Identification of OCT6 as a novel organic cation transporter preferentially expressed in hematopoietic cells and leukemias

Experimental Hematology

Volumn 30, Issue 10, 2002, Pages 1162-1169

  Gong, Shimei ^a   Lu, Xin ^a   Xu, Yongsheng ^a   Swiderski, Carol F ^a   Jordan, Craig T ^a   Moscow, Jeffrey A ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD34 ANTIGEN;

ARTICLE; BONE MARROW; CANCER CELL CULTURE; CATION TRANSPORT; CELL MEMBRANE TRANSPORT; CELL POPULATION; CELL STRAIN HL 60; CONTROLLED STUDY; DATA BASE; FETUS LIVER; GENE; GENE EXPRESSION; GENE ISOLATION; HEMATOPOIETIC CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; KIDNEY; LEUKEMIA; LEUKEMIA CELL LINE; LEUKOCYTE; NUCLEOTIDE SEQUENCE; OCT GENE; PLACENTA; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE HOMOLOGY; TESTIS;

AMINO ACID SEQUENCE; BASE SEQUENCE; BLAST CRISIS; DNA PRIMERS; EXPRESSED SEQUENCE TAGS; HEMATOPOIETIC STEM CELLS; HUMANS; LEUKEMIA; MOLECULAR SEQUENCE DATA; ORGANIC CATION TRANSPORT PROTEINS; POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; TUMOR CELLS, CULTURED;

EID: 0036792072     PISSN: 0301472X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0301-472X(02)00901-3     Document Type: Article

References (22)

1. Koepsell H. Organic cation transporters in intestine, kidney, liver and brain. Annu Rev Physiol. 60:1998;243.
2. Grundemann D., Gorboulev V., Gambaryan S., Veyhl M., Koepsell H. Drug excretion mediated by a new prototype of polyspecific transporter. Nature. 372:1994;549.
3. Zhang L., Brett C.M., Giacomini K.M. Role of organic cation transporters in drug absorption and elimination. Annu Rev Pharmacol Toxicol. 38:1998;431.
4. Giacomini K.M. Membrane transporters in drug disposition. J Pharmacokinet Biopharm. 25:1997;731.
5. Gorboulev V., Ulzheimer J.C., Akhoundova A.et al. Cloning and characterization of two human polyspecific organic cation transporters. DNA Cell Biol. 16:1997;871.
6. Koepsell H., Gorboulev V., Arndt P. Molecular pharmacology of organic cation transporters in kidney. J Membr Biol. 167:1999;103.
7. Okuda M., Saito H., Urakami Y., Takano M., Inui K. cDNA cloning and functional expression of a novel rat kidney organic cation transporter, OCT2. Biochem Biophys Res Commun. 224:1996;500.
8. Zhang L., Dresser M.J., Chun J.K., Babbitt P.C., Giacomini K.M. Cloning and functional characterization of a rat renal organic cation transporter isoform (rOCT1A). J Biol Chem. 272:1997;16548.
9. Kekuda R., Prasad P.D., Wu X.et al. Cloning and functional characterization of a potential-sensitive, polyspecific organic cation transporter (OCT3) most abundantly expressed in placenta. J Biol Chem. 273:1998;15971.
10. Wu X., Kekuda R., Huang W.et al. Identity of the organic cation transporter OCT3 as the extraneuronal monoamine transporter (uptake2) and evidence for the expression of the transporter in the brain. J Biol Chem. 273:1998;32776.
11. Dhillon U., Shenton J., Cook V., Harper P., Watson-Macdonnel J., Ito S. The expression of the human organic cation transporter hOCT1 in mammary gland. Clin Pharmacol Ther. 65:1999;205.
12. Tamai I., Yabuuchi H., Nezu J.et al. Cloning and characterization of a novel human pH-dependent organic cation transporter, OCTN1. FEBS Lett. 419:1997;107.
13. Yabuuchi H., Tamai I., Nezu J.et al. Novel membrane transporter OCTN1 mediates multispecific, bidirectional, and pH-dependent transport of organic cations. J Pharmacol Exp Ther. 289:1999;768.
14. Wu X., Prasad P.D., Leibach F.H., Ganapathy V. cDNA sequence, transport function, and genomic organization of human OCTN2, a new member of the organic cation transporter family. Biochem Biophys Res Commun. 246:1998;589.
15. Thompson J.D., Higgins D.G., Gibson T.J. Clustal w. improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice Nucleic Acids Res. 22:1994;4673.
16. Moscow J.A., Schneider E.S., Ivy S.P., Cowan K.H. Multidrug resistance. Pinedo H.M., Longo D.L., Chabner B.A. Cancer chemotherapy and biological response modifiers. Annual 17. 1997;Elsevier, New York. 139p.
17. Moscow J.A., Gong M., He R.et al. Isolation of a gene encoding a human reduced folate carrier (RFC1) and analysis of its expression in transport-deficient, methotrexate-resistant human breast cancer cells. Cancer Res. 55:1995;3790.
18. Moscow J.A., Connolly T., Myers T., Paull K., Cheng C.C., Cowan K.H. Reduced folate carrier gene expression in transfected and non-selected cell lines. Int J Cancer. 72:1997;184.
19. Huhn D., von Schilling C., Wilhelm M.et al. Rituximab therapy of patients with B-cell chronic lymphocytic leukemia. Blood. 98:2001;1326.
20. Kreitman R.J., Wilson W.H., Bergeron K.et al. Efficacy of the anti-CD22 recombinant immunotoxin BL22 in chemotherapy-resistant hairy-cell leukemia. N Engl J Med. 345:2001;241.
21. Bunjes D., Buchmann I., Duncker C.et al. Rhenium 188-labeled anti-CD66 (a, b, c, e) monoclonal antibody to intensify the conditioning regimen prior to stem cell transplantation for patients with high-risk acute myeloid leukemia or myelodysplastic syndrome. results of a phase I-II study Blood. 98:2001;565.
22. Sievers E.L., Larson R.A., Stadtmauer E.A.et al. Efficacy and safety of gemtuzumab ozogamicin in patients with CD33-positive acute myeloid leukemia in first relapse. J Clin Oncol. 19:2001;3244.