Dirnhuber, M., Waller, D.G. and George, C.F. (1993) Quercetin, an in vitro inhibitor of CYP3A, does not contribute to the interaction between nifedipine and grapefruit juice. Br. J. Clin. Pharmacol. 36, 460-463.
    • (1993) Br. J. Clin. Pharmacol. , vol.36 , pp. 460-463
    • Rashid, J.1    McKinstry, C.2    Renwick, A.G.3    Dirnhuber, M.4    Waller, D.G.5    George, C.F.6
  • 56
    • 0025685663 scopus 로고
    • In vitro inhibition of dihydropyridine oxidation and aflatoxin B1 activation in human liver microsomes by naringenin and other flavonoids
    • Guengerich, F.P. and Kim, D.-H. (1990) In vitro inhibition of dihydropyridine oxidation and aflatoxin B1 activation in human liver microsomes by naringenin and other flavonoids. Carcinogenesis 11, 2275-2279.
    • (1990) Carcinogenesis , vol.11 , pp. 2275-2279
    • Guengerich, F.P.1    Kim, D.-H.2
  • 57
    • 0026771041 scopus 로고
    • Inhibition of dihydropyridine metabolism in rat and human liver microsomes by flavonoids found in grapefruit juice
    • Miniscalco, A., Lundahl, J., Regårdh, C.G., Edgar, B. and Eriksson, U.G. (1992) Inhibition of dihydropyridine metabolism in rat and human liver microsomes by flavonoids found in grapefruit juice. J. Pharmacol. Exp. Ther. 261, 1195-1199.
    • (1992) J. Pharmacol. Exp. Ther. , vol.261 , pp. 1195-1199
    • Miniscalco, A.1    Lundahl, J.2    Regårdh, C.G.3    Edgar, B.4    Eriksson, U.G.5
  • 58
    • 0028944022 scopus 로고
    • Influence of chronic ingestion of grapefruit juice on steady-state blood concentrations of cyclosporine a in renal transplant patients with stable graft function
    • Proppe, D.G., Hoch, O.D., McLean, A.J. and Visser, K.E. (1995) Influence of chronic ingestion of grapefruit juice on steady-state blood concentrations of cyclosporine A in renal transplant patients with stable graft function. Br. J. Clin. Pharmacol. 39, 337-338.
    • (1995) Br. J. Clin. Pharmacol. , vol.39 , pp. 337-338
    • Proppe, D.G.1    Hoch, O.D.2    McLean, A.J.3    Visser, K.E.4
  • 60
    • 0028641539 scopus 로고
    • Inhibition of 17β-estradiol metabolism in grapefruit juice in ovarectomized women
    • Schubert, W., Cullberg, G., Edgar, B. and Hedner, T. (1995) Inhibition of 17β-estradiol metabolism in grapefruit juice in ovarectomized women. Maturitas 20, 155-163.
    • (1995) Maturitas , vol.20 , pp. 155-163
    • Schubert, W.1    Cullberg, G.2    Edgar, B.3    Hedner, T.4
  • 61
    • 0027981753 scopus 로고
    • Effects of flavonoids on cytochrome P450-dependent acetaminophen metabolism in rats and human liver microsomes
    • Li, Y., Wang, E., Patten, C.J., Chen, L. and Yang, C.S. (1994) Effects of flavonoids on cytochrome P450-dependent acetaminophen metabolism in rats and human liver microsomes. Drug Metab. Dispos. 22, 566-571.
    • (1994) Drug Metab. Dispos. , vol.22 , pp. 566-571
    • Li, Y.1    Wang, E.2    Patten, C.J.3    Chen, L.4    Yang, C.S.5
  • 62
    • 0027510377 scopus 로고
    • Inhibitory effect of grapefruit juice and its bitter principal, naringenin, on CYP1A2 dependent metabolism of caffeine in man
    • Fuhr, U., Klittich, K. and Staib, A.H. (1993) Inhibitory effect of grapefruit juice and its bitter principal, naringenin, on CYP1A2 dependent metabolism of caffeine in man. Br. J. Clin. Pharmacol. 35, 431-436.
    • (1993) Br. J. Clin. Pharmacol. , vol.35 , pp. 431-436
    • Fuhr, U.1    Klittich, K.2    Staib, A.H.3
  • 63
    • 0028218139 scopus 로고
    • Grapefruit juice inhibits 7-hydroxylation of coumarin in healthy volunteers
    • Merkel, U., Sigusch, H. and Hoffmann A. (1994) Grapefruit juice inhibits 7-hydroxylation of coumarin in healthy volunteers. Eur. J. Clin. Pharmacol. 46, 175-177.
    • (1994) Eur. J. Clin. Pharmacol. , vol.46 , pp. 175-177
    • Merkel, U.1    Sigusch, H.2    Hoffmann, A.3
  • 64
    • 0026514642 scopus 로고
    • Metabolism of food-derived heterocyclic amines in human and rabbit tissues by P4503A proteins in the presence of flavonoids
    • McKinnon, R.A., Burgess, W.M., Hall, P., de la M., Abdul-Aziz, Z. and McManus, M.E. (1992) Metabolism of food-derived heterocyclic amines in human and rabbit tissues by P4503A proteins in the presence of flavonoids. Cancer Res. 52 (suppl.), 2108S-2113S.
    • (1992) Cancer Res. , vol.52 , Issue.SUPPL.
    • McKinnon, R.A.1    Burgess, W.M.2    Hall, P.3    De La, M.4    Abdul-Aziz, Z.5    McManus, M.E.6
  • 67
    • 0027988313 scopus 로고
    • Cyclosporine pharmacokinetics and variability from a microemulsion formulation - A multicenter investigation in kidney transplant patients
    • Kovarik, J.M., Mueller, E.A., van Bree, J.B., Fluckiger, S.S., Lange, H., Schmidt, B., Boesken, W.H., Lison, A.E. and Kutz, K. (1994) Cyclosporine pharmacokinetics and variability from a microemulsion formulation - a multicenter investigation in kidney transplant patients. Transplantation 58, 658-663.
    • (1994) Transplantation , vol.58 , pp. 658-663
    • Kovarik, J.M.1    Mueller, E.A.2    Van Bree, J.B.3    Fluckiger, S.S.4    Lange, H.5    Schmidt, B.6    Boesken, W.H.7    Lison, A.E.8    Kutz, K.9
  • 69
    • 0028952478 scopus 로고
    • Reduced inter- And intrasubject variability in cyclosporine pharmacokinetics in renal transplant recipients with a microemulsion formulation in conjunction with fasting, low-fat meals or high-fat meals
    • Kahan, B.D., Dunn, J., Fitts, C., van Buren, D., Wombolt, D., Pollak, R., Carson, R., Alexander, J.W., Choc, M., Wong, R. and Hwang, D.S. (1995) Reduced inter- and intrasubject variability in cyclosporine pharmacokinetics in renal transplant recipients with a microemulsion formulation in conjunction with fasting, low-fat meals or high-fat meals. Transplantation 59, 505-511.
    • (1995) Transplantation , vol.59 , pp. 505-511
    • Kahan, B.D.1    Dunn, J.2    Fitts, C.3    Van Buren, D.4    Wombolt, D.5    Pollak, R.6    Carson, R.7    Alexander, J.W.8    Choc, M.9    Wong, R.10    Hwang, D.S.11
  • 70
    • 0027934256 scopus 로고
    • Cyclosporine disposition and metabolite profiles in renal transplant recipients receiving a microemulsion formulation
    • Kovarik, J.M., Vernillet, L., Mueller, E.A., Freiburghaus, R., Niederberger, W. and Kutz, K. (1994). Cyclosporine disposition and metabolite profiles in renal transplant recipients receiving a microemulsion formulation. Ther. Drug Monit. 16, 519-525.
    • (1994) Ther. Drug Monit. , vol.16 , pp. 519-525
    • Kovarik, J.M.1    Vernillet, L.2    Mueller, E.A.3    Freiburghaus, R.4    Niederberger, W.5    Kutz, K.6
  • 71
    • 33645830172 scopus 로고
    • A surface glycoprotein modulating drug permeability in chinese hamster ovary cell mutants
    • Juliano, R.L. and Ling, V. (1976) A surface glycoprotein modulating drug permeability in chinese hamster ovary cell mutants. Biochim. Biophys. Acta 455, 152-162.
    • (1976) Biochim. Biophys. Acta , vol.455 , pp. 152-162
    • Juliano, R.L.1    Ling, V.2
  • 72
    • 0027345632 scopus 로고
    • Function and regulation of the human multidrug resistance gene
    • Chin, K.V., Pastan, I. and Gottesman, M.M. (1993) Function and regulation of the human multidrug resistance gene. Adv. Cancer Res. 60, 157-179.
    • (1993) Adv. Cancer Res. , vol.60 , pp. 157-179
    • Chin, K.V.1    Pastan, I.2    Gottesman, M.M.3
  • 73
  • 75
    • 0026487058 scopus 로고
    • Human P-glycoprotein transports cortisol, aldosterone and dexamethasone, but not progesterone
    • Ueda, K., Okamura, N., Tanigwara, Y., Saeki, T., Kioka, N., Komano, T. and Hori, R. (1992) Human P-glycoprotein transports cortisol, aldosterone and dexamethasone, but not progesterone. J. Biol. Chem. 267, 24248-24252.
    • (1992) J. Biol. Chem. , vol.267 , pp. 24248-24252
    • Ueda, K.1    Okamura, N.2    Tanigwara, Y.3    Saeki, T.4    Kioka, N.5    Komano, T.6    Hori, R.7
  • 76
    • 0027267598 scopus 로고
    • Evidence for a polarized efflux for peptides in the apical membrane of Caco-2 cells
    • Burton, P.S., Conradi, R.A., Hilgers, A.R. and Ho, N.F.H. (1993) Evidence for a polarized efflux for peptides in the apical membrane of Caco-2 cells. Biochem. Biophys. Res. Commun. 190, 760-766.
    • (1993) Biochem. Biophys. Res. Commun. , vol.190 , pp. 760-766
    • Burton, P.S.1    Conradi, R.A.2    Hilgers, A.R.3    Ho, N.F.H.4
  • 77
    • 0027218689 scopus 로고
    • Biochemistry of multidrug resistance mediated by the multidrug transporter
    • Gottesman, M.M. and Pastan, I. (1993) Biochemistry of multidrug resistance mediated by the multidrug transporter. Annu. Rev. Biochem. 62, 385-427.
    • (1993) Annu. Rev. Biochem. , vol.62 , pp. 385-427
    • Gottesman, M.M.1    Pastan, I.2
  • 78
    • 0027169368 scopus 로고
    • Modulation of multidrug resistance gene expression by dexamethasone in cultured hepatoma cells
    • Zhao, J.-Y., Ikeguchi, M., Eckersberg, T. and Kuo, M.T. (1993) Modulation of multidrug resistance gene expression by dexamethasone in cultured hepatoma cells. Endocrinology 133, 521-528.
    • (1993) Endocrinology , vol.133 , pp. 521-528
    • Zhao, J.-Y.1    Ikeguchi, M.2    Eckersberg, T.3    Kuo, M.T.4
  • 79
    • 0030059953 scopus 로고    scopus 로고
    • Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately upregulate these proteins in human colon carcinoma cell
    • Schuetz, E.G., Beck, W.T. and Schuetz, J.D. (1996) Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately upregulate these proteins in human colon carcinoma cell. Mol. Pharmacol. 49, 311-318.
    • (1996) Mol. Pharmacol. , vol.49 , pp. 311-318
    • Schuetz, E.G.1    Beck, W.T.2    Schuetz, J.D.3
  • 80
    • 0028801904 scopus 로고
    • Inhibition of intestinal P-glycoprotein and effects on etoposide absorption
    • Leu, B.-L. and Huang, J.-D. (1995) Inhibition of intestinal P-glycoprotein and effects on etoposide absorption. Cancer Chemother. Pharmacol. 35, 432-436.
    • (1995) Cancer Chemother. Pharmacol. , vol.35 , pp. 432-436
    • Leu, B.-L.1    Huang, J.-D.2
  • 81
    • 0027180795 scopus 로고
    • Drug absorption limited by P-glycoprotein-mediated secretory drug transport in human intestinal epithelial Caco-2 cell layers
    • Hunter, J., Hirst, B.H. and Simmons, N.L. (1993) Drug absorption limited by P-glycoprotein-mediated secretory drug transport in human intestinal epithelial Caco-2 cell layers. Pharm. Res. 10, 743-749.
    • (1993) Pharm. Res. , vol.10 , pp. 743-749
    • Hunter, J.1    Hirst, B.H.2    Simmons, N.L.3
  • 82
    • 0027181852 scopus 로고
    • Functional expression of P-glycoprotein in apical membranes of human intestinal Caco-2 cells
    • Hunter, J., Jepson, M.A., Tsuruo, T., Simmons, N.L. and Hirst, B.H. (1993) Functional expression of P-glycoprotein in apical membranes of human intestinal Caco-2 cells. J. Biol. Chem. 268, 14991-14997.
    • (1993) J. Biol. Chem. , vol.268 , pp. 14991-14997
    • Hunter, J.1    Jepson, M.A.2    Tsuruo, T.3    Simmons, N.L.4    Hirst, B.H.5
  • 84
    • 0011794174 scopus 로고
    • The use of surfactants to enhance the permeability of peptides through Caco-2 cells by inhibition of an apically polarized efflux system
    • in press
    • Nerurkar, M.M., Burton, P.S. and Borchardt, R.T. (1995) The use of surfactants to enhance the permeability of peptides through Caco-2 cells by inhibition of an apically polarized efflux system. Pharm. Res., in press.
    • (1995) Pharm. Res.
    • Nerurkar, M.M.1    Burton, P.S.2    Borchardt, R.T.3
  • 87
    • 0011791752 scopus 로고
    • Effect of quinidine on digoxin absorption in the rat: Interaction on P-glycoprotein in the small intestine
    • Huang, J.-D. and Su, S.-F. (1995) Effect of quinidine on digoxin absorption in the rat: interaction on P-glycoprotein in the small intestine. [Abstract] FASEB J. 9, A691. Huang, J.-D. and Su, S.-F. (1996) Inhibition of the intestinal digoxin absorption and exsorption by quinidine. Drug Metab. Dispos., submitted.
    • (1995) FASEB J. , vol.9
    • Huang, J.-D.1    Su, S.-F.2
  • 88
    • 9044245300 scopus 로고    scopus 로고
    • Inhibition of the intestinal digoxin absorption and exsorption by quinidine
    • submitted
    • Huang, J.-D. and Su, S.-F. (1995) Effect of quinidine on digoxin absorption in the rat: interaction on P-glycoprotein in the small intestine. [Abstract] FASEB J. 9, A691. Huang, J.-D. and Su, S.-F. (1996) Inhibition of the intestinal digoxin absorption and exsorption by quinidine. Drug Metab. Dispos., submitted.
    • (1996) Drug Metab. Dispos.
    • Huang, J.-D.1    Su, S.-F.2
  • 89
    • 0001542379 scopus 로고
    • Formation and polarized efflux of cyclosporin a metabolites in the in vitro Caco-2 cell culture
    • Gan, L.-S., Moseley, A., Khosla, B., Augustijns, P., Bradshaw, T., Hendren, W and Thakker, D. (1995) Formation and polarized efflux of cyclosporin A metabolites in the in vitro Caco-2 cell culture. [Abstract] FASEB J. 9, A367.
    • (1995) FASEB J. , vol.9
    • Gan, L.-S.1    Moseley, A.2    Khosla, B.3    Augustijns, P.4    Bradshaw, T.5    Hendren, W.6    Thakker, D.7
  • 90
    • 0029150026 scopus 로고
    • Differential interaction of human renal P-glycoprotein with various metabolites and analogs of cyclosporine A
    • Charuk, J.H.M., Wong, P.Y. and Reithmeier R.A.F. (1995) Differential interaction of human renal P-glycoprotein with various metabolites and analogs of cyclosporine A. Am. J. Physiol. 269, F31-F39.
    • (1995) Am. J. Physiol. , vol.269
    • Charuk, J.H.M.1    Wong, P.Y.2    Reithmeier, R.A.F.3


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