The breast cancer resistance protein transporter ABCG2 is expressed in the human kidney proximal tubule apical membrane

Kidney International

Volumn 73, Issue 2, 2008, Pages 220-225

  Huls, M ^a   Brown, C D A ^b   Windass, A S ^b   Sayer, R ^b   Van Den Heuvel, J J M W ^a   Heemskerk, S ^a   Russel, F G M ^a   Masereeuw, R ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

ABC transporter; Cell and transport physiology; Drug excretion; Immunostaining

Indexed keywords

ABC TRANSPORTER; BREAST CANCER RESISTANCE PROTEIN; FUMITREMORGIN C; GLYCOPROTEIN P; MULTIDRUG RESISTANCE PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 2; MULTIDRUG RESISTANCE PROTEIN 4; NELFINAVIR;

ANIMAL TISSUE; APICAL MEMBRANE; ARTICLE; DRUG EXCRETION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KIDNEY PROXIMAL TUBULE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT;

EID: 37549068911     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/sj.ki.5002645     Document Type: Article

References (28)

1. Krishnamurthy P, Ross DD, Nakanishi T et al. The stem cell marker Bcrp/ABCG2 enhances hypoxic cell survival through interactions with heme. J Biol Chem 2004; 279: 24218-24225.
2. Mao Q, Unadkat JD. Role of the breast cancer resistance protein (ABCG2) in drug transport. AAPS J 2005; 7: E118-E133.
3. 2) into milk. Mol Cell Biol 2007; 27: 1247-1253.
4. Chen ZS, Robey RW, Belinsky MG et al. Transport of methotrexate, methotrexate polyglutamates, and 17beta-estradiol 17-(beta-D- glucuronide) by ABCG2: effects of acquired mutations at R482 on methotrexate transport. Cancer Res 2003; 63: 4048-4054.
5. Leslie EM, Deeley RG, Cole SP. Multidrug resistance proteins: role of P-glycoprotein MRP1, MRP2, and BCRP (ABCG2) in tissue defense. Toxicol Appl Pharmacol 2005; 204: 216-237.
6. Jonker JW, Merino G, Musters S et al. The breast cancer resistance protein BCRP (ABCG2) concentrates drugs and carcinogenic xenotoxins into milk. Nat Med 2005; 11: 127-129.
7. Doyle LA, Ross DD. Multidrug resistance mediated by the breast cancer resistance protein BCRP (ABCG2). Oncogene 2003; 22: 7340-7358.
8. Maliepaard M, Scheffer GL, Faneyte IF et al. Subcellular localization and distribution of the breast cancer resistance protein transporter in normal human tissues. Cancer Res 2001; 61: 3458-3464.
9. Diestra JE, Scheffer GL, Catala I et al. Frequent expression of the multidrug resistance-associated protein BCRP/MXR/ABCP/ABCG2 in human tumours detected by the BXP-21 monoclonal antibody in paraffin-embedded material. J Pathol 2002; 198: 213-219.
10. Scheffer GL, Maliepaard M, Pijnenborg AC et al. Breast cancer resistance protein is localized at the plasma membrane in mitoxantrone- and topotecan-resistant cell lines. Cancer Res 2000; 60: 2589-2593.
11. Huls M, van den Heuvel JJ, Dijkman HB et al. ABC transporter expression profiling after ischemic reperfusion injury in mouse kidney. Kidney Int 2006; 69: 2186-2193.
12. Jonker JW, Buitelaar M, Wagenaar E et al. The breast cancer resistance protein protects against a major chlorophyll-derived dietary phototoxin and protoporphyria. Proc Natl Acad Sci USA 2002; 99: 15649-15654.
13. Brown CDA, Windass A, Sayer R. Primary cultures of Human renal proximal tubules as a model of renal xenobiotic secretion. AAPS J 2006; 8.
14. Wilmer MJ, Graaf-Hess A, Blom HJ et al. Elevated oxidized glutathione in cystinotic proximal tubular epithelial cells. Biochem Biophys Res Commun 2005; 337: 610-614.
15. Scharenberg CW, Harkey MA, Torok-Storb B. The ABCG2 transporter is an efficient Hoechst 33342 efflux pump and is preferentially expressed by immature human hematopoietic progenitors. Blood 2002; 99: 507-512.
16. Schinkel AH, Jonker JW. Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview. Adv Drug Deliv Rev 2003; 55: 3-29.
17. Choo EF, Leake B, Wandel C et al. Pharmacological inhibition of P-glycoprotein transport enhances the distribution of HIV-1 protease inhibitors into brain and testes. Drug Metab Dispos 2000; 28: 655-660.
18. Schwab D, Fischer H, Tabatabaei A et al. Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery. J Med Chem 2003; 46: 1716-1725.
19. Meyer zu Schwabedissen HE, Grube M, Dreisbach A et al. Epidermal growth factor-mediated activation of the map kinase cascade results in altered expression and function of ABCG2 (BCRP). Drug Metab Dispos 2006; 34: 524-533.
20. Leggas M, Panetta JC, Zhuang Y et al. Gefitinib modulates the function of multiple ATP-binding cassette transporters in vivo. Cancer Res 2006; 66: 4802-4807.
21. Evseenko DA, Paxton JW, Keelan JA. Independent regulation of apical and basolateral drug transporter expression and function in placental trophoblasts by cytokines, steroids and growth factors. Drug Metab Dispos 2007; 35: 595-601.
22. Bauer B, Hartz AM, Miller DS. TNF-{alpha} and endothelin-1 increase P-glycoprotein expression and transport activity at the blood-brain barrier. Mol Pharmacol 2007; 71: 667-675.
23. Tanaka Y, Slitt AL, Leazer TM et al. Tissue distribution and hormonal regulation of the breast cancer resistance protein (Bcrp/Abcg2) in rats and mice. Biochem Biophys Res Commun 2005; 326: 181-187.
24. van de Water FM, Masereeuw R, Russel FG. Function and regulation of multidrug resistance proteins (MRPs) in the renal elimination of organic anions. Drug Metab Rev 2005; 37: 443-471.
25. Helbert MJ, Dauwe S, De Broe ME. Flow cytometric immunodissection of the human nephron in vivo and in vitro. Exp Nephrol 1999; 7: 360-376.
26. Helbert MJ, Dauwe SE, Van der Biest I et al. Immunodissection of the human proximal nephron: flow sorting of S1S2S3, S1S2 and S3 proximal tubular cells. Kidney Int 1997; 52: 414-428.
27. Gibson-D'Ambrosio RE, Samuel M, Chang CC et al. Characteristics of long-term human epithelial cell cultures derived from normal human fetal kidney. In Vitro Cell Dev Biol 1987; 23: 279-287.
28. Russel FG, van der Linden PE, Vermeulen WG et al. Na+ and H+ gradient-dependent transport of p-aminohippurate in membrane vesicles from dog kidney cortex. Biochem Pharmacol 1988; 37: 2639-2649.