Genetically polymorphic OCT1: Another piece in the puzzle of the variable pharmacokinetics and pharmacodynamics of the opioidergic drug tramadol

Clinical Pharmacology and Therapeutics

Volumn 90, Issue 1, 2011, Pages 143-150

  Tzvetkov, M V ^a   Saadatmand, A R ^a   Lotsch J ^b   Tegeder, I ^b   Stingl, J C ^c   Brockmoller J ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

^b GOETHE UNIVERSITY   (Germany)

^c UNIVERSITY OF ULM   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

O NORTRAMADOL; ORGANIC CATION TRANSPORTER 1; TRAMADOL;

ADULT; AREA UNDER THE CURVE; ARTICLE; CELL STRAIN HEK293; CLINICAL ARTICLE; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG ELIMINATION; DRUG HALF LIFE; DRUG MECHANISM; DRUG UPTAKE; GENETIC POLYMORPHISM; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; MEMBRANE PERMEABILITY; MIOSIS; NORMAL HUMAN; PRIORITY JOURNAL;

ADOLESCENT; ADULT; ALGORITHMS; ALLELES; ANALGESICS, OPIOID; AREA UNDER CURVE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 CYP2D6; GENOTYPE; HEK293 CELLS; HUMANS; KINETICS; MEMBRANES, ARTIFICIAL; MIOSIS; ORGANIC CATION TRANSPORTER 1; POLYMORPHISM, GENETIC; PUPIL; TRAMADOL; YOUNG ADULT;

EID: 79959375990     PISSN: 00099236     EISSN: 15326535     Source Type: Journal    
DOI: 10.1038/clpt.2011.56     Document Type: Article

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