Polyspecific organic cation transporters: Their functions and interactions with drugs

Trends in Pharmacological Sciences

Volumn 25, Issue 7, 2004, Pages 375-381

  Koepsell, Hermann ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACEBUTOLOL; ACICLOVIR; ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; ANTIDEPRESSANT AGENT; ANTIDIABETIC AGENT; ANTIVIRUS AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CLONIDINE; DESIPRAMINE; DISOPYRAMIDE; GANCICLOVIR; IMIPRAMINE; INDINAVIR; ISOPRENALINE; METFORMIN; MIDAZOLAM; NELFINAVIR; PHENFORMIN; PHENOXYBENZAMINE; PIPERPHENAMINE; PRAZOSIN; PROCAINAMIDE; QUINIDINE; QUININE; RECEPTOR BLOCKING AGENT; RITONAVIR; SODIUM CHANNEL BLOCKING AGENT; UNINDEXED DRUG; VECURONIUM; VERAPAMIL;

BINDING SITE; DIFFUSION; DNA POLYMORPHISM; DRUG TRANSPORT; DRUG UPTAKE; ENZYME SPECIFICITY; HEART; KIDNEY; KIDNEY PROXIMAL TUBULE; LIVER; LIVER METABOLISM; NEUROTRANSMISSION; NONHUMAN; PLACENTA; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVIEW; SMALL INTESTINE;

ANIMALS; DRUG INTERACTIONS; HUMANS; METABOLIC DETOXICATION, DRUG; ORGANIC CATION TRANSPORT PROTEINS; PHARMACEUTICAL PREPARATIONS;

EID: 3042569768     PISSN: 01656147     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tips.2004.05.005     Document Type: Review

References (63)

1. Schinkel A.H., Jonker J.W. Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview. Adv. Drug Deliv. Rev. 55:2003;3-29
2. Daniel H., Kottra G. The proton oligopeptide cotransporter family SLC15 in physiology and pharmacology. Pflugers Arch. 447:2004;610-618
3. Hagenbuch B., Meier P.J. Organic anion transporting polypeptides of the OATP/SLC21 family: phylogenetic classification as OATP/SLCO superfamily, new nomenclature and molecular/functional properties. Pflugers Arch. 447:2004;653-665
4. Van Montfoort J.E., et al. Drug uptake systems in liver and kidney. Curr. Drug Metab. 4:2003;185-211
5. Koepsell H., Endou H. The SLC22 drug transporter family. Pflugers Arch. 447:2004;666-676
6. Koepsell H., et al. Organic cation transporters. Rev. Physiol. Biochem. Pharmacol. 150:2003;36-90
7. Pao S.S., et al. Major facilitator superfamily. Microbiol. Mol. Biol. Rev. 62:1998;1-34
8. Gründemann D., et al. Drug excretion mediated by a new prototype of polyspecific transporter. Nature. 372:1994;549-552
9. Eraly S.A., et al. Organic anion and cation transporters occur in pairs of similar and similarly expressed genes. Biochem. Biophys. Res. Commun. 300:2003;333-342
10. Dresser M.J., et al. Transporters involved in the elimination of drugs in the kidney: organic anion transporters and organic cation transporters. J. Pharm. Sci. 90:2001;397-421
11. 2) and evidence for the expression of the transporter in the brain. J. Biol. Chem. 273:1998;32776-32786
12. Gründemann D., et al. Molecular identification of the corticosterone-sensitive extraneuronal catecholamine transporter. Nat. Neurosci. 1:1998;349-352
13. Barendt W.M., Wright S.H. The human organic cation transporter (hOCT2) recognizes the degree of substrate ionization. J. Biol. Chem. 277:2002;22491-22496
14. Kimura H., et al. Human organic anion transporters and human organic cation transporters mediate renal transport of prostaglandins. J. Pharmacol. Exp. Ther. 301:2002;293-298
15. Gründemann D., et al. Agmatine is efficiently transported by non-neuronal monoamine transporters extraneuronal monoamine transporter (EMT) and organic cation transporter 2 (OCT2). J. Pharmacol. Exp. Ther. 304:2003;810-817
16. Slitt A.L., et al. Tissue distribution and renal developmental changes in rat organic cation transporter mRNA levels. Drug Metab. Dispos. 30:2002;212-219
17. Choudhuri S., et al. Constitutive expression of various xenobiotic and endobiotic transporter mRNAs in the choroid plexus of rats. Drug Metab. Dispos. 31:2003;1337-1345
18. Chen J.J., et al. Maintenance of serotonin in the intestinal mucosa and ganglia of mice that lack the high-affinity serotonin transporter: abnormal intestinal motility and the expression of cation transporters. J. Neurosci. 21:2001;6348-6361
19. Schmitt A., et al. Organic cation transporter capable of transporting serotonin is up-regulated in serotonin transporter-deficient mice. J. Neurosci. Res. 71:2003;701-709
20. Karbach U., et al. Localization of organic cation transporters OCT1 and OCT2 in rat kidney. Am. J. Physiol. Renal Physiol. 279:2000;F679-F687
21. Meyer-Wentrup F., et al. Membrane localization of the electrogenic cation transporter rOCT1 in rat liver. Biochem. Biophys. Res. Commun. 248:1998;673-678
22. Sugawara-Yokoo M., et al. Differential localization of organic cation transporters rOCT1 and rOCT2 in the basolateral membrane of rat kidney proximal tubules. Histochem. Cell Biol. 114:2000;175-180
23. Moseley R.H., et al. Organic cation transport by rat liver plasma membrane vesicles: studies with tetraethylammonium. Am. J. Physiol. 263:1992;G775-G785
24. Busch A.E., et al. Human neurons express the polyspecific cation transporter hOCT2, which translocates monoamine neurotransmitters, amantadine, and memantine. Mol. Pharmacol. 54:1998;342-352
25. Beéry E., et al. Molecular evidence of organic ion transporters in the rat adrenal cortex with adrenocorticotropin-regulated zonal expression. Endocrinology. 144:2003;4519-4526
26. Sweet D.H., et al. Ventricular choline transport. A role for organic cation transporter 2 expressed in choroid plexus. J. Biol. Chem. 276:2001;41611-41619
27. Gorboulev V., et al. Cloning and characterization of two human polyspecific organic cation transporters. DNA Cell Biol. 16:1997;871-881
28. Motohashi H., et al. Gene expression levels and immunolocalization of organic ion transporters in the human kidney. J. Am. Soc. Nephrol. 13:2002;866-874
29. Acara M., Rennick B. Regulation of plasma choline by the renal tubule: bidirectional transport of choline. Am. J. Physiol. 225:1973;1123-1128
30. Wright S.H., et al. choline transporter in renal brush-border membrane vesicles: energetics and structural specificity. J. Membr. Biol. 126:1992;51-65
31. 4-groups, methylaminostyryl, rhodamine, acridine, phenanthrene and cyanine compounds. Pflugers Arch. 432:1996;471-485
32. Urakami Y., et al. cDNA cloning, functional characterization, and tissue distribution of an alternatively spliced variant of organic cation transporter hOCT2 predominantly expressed in the human kidney. J. Am. Soc. Nephrol. 13:2002;1703-1710
33. Shang T., et al. 1-Methyl-4-phenylpyridinium accumulates in cerebellar granule neurons via organic cation transporter 3. J. Neurochem. 85:2003;358-367
34. Kristufek D., et al. Organic cation transporter mRNA and function in the rat superior cervical ganglion. J. Physiol. 543:2002;117-134
35. Inazu M., et al. Expression and functional characterization of the extraneuronal transporter in normal human astrocytes. J. Neurochem. 84:2003;43-52
36. Haag C., et al. The localization of the extraneuronal monoamine transporter (EMT) in rat brain. J. Neurochem. 88:2004;291-297
37. Budiman T., et al. Mechanism of electrogenic cation transport by the cloned organic cation transporter 2 from rat. J. Biol. Chem. 275:2000;29413-29420
38. Volk C., et al. Different affinities of inhibitors to the outwardly and inwardly directed substrate binding site of organic cation transporter 2. Mol. Pharmacol. 64:2003;1037-1047
39. Gorboulev V., et al. Selectivity of the polyspecific cation transporter rOCT1 is changed by mutation of aspartate 475 to glutamate. Mol. Pharmacol. 56:1999;1254-1261
40. Eisenhofer G. The role of neuronal and extraneuronal plasma membrane transporters in the inactivation of peripheral catecholamines. Pharmacol. Ther. 91:2001;35-62
41. Horvath G., et al. Norepinephrine transport by the extraneuronal monoamine transporter in human bronchial arterial smooth muscle cells. Am. J. Physiol. Lung Cell. Mol. Physiol. 285:2003;L829-L837
42. Wessler I., et al. Release of non-neuronal acetylcholine from the isolated human placenta is mediated by organic cation transporters. Br. J. Pharmacol. 134:2001;951-956
43. Urakami Y., et al. Gender differences in expression of organic cation transporter OCT2 in rat kidney. FEBS Lett. 461:1999;339-342
44. Urakami Y., et al. Hormonal regulation of organic cation transporter OCT2 expression in rat kidney. FEBS Lett. 473:2000;173-176
45. Mehrens T., et al. The affinity of the organic cation transporter rOCT1 is increased by protein kinase C-dependent phosphorylation. J. Am. Soc. Nephrol. 11:2000;1216-1224
46. Çetinkaya I., et al. Regulation of human organic cation transporter hOCT2 by PKA, PI3K, and calmodulin-dependent kinases. Am. J. Physiol. Renal Physiol. 284:2003;F293-F302
47. Ciarimboli, G., et al. Regulation of the human organic cation transporter hOCT1. J. Cell. Physiol. (DOI 10.1002/jcp.20081).
48. Martel F., et al. Regulation of human extraneuronal monoamine transporter (hEMT) expressed in HEK293 cells by intracellular second messenger systems. Naunyn Schmiedebergs Arch. Pharmacol. 364:2001;487-495
49. Jonker J.W., et al. Reduced hepatic uptake and intestinal excretion of organic cations in mice with a targeted disruption of the organic cation transporter 1 (oct1[Slc22a1]) gene. Mol. Cell. Biol. 21:2001;5471-5477
50. Zwart R., et al. Impaired activity of the extraneuronal monoamine transporter system known as uptake-2 in Orct3/Slc22a3-deficient mice. Mol. Cell. Biol. 21:2001;4188-4196
51. Jonker J.W., et al. Deficiency in the organic cation transporters 1 and 2 (oct1/oct2 [slc22a1/slc22a2]) in mice abolishes renal secretion of organic cations. Mol. Cell. Biol. 23:2003;7902-7908
52. Wang D.-S., et al. Involvement of organic cation transporter 1 in hepatic and intestinal distribution of metformin. J. Pharmacol. Exp. Ther. 302:2002;510-515
53. Kerb R., et al. Identification of genetic variations of the human organic cation transporter hOCT1 and their functional consequences. Pharmacogenetics. 12:2002;1-5
54. Leabman M.K., et al. Polymorphisms in a human kidney xenobiotic transporter, OCT2, exhibit altered function. Pharmacogenetics. 12:2002;395-405
55. Shu Y., et al. Evolutionary conservation predicts function of variants of the human organic cation transporter, OCT1. Proc. Natl. Acad. Sci. U. S. A. 100:2003;5902-5907
56. Lazar A., et al. Genetic variability of the extraneuronal monoamine transporter EMT (SLC22A3). J. Hum. Genet. 48:2003;226-230
57. Kimelblatt B.J., et al. Dose and serum concentration relationships in cimetidine-associated mental confusion. Gastroenterology. 78:1980;791-795
58. Ji L., et al. Down-regulation of rat organic cation transporter rOCT2 by 5/6 nephrectomy. Kidney Int. 62:2002;514-524
59. Denk U.G., et al. Down-regulation of the organic cation transporter 1 of rat liver in obstructive cholestasis. Hepatology. 39:2004;1382-1389
60. Grover B., et al. Functional impairment of renal organic cation transport in experimental diabetes. Pharmacol. Toxicol. 90:2002;181-186
61. Davidson M.B., Peters A.L. An overview of metformin in the treatment of type 2 diabetes mellitus. Am. J. Med. 102:1997;99-110
62. Owen M.R., et al. Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain. Biochem. J. 348:2000;607-614
63. Wang D.-S., et al. Involvement of organic cation transporter 1 in the lactic acidosis caused by metformin. Mol. Pharmacol. 63:2003;844-848