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Volumn 34, Issue 1, 2013, Pages 29-44

Pharmacological and pathophysiological roles of carnitine/organic cation transporters (OCTNs: SLC22A4, SLC22A5 and Slc22a21)

Author keywords

carnitine; carnitine deficiency; OCTN; organic cation; SLC22A4; SLC22A5; tetraethylammonium; transporter

Indexed keywords

ADENOSINE TRIPHOSPHATE; CARNITINE; CEFALORIDINE; CISPLATIN; IMATINIB; LONG CHAIN FATTY ACID; MELDONIUM; MEPYRAMINE; ORGANIC CATION TRANSPORTER 1; ORGANIC CATION TRANSPORTER 2; ORGANIC CATION TRANSPORTER 3; OXALIPLATIN; QUINIDINE; SPIRONOLACTONE; TRANSCRIPTION FACTOR RUNX1; VALPROIC ACID; VERAPAMIL;

EID: 84872688669     PISSN: 01422782     EISSN: 1099081X     Source Type: Journal    
DOI: 10.1002/bdd.1816     Document Type: Review
Times cited : (130)

References (100)
  • 2
    • 0031434178 scopus 로고    scopus 로고
    • Cloning and characterization of a novel human pH-dependent organic cation transporter, OCTN1
    • Tamai I, Yabuuchi H, Nezu J, et al,. Cloning and characterization of a novel human pH-dependent organic cation transporter, OCTN1. FEBS Lett 1997; 419: 107-111.
    • (1997) FEBS Lett , vol.419 , pp. 107-111
    • Tamai, I.1    Yabuuchi, H.2    Nezu, J.3
  • 3
    • 0032493741 scopus 로고    scopus 로고
    • Molecular and functional identification of sodium ion-dependent, high affinity human carnitine transporter OCTN2
    • Tamai I, Ohashi R, Nezu J, et al,. Molecular and functional identification of sodium ion-dependent, high affinity human carnitine transporter OCTN2. J Biol Chem 1998; 273: 20378-20382.
    • (1998) J Biol Chem , vol.273 , pp. 20378-20382
    • Tamai, I.1    Ohashi, R.2    Nezu, J.3
  • 4
    • 0034704135 scopus 로고    scopus 로고
    • Molecular and functional characterization of organic cation/carnitine transporter family in mice
    • Tamai I, Ohashi R, Nezu J, et al,. Molecular and functional characterization of organic cation/carnitine transporter family in mice. J Biol Chem 2000; 275: 40064-40072.
    • (2000) J Biol Chem , vol.275 , pp. 40064-40072
    • Tamai, I.1    Ohashi, R.2    Nezu, J.3
  • 5
    • 0032953645 scopus 로고    scopus 로고
    • Primary systemic carnitine deficiency is caused by mutations in a gene encoding sodium ion-dependent carnitine transporter
    • Nezu J, Tamai I, Oku A, et al,. Primary systemic carnitine deficiency is caused by mutations in a gene encoding sodium ion-dependent carnitine transporter. Nature Genet 1999; 21: 91-94.
    • (1999) Nature Genet , vol.21 , pp. 91-94
    • Nezu, J.1    Tamai, I.2    Oku, A.3
  • 6
    • 0345974472 scopus 로고    scopus 로고
    • Involvement of OCTN1 (SLC22A4) in pH-dependent transport of organic cations
    • Tamai I, Nakanishi T, Kobayashi D, et al,. Involvement of OCTN1 (SLC22A4) in pH-dependent transport of organic cations. Mol Pharm 2004; 1: 57-66.
    • (2004) Mol Pharm , vol.1 , pp. 57-66
    • Tamai, I.1    Nakanishi, T.2    Kobayashi, D.3
  • 8
    • 48849114009 scopus 로고    scopus 로고
    • Functional characterization of ergothioneine transport by rat organic cation/carnitine transporter Octn1 (slc22a4)
    • Nakamura T, Yoshida K, Yabuuchi H, Maeda T, Tamai I,. Functional characterization of ergothioneine transport by rat organic cation/carnitine transporter Octn1 (slc22a4). Biol Pharm Bull 2008; 31: 1580-1584.
    • (2008) Biol Pharm Bull , vol.31 , pp. 1580-1584
    • Nakamura, T.1    Yoshida, K.2    Yabuuchi, H.3    Maeda, T.4    Tamai, I.5
  • 9
    • 0344364566 scopus 로고    scopus 로고
    • An intronic SNP in a RUNX1 binding site of SLC22A4, encoding an organic cation transporter, is associated with rheumatoid arthritis
    • Tokuhiro S, Yamada R, Chang X, et al,. An intronic SNP in a RUNX1 binding site of SLC22A4, encoding an organic cation transporter, is associated with rheumatoid arthritis. Nat Genet 2003; 35: 341-348.
    • (2003) Nat Genet , vol.35 , pp. 341-348
    • Tokuhiro, S.1    Yamada, R.2    Chang, X.3
  • 10
    • 33847411467 scopus 로고    scopus 로고
    • Mechanism of the regulation of OCTN1 transporter (SLC22A4) by rheumatoid arthritis-associated transcriptional factor RUNX1 and inflammatory cytokines
    • Maeda T, Hirayama M, Kobayashi D, Miyazawa K, Tamai I,. Mechanism of the regulation of OCTN1 transporter (SLC22A4) by rheumatoid arthritis-associated transcriptional factor RUNX1 and inflammatory cytokines. Drug Metab Dispos 2007; 35: 394-401.
    • (2007) Drug Metab Dispos , vol.35 , pp. 394-401
    • Maeda, T.1    Hirayama, M.2    Kobayashi, D.3    Miyazawa, K.4    Tamai, I.5
  • 11
    • 2442585704 scopus 로고    scopus 로고
    • Functional variants of OCTN cation transporter genes are associated with Crohn disease
    • Peltekova VD, Wintle RF, Rubin LA, et al,. Functional variants of OCTN cation transporter genes are associated with Crohn disease. Nat Genet 2004; 36: 471-475.
    • (2004) Nat Genet , vol.36 , pp. 471-475
    • Peltekova, V.D.1    Wintle, R.F.2    Rubin, L.A.3
  • 12
    • 77953293346 scopus 로고    scopus 로고
    • Gene knockout and metabolome analysis of carnitine/organic cation transporter OCTN1
    • Kato Y, Kubo Y, Iwata D, et al,. Gene knockout and metabolome analysis of carnitine/organic cation transporter OCTN1. Pharm Res 2010; 27: 832-840.
    • (2010) Pharm Res , vol.27 , pp. 832-840
    • Kato, Y.1    Kubo, Y.2    Iwata, D.3
  • 13
    • 0032935034 scopus 로고    scopus 로고
    • Novel membrane transporter OCTN1 mediates multispecific, bidirectional and pH-dependent transport of organic cations
    • Yabuuchi H, Tamai I, Nezu J, et al,. Novel membrane transporter OCTN1 mediates multispecific, bidirectional and pH-dependent transport of organic cations. J Pharmacol Exp Ther 1999; 289: 768-773.
    • (1999) J Pharmacol Exp Ther , vol.289 , pp. 768-773
    • Yabuuchi, H.1    Tamai, I.2    Nezu, J.3
  • 14
    • 79960525836 scopus 로고    scopus 로고
    • Oxaliplatin transport mediated by organic cation/carnitine transporters OCTN1 and OCTN2 in overexpressing human embryonic kidney 293 cells and rat dorsal root ganglion neurons
    • Jong NN, Nakanishi T, Liu JJ, Tamai I, McKeage MJ,. Oxaliplatin transport mediated by organic cation/carnitine transporters OCTN1 and OCTN2 in overexpressing human embryonic kidney 293 cells and rat dorsal root ganglion neurons. J Pharmacol Exp Ther 2011; 338: 537-547.
    • (2011) J Pharmacol Exp Ther , vol.338 , pp. 537-547
    • Jong, N.N.1    Nakanishi, T.2    Liu, J.J.3    Tamai, I.4    McKeage, M.J.5
  • 15
    • 39449103552 scopus 로고    scopus 로고
    • Effects of genetic variation in the novel organic cation transporter, OCTN1, on the renal clearance of gabapentin
    • Urban TJ, Brown C, Castro RA, et al,. Effects of genetic variation in the novel organic cation transporter, OCTN1, on the renal clearance of gabapentin. Clin Pharmacol Ther 2008; 83: 416-421.
    • (2008) Clin Pharmacol Ther , vol.83 , pp. 416-421
    • Urban, T.J.1    Brown, C.2    Castro, R.A.3
  • 17
    • 0023837255 scopus 로고
    • Infantile disease with microvesicular fatty infiltration of viscera spontaneously occurring in the C3H-H-2 strain of mouse with similarities to Reye's syndrome
    • Koizumi T, Nikaido H, Hayakawa J, Nonomura A, Yoneda T,. Infantile disease with microvesicular fatty infiltration of viscera spontaneously occurring in the C3H-H-2 strain of mouse with similarities to Reye's syndrome. Lab Anim 1988; 22: 83-87.
    • (1988) Lab Anim , vol.22 , pp. 83-87
    • Koizumi, T.1    Nikaido, H.2    Hayakawa, J.3    Nonomura, A.4    Yoneda, T.5
  • 18
    • 0032952772 scopus 로고    scopus 로고
    • Decreased tissue distribution of l -carnitine in juvenile visceral steatosis mice
    • Yokogawa K, Higashi Y, Tamai I, et al,. Decreased tissue distribution of l -carnitine in juvenile visceral steatosis mice. J Pharmacol Exp Ther 1999; 289: 224-230.
    • (1999) J Pharmacol Exp Ther , vol.289 , pp. 224-230
    • Yokogawa, K.1    Higashi, Y.2    Tamai, I.3
  • 19
    • 0032525016 scopus 로고    scopus 로고
    • Gene-dose effect on carnitine transport activity in embryonic fibroblasts of JVS mice as a model of human carnitine transporter deficiency
    • Hashimoto N, Suzuki F, Tamai I, et al,. Gene-dose effect on carnitine transport activity in embryonic fibroblasts of JVS mice as a model of human carnitine transporter deficiency. Biochem Pharmacol 1998; 55: 1729-1732.
    • (1998) Biochem Pharmacol , vol.55 , pp. 1729-1732
    • Hashimoto, N.1    Suzuki, F.2    Tamai, I.3
  • 20
    • 0021024932 scopus 로고
    • Carnitine - Metabolism and functions
    • Bremer J,. Carnitine-metabolism and functions. Physiol Rev 1983; 63: 1420-1480.
    • (1983) Physiol Rev , vol.63 , pp. 1420-1480
    • Bremer, J.1
  • 21
    • 0027232794 scopus 로고
    • Cardiac hypertrophy in juvenile visceral steatosis (jvs) mice with systemic carnitine deficiency
    • Horiuchi M, Yoshida H, Kobayashi K, et al,. Cardiac hypertrophy in juvenile visceral steatosis (jvs) mice with systemic carnitine deficiency. FEBS Lett 1993; 326: 267-271.
    • (1993) FEBS Lett , vol.326 , pp. 267-271
    • Horiuchi, M.1    Yoshida, H.2    Kobayashi, K.3
  • 22
    • 0035815991 scopus 로고    scopus 로고
    • +-coupled transport of l -carnitine via high-affinity carnitine transporter OCTN2 and its subcellular localization in kidney
    • +-coupled transport of l -carnitine via high-affinity carnitine transporter OCTN2 and its subcellular localization in kidney. Biochim Biophys Acta 2011; 1512: 273-284.
    • (2011) Biochim Biophys Acta , vol.1512 , pp. 273-284
    • Tamai, I.1    China, K.2    Sai, Y.3
  • 23
    • 77950791855 scopus 로고    scopus 로고
    • Expression of OCTN2 and OCTN3 in the apical membrane of rat renal cortex and medulla
    • Cano MM, Calonge ML, Ilundain AA,. Expression of OCTN2 and OCTN3 in the apical membrane of rat renal cortex and medulla. J Cell Physiol 2010; 223: 451-459.
    • (2010) J Cell Physiol , vol.223 , pp. 451-459
    • Cano, M.M.1    Calonge, M.L.2    Ilundain, A.A.3
  • 24
    • 82955169678 scopus 로고    scopus 로고
    • Functional characterization of apical transporters expressed in rat proximal tubular cells (PTCs) in primary culture
    • Nakanishi T, Fukushi A, Sato M, et al,. Functional characterization of apical transporters expressed in rat proximal tubular cells (PTCs) in primary culture. Mol Pharm 2011; 8: 2142-2150.
    • (2011) Mol Pharm , vol.8 , pp. 2142-2150
    • Nakanishi, T.1    Fukushi, A.2    Sato, M.3
  • 25
    • 33750709746 scopus 로고    scopus 로고
    • Membrane transport function in primary cultures of human proximal tubular cells
    • Lash LH, Putt DA, Cai H,. Membrane transport function in primary cultures of human proximal tubular cells. Toxicology 2006; 228: 200-218.
    • (2006) Toxicology , vol.228 , pp. 200-218
    • Lash, L.H.1    Putt, D.A.2    Cai, H.3
  • 26
    • 14944364233 scopus 로고    scopus 로고
    • PDZK1 directly regulates the function of organic cation/carnitine transporter OCTN2
    • Kato Y, Sai Y, Yoshida K, Watanabe C, Hirata T, Tsuji A,. PDZK1 directly regulates the function of organic cation/carnitine transporter OCTN2. Mol Pharmacol 2005; 67: 734-743.
    • (2005) Mol Pharmacol , vol.67 , pp. 734-743
    • Kato, Y.1    Sai, Y.2    Yoshida, K.3    Watanabe, C.4    Hirata, T.5    Tsuji, A.6
  • 29
    • 0025173910 scopus 로고
    • Uptake of l -carnitine by rat jejuna brush border microvillous membrane vesicles. Evidence of passive diffusion
    • Li BUK, Bummer PM, Hamilton JW, Gudjonsson H, Zografi G, Olsen WA,. Uptake of l -carnitine by rat jejuna brush border microvillous membrane vesicles. Evidence of passive diffusion. Dig Dis Sci 1990; 35: 333-339.
    • (1990) Dig Dis Sci , vol.35 , pp. 333-339
    • Li, B.U.K.1    Bummer, P.M.2    Hamilton, J.W.3    Gudjonsson, H.4    Zografi, G.5    Olsen, W.A.6
  • 30
    • 0029834047 scopus 로고    scopus 로고
    • Uptake of l -carnitine by human intestinal epithelial cell line, Caco-2
    • McCloud E, Ma TY, Grant KE, Mathis RK, Said HM,. Uptake of l -carnitine by human intestinal epithelial cell line, Caco-2. Gastroenterology 1996; 111: 1534-1540.
    • (1996) Gastroenterology , vol.111 , pp. 1534-1540
    • McCloud, E.1    Ma, T.Y.2    Grant, K.E.3    Mathis, R.K.4    Said, H.M.5
  • 31
    • 34047170808 scopus 로고    scopus 로고
    • Regional distribution of solute carrier mRNA expression along the human intestinal tract
    • Meier Y, Eloranta JJ, Darimont J, et al,. Regional distribution of solute carrier mRNA expression along the human intestinal tract. Drug Metab Dispos 2007; 35: 590-594.
    • (2007) Drug Metab Dispos , vol.35 , pp. 590-594
    • Meier, Y.1    Eloranta, J.J.2    Darimont, J.3
  • 32
    • 27744561652 scopus 로고    scopus 로고
    • Expression profiles of various transporters for oligopeptides, amino acids and organic ions along the human digestive tract
    • Terada T, Shimada Y, Pan X, et al,. Expression profiles of various transporters for oligopeptides, amino acids and organic ions along the human digestive tract. Biochem Pharmacol 2005; 70: 1756-1763.
    • (2005) Biochem Pharmacol , vol.70 , pp. 1756-1763
    • Terada, T.1    Shimada, Y.2    Pan, X.3
  • 33
    • 33747618018 scopus 로고    scopus 로고
    • Organic cation/carnitine transporter OCTN2 (Slc22a5) is responsible for carnitine transport across apical membranes of small intestinal epithelial cells in mouse
    • Kato Y, Sugiura M, Sugiura T, et al,. Organic cation/carnitine transporter OCTN2 (Slc22a5) is responsible for carnitine transport across apical membranes of small intestinal epithelial cells in mouse. Mol Pharmacol 2006; 70: 829-837.
    • (2006) Mol Pharmacol , vol.70 , pp. 829-837
    • Kato, Y.1    Sugiura, M.2    Sugiura, T.3
  • 34
    • 44149117976 scopus 로고    scopus 로고
    • PDZK1 regulates two intestinal solute carriers (Slc15a1 and Slc22a5) in mice
    • Sugiura T, Kato Y, Wakayama T, et al,. PDZK1 regulates two intestinal solute carriers (Slc15a1 and Slc22a5) in mice. Drug Metab Dispos 2008; 36: 1181-1188.
    • (2008) Drug Metab Dispos , vol.36 , pp. 1181-1188
    • Sugiura, T.1    Kato, Y.2    Wakayama, T.3
  • 36
    • 33645310407 scopus 로고    scopus 로고
    • Uptake of cardiovascular drugs into the human heart: Expression, regulation, and function of the carnitine transporter OCTN2 (SLC22A5)
    • Grube M, Meyer zu Schwabedissen HE, Präger D, et al,. Uptake of cardiovascular drugs into the human heart: expression, regulation, and function of the carnitine transporter OCTN2 (SLC22A5). Circulation 2006; 113: 1114-1122.
    • (2006) Circulation , vol.113 , pp. 1114-1122
    • Grube, M.1    Meyer Zu Schwabedissen, H.E.2    Präger, D.3
  • 37
    • 0030772205 scopus 로고    scopus 로고
    • Deficient muscle carnitine transport in primary carnitine deficiency
    • Pons R, Carrozzo R, Tein I, et al,. Deficient muscle carnitine transport in primary carnitine deficiency. Pediatr Res 1997; 42: 583-587.
    • (1997) Pediatr Res , vol.42 , pp. 583-587
    • Pons, R.1    Carrozzo, R.2    Tein, I.3
  • 39
    • 0017612714 scopus 로고
    • Carnitine uptake into human heart cells in culture
    • Böhmer T, Eiklid K, Jonsen J,. Carnitine uptake into human heart cells in culture. Biochim Biophys Acta 1977; 465: 627-633.
    • (1977) Biochim Biophys Acta , vol.465 , pp. 627-633
    • Böhmer, T.1    Eiklid, K.2    Jonsen, J.3
  • 40
    • 0032862728 scopus 로고    scopus 로고
    • Loss of wild-type carrier-mediated l -carnitine transport activity in hepatocytes of juvenile visceral steatosis mice
    • Yokogawa K, Yonekawa M, Tamai I, et al,. Loss of wild-type carrier-mediated l -carnitine transport activity in hepatocytes of juvenile visceral steatosis mice. Hepatology 1999; 30: 997-1001.
    • (1999) Hepatology , vol.30 , pp. 997-1001
    • Yokogawa, K.1    Yonekawa, M.2    Tamai, I.3
  • 41
    • 0036471216 scopus 로고    scopus 로고
    • Carnitine biosynthesis in mammals
    • Vaz FM, Wanders RJA,. Carnitine biosynthesis in mammals. Biochem J 2002; 361: 417-429.
    • (2002) Biochem J , vol.361 , pp. 417-429
    • Vaz, F.M.1    Wanders, R.J.A.2
  • 42
    • 70349750212 scopus 로고    scopus 로고
    • Hepatic uptake of γ-butyrobetaine, a precursor of carnitine biosynthesis, in rats
    • Fujita M, Nakanishi T, Shibue Y, et al,. Hepatic uptake of γ-butyrobetaine, a precursor of carnitine biosynthesis, in rats. Am J Physiol Gastrointest Liver Physiol 2009; 297: 681-686.
    • (2009) Am J Physiol Gastrointest Liver Physiol , vol.297 , pp. 681-686
    • Fujita, M.1    Nakanishi, T.2    Shibue, Y.3
  • 43
    • 84855209786 scopus 로고    scopus 로고
    • Carnitine precursor γ-butyrobetaine is a novel substrate of the Na(+)- and Cl(-)-dependent GABA transporter Gat2
    • Nakanishi T, Fukuyama Y, Fujita M, Shirasaka Y, Tamai I,. Carnitine precursor γ-butyrobetaine is a novel substrate of the Na(+)- and Cl(-)-dependent GABA transporter Gat2. Drug Metab Pharmacokinet 2011; 26: 632-636.
    • (2011) Drug Metab Pharmacokinet , vol.26 , pp. 632-636
    • Nakanishi, T.1    Fukuyama, Y.2    Fujita, M.3    Shirasaka, Y.4    Tamai, I.5
  • 44
    • 0035038184 scopus 로고    scopus 로고
    • Effect of gamma-butyrobetaine on fatty liver in juvenile visceral steatosis mice
    • Higashi Y, Yokogawa K, Takeuchi N, et al,. Effect of gamma-butyrobetaine on fatty liver in juvenile visceral steatosis mice. J Pharm Pharmacol 2001; 53: 527-533.
    • (2001) J Pharm Pharmacol , vol.53 , pp. 527-533
    • Higashi, Y.1    Yokogawa, K.2    Takeuchi, N.3
  • 45
    • 0024786493 scopus 로고
    • Double-blind, placebo controlled study of acetyl- l -carnitine in patients with Alzheimer's dementia
    • Rai G, Wright G, Scott L, Beston B, Rest J, Exton-Smith AN,. Double-blind, placebo controlled study of acetyl- l -carnitine in patients with Alzheimer's dementia. Curr Med Res Opin 1990; 11: 638-647.
    • (1990) Curr Med Res Opin , vol.11 , pp. 638-647
    • Rai, G.1    Wright, G.2    Scott, L.3    Beston, B.4    Rest, J.5    Exton-Smith, A.N.6
  • 46
    • 77952496964 scopus 로고    scopus 로고
    • Acetyl- l -carnitine
    • No Authors
    • No Authors. Acetyl- l -carnitine. Monograph. Altern Med Rev 2010; 15: 76-83.
    • (2010) Monograph. Altern Med Rev , vol.15 , pp. 76-83
  • 47
    • 0031566238 scopus 로고    scopus 로고
    • High uptake of [2-11C]acetyl- l -carnitine into the brain: A PET study
    • Kuratsune H, Watanabe Y, Yamaguti K, et al,. High uptake of [2-11C]acetyl- l -carnitine into the brain: a PET study. Biochem Biophys Res Commun 1997; 231: 488-493.
    • (1997) Biochem Biophys Res Commun , vol.231 , pp. 488-493
    • Kuratsune, H.1    Watanabe, Y.2    Yamaguti, K.3
  • 48
    • 0035209172 scopus 로고    scopus 로고
    • Functional relevance of carnitine transporter OCTN2 to brain distribution of l -carnitine and acetyl- l -carnitine across the blood-brain barrier
    • Kido Y, Tamai I, Ohnari A, et al,. Functional relevance of carnitine transporter OCTN2 to brain distribution of l -carnitine and acetyl- l -carnitine across the blood-brain barrier. J Neurochem 2001; 79: 959-969.
    • (2001) J Neurochem , vol.79 , pp. 959-969
    • Kido, Y.1    Tamai, I.2    Ohnari, A.3
  • 49
    • 0242624720 scopus 로고    scopus 로고
    • Acetyl- l -carnitine permeability across the blood-brain barrier and involvement of carnitine transporter OCTN2
    • Inano A, Sai Y, Nikaido H, et al,. Acetyl- l -carnitine permeability across the blood-brain barrier and involvement of carnitine transporter OCTN2. Biopharm Drug Dispos 2003; 24: 357-365.
    • (2003) Biopharm Drug Dispos , vol.24 , pp. 357-365
    • Inano, A.1    Sai, Y.2    Nikaido, H.3
  • 50
    • 8644266719 scopus 로고    scopus 로고
    • 0,+ in the transport of carnitine through an in vitro model of the blood-brain barrier
    • 0,+ in the transport of carnitine through an in vitro model of the blood-brain barrier. J Neurochem 2004; 91: 860-872.
    • (2004) J Neurochem , vol.91 , pp. 860-872
    • Berezowski, V.1    Miecz, D.2    Marszałek, M.3
  • 51
    • 37249013935 scopus 로고    scopus 로고
    • Localization of organic cation/carnitine transporter (OCTN2) in cells forming the blood-brain barrier
    • Miecz D, Januszewicz E, Czeredys M, et al,. Localization of organic cation/carnitine transporter (OCTN2) in cells forming the blood-brain barrier. J Neurochem 2008; 104: 113-123.
    • (2008) J Neurochem , vol.104 , pp. 113-123
    • Miecz, D.1    Januszewicz, E.2    Czeredys, M.3
  • 52
    • 0017727930 scopus 로고
    • Carnitine content of blood and amniotic fluid
    • Hahn P, Skala JP, Seccombe DW, et al,. Carnitine content of blood and amniotic fluid. Pediatr Res 1977; 11: 878-880.
    • (1977) Pediatr Res , vol.11 , pp. 878-880
    • Hahn, P.1    Skala, J.P.2    Seccombe, D.W.3
  • 54
    • 11144281351 scopus 로고    scopus 로고
    • Expression, localization, and function of the carnitine transporter octn2 (slc22a5) in human placenta
    • Grube M, Meyer Zu Schwabedissen H, Draber K, et al,. Expression, localization, and function of the carnitine transporter octn2 (slc22a5) in human placenta. Drug Metab Dispos 2005; 33: 31-37.
    • (2005) Drug Metab Dispos , vol.33 , pp. 31-37
    • Grube, M.1    Meyer Zu Schwabedissen, H.2    Draber, K.3
  • 55
    • 4344611974 scopus 로고    scopus 로고
    • Carnitine content and expression of mitochondrial beta-oxidation enzymes in placentas of wild-type (OCTN2(+/+)) and OCTN2 null (OCTN2(-/-)) mice
    • Shekhawat PS, Yang HS, Bennett MJ, et al,. Carnitine content and expression of mitochondrial beta-oxidation enzymes in placentas of wild-type (OCTN2(+/+)) and OCTN2 null (OCTN2(-/-)) mice. Pediatr Res 2004; 56: 323-328.
    • (2004) Pediatr Res , vol.56 , pp. 323-328
    • Shekhawat, P.S.1    Yang, H.S.2    Bennett, M.J.3
  • 56
    • 0017084672 scopus 로고
    • Maternal-fetal carnitine relationship and neonatal ketosis in the rat
    • Robles-Valdes C, McGarry JD, Foster DW,. Maternal-fetal carnitine relationship and neonatal ketosis in the rat. J Biol Chem 1976; 251: 6007-6012.
    • (1976) J Biol Chem , vol.251 , pp. 6007-6012
    • Robles-Valdes, C.1    McGarry, J.D.2    Foster, D.W.3
  • 58
    • 33645413227 scopus 로고    scopus 로고
    • Carnitine/xenobiotics transporters in the human mammary gland epithelia, MCF12A
    • Kwok B, Yamauchi A, Rajesan R, et al,. Carnitine/xenobiotics transporters in the human mammary gland epithelia, MCF12A. Am J Physiol Regul Integr Comp Physiol 2006; 290: R793-R802.
    • (2006) Am J Physiol Regul Integr Comp Physiol , vol.290
    • Kwok, B.1    Yamauchi, A.2    Rajesan, R.3
  • 60
    • 0029929975 scopus 로고    scopus 로고
    • Role of free l -carnitine and acetyl- l -carnitine in post-gonadal maturation of mammalian spermatozoa
    • Jeulin C, Kewin LM,. Role of free l -carnitine and acetyl- l -carnitine in post-gonadal maturation of mammalian spermatozoa. Hum Reprod Update 1996; 2: 87-102.
    • (1996) Hum Reprod Update , vol.2 , pp. 87-102
    • Jeulin, C.1    Kewin, L.M.2
  • 61
    • 0037184037 scopus 로고    scopus 로고
    • Molecular identification of a novel carnitine transporter specific to human testis. Insights into the mechanism of carnitine recognition
    • Enomoto A, Wempe MF, Tsuchida H, et al,. Molecular identification of a novel carnitine transporter specific to human testis. Insights into the mechanism of carnitine recognition. J Biol Chem 2002; 277: 36262-36271.
    • (2002) J Biol Chem , vol.277 , pp. 36262-36271
    • Enomoto, A.1    Wempe, M.F.2    Tsuchida, H.3
  • 62
    • 0035870096 scopus 로고    scopus 로고
    • --coupled active transport of carnitine by the amino acid transporter ATB(0,+) from mouse colon expressed in HRPE cells and Xenopus oocytes
    • --coupled active transport of carnitine by the amino acid transporter ATB(0,+) from mouse colon expressed in HRPE cells and Xenopus oocytes. J Physiol 2001; 532: 297-304.
    • (2001) J Physiol , vol.532 , pp. 297-304
    • Nakanishi, T.1    Hatanaka, T.2    Huang, W.3
  • 63
    • 21044458761 scopus 로고    scopus 로고
    • OCTN2-mediated carnitine transport across the blood-testis barrier
    • Kobayashi D, Goto A, Maeda T, Tsuji A, Tamai I,. OCTN2-mediated carnitine transport across the blood-testis barrier. Reproduction 2005; 129: 729-736.
    • (2005) Reproduction , vol.129 , pp. 729-736
    • Kobayashi, D.1    Goto, A.2    Maeda, T.3    Tsuji, A.4    Tamai, I.5
  • 64
    • 34548163424 scopus 로고    scopus 로고
    • Transport of organic cations across the blood-testis barrier
    • Maeda T, Goto A, Kobayashi D, Tamai I,. Transport of organic cations across the blood-testis barrier. Mol Pharm 2007; 4: 600-607.
    • (2007) Mol Pharm , vol.4 , pp. 600-607
    • Maeda, T.1    Goto, A.2    Kobayashi, D.3    Tamai, I.4
  • 65
    • 29244432787 scopus 로고    scopus 로고
    • Carnitine/organic cation transporter OCTN2-mediated transport of carnitine in primary-cultured epididymal epithelial cells
    • Kobayashi D, Irokawa M, Maeda T, Tsuji A, Tamai I,. Carnitine/organic cation transporter OCTN2-mediated transport of carnitine in primary-cultured epididymal epithelial cells. Reproduction 2005; 130: 931-937.
    • (2005) Reproduction , vol.130 , pp. 931-937
    • Kobayashi, D.1    Irokawa, M.2    Maeda, T.3    Tsuji, A.4    Tamai, I.5
  • 66
    • 0036088745 scopus 로고    scopus 로고
    • Organic cation/carnitine transporter, OCTN2, is differentially expressed in the adult rat epididymis
    • Rodríguez CM, Labus JC, Hinton BT,. Organic cation/carnitine transporter, OCTN2, is differentially expressed in the adult rat epididymis. Biol Reprod 2002; 67: 314-319.
    • (2002) Biol Reprod , vol.67 , pp. 314-319
    • Rodríguez, C.M.1    Labus, J.C.2    Hinton, B.T.3
  • 67
    • 33744796298 scopus 로고    scopus 로고
    • Expression and distribution of OCTN2 in mouse epididymis and its association with obstructive azoospermia in juvenile visceral steatosis mice
    • Yakushiji K, Kai S, Yamauchi M, Kuwajima M, Osada Y, Toshimori K,. Expression and distribution of OCTN2 in mouse epididymis and its association with obstructive azoospermia in juvenile visceral steatosis mice. Int J Urol 2006; 13: 420-426.
    • (2006) Int J Urol , vol.13 , pp. 420-426
    • Yakushiji, K.1    Kai, S.2    Yamauchi, M.3    Kuwajima, M.4    Osada, Y.5    Toshimori, K.6
  • 68
    • 73249132201 scopus 로고    scopus 로고
    • Organic cation/carnitine transporter, OCTN2, transcriptional activity is regulated by osmotic stress in epididymal cells
    • Cotton LM, Rodriguez CM, Suzuki K, Orgebin-Crist MC, Hinton BT,. Organic cation/carnitine transporter, OCTN2, transcriptional activity is regulated by osmotic stress in epididymal cells. Mol Reprod Dev 2010; 77: 114-125.
    • (2010) Mol Reprod Dev , vol.77 , pp. 114-125
    • Cotton, L.M.1    Rodriguez, C.M.2    Suzuki, K.3    Orgebin-Crist, M.C.4    Hinton, B.T.5
  • 69
    • 0032997519 scopus 로고    scopus 로고
    • Dysfunctions of the epididymis as a result of primary carnitine deficiency in juvenile visceral steatosis mice
    • Toshimori K, Kuwajima M, Yoshinaga K, Wakayama T, Shima K,. Dysfunctions of the epididymis as a result of primary carnitine deficiency in juvenile visceral steatosis mice. FEBS Lett 1999; 446: 323-326.
    • (1999) FEBS Lett , vol.446 , pp. 323-326
    • Toshimori, K.1    Kuwajima, M.2    Yoshinaga, K.3    Wakayama, T.4    Shima, K.5
  • 70
    • 36348965914 scopus 로고    scopus 로고
    • Transport of carnitine and acetylcarnitine by octn2 and octn3 into epididymal spermatozoa
    • Kobayashi D, Tamai I, Yoshida K, et al,. Transport of carnitine and acetylcarnitine by octn2 and octn3 into epididymal spermatozoa. Reproduction 2007; 134: 651-658.
    • (2007) Reproduction , vol.134 , pp. 651-658
    • Kobayashi, D.1    Tamai, I.2    Yoshida, K.3
  • 71
    • 0038042481 scopus 로고    scopus 로고
    • Carnitine transport: Pathophysiology and metabolism of known molecular defects
    • Tein I,. Carnitine transport: pathophysiology and metabolism of known molecular defects. J Inherit Metab Dis 2003; 26: 147-169.
    • (2003) J Inherit Metab Dis , vol.26 , pp. 147-169
    • Tein, I.1
  • 72
    • 77957126905 scopus 로고    scopus 로고
    • Functional expression of carnitine/organic cation transporter OCTN1/SLC22A4 in mouse small intestine and liver
    • Sugiura T, Kato S, Shimizu T, et al,. Functional expression of carnitine/organic cation transporter OCTN1/SLC22A4 in mouse small intestine and liver. Drug Metab Dispos 2010; 38: 1665-1672.
    • (2010) Drug Metab Dispos , vol.38 , pp. 1665-1672
    • Sugiura, T.1    Kato, S.2    Shimizu, T.3
  • 73
    • 84857039485 scopus 로고    scopus 로고
    • Association between OCTN1/2 gene polymorphisms (1672C-T, 207G-C) and susceptibility of Crohn's disease: A meta-analysis
    • Xuan C, Zhang BB, Yang T, Deng KF, Li M, Tian RJ,. Association between OCTN1/2 gene polymorphisms (1672C-T, 207G-C) and susceptibility of Crohn's disease: a meta-analysis. Int J Colorectal Dis 2012; 27: 11-19.
    • (2012) Int J Colorectal Dis , vol.27 , pp. 11-19
    • Xuan, C.1    Zhang, B.B.2    Yang, T.3    Deng, K.F.4    Li, M.5    Tian, R.J.6
  • 74
    • 77957113600 scopus 로고    scopus 로고
    • GABRIEL Consortium. A large-scale, consortium-based genomewide association study of asthma
    • Moffatt MF, Gut IG, Demenais F, et al,. GABRIEL Consortium. A large-scale, consortium-based genomewide association study of asthma. N Engl J Med 2010; 363: 1211-1221.
    • (2010) N Engl J Med , vol.363 , pp. 1211-1221
    • Moffatt, M.F.1    Gut, I.G.2    Demenais, F.3
  • 75
    • 33846100266 scopus 로고    scopus 로고
    • Epithelial organic cation transporters ensure pH-dependent drug absorption in the airway
    • Horvath G, Schmid N, Fragoso MA, et al,. Epithelial organic cation transporters ensure pH-dependent drug absorption in the airway. Am J Respir Cell Mol Biol 2007; 36: 53-60.
    • (2007) Am J Respir Cell Mol Biol , vol.36 , pp. 53-60
    • Horvath, G.1    Schmid, N.2    Fragoso, M.A.3
  • 76
    • 76249120508 scopus 로고    scopus 로고
    • Transport of ipratropium, an anti-chronic obstructive pulmonary disease drug, is mediated by organic cation/carnitine transporters in human bronchial epithelial cells: Implications for carrier-mediated pulmonary absorption
    • Nakamura T, Nakanishi T, Haruta T, Shirasaka Y, Keogh JP, Tamai I,. Transport of ipratropium, an anti-chronic obstructive pulmonary disease drug, is mediated by organic cation/carnitine transporters in human bronchial epithelial cells: implications for carrier-mediated pulmonary absorption. Mol Pharm 2010; 7: 187-195.
    • (2010) Mol Pharm , vol.7 , pp. 187-195
    • Nakamura, T.1    Nakanishi, T.2    Haruta, T.3    Shirasaka, Y.4    Keogh, J.P.5    Tamai, I.6
  • 77
    • 0032577202 scopus 로고    scopus 로고
    • CDNA sequence, transport function, and genomic organization of human OCTN2, a new member of the organic cation transporter family
    • Wu X, Prasad PD, Leibach FH, Ganapathy V,. cDNA sequence, transport function, and genomic organization of human OCTN2, a new member of the organic cation transporter family. Biochem Biophys Res Commun 1998; 246: 589-595.
    • (1998) Biochem Biophys Res Commun , vol.246 , pp. 589-595
    • Wu, X.1    Prasad, P.D.2    Leibach, F.H.3    Ganapathy, V.4
  • 78
    • 16544379186 scopus 로고    scopus 로고
    • Functional regions of organic cation/carnitine transporter OCTN2 (SLC22A5): Roles in carnitine recognition
    • Inano A, Sai Y, Kato Y, Tamai I, Ishiguro M, Tsuji A,. Functional regions of organic cation/carnitine transporter OCTN2 (SLC22A5): roles in carnitine recognition. Drug Metab Pharmacokinet 2004; 19: 180-189.
    • (2004) Drug Metab Pharmacokinet , vol.19 , pp. 180-189
    • Inano, A.1    Sai, Y.2    Kato, Y.3    Tamai, I.4    Ishiguro, M.5    Tsuji, A.6
  • 79
    • 0032696186 scopus 로고    scopus 로고
    • Na(+)-dependent carnitine transport by organic cation transporter (OCTN2): Its pharmacological and toxicological relevance
    • Ohashi R, Tamai I, Yabuuchi H, et al,. Na(+)-dependent carnitine transport by organic cation transporter (OCTN2): its pharmacological and toxicological relevance. J Pharmacol Exp Ther 1999; 291: 778-784.
    • (1999) J Pharmacol Exp Ther , vol.291 , pp. 778-784
    • Ohashi, R.1    Tamai, I.2    Yabuuchi, H.3
  • 80
    • 0034695673 scopus 로고    scopus 로고
    • Beta-lactam antibiotics as substrates for OCTN2, an organic cation/carnitine transporter
    • Ganapathy ME, Huang W, Rajan DP, et al,. Beta-lactam antibiotics as substrates for OCTN2, an organic cation/carnitine transporter. J Biol Chem 2000; 275: 1699-1707.
    • (2000) J Biol Chem , vol.275 , pp. 1699-1707
    • Ganapathy, M.E.1    Huang, W.2    Rajan, D.P.3
  • 81
    • 66449112180 scopus 로고    scopus 로고
    • Carnitine/organic cation transporter OCTN2 (Slc22a5) is responsible for renal secretion of cephaloridine in mice
    • Kano T, Kato Y, Ito K, Ogihara T, Kubo Y, Tsuji A,. Carnitine/organic cation transporter OCTN2 (Slc22a5) is responsible for renal secretion of cephaloridine in mice. Drug Metab Dispos 2009; 37: 1009-1016.
    • (2009) Drug Metab Dispos , vol.37 , pp. 1009-1016
    • Kano, T.1    Kato, Y.2    Ito, K.3    Ogihara, T.4    Kubo, Y.5    Tsuji, A.6
  • 82
    • 49649092002 scopus 로고    scopus 로고
    • Interaction of imatinib with human organic ion carriers
    • Hu S, Franke RM, Filipski KK, et al,. Interaction of imatinib with human organic ion carriers. Clin Cancer Res 2008; 14: 3141-3148.
    • (2008) Clin Cancer Res , vol.14 , pp. 3141-3148
    • Hu, S.1    Franke, R.M.2    Filipski, K.K.3
  • 83
    • 59649127836 scopus 로고    scopus 로고
    • The carnitine transporter SLC22A5 is not a general drug transporter, but it efficiently translocates mildronate
    • Grigat S, Fork C, Bach M, et al,. The carnitine transporter SLC22A5 is not a general drug transporter, but it efficiently translocates mildronate. Drug Metab Dispos 2009; 37: 330-337.
    • (2009) Drug Metab Dispos , vol.37 , pp. 330-337
    • Grigat, S.1    Fork, C.2    Bach, M.3
  • 84
    • 84859361240 scopus 로고    scopus 로고
    • A substrate pharmacophore for the human organic cation/carnitine transporter identifies compounds associated with rhabdomyolysis
    • Ekins S, Diao L, Polli JE,. A substrate pharmacophore for the human organic cation/carnitine transporter identifies compounds associated with rhabdomyolysis. Mol Pharm 2012; 9: 905-913.
    • (2012) Mol Pharm , vol.9 , pp. 905-913
    • Ekins, S.1    Diao, L.2    Polli, J.E.3
  • 85
    • 0036721409 scopus 로고    scopus 로고
    • Studies on functional sites of organic cation/carnitine transporter OCTN2 (SLC22A5) using a Ser467Cys mutant protein
    • Ohashi R, Tamai I, Inano A, et al,. Studies on functional sites of organic cation/carnitine transporter OCTN2 (SLC22A5) using a Ser467Cys mutant protein. J Pharmacol Exp Ther 2002; 302: 1286-1294.
    • (2002) J Pharmacol Exp Ther , vol.302 , pp. 1286-1294
    • Ohashi, R.1    Tamai, I.2    Inano, A.3
  • 86
    • 0035132434 scopus 로고    scopus 로고
    • Molecular and physiological evidence for multifunctionality of carnitine/organic cation transporter OCTN2
    • Ohashi R, Tamai I, Nezu Ji J, et al,. Molecular and physiological evidence for multifunctionality of carnitine/organic cation transporter OCTN2. Mol Pharmacol 2001; 59: 358-366.
    • (2001) Mol Pharmacol , vol.59 , pp. 358-366
    • Ohashi, R.1    Tamai, I.2    Nezu Ji, J.3
  • 87
    • 33847213858 scopus 로고    scopus 로고
    • OCTN2-mediated carnitine uptake in a newly discovered human proximal tubule cell line (Caki-1)
    • Glube N, Closs E, Langguth P,. OCTN2-mediated carnitine uptake in a newly discovered human proximal tubule cell line (Caki-1). Mol Pharm 2007; 4: 160-168.
    • (2007) Mol Pharm , vol.4 , pp. 160-168
    • Glube, N.1    Closs, E.2    Langguth, P.3
  • 88
    • 78650755420 scopus 로고    scopus 로고
    • Organic cation transporter-mediated renal secretion of ipratropium and tiotropium in rats and humans
    • Nakanishi T, Haruta T, Shirasaka Y, Tamai I,. Organic cation transporter-mediated renal secretion of ipratropium and tiotropium in rats and humans. Drug Metab Dispos 2010; 39: 117-122.
    • (2010) Drug Metab Dispos , vol.39 , pp. 117-122
    • Nakanishi, T.1    Haruta, T.2    Shirasaka, Y.3    Tamai, I.4
  • 89
    • 80053474357 scopus 로고    scopus 로고
    • Synthesis, transport and mechanism of a type i prodrug: L -carnitine ester of prednisolone
    • Mo JX, Shi SJ, Zhang Q, Gong T, Sun X, Zhang ZR,. Synthesis, transport and mechanism of a type I prodrug: l -carnitine ester of prednisolone. Mol Pharm 2011; 8: 1629-1640.
    • (2011) Mol Pharm , vol.8 , pp. 1629-1640
    • Mo, J.X.1    Shi, S.J.2    Zhang, Q.3    Gong, T.4    Sun, X.5    Zhang, Z.R.6
  • 91
    • 21844457187 scopus 로고    scopus 로고
    • Polyspecific cation transporters mediate luminal release of acetylcholine from bronchial epithelium
    • Lips KS, Volk C, Schmitt BM, et al,. Polyspecific cation transporters mediate luminal release of acetylcholine from bronchial epithelium. Am J Respir Cell Mol Biol 2005; 33: 79-88.
    • (2005) Am J Respir Cell Mol Biol , vol.33 , pp. 79-88
    • Lips, K.S.1    Volk, C.2    Schmitt, B.M.3
  • 92
    • 84857792529 scopus 로고    scopus 로고
    • Evaluation of air-interfaced Calu-3 cell layers for investigation of inhaled drug interactions with organic cation transporters in vitro
    • Mukherjee M, Pritchard DI, Bosquillon C,. Evaluation of air-interfaced Calu-3 cell layers for investigation of inhaled drug interactions with organic cation transporters in vitro. Int J Pharm 2012; 426: 7-14.
    • (2012) Int J Pharm , vol.426 , pp. 7-14
    • Mukherjee, M.1    Pritchard, D.I.2    Bosquillon, C.3
  • 93
    • 3042723541 scopus 로고    scopus 로고
    • Nephrotoxicity of platinum complexes is related to basolateral organic cation transport
    • Ludwig T, Riethmüller C, Gekle M, Schwerdt G, Oberleithner H,. Nephrotoxicity of platinum complexes is related to basolateral organic cation transport. Kidney Int 2004; 66: 196-202.
    • (2004) Kidney Int , vol.66 , pp. 196-202
    • Ludwig, T.1    Riethmüller, C.2    Gekle, M.3    Schwerdt, G.4    Oberleithner, H.5
  • 94
    • 79952132912 scopus 로고    scopus 로고
    • Role of organic cation transporters in drug-induced toxicity
    • Ciarimboli G,. Role of organic cation transporters in drug-induced toxicity. Expert Opin Drug Metab Toxicol 2011; 7: 159-174.
    • (2011) Expert Opin Drug Metab Toxicol , vol.7 , pp. 159-174
    • Ciarimboli, G.1
  • 95
    • 0141890143 scopus 로고    scopus 로고
    • Oxaliplatin-safety profile: Neurotoxicity
    • Grothey A,. Oxaliplatin-safety profile: neurotoxicity. Semin Oncol 2003; 30 (4 Suppl 15): 5-13.
    • (2003) Semin Oncol , vol.30 , Issue.4 SUPPL. 15 , pp. 5-13
    • Grothey, A.1
  • 96
    • 0037385524 scopus 로고    scopus 로고
    • Impact on carnitine homeostasis of short-term treatment with the pivalate prodrug cefditoren pivoxil
    • Brass EP, Mayer MD, Mulford DJ, Stickler TK, Hoppel CL,. Impact on carnitine homeostasis of short-term treatment with the pivalate prodrug cefditoren pivoxil. Clin Pharmacol Ther 2003; 73: 338-347.
    • (2003) Clin Pharmacol Ther , vol.73 , pp. 338-347
    • Brass, E.P.1    Mayer, M.D.2    Mulford, D.J.3    Stickler, T.K.4    Hoppel, C.L.5
  • 98
    • 33746926424 scopus 로고    scopus 로고
    • Involvement of recognition and interaction of carnitine transporter in the decrease of l -carnitine concentration induced by pivalic acid and valproic acid
    • Okamura N, Ohnishi S, Shimaoka H, Norikura R, Hasegawa H,. Involvement of recognition and interaction of carnitine transporter in the decrease of l -carnitine concentration induced by pivalic acid and valproic acid. Pharm Res 2006; 23: 1729-1735.
    • (2006) Pharm Res , vol.23 , pp. 1729-1735
    • Okamura, N.1    Ohnishi, S.2    Shimaoka, H.3    Norikura, R.4    Hasegawa, H.5
  • 99
    • 56149095274 scopus 로고    scopus 로고
    • Role of Na+/L-carnitine transporter (OCTN2) in renal handling of pivaloylcarnitine and valproylcarnitine formed during pivalic acid-containing prodrugs and valproic acid treatment
    • Ohnishi S, Okamura N, Sakamoto S, et al,. Role of Na+/L-carnitine transporter (OCTN2) in renal handling of pivaloylcarnitine and valproylcarnitine formed during pivalic acid-containing prodrugs and valproic acid treatment. Drug Metab Pharmacokinet 2008; 23: 293-303.
    • (2008) Drug Metab Pharmacokinet , vol.23 , pp. 293-303
    • Ohnishi, S.1    Okamura, N.2    Sakamoto, S.3
  • 100
    • 67349194946 scopus 로고    scopus 로고
    • Interaction between pivaloylcarnitine and l -carnitine transport into L6 cells overexpressing hOCTN2
    • Todesco L, Bodmer M, Vonwil K, Häussinger D, Krähenbühl S,. Interaction between pivaloylcarnitine and l -carnitine transport into L6 cells overexpressing hOCTN2. Chem Biol Interact 2009; 180: 472-477.
    • (2009) Chem Biol Interact , vol.180 , pp. 472-477
    • Todesco, L.1    Bodmer, M.2    Vonwil, K.3    Häussinger, D.4    Krähenbühl, S.5


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