-
1
-
-
0035831094
-
Characterization of bile acid transport mediated by multidrug resistance associated protein 2 and bile salt export pump
-
Akita H, Suzuki H, Ito K, Kinoshita S, Sato N, Takikawa H, Sugiyama Y (2001) Characterization of bile acid transport mediated by multidrug resistance associated protein 2 and bile salt export pump. Biochim Biophys Acta 1511:7-16
-
(2001)
Biochim Biophys Acta
, vol.1511
, pp. 7-16
-
-
Akita, H.1
Suzuki, H.2
Ito, K.3
Kinoshita, S.4
Sato, N.5
Takikawa, H.6
Sugiyama, Y.7
-
2
-
-
2342516133
-
Expression and cellular distribution of multidrug resistance-related proteins in the hippocampus of patients with mesial temporal lobe epilepsy
-
Aronica E, Gorter JA, Ramkema M, Redeker S, Ozbas-Gerceker F, van Vliet EA, Scheffer GL, Scheper RJ, van der Valk P, Baayen JC, Troost D (2004) Expression and cellular distribution of multidrug resistance-related proteins in the hippocampus of patients with mesial temporal lobe epilepsy. Epilepsia 45:441-451
-
(2004)
Epilepsia
, vol.45
, pp. 441-451
-
-
Aronica, E.1
Gorter, J.A.2
Ramkema, M.3
Redeker, S.4
Ozbas-Gerceker, F.5
van Vliet, E.A.6
Scheffer, G.L.7
Scheper, R.J.8
van der Valk, P.9
Baayen, J.C.10
Troost, D.11
-
3
-
-
0032740801
-
Drug resistance-associated markers P-glycoprotein, multidrug resistance-associated protein 1, multidrug resistance-associated protein 2, and lung resistance protein as prognostic factors in ovarian carcinoma
-
Arts HJ, Katsaros D, de Vries EG, Massobrio M, Genta F, Danese S, Arisio R, Scheper RJ, Kool M, Scheffer GL, Willemse PH, van der Zee AG, Suurmeijer AJ (1999) Drug resistance-associated markers P-glycoprotein, multidrug resistance-associated protein 1, multidrug resistance-associated protein 2, and lung resistance protein as prognostic factors in ovarian carcinoma. Clin Cancer Res 5:2798-2805
-
(1999)
Clin Cancer Res
, vol.5
, pp. 2798-2805
-
-
Arts, H.J.1
Katsaros, D.2
de Vries, E.G.3
Massobrio, M.4
Genta, F.5
Danese, S.6
Arisio, R.7
Scheper, R.J.8
Kool, M.9
Scheffer, G.L.10
Willemse, P.H.11
van der Zee, A.G.12
Suurmeijer, A.J.13
-
4
-
-
0034072174
-
Interactions of the human multidrug resistance proteins MRP1 and MRP2 with organic anions
-
Bakos E, Evers R, Sinko E, Varadi A, Borst P, Sarkadi B (2000) Interactions of the human multidrug resistance proteins MRP1 and MRP2 with organic anions. Mol Pharmacol 57:760-768
-
(2000)
Mol Pharmacol
, vol.57
, pp. 760-768
-
-
Bakos, E.1
Evers, R.2
Sinko, E.3
Varadi, A.4
Borst, P.5
Sarkadi, B.6
-
5
-
-
4444310389
-
The distribution of drug-efflux pumps, P-gp, BCRP, MRP1 and MRP2, in the normal blood-testis barrier and in primary testicular tumours
-
Bart J, Hollema H, Groen HJ, de Vries EG, Hendrikse NH, Sleijfer DT, Wegman TD, Vaalburg W, van der Graaf WT (2004) The distribution of drug-efflux pumps, P-gp, BCRP, MRP1 and MRP2, in the normal blood-testis barrier and in primary testicular tumours. Eur J Cancer 40:2064-2070
-
(2004)
Eur J Cancer
, vol.40
, pp. 2064-2070
-
-
Bart, J.1
Hollema, H.2
Groen, H.J.3
de Vries, E.G.4
Hendrikse, N.H.5
Sleijfer, D.T.6
Wegman, T.D.7
Vaalburg, W.8
van der Graaf, W.T.9
-
6
-
-
21544456938
-
Analysis of ABCC6 (MRP6) in normal human tissues
-
Beck K, Hayashi K, Dang K, Hayashi M, Boyd CD (2005) Analysis of ABCC6 (MRP6) in normal human tissues. Histochem Cell Biol 123:517-528
-
(2005)
Histochem Cell Biol
, vol.123
, pp. 517-528
-
-
Beck, K.1
Hayashi, K.2
Dang, K.3
Hayashi, M.4
Boyd, C.D.5
-
7
-
-
0035038177
-
Tauroursodeoxycholic acid inserts the apical conjugate export pump, Mrp2, into canalicular membranes and stimulates organic anion secretion by protein kinase C-dependent mechanisms in cholestatic rat liver
-
Beuers U, Bilzer M, Chittattu A, Kullak-Ublick GA, Keppler D, Paumgartner G, Dombrowski F (2001) Tauroursodeoxycholic acid inserts the apical conjugate export pump, Mrp2, into canalicular membranes and stimulates organic anion secretion by protein kinase C-dependent mechanisms in cholestatic rat liver. Hepatology 33:1206-1216
-
(2001)
Hepatology
, vol.33
, pp. 1206-1216
-
-
Beuers, U.1
Bilzer, M.2
Chittattu, A.3
Kullak-Ublick, G.A.4
Keppler, D.5
Paumgartner, G.6
Dombrowski, F.7
-
8
-
-
0032532134
-
SXR, a novel steroid and xenobiotic-sensing nuclear receptor
-
Blumberg B, Sabbagh W Jr, Juguilon H, Bolado J Jr, van Meter CM, Ong ES, Evans RM (1998) SXR, a novel steroid and xenobiotic-sensing nuclear receptor. Genes Dev 12:3195-3205
-
(1998)
Genes Dev
, vol.12
, pp. 3195-3205
-
-
Blumberg, B.1
Sabbagh Jr, W.2
Juguilon, H.3
Bolado Jr, J.4
van Meter, C.M.5
Ong, E.S.6
Evans, R.M.7
-
9
-
-
0033954736
-
Coordinate induction by antioxidants of UDP-glucuronosyltransferase UGT1A6 and the apical conjugate export pump MRP2 (multidrug resistance protein 2) in Caco-2 cells
-
Bock KW, Eckle T, Ouzzine M, Fournel-Gigleux S (2000) Coordinate induction by antioxidants of UDP-glucuronosyltransferase UGT1A6 and the apical conjugate export pump MRP2 (multidrug resistance protein 2) in Caco-2 cells. Biochem Pharmacol 59:467-470
-
(2000)
Biochem Pharmacol
, vol.59
, pp. 467-470
-
-
Bock, K.W.1
Eckle, T.2
Ouzzine, M.3
Fournel-Gigleux, S.4
-
10
-
-
0034524664
-
ERM-Merlin and EBP50 protein families in plasma membrane organization and function
-
Bretscher A, Chambers D, Nguyen R, Reczek D (2000) ERM-Merlin and EBP50 protein families in plasma membrane organization and function. Annu Rev Cell Dev Biol 16:113-143
-
(2000)
Annu Rev Cell Dev Biol
, vol.16
, pp. 113-143
-
-
Bretscher, A.1
Chambers, D.2
Nguyen, R.3
Reczek, D.4
-
11
-
-
0029910521
-
Homologues of the human multidrug resistance genes MRP and MDR contribute to heavy metal resistance in the soil nematode Caenorhabditis elegans
-
Broeks A, Gerrard B, Allikmets R, Dean M, Plasterk RHA (1996) Homologues of the human multidrug resistance genes MRP and MDR contribute to heavy metal resistance in the soil nematode Caenorhabditis elegans. EMBO J 15:6132-6143
-
(1996)
EMBO J
, vol.15
, pp. 6132-6143
-
-
Broeks, A.1
Gerrard, B.2
Allikmets, R.3
Dean, M.4
Plasterk, R.H.A.5
-
12
-
-
29244441701
-
ABCC drug efflux pumps and organic anion uptake transporters in human gliomas and the blood-tumor barrier
-
Bronger H, König J, Kopplow K, Steiner HH, Ahmadi R, Herold-Mende C, Keppler D, Nies AT (2005) ABCC drug efflux pumps and organic anion uptake transporters in human gliomas and the blood-tumor barrier. Cancer Res 65:11419-11428
-
(2005)
Cancer Res
, vol.65
, pp. 11419-11428
-
-
Bronger, H.1
König, J.2
Kopplow, K.3
Steiner, H.H.4
Ahmadi, R.5
Herold-Mende, C.6
Keppler, D.7
Nies, A.T.8
-
13
-
-
0040761368
-
cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMRP, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats
-
Büchler M, König J, Brom M, Kartenbeck J, Spring H, Horie T, Keppler D (1996) cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMRP, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats. J Biol Chem 271:15091-15098
-
(1996)
J Biol Chem
, vol.271
, pp. 15091-15098
-
-
Büchler, M.1
König, J.2
Brom, M.3
Kartenbeck, J.4
Spring, H.5
Horie, T.6
Keppler, D.7
-
14
-
-
0033998261
-
MRP2, a human conjugate export pump, is present and transports Fluo-3 into apical vacuoles of HepG2 cells
-
Cantz T, Nies AT, Brom M, Hofmann AF, Keppler D (2000) MRP2, a human conjugate export pump, is present and transports Fluo-3 into apical vacuoles of HepG2 cells. Am J Physiol Gasterointest Liver Physiol 278:G522-G531
-
(2000)
Am J Physiol Gasterointest Liver Physiol
, vol.278
-
-
Cantz, T.1
Nies, A.T.2
Brom, M.3
Hofmann, A.F.4
Keppler, D.5
-
15
-
-
0036721559
-
Expression of rat hepatic multidrug resistance-associated proteins and organic anion transporters in pregnancy
-
Cao J, Stieger B, Meier PJ, Vore M (2002) Expression of rat hepatic multidrug resistance-associated proteins and organic anion transporters in pregnancy. Am J Physiol Gasterointest Liver Physiol 283:G757-G766
-
(2002)
Am J Physiol Gasterointest Liver Physiol
, vol.283
-
-
Cao, J.1
Stieger, B.2
Meier, P.J.3
Vore, M.4
-
16
-
-
22344450518
-
Dual hereditary jaundice: Simultaneous occurrence of mutations causing Gilbert's and Dubin-Johnson syndrome
-
Cebecauerova D, Jirasek T, Budisova L, Mandys V, Volf V, Novotna Z, Subhanova I, Hrebicek M, Elleder M, Jirsa M (2005) Dual hereditary jaundice: simultaneous occurrence of mutations causing Gilbert's and Dubin-Johnson syndrome. Gastroenterology 129:315-320
-
(2005)
Gastroenterology
, vol.129
, pp. 315-320
-
-
Cebecauerova, D.1
Jirasek, T.2
Budisova, L.3
Mandys, V.4
Volf, V.5
Novotna, Z.6
Subhanova, I.7
Hrebicek, M.8
Elleder, M.9
Jirsa, M.10
-
17
-
-
0032753749
-
Effect of multidrug resistance-reversing agents on transporting activity of human canalicular multispecific organic anion transporter
-
Chen ZS, Kawabe T, Ono M, Aoki S, Sumizawa T, Furukawa T, Uchiumi T, Wada M, Kuwano M, Akiyama SI (1999) Effect of multidrug resistance-reversing agents on transporting activity of human canalicular multispecific organic anion transporter. Mol Pharmacol 56:1219-1228
-
(1999)
Mol Pharmacol
, vol.56
, pp. 1219-1228
-
-
Chen, Z.S.1
Kawabe, T.2
Ono, M.3
Aoki, S.4
Sumizawa, T.5
Furukawa, T.6
Uchiumi, T.7
Wada, M.8
Kuwano, M.9
Akiyama, S.I.10
-
18
-
-
33645868291
-
Characterization of mice lacking the multidrug resistance protein Mrp2 (Abcc2)
-
Chu X, Strauss JR, Mariano MA, Li J, Newton DJ, Cai X, Wang RW, Yabut J, Hartley DP, Evans DC, Evers R (2006) Characterization of mice lacking the multidrug resistance protein Mrp2 (Abcc2). J Pharmacol Exp Ther 317:579-589
-
(2006)
J Pharmacol Exp Ther
, vol.317
, pp. 579-589
-
-
Chu, X.1
Strauss, J.R.2
Mariano, M.A.3
Li, J.4
Newton, D.J.5
Cai, X.6
Wang, R.W.7
Yabut, J.8
Hartley, D.P.9
Evans, D.C.10
Evers, R.11
-
19
-
-
0030959378
-
Multispecific organic anion transporter is responsible for the biliary excretion of the camptothecin derivative irinotecan and its metabolites in rats
-
Chu XY, Kato Y, Niinuma K, Sudo KI, Hakusui H, Sugiyama Y (1997) Multispecific organic anion transporter is responsible for the biliary excretion of the camptothecin derivative irinotecan and its metabolites in rats. J Pharmacol Exp Ther 281:304-314
-
(1997)
J Pharmacol Exp Ther
, vol.281
, pp. 304-314
-
-
Chu, X.Y.1
Kato, Y.2
Niinuma, K.3
Sudo, K.I.4
Hakusui, H.5
Sugiyama, Y.6
-
20
-
-
1642330416
-
Transport of ethinylestradiol glucuronide and ethinylestradiol sulfate by the multidrug resistance proteins MRP1, MRP2, and MRP3
-
Chu XY, Huskey SE, Braun MP, Sarkadi B, Evans DC, Evers R (2004) Transport of ethinylestradiol glucuronide and ethinylestradiol sulfate by the multidrug resistance proteins MRP1, MRP2, and MRP3. J Pharmacol Exp Ther 309:156-164
-
(2004)
J Pharmacol Exp Ther
, vol.309
, pp. 156-164
-
-
Chu, X.Y.1
Huskey, S.E.2
Braun, M.P.3
Sarkadi, B.4
Evans, D.C.5
Evers, R.6
-
21
-
-
0027095653
-
Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line
-
Cole SPC, Bhardwaj G, Gerlach JH, Mackie JE, Grant CE, Almquist KC, Stewart AJ, Kurz EU, Duncan AMV, Deeley RG (1992) Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line. Science 258:1650-1654
-
(1992)
Science
, vol.258
, pp. 1650-1654
-
-
Cole, S.P.C.1
Bhardwaj, G.2
Gerlach, J.H.3
Mackie, J.E.4
Grant, C.E.5
Almquist, K.C.6
Stewart, A.J.7
Kurz, E.U.8
Duncan, A.M.V.9
Deeley, R.G.10
-
22
-
-
0035793123
-
Sequencing and tissue distribution of the canine MRP2 gene compared with MRP1 and MDR1
-
Conrad S, Viertelhaus A, Orzechowski A, Hoogstraate J, Gjellan K, Schrenk D, Kauffmann HM (2001) Sequencing and tissue distribution of the canine MRP2 gene compared with MRP1 and MDR1. Toxicology 156:81-91
-
(2001)
Toxicology
, vol.156
, pp. 81-91
-
-
Conrad, S.1
Viertelhaus, A.2
Orzechowski, A.3
Hoogstraate, J.4
Gjellan, K.5
Schrenk, D.6
Kauffmann, H.M.7
-
23
-
-
0033386105
-
Differential regulation of canalicular multispecific organic anion transporter (cMOAT) expression by the chemopreventive agent oltipraz in primary rat hepatocytes and in rat liver
-
Courtois A, Payen L, Vernhet L, Morel F, Guillouzo A, Fardel O (1999) Differential regulation of canalicular multispecific organic anion transporter (cMOAT) expression by the chemopreventive agent oltipraz in primary rat hepatocytes and in rat liver. Carcinogenesis 20:2327-2330
-
(1999)
Carcinogenesis
, vol.20
, pp. 2327-2330
-
-
Courtois, A.1
Payen, L.2
Vernhet, L.3
Morel, F.4
Guillouzo, A.5
Fardel, O.6
-
24
-
-
0345299165
-
Drug resistance and ATP-dependent conjugate transport mediated by the apical multidrug resistance protein, MRP2, permanently expressed in human and canine cells
-
Cui Y, König J, Buchholz U, Spring H, Leier I, Keppler D (1999) Drug resistance and ATP-dependent conjugate transport mediated by the apical multidrug resistance protein, MRP2, permanently expressed in human and canine cells. Mol Pharmacol 55:929-937
-
(1999)
Mol Pharmacol
, vol.55
, pp. 929-937
-
-
Cui, Y.1
König, J.2
Buchholz, U.3
Spring, H.4
Leier, I.5
Keppler, D.6
-
25
-
-
0034753042
-
Vectorial transport by double-transfected cells expressing the human uptake transporter SLC21A8 and the apical export pump ABCC2
-
Cui Y, König J, Keppler D (2001) Vectorial transport by double-transfected cells expressing the human uptake transporter SLC21A8 and the apical export pump ABCC2. Mol Pharmacol 60:934-943
-
(2001)
Mol Pharmacol
, vol.60
, pp. 934-943
-
-
Cui, Y.1
König, J.2
Keppler, D.3
-
26
-
-
0033987736
-
Mutation nomenclature extensions and suggestions to describe complex mutations: A discussion
-
den Dunnen JT, Antonarakis SE (2000) Mutation nomenclature extensions and suggestions to describe complex mutations: a discussion. Human Mutat 15:7-12
-
(2000)
Human Mutat
, vol.15
, pp. 7-12
-
-
den Dunnen, J.T.1
Antonarakis, S.E.2
-
27
-
-
0036329226
-
Organ-specific alterations in RAR alpha:RXR alpha abundance regulate rat Mrp2 (Abcc2) expression in obstructive cholestasis
-
Denson LA, Bohan A, Held MA, Boyer JL (2002) Organ-specific alterations in RAR alpha:RXR alpha abundance regulate rat Mrp2 (Abcc2) expression in obstructive cholestasis. Gastroenterology 123:599-607
-
(2002)
Gastroenterology
, vol.123
, pp. 599-607
-
-
Denson, L.A.1
Bohan, A.2
Held, M.A.3
Boyer, J.L.4
-
28
-
-
1842479142
-
Consequences of bile duct obstruction on intestinal expression and function of multidrug resistance-associated protein 2
-
Dietrich CG, Geier A, Salein N, Lammert F, Roeb E, Oude Elferink RP, Matern S, Gartung C (2004) Consequences of bile duct obstruction on intestinal expression and function of multidrug resistance-associated protein 2. Gastroenterology 126:1044-1053
-
(2004)
Gastroenterology
, vol.126
, pp. 1044-1053
-
-
Dietrich, C.G.1
Geier, A.2
Salein, N.3
Lammert, F.4
Roeb, E.5
Oude Elferink, R.P.6
Matern, S.7
Gartung, C.8
-
29
-
-
0034657167
-
Electron-microscopic demonstration of multidrug resistance protein 2 (Mrp2) retrieval from the canalicular membrane in response to hyperosmolarity and lipopolysaccharide
-
Dombrowski F, Kubitz R, Chittattu A, Wettstein M, Saha N, Häussinger D (2000) Electron-microscopic demonstration of multidrug resistance protein 2 (Mrp2) retrieval from the canalicular membrane in response to hyperosmolarity and lipopolysaccharide. Biochem J 348:183-188
-
(2000)
Biochem J
, vol.348
, pp. 183-188
-
-
Dombrowski, F.1
Kubitz, R.2
Chittattu, A.3
Wettstein, M.4
Saha, N.5
Häussinger, D.6
-
30
-
-
0034928631
-
Up-regulation of basolateral multidrug resistance protein 3 (Mrp3) in cholestatic rat liver
-
Donner MG, Keppler D (2001) Up-regulation of basolateral multidrug resistance protein 3 (Mrp3) in cholestatic rat liver. Hepatology 34:351-359
-
(2001)
Hepatology
, vol.34
, pp. 351-359
-
-
Donner, M.G.1
Keppler, D.2
-
31
-
-
0000552161
-
Chronic idiopathic jaundice with unidentified pigment in liver cells; a new clinicopathologic entity with report of 12 cases
-
Dubin IN, Johnson FB (1954) Chronic idiopathic jaundice with unidentified pigment in liver cells; a new clinicopathologic entity with report of 12 cases. Medicine (Baltimore) 33:155-179
-
(1954)
Medicine (Baltimore)
, vol.33
, pp. 155-179
-
-
Dubin, I.N.1
Johnson, F.B.2
-
32
-
-
0001308329
-
Drug export activity of the human canalicular multispecific organic anion transporter in polarized kidney MDCK cells expressing cMOAT (MRP2) cDNA
-
Evers R, Kool M, van Deemter L, Janssen H, Calafat J, Oomen LCJM, Paulusma CC, Oude Elferink RPJ, Baas F, Schinkel AH, Borst P (1998) Drug export activity of the human canalicular multispecific organic anion transporter in polarized kidney MDCK cells expressing cMOAT (MRP2) cDNA. J Clin Invest 101:1310-1319
-
(1998)
J Clin Invest
, vol.101
, pp. 1310-1319
-
-
Evers, R.1
Kool, M.2
van Deemter, L.3
Janssen, H.4
Calafat, J.5
Oomen, L.C.J.M.6
Paulusma, C.C.7
Oude Elferink, R.P.J.8
Baas, F.9
Schinkel, A.H.10
Borst, P.11
-
33
-
-
0024804064
-
Direct photoaffinity labeling of leukotriene binding sites
-
Falk E, Müller M, Huber M, Keppler D, Kurz G (1989) Direct photoaffinity labeling of leukotriene binding sites. Eur J Biochem 186:741-747
-
(1989)
Eur J Biochem
, vol.186
, pp. 741-747
-
-
Falk, E.1
Müller, M.2
Huber, M.3
Keppler, D.4
Kurz, G.5
-
34
-
-
0037163124
-
Role of the N-terminal transmembrane region of the multidrug resistance protein MRP2 in routing to the apical membrane in MDCKII cells
-
Fernandez SB, Hollo Z, Kern A, Bakos E, Fischer PA, Borst P, Evers R (2002) Role of the N-terminal transmembrane region of the multidrug resistance protein MRP2 in routing to the apical membrane in MDCKII cells. J Biol Chem 277:31048-31055
-
(2002)
J Biol Chem
, vol.277
, pp. 31048-31055
-
-
Fernandez, S.B.1
Hollo, Z.2
Kern, A.3
Bakos, E.4
Fischer, P.A.5
Borst, P.6
Evers, R.7
-
35
-
-
0026511550
-
Canalicular transport of reduced glutathione in normal and mutant Eisai hyperbilirubinemic rats
-
Fernandez-Checa JC, Takikawa H, Horie T, Ookhtens M, Kaplowitz N (1992) Canalicular transport of reduced glutathione in normal and mutant Eisai hyperbilirubinemic rats. J Biol Chem 267:1667-1673
-
(1992)
J Biol Chem
, vol.267
, pp. 1667-1673
-
-
Fernandez-Checa, J.C.1
Takikawa, H.2
Horie, T.3
Ookhtens, M.4
Kaplowitz, N.5
-
36
-
-
0034949811
-
Effects of ursodeoxycholic and cholic acid feeding on hepatocellular transporter expression in mouse liver
-
Fickert P, Zollner G, Fuchsbichler A, Stumptner C, Pojer C, Zenz R, Lammert F, Stieger B, Meier PJ, Zatloukal K, Denk H, Trauner M (2001) Effects of ursodeoxycholic and cholic acid feeding on hepatocellular transporter expression in mouse liver. Gastroenterology 121:170-183
-
(2001)
Gastroenterology
, vol.121
, pp. 170-183
-
-
Fickert, P.1
Zollner, G.2
Fuchsbichler, A.3
Stumptner, C.4
Pojer, C.5
Zenz, R.6
Lammert, F.7
Stieger, B.8
Meier, P.J.9
Zatloukal, K.10
Denk, H.11
Trauner, M.12
-
38
-
-
0033724658
-
The effect of rifampin treatment on intestinal expression of human MRP transporters
-
Fromm MF, Kauffmann HM, Fritz P, Burk O, Kroemer HK, Warzok RW, Eichelbaum M, Siegmund W, Schrenk D (2000) The effect of rifampin treatment on intestinal expression of human MRP transporters. Am J Pathol 157:1575-1580
-
(2000)
Am J Pathol
, vol.157
, pp. 1575-1580
-
-
Fromm, M.F.1
Kauffmann, H.M.2
Fritz, P.3
Burk, O.4
Kroemer, H.K.5
Warzok, R.W.6
Eichelbaum, M.7
Siegmund, W.8
Schrenk, D.9
-
40
-
-
0036070539
-
Regulation of expression of the multidrug resistance-associated protein 2 (MRP2) and its role in drug disposition
-
Gerk PM, Vore M (2002) Regulation of expression of the multidrug resistance-associated protein 2 (MRP2) and its role in drug disposition. J Pharmacol Exp Ther 302:407-415
-
(2002)
J Pharmacol Exp Ther
, vol.302
, pp. 407-415
-
-
Gerk, P.M.1
Vore, M.2
-
41
-
-
0032702726
-
The orphan human pregnane X receptor mediates the transcriptional activation of CYP3A4 by rifampicin through a distal enhancer module
-
Goodwin B, Hodgson E, Liddle C (1999) The orphan human pregnane X receptor mediates the transcriptional activation of CYP3A4 by rifampicin through a distal enhancer module. Mol Pharmacol 56:1329-1339
-
(1999)
Mol Pharmacol
, vol.56
, pp. 1329-1339
-
-
Goodwin, B.1
Hodgson, E.2
Liddle, C.3
-
42
-
-
0034958172
-
Effect of phenobarbital on the expression of bile salt and organic anion transporters of rat liver
-
Hagenbuch N, Reichel C, Stieger B, Cattori V, Fattinger KE, Landmann L, Meier PJ, Kullak-Ublick GA (2001) Effect of phenobarbital on the expression of bile salt and organic anion transporters of rat liver. J Hepatol 34:881-887
-
(2001)
J Hepatol
, vol.34
, pp. 881-887
-
-
Hagenbuch, N.1
Reichel, C.2
Stieger, B.3
Cattori, V.4
Fattinger, K.E.5
Landmann, L.6
Meier, P.J.7
Kullak-Ublick, G.A.8
-
43
-
-
0033214154
-
Purification of the human apical conjugate export pump MRP2. Reconstitution and functional characterization as substrate-stimulated ATPase
-
Hagmann W, Nies AT, König J, Frey M, Zentgraf H, Keppler D (1999) Purification of the human apical conjugate export pump MRP2. Reconstitution and functional characterization as substrate-stimulated ATPase. Eur J Biochem 265:281-289
-
(1999)
Eur J Biochem
, vol.265
, pp. 281-289
-
-
Hagmann, W.1
Nies, A.T.2
König, J.3
Frey, M.4
Zentgraf, H.5
Keppler, D.6
-
44
-
-
0036347975
-
Reconstitution of transport-active multidrug resistance protein 2 (MRP2; ABCC2) in proteoliposomes
-
Hagmann W, Schubert J, König J, Keppler D (2002) Reconstitution of transport-active multidrug resistance protein 2 (MRP2; ABCC2) in proteoliposomes. Biol Chem 383:1001-1009
-
(2002)
Biol Chem
, vol.383
, pp. 1001-1009
-
-
Hagmann, W.1
Schubert, J.2
König, J.3
Keppler, D.4
-
45
-
-
1242335471
-
The MRP-related and BCRP/ABCG2 multidrug resistance proteins: Biology, substrate specificity and regulation
-
Haimeur A, Conseil G, Deeley RG, Cole SP (2004) The MRP-related and BCRP/ABCG2 multidrug resistance proteins: biology, substrate specificity and regulation. Curr Drug Metab 5:21-53
-
(2004)
Curr Drug Metab
, vol.5
, pp. 21-53
-
-
Haimeur, A.1
Conseil, G.2
Deeley, R.G.3
Cole, S.P.4
-
46
-
-
0035877805
-
-
Harris MJ, Kuwano M, Webb M, Board 2001 Identification of the apical membrane-targeting signal of the multidrug resistance-associated protein 2 (MRP2/MOAT). J Biol Chem 276:20876-20881
-
Harris MJ, Kuwano M, Webb M, Board PG (2001) Identification of the apical membrane-targeting signal of the multidrug resistance-associated protein 2 (MRP2/MOAT). J Biol Chem 276:20876-20881
-
-
-
-
47
-
-
0036830243
-
Trafficking and functional defects by mutations of the ATP-binding domains in MRP2 in patients with Dubin-Johnson syndrome
-
Hashimoto K, Uchiumi T, Konno T, Ebihara T, Nakamura T, Wada M, Sakisaka S, Maniwa F, Amachi T, Ueda K, Kuwano M (2002) Trafficking and functional defects by mutations of the ATP-binding domains in MRP2 in patients with Dubin-Johnson syndrome. Hepatology 36:1236-1245
-
(2002)
Hepatology
, vol.36
, pp. 1236-1245
-
-
Hashimoto, K.1
Uchiumi, T.2
Konno, T.3
Ebihara, T.4
Nakamura, T.5
Wada, M.6
Sakisaka, S.7
Maniwa, F.8
Amachi, T.9
Ueda, K.10
Kuwano, M.11
-
48
-
-
0037436789
-
C-terminal phosphorylation of MRP2 modulates its interaction with PDZ proteins
-
Hegedus T, Sessler T, Scott R, Thelin W, Bakos E, Varadi A, Szabo K, Homolya L, Milgram SL, Sarkadi B (2003) C-terminal phosphorylation of MRP2 modulates its interaction with PDZ proteins. Biochem Biophys Res Commun 302:454-461
-
(2003)
Biochem Biophys Res Commun
, vol.302
, pp. 454-461
-
-
Hegedus, T.1
Sessler, T.2
Scott, R.3
Thelin, W.4
Bakos, E.5
Varadi, A.6
Szabo, K.7
Homolya, L.8
Milgram, S.L.9
Sarkadi, B.10
-
49
-
-
0034046035
-
Increased expression of an ATP-binding cassette superfamily transporter, multidrug resistance protein 2, in human colorectal carcinomas
-
Hinoshita E, Uchiumi T, Taguchi K, Kinukawa N, Tsuneyoshi M, Maehara Y, Sugimachi K, Kuwano M (2000) Increased expression of an ATP-binding cassette superfamily transporter, multidrug resistance protein 2, in human colorectal carcinomas. Clin Cancer Res 6:2401-2407
-
(2000)
Clin Cancer Res
, vol.6
, pp. 2401-2407
-
-
Hinoshita, E.1
Uchiumi, T.2
Taguchi, K.3
Kinukawa, N.4
Tsuneyoshi, M.5
Maehara, Y.6
Sugimachi, K.7
Kuwano, M.8
-
50
-
-
3543004158
-
Characterization of the cellular localization, expression level, and function of SNP variants of MRP2/ABCC2
-
Hirouchi M, Suzuki H, Itoda M, Ozawa S, Sawada J, Ieiri I, Ohtsubo K, Sugiyama Y (2004) Characterization of the cellular localization, expression level, and function of SNP variants of MRP2/ABCC2. Pharm Res 21:742-748
-
(2004)
Pharm Res
, vol.21
, pp. 742-748
-
-
Hirouchi, M.1
Suzuki, H.2
Itoda, M.3
Ozawa, S.4
Sawada, J.5
Ieiri, I.6
Ohtsubo, K.7
Sugiyama, Y.8
-
51
-
-
0842334728
-
Identification of novel single nucleotide polymorphisms in the multidrug resistance-associated protein 2 (MRP2)
-
abstract
-
Ho RH, Kim RB (2003) Identification of novel single nucleotide polymorphisms in the multidrug resistance-associated protein 2 (MRP2). Proc Am Assoc Cancer Res 44:4663 (abstract)
-
(2003)
Proc Am Assoc Cancer Res
, vol.44
, pp. 4663
-
-
Ho, R.H.1
Kim, R.B.2
-
52
-
-
33646001745
-
Expression of the multidrug transporter MRP2 in the bloodbrain barrier after pilocarpine-induced seizures in rats
-
Hoffmann K, Gastens AM, Volk HA, Loscher W (2006) Expression of the multidrug transporter MRP2 in the bloodbrain barrier after pilocarpine-induced seizures in rats. Epilepsy Res 69:1-14
-
(2006)
Epilepsy Res
, vol.69
, pp. 1-14
-
-
Hoffmann, K.1
Gastens, A.M.2
Volk, H.A.3
Loscher, W.4
-
53
-
-
0033152212
-
Antifolate resistance mediated by the multidrug resistance proteins MRP1 and MRP2
-
Hooijberg JH, Broxterman HJ, Kool M, Assaraf YG, Peters GJ, Noordhuis P, Scheper RJ, Borst P, Pinedo HM, Jansen G (1999) Antifolate resistance mediated by the multidrug resistance proteins MRP1 and MRP2. Cancer Res 59:2532-2535
-
(1999)
Cancer Res
, vol.59
, pp. 2532-2535
-
-
Hooijberg, J.H.1
Broxterman, H.J.2
Kool, M.3
Assaraf, Y.G.4
Peters, G.J.5
Noordhuis, P.6
Scheper, R.J.7
Borst, P.8
Pinedo, H.M.9
Jansen, G.10
-
54
-
-
0026519238
-
A new rat mutant with chronic conjugated hyperbilirubinemia and renal glomerular lesions
-
Hosokawa S, Tagaya O, Mikami T, Nozaki Y, Kawaguchi A, Yamatsu K, Shamoto M (1992) A new rat mutant with chronic conjugated hyperbilirubinemia and renal glomerular lesions. Lab Anim Sci 42:27-34
-
(1992)
Lab Anim Sci
, vol.42
, pp. 27-34
-
-
Hosokawa, S.1
Tagaya, O.2
Mikami, T.3
Nozaki, Y.4
Kawaguchi, A.5
Yamatsu, K.6
Shamoto, M.7
-
55
-
-
0023185436
-
Hereditary defect of hepatobiliary cysteinyl leukotriene elimination in mutant rats with defective hepatic anion excretion
-
Huber M, Guhlmann A, Jansen PL, Keppler D (1987) Hereditary defect of hepatobiliary cysteinyl leukotriene elimination in mutant rats with defective hepatic anion excretion. Hepatology 7:224-228
-
(1987)
Hepatology
, vol.7
, pp. 224-228
-
-
Huber, M.1
Guhlmann, A.2
Jansen, P.L.3
Keppler, D.4
-
56
-
-
21044455712
-
A mutation in the drug transporter gene ABCC2 associated with impaired methotrexate elimination
-
Hulot JS, Villard E, Maguy A, Morel V, Mir L, Tostivint I, William-Faltaos D, Fernandez C, Hatem S, Deray G, Komajda M, Leblond V, Lechat P (2005) A mutation in the drug transporter gene ABCC2 associated with impaired methotrexate elimination. Pharmacogenet Genomics 15:277-285
-
(2005)
Pharmacogenet Genomics
, vol.15
, pp. 277-285
-
-
Hulot, J.S.1
Villard, E.2
Maguy, A.3
Morel, V.4
Mir, L.5
Tostivint, I.6
William-Faltaos, D.7
Fernandez, C.8
Hatem, S.9
Deray, G.10
Komajda, M.11
Leblond, V.12
Lechat, P.13
-
57
-
-
0025132673
-
ATP-dependent primary active transport of cysteinyl leukotrienes across liver canalicular membrane: Role of the ATP-dependent transport system for glutathione S-conjugates
-
Ishikawa T, Müller M, Klünemann C, Schaub T, Keppler D (1990) ATP-dependent primary active transport of cysteinyl leukotrienes across liver canalicular membrane: role of the ATP-dependent transport system for glutathione S-conjugates. J Biol Chem 265:19279-19286
-
(1990)
J Biol Chem
, vol.265
, pp. 19279-19286
-
-
Ishikawa, T.1
Müller, M.2
Klünemann, C.3
Schaub, T.4
Keppler, D.5
-
58
-
-
0030951558
-
Temocaprilat, a novel angiotensin-converting enzyme inhibitor, is excreted in bile via an ATP-dependent active transporter (cMOAT) that is deficient in Eisai hyperbilirubinemic mutant rats (EHBR)
-
Ishizuka H, Konno K, Naganuma H, Sasahara K, Kawahara Y, Niinuma K, Suzuki H, Sugiyama Y (1997) Temocaprilat, a novel angiotensin-converting enzyme inhibitor, is excreted in bile via an ATP-dependent active transporter (cMOAT) that is deficient in Eisai hyperbilirubinemic mutant rats (EHBR). J Pharmacol Exp Ther 280:1304-1311
-
(1997)
J Pharmacol Exp Ther
, vol.280
, pp. 1304-1311
-
-
Ishizuka, H.1
Konno, K.2
Naganuma, H.3
Sasahara, K.4
Kawahara, Y.5
Niinuma, K.6
Suzuki, H.7
Sugiyama, Y.8
-
59
-
-
0027525576
-
The peroxisome proliferator-activated receptor:retinoid X receptor heterodimer is activated by fatty acids and fibrate hypolipidaemic drugs
-
Issemann I, Prince RA, Tugwood JD, Green S (1993) The peroxisome proliferator-activated receptor:retinoid X receptor heterodimer is activated by fatty acids and fibrate hypolipidaemic drugs. J Mol Endocrinol 11:37-47
-
(1993)
J Mol Endocrinol
, vol.11
, pp. 37-47
-
-
Issemann, I.1
Prince, R.A.2
Tugwood, J.D.3
Green, S.4
-
60
-
-
0031031247
-
Molecular cloning of canalicular multispecific organic anion transporter defective in EHBR
-
Ito K, Suzuki H, Hirohashi T, Kume K, Shimizu T, Sugiyama Y (1997) Molecular cloning of canalicular multispecific organic anion transporter defective in EHBR. Am J Physiol 272:G16-G22
-
(1997)
Am J Physiol
, vol.272
-
-
Ito, K.1
Suzuki, H.2
Hirohashi, T.3
Kume, K.4
Shimizu, T.5
Sugiyama, Y.6
-
61
-
-
0031916830
-
Functional analysis of a canalicular multispecific organic anion transporter cloned from rat liver
-
Ito K, Suzuki H, Hirohashi T, Kume K, Shimizu T, Sugiyama Y (1998) Functional analysis of a canalicular multispecific organic anion transporter cloned from rat liver. J Biol Chem 273:1684-1688
-
(1998)
J Biol Chem
, vol.273
, pp. 1684-1688
-
-
Ito, K.1
Suzuki, H.2
Hirohashi, T.3
Kume, K.4
Shimizu, T.5
Sugiyama, Y.6
-
62
-
-
0035103009
-
Polymorphisms of the ABC transporter genes, MDR1, MRP1 and MRP2/cMOAT, in healthy Japanese subjects
-
Ito S, Ieiri I, Tanabe M, Suzuki A, Higuchi S, Otsubo K (2001) Polymorphisms of the ABC transporter genes, MDR1, MRP1 and MRP2/cMOAT, in healthy Japanese subjects. Pharmacogenetics 11:175-184
-
(2001)
Pharmacogenetics
, vol.11
, pp. 175-184
-
-
Ito, S.1
Ieiri, I.2
Tanabe, M.3
Suzuki, A.4
Higuchi, S.5
Otsubo, K.6
-
63
-
-
0036206860
-
Polymorphisms in the ABCC2 (cMOAT/MRP2) gene found in 72 established cell lines derived from Japanese individuals: An association between single nucleotide polymorphisms in the 5′-untranslated region and exon 28
-
Itoda M, Saito Y, Soyama A, Saeki M, Murayama N, Ishida S, Sai K, Nagano M, Suzuki H, Sugiyama Y, Ozawa S, Sawada J (2002) Polymorphisms in the ABCC2 (cMOAT/MRP2) gene found in 72 established cell lines derived from Japanese individuals: an association between single nucleotide polymorphisms in the 5′-untranslated region and exon 28. Drug Metab Dispos 30:363-364
-
(2002)
Drug Metab Dispos
, vol.30
, pp. 363-364
-
-
Itoda, M.1
Saito, Y.2
Soyama, A.3
Saeki, M.4
Murayama, N.5
Ishida, S.6
Sai, K.7
Nagano, M.8
Suzuki, H.9
Sugiyama, Y.10
Ozawa, S.11
Sawada, J.12
-
64
-
-
0021804301
-
Hereditary chronic conjugated hyperbilirubinemia in mutants rats caused by defective hepatic anion transport
-
Jansen PLM, Peters WHM, Lamers WH (1985) Hereditary chronic conjugated hyperbilirubinemia in mutants rats caused by defective hepatic anion transport. Hepatology 5:573-579
-
(1985)
Hepatology
, vol.5
, pp. 573-579
-
-
Jansen, P.L.M.1
Peters, W.H.M.2
Lamers, W.H.3
-
65
-
-
0036365007
-
Transport of leukotriene C4 and structurally related conjugates
-
Jedlitschky G, Keppler D (2002) Transport of leukotriene C4 and structurally related conjugates. Vitam Horm 64:153-184
-
(2002)
Vitam Horm
, vol.64
, pp. 153-184
-
-
Jedlitschky, G.1
Keppler, D.2
-
66
-
-
0028001416
-
-
Jedlitschky G, Leier I, Buchholz U, Center M, Keppler D (1994) ATP-dependent transport of glutathione S-conjugates by the multidrug resistance-associated protein. Cancer Res 54:4833-4836
-
Jedlitschky G, Leier I, Buchholz U, Center M, Keppler D (1994) ATP-dependent transport of glutathione S-conjugates by the multidrug resistance-associated protein. Cancer Res 54:4833-4836
-
-
-
-
67
-
-
0030668526
-
ATP-dependent transport of bilirubin glucuronides by the multidrug resistance protein MRP1 and its hepatocyte canalicular isoform MRP2
-
Jedlitschky G, Leier I, Buchholz U, Hummel-Eisenbeiss J, Burchell B, Keppler D (1997) ATP-dependent transport of bilirubin glucuronides by the multidrug resistance protein MRP1 and its hepatocyte canalicular isoform MRP2. Biochem J 327:305-310
-
(1997)
Biochem J
, vol.327
, pp. 305-310
-
-
Jedlitschky, G.1
Leier, I.2
Buchholz, U.3
Hummel-Eisenbeiss, J.4
Burchell, B.5
Keppler, D.6
-
68
-
-
0036303955
-
Regulation of rat multidrug resistance protein 2 by classes of prototypical microsomal enzyme inducers that activate distinct transcription pathways
-
Johnson DR, Klaassen CD (2002) Regulation of rat multidrug resistance protein 2 by classes of prototypical microsomal enzyme inducers that activate distinct transcription pathways. Toxicol Sci 67:182-189
-
(2002)
Toxicol Sci
, vol.67
, pp. 182-189
-
-
Johnson, D.R.1
Klaassen, C.D.2
-
69
-
-
23944487498
-
The role of protein synthesis and degradation in the post-transcriptional regulation of rat multidrug resistance-associated protein 2 (Mrp2, Abcc2)
-
Jones BR, Li W, Cao J, Hoffman TA, Gerk PM, Vore M (2005) The role of protein synthesis and degradation in the post-transcriptional regulation of rat multidrug resistance-associated protein 2 (Mrp2, Abcc2). Mol Pharmacol 68:701-710
-
(2005)
Mol Pharmacol
, vol.68
, pp. 701-710
-
-
Jones, B.R.1
Li, W.2
Cao, J.3
Hoffman, T.A.4
Gerk, P.M.5
Vore, M.6
-
70
-
-
0032545447
-
A splice mutation in the human canalicular multispecific organic anion transporter gene causes Dubin-Johnson syndrome
-
Kajihara S, Hisatomi A, Mizuta T, Hara T, Ozaki I, Wada I, Yamamoto K (1998) A splice mutation in the human canalicular multispecific organic anion transporter gene causes Dubin-Johnson syndrome. Biochem Biophys Res Comm 253:454-457
-
(1998)
Biochem Biophys Res Comm
, vol.253
, pp. 454-457
-
-
Kajihara, S.1
Hisatomi, A.2
Mizuta, T.3
Hara, T.4
Ozaki, I.5
Wada, I.6
Yamamoto, K.7
-
71
-
-
0032769284
-
Transport of monoglucuronosyl and bisglucuronosyl bilirubin by recombinant human and rat multidrug resistance protein 2
-
Kamisako T, Leier I, Cui Y, König J, Buchholz U, Hummel-Eisenbeiss J, Keppler D (1999) Transport of monoglucuronosyl and bisglucuronosyl bilirubin by recombinant human and rat multidrug resistance protein 2. Hepatology 30:485-490
-
(1999)
Hepatology
, vol.30
, pp. 485-490
-
-
Kamisako, T.1
Leier, I.2
Cui, Y.3
König, J.4
Buchholz, U.5
Hummel-Eisenbeiss, J.6
Keppler, D.7
-
72
-
-
0029986408
-
Absence of the canalicular isoform of the MRP gene-encoded conjugate export pump from the hepatocytes in Dubin-Johnson syndrome
-
Kartenbeck J, Leuschner U, Mayer R, Keppler D (1996) Absence of the canalicular isoform of the MRP gene-encoded conjugate export pump from the hepatocytes in Dubin-Johnson syndrome. Hepatology 23:1061-1066
-
(1996)
Hepatology
, vol.23
, pp. 1061-1066
-
-
Kartenbeck, J.1
Leuschner, U.2
Mayer, R.3
Keppler, D.4
-
73
-
-
0037169551
-
Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor
-
Kast HR, Goodwin B, Tarr PT, Jones SA, Anisfeld AM, Stoltz CM, Tontonoz P, Kliewer S, Willson TM, Edwards PA (2002) Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor. J Biol Chem 277:2908-2915
-
(2002)
J Biol Chem
, vol.277
, pp. 2908-2915
-
-
Kast, H.R.1
Goodwin, B.2
Tarr, P.T.3
Jones, S.A.4
Anisfeld, A.M.5
Stoltz, C.M.6
Tontonoz, P.7
Kliewer, S.8
Willson, T.M.9
Edwards, P.A.10
-
74
-
-
0032540101
-
Sequence analysis and functional characterization of the 5′-flanking region of the rat multidrug resistance protein 2 (mrp2) gene
-
Kauffmann HM, Schrenk D (1998) Sequence analysis and functional characterization of the 5′-flanking region of the rat multidrug resistance protein 2 (mrp2) gene. Biochem Biophys Res Commun 245:325-331
-
(1998)
Biochem Biophys Res Commun
, vol.245
, pp. 325-331
-
-
Kauffmann, H.M.1
Schrenk, D.2
-
75
-
-
0030817669
-
Induction of cMrp/cMoat gene expression by cisplatin, 2-acetylaminofluorene, or cycloheximide in rat hepatocytes
-
Kauffmann HM, Keppler D, Kartenbeck J, Schrenk D (1997) Induction of cMrp/cMoat gene expression by cisplatin, 2-acetylaminofluorene, or cycloheximide in rat hepatocytes. Hepatology 26:980-985
-
(1997)
Hepatology
, vol.26
, pp. 980-985
-
-
Kauffmann, H.M.1
Keppler, D.2
Kartenbeck, J.3
Schrenk, D.4
-
76
-
-
0032432662
-
Induction of hepatic mrp2 (cmrp/cmoat) gene expression in nonhuman primates treated with rifampicin or tamoxifen
-
Kauffmann HM, Keppler D, Gant TW, Schrenk D (1998) Induction of hepatic mrp2 (cmrp/cmoat) gene expression in nonhuman primates treated with rifampicin or tamoxifen. Arch Toxicol 72:763-768
-
(1998)
Arch Toxicol
, vol.72
, pp. 763-768
-
-
Kauffmann, H.M.1
Keppler, D.2
Gant, T.W.3
Schrenk, D.4
-
77
-
-
1542406588
-
ATP-dependent transport of a novel thromboxane A2 receptor antagonist, [2-(4-chlorophenyl-sulfonylaminomethyl) indan-5-yl]acetate (Z-335) and its xenobiotic taurine conjugate (Z-335-Tau) by rat bile canalicular membrane vesicles
-
Kawabata Y, Kamada E, Furuta S, Takei M, Kurimoto T, Okudaira K, Nishigaki R (2004) ATP-dependent transport of a novel thromboxane A2 receptor antagonist, [2-(4-chlorophenyl-sulfonylaminomethyl) indan-5-yl]acetate (Z-335) and its xenobiotic taurine conjugate (Z-335-Tau) by rat bile canalicular membrane vesicles. Pharm Res 21:467-475
-
(2004)
Pharm Res
, vol.21
, pp. 467-475
-
-
Kawabata, Y.1
Kamada, E.2
Furuta, S.3
Takei, M.4
Kurimoto, T.5
Okudaira, K.6
Nishigaki, R.7
-
78
-
-
0032781499
-
Enhanced transport of anticancer agents and leukotriene C4 by the human canalicular multi-specific organic anion transporter (cMOAT/MRP2)
-
Kawabe T, Chen ZS, Wada M, Uchiumi T, Ono M, Akiyama S, Kuwano M (1999) Enhanced transport of anticancer agents and leukotriene C4 by the human canalicular multi-specific organic anion transporter (cMOAT/MRP2). FEBS Lett 456:327-331
-
(1999)
FEBS Lett
, vol.456
, pp. 327-331
-
-
Kawabe, T.1
Chen, Z.S.2
Wada, M.3
Uchiumi, T.4
Ono, M.5
Akiyama, S.6
Kuwano, M.7
-
79
-
-
0033652766
-
Impaired protein maturation of the conjugate export pump multidrug resistance protein 2 as a consequence of a deletion mutation in Dubin-Johnson syndrome
-
Keitel V, Kartenbeck J, Nies AT, Spring H, Brom M, Keppler D (2000) Impaired protein maturation of the conjugate export pump multidrug resistance protein 2 as a consequence of a deletion mutation in Dubin-Johnson syndrome. Hepatology 32:1317-1328
-
(2000)
Hepatology
, vol.32
, pp. 1317-1328
-
-
Keitel, V.1
Kartenbeck, J.2
Nies, A.T.3
Spring, H.4
Brom, M.5
Keppler, D.6
-
80
-
-
0037229540
-
A common Dubin-Johnson syndrome mutation impairs protein maturation and transport activity of MRP2 (ABCC2)
-
Keitel V, Nies AT, Brom M, Hummel-Eisenbeiss J, Spring H, Keppler D (2003) A common Dubin-Johnson syndrome mutation impairs protein maturation and transport activity of MRP2 (ABCC2). Am J Physiol Gasterointest Liver Physiol 284:G165-G174
-
(2003)
Am J Physiol Gasterointest Liver Physiol
, vol.284
-
-
Keitel, V.1
Nies, A.T.2
Brom, M.3
Hummel-Eisenbeiss, J.4
Spring, H.5
Keppler, D.6
-
81
-
-
30144440911
-
Uptake and efflux transporters for conjugates in human hepatocytes
-
Keppler D (2005) Uptake and efflux transporters for conjugates in human hepatocytes. Methods Enzymol 400:531-542
-
(2005)
Methods Enzymol
, vol.400
, pp. 531-542
-
-
Keppler, D.1
-
82
-
-
0029849789
-
The canalicular conjugate export pump encoded by the cmrp/cmoat gene
-
Boyer JL, Ockner RK eds, Saunders, Philadelphia, pp
-
Keppler D, Kartenbeck J (1996) The canalicular conjugate export pump encoded by the cmrp/cmoat gene. In: Boyer JL, Ockner RK (eds) Progress in liver diseases. Saunders, Philadelphia, pp 55-67
-
(1996)
Progress in liver diseases
, pp. 55-67
-
-
Keppler, D.1
Kartenbeck, J.2
-
83
-
-
0031160517
-
Expression and localization of the conjugate export pump encoded by the MRP2 (cMRP/cMOAT) gene in liver
-
Keppler D, König J (1997) Expression and localization of the conjugate export pump encoded by the MRP2 (cMRP/cMOAT) gene in liver. FASEB J 11:509-516
-
(1997)
FASEB J
, vol.11
, pp. 509-516
-
-
Keppler, D.1
König, J.2
-
84
-
-
0036648878
-
Radixin deficiency causes conjugated hyperbilirubinemia with loss of Mrp2 from bile canalicular membranes
-
Kikuchi S, Hata M, Fukumoto K, Yamane Y, Matsui T, Tamura A, Yonemura S, Yamagishi H, Keppler D, Tsukita S (2002) Radixin deficiency causes conjugated hyperbilirubinemia with loss of Mrp2 from bile canalicular membranes. Nat Genet 31:320-325
-
(2002)
Nat Genet
, vol.31
, pp. 320-325
-
-
Kikuchi, S.1
Hata, M.2
Fukumoto, K.3
Yamane, Y.4
Matsui, T.5
Tamura, A.6
Yonemura, S.7
Yamagishi, H.8
Keppler, D.9
Tsukita, S.10
-
85
-
-
0032498303
-
An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway
-
Kliewer SA, Moore JT, Wade L, Staudinger JL, Watson MA, Jones SA, McKee DD, Oliver BB, Willson TM, Zetterstrom RH, Perlmann T, Lehmann JM (1998) An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway. Cell 92:73-82
-
(1998)
Cell
, vol.92
, pp. 73-82
-
-
Kliewer, S.A.1
Moore, J.T.2
Wade, L.3
Staudinger, J.L.4
Watson, M.A.5
Jones, S.A.6
McKee, D.D.7
Oliver, B.B.8
Willson, T.M.9
Zetterstrom, R.H.10
Perlmann, T.11
Lehmann, J.M.12
-
86
-
-
0032884024
-
PDZK1, a novel PDZ domain-containing protein up-regulated in carcinomas and mapped to chromosome 1q21, interacts with cMOAT (MRP2), the multidrug resistance-associated protein
-
Kocher O, Comella N, Gilchrist A, Pal R, Tognazzi K, Brown LF, Knoll JH (1999) PDZK1, a novel PDZ domain-containing protein up-regulated in carcinomas and mapped to chromosome 1q21, interacts with cMOAT (MRP2), the multidrug resistance-associated protein. Lab Invest 79:1161-1170
-
(1999)
Lab Invest
, vol.79
, pp. 1161-1170
-
-
Kocher, O.1
Comella, N.2
Gilchrist, A.3
Pal, R.4
Tognazzi, K.5
Brown, L.F.6
Knoll, J.H.7
-
87
-
-
0037315288
-
Targeted disruption of the PDZK1 gene by homologous recombination
-
Kocher O, Pal R, Roberts M, Cirovic C, Gilchrist A (2003) Targeted disruption of the PDZK1 gene by homologous recombination. Mol Cell Biol 23:1175-1180
-
(2003)
Mol Cell Biol
, vol.23
, pp. 1175-1180
-
-
Kocher, O.1
Pal, R.2
Roberts, M.3
Cirovic, C.4
Gilchrist, A.5
-
88
-
-
0242690430
-
Changes in the expression and localization of hepatocellular transporters and radixin in primary biliary cirrhosis
-
Kojima H, Nies AT, König J, Hagmann W, Spring H, Uemura M, Fukui H, Keppler D (2003) Changes in the expression and localization of hepatocellular transporters and radixin in primary biliary cirrhosis. J Hepatol 39:693-702
-
(2003)
J Hepatol
, vol.39
, pp. 693-702
-
-
Kojima, H.1
Nies, A.T.2
König, J.3
Hagmann, W.4
Spring, H.5
Uemura, M.6
Fukui, H.7
Keppler, D.8
-
89
-
-
0344927562
-
Conjugate export pumps of the multidrug resistance protein (MRP) family: Localization, substrate specificity, and MRP2-mediated drug resistance
-
König J, Nies AT, Cui Y, Leier I, Keppler D (1999) Conjugate export pumps of the multidrug resistance protein (MRP) family: localization, substrate specificity, and MRP2-mediated drug resistance. Biochim Biophys Acta 1461:377-394
-
(1999)
Biochim Biophys Acta
, vol.1461
, pp. 377-394
-
-
König, J.1
Nies, A.T.2
Cui, Y.3
Leier, I.4
Keppler, D.5
-
90
-
-
0032926354
-
Characterization of the human multidrug resistance protein isoform MRP3 localized to the basolateral hepatocyte membrane
-
König J, Rost D, Cui Y, Keppler D (1999) Characterization of the human multidrug resistance protein isoform MRP3 localized to the basolateral hepatocyte membrane. Hepatology 29:1156-1163
-
(1999)
Hepatology
, vol.29
, pp. 1156-1163
-
-
König, J.1
Rost, D.2
Cui, Y.3
Keppler, D.4
-
91
-
-
85163548581
-
MRP2, the apical export pump for anionic conjugates
-
Holland IB, Kuchler K, Higgins C, Cole SPC eds, Academic, London, pp
-
König J, Nies AT, Cui Y, Keppler D (2003) MRP2, the apical export pump for anionic conjugates. In: Holland IB, Kuchler K, Higgins C, Cole SPC (eds) ABC proteins: from bacteria to man. Academic, London, pp 423-443
-
(2003)
ABC proteins: From bacteria to man
, pp. 423-443
-
-
König, J.1
Nies, A.T.2
Cui, Y.3
Keppler, D.4
-
92
-
-
18644378003
-
Expression and localization of human multidrug resistance protein (ABCC) family members in pancreatic carcinoma
-
König J, Hartel M, Nies AT, Martignoni ME, Guo J, Büchler MW, Friess H, Keppler D (2005) Expression and localization of human multidrug resistance protein (ABCC) family members in pancreatic carcinoma. Int J Cancer 115:359-367
-
(2005)
Int J Cancer
, vol.115
, pp. 359-367
-
-
König, J.1
Hartel, M.2
Nies, A.T.3
Martignoni, M.E.4
Guo, J.5
Büchler, M.W.6
Friess, H.7
Keppler, D.8
-
93
-
-
0037927606
-
Identification of domains participating in the substrate specificity and subcellular localization of the multidrug resistance proteins MRP1 and MRP2
-
Konno T, Ebihara T, Hisaeda K, Uchiumi T, Nakamura T, Shirakusa T, Kuwano M, Wada M (2003) Identification of domains participating in the substrate specificity and subcellular localization of the multidrug resistance proteins MRP1 and MRP2. J Biol Chem 278:22908-22917
-
(2003)
J Biol Chem
, vol.278
, pp. 22908-22917
-
-
Konno, T.1
Ebihara, T.2
Hisaeda, K.3
Uchiumi, T.4
Nakamura, T.5
Shirakusa, T.6
Kuwano, M.7
Wada, M.8
-
94
-
-
13044294031
-
MRP3, an organic anion transporter able to transport anti-cancer drugs
-
Kool M, van der Linden M, de Haas M, Scheffer GL, de Vree JM, Smith AJ, Jansen G, Peters GJ, Ponne N, Scheper RJ, Elferink RP, Baas F, Borst P (1999) MRP3, an organic anion transporter able to transport anti-cancer drugs. Proc Natl Acad Sci USA 96:6914-6919
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 6914-6919
-
-
Kool, M.1
van der Linden, M.2
de Haas, M.3
Scheffer, G.L.4
de Vree, J.M.5
Smith, A.J.6
Jansen, G.7
Peters, G.J.8
Ponne, N.9
Scheper, R.J.10
Elferink, R.P.11
Baas, F.12
Borst, P.13
-
95
-
-
25144494314
-
Human hepatobiliary transport of organic anions analyzed by quadruple-transfected cells
-
Kopplow K, Letschert K, König J, Walter B, Keppler D (2005) Human hepatobiliary transport of organic anions analyzed by quadruple-transfected cells. Mol Pharmacol 68:1031-1038
-
(2005)
Mol Pharmacol
, vol.68
, pp. 1031-1038
-
-
Kopplow, K.1
Letschert, K.2
König, J.3
Walter, B.4
Keppler, D.5
-
96
-
-
0345724724
-
The MRP family of drug efflux pumps
-
Kruh GD, Belinsky MG (2003) The MRP family of drug efflux pumps. Oncogene 22:7537-7552
-
(2003)
Oncogene
, vol.22
, pp. 7537-7552
-
-
Kruh, G.D.1
Belinsky, M.G.2
-
97
-
-
0030731742
-
Osmodependent dynamic localization of the multidrug resistance protein 2 in the rat hepatocyte canalicular membrane
-
Kubitz R, D'Urso D, Keppler D, Häussinger D (1997) Osmodependent dynamic localization of the multidrug resistance protein 2 in the rat hepatocyte canalicular membrane. Gastroenterology 113:1438-1442
-
(1997)
Gastroenterology
, vol.113
, pp. 1438-1442
-
-
Kubitz, R.1
D'Urso, D.2
Keppler, D.3
Häussinger, D.4
-
98
-
-
0033564937
-
Dexamethasone- and osmolarity-dependent expression of the multidrug-resistance protein 2 in cultured rat hepatocytes
-
Kubitz R, Warskulat U, Schmitt M, Häussinger D (1999) Dexamethasone- and osmolarity-dependent expression of the multidrug-resistance protein 2 in cultured rat hepatocytes. Biochem J 340:585-591
-
(1999)
Biochem J
, vol.340
, pp. 585-591
-
-
Kubitz, R.1
Warskulat, U.2
Schmitt, M.3
Häussinger, D.4
-
99
-
-
0032944048
-
Regulation of the multidrug resistance protein 2 in the rat liver by lipopolysaccharide and dexamethasone
-
Kubitz R, Wettstein M, Warskulat U, Häussinger D (1999) Regulation of the multidrug resistance protein 2 in the rat liver by lipopolysaccharide and dexamethasone. Gastroenterology 116:401-410
-
(1999)
Gastroenterology
, vol.116
, pp. 401-410
-
-
Kubitz, R.1
Wettstein, M.2
Warskulat, U.3
Häussinger, D.4
-
100
-
-
0034917954
-
Protein kinase C-dependent distribution of the multidrug resistance protein 2 fromthe canalicular to the basolateral membrane in human HepG2 cells
-
Kubitz R, Huth C, Schmitt M, Horbach A, Kullak-Ublick G, Häussinger D (2001) Protein kinase C-dependent distribution of the multidrug resistance protein 2 fromthe canalicular to the basolateral membrane in human HepG2 cells. Hepatology 34:340-350
-
(2001)
Hepatology
, vol.34
, pp. 340-350
-
-
Kubitz, R.1
Huth, C.2
Schmitt, M.3
Horbach, A.4
Kullak-Ublick, G.5
Häussinger, D.6
-
101
-
-
0036590564
-
Expression of the hepatocyte canalicular multidrug resistance protein (MRP2) in primary biliary cirrhosis
-
Kullak-Ublick GA, Baretton GB, Oswald M, Renner EL, Paumgartner G, Beuers U (2002) Expression of the hepatocyte canalicular multidrug resistance protein (MRP2) in primary biliary cirrhosis. Hepatol Res 23:78-82
-
(2002)
Hepatol Res
, vol.23
, pp. 78-82
-
-
Kullak-Ublick, G.A.1
Baretton, G.B.2
Oswald, M.3
Renner, E.L.4
Paumgartner, G.5
Beuers, U.6
-
102
-
-
0346100571
-
Enterohepatic bile salt transporters in normal physiology and liver disease
-
Kullak-Ublick GA, Stieger B, Meier PJ (2004) Enterohepatic bile salt transporters in normal physiology and liver disease. Gastroenterology 126:322-342
-
(2004)
Gastroenterology
, vol.126
, pp. 322-342
-
-
Kullak-Ublick, G.A.1
Stieger, B.2
Meier, P.J.3
-
103
-
-
0035207243
-
Adaptive regulation of bile salt transporters in kidney and liver in obstructive cholestasis in the rat
-
Lee J, Azzaroli F, Wang L, Soroka CJ, Gigliozzi A, Setchell KD, Kramer W, Boyer JL (2001) Adaptive regulation of bile salt transporters in kidney and liver in obstructive cholestasis in the rat. Gastroenterology 121:1473-1484
-
(2001)
Gastroenterology
, vol.121
, pp. 1473-1484
-
-
Lee, J.1
Azzaroli, F.2
Wang, L.3
Soroka, C.J.4
Gigliozzi, A.5
Setchell, K.D.6
Kramer, W.7
Boyer, J.L.8
-
104
-
-
33646704737
-
Neonatal Dubin-Johnson syndrome: Long-term follow-up and MRP2 mutations study
-
Lee JH, Chen HL, Chen HL, Ni YH, Hsu HY, Chang MH (2006) Neonatal Dubin-Johnson syndrome: long-term follow-up and MRP2 mutations study. Pediatr Res 59:584-589
-
(2006)
Pediatr Res
, vol.59
, pp. 584-589
-
-
Lee, J.H.1
Chen, H.L.2
Chen, H.L.3
Ni, Y.H.4
Hsu, H.Y.5
Chang, M.H.6
-
105
-
-
0027984511
-
The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates
-
Leier I, Jedlitschky G, Buchholz U, Cole SPC, Deeley RG, Keppler D (1994) The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates. J Biol Chem 269:27807-27810
-
(1994)
J Biol Chem
, vol.269
, pp. 27807-27810
-
-
Leier, I.1
Jedlitschky, G.2
Buchholz, U.3
Cole, S.P.C.4
Deeley, R.G.5
Keppler, D.6
-
106
-
-
0028347079
-
Characterization of the ATP-dependent leukotriene C4 export carrier in mastocytoma cells
-
Leier I, Jedlitschky G, Buchholz U, Keppler D (1994) Characterization of the ATP-dependent leukotriene C4 export carrier in mastocytoma cells. Eur J Biochem 220:599-606
-
(1994)
Eur J Biochem
, vol.220
, pp. 599-606
-
-
Leier, I.1
Jedlitschky, G.2
Buchholz, U.3
Keppler, D.4
-
107
-
-
0034083906
-
ATP-dependent para-aminohippurate transport by apical multidrug resistance protein MRP2
-
Leier I, Hummel-Eisenbeiss J, Cui Y, Keppler D (2000) ATP-dependent para-aminohippurate transport by apical multidrug resistance protein MRP2. Kidney Int 57:1636-1642
-
(2000)
Kidney Int
, vol.57
, pp. 1636-1642
-
-
Leier, I.1
Hummel-Eisenbeiss, J.2
Cui, Y.3
Keppler, D.4
-
108
-
-
3242765929
-
Mutations in the SLCO1B3 gene affecting the substrate specificity of the hepatocellular uptake transporter OATP1B3 (OATP8)
-
Letschert K, Keppler D, König J (2004) Mutations in the SLCO1B3 gene affecting the substrate specificity of the hepatocellular uptake transporter OATP1B3 (OATP8). Pharmacogenetics 14:441-452
-
(2004)
Pharmacogenetics
, vol.14
, pp. 441-452
-
-
Letschert, K.1
Keppler, D.2
König, J.3
-
109
-
-
18044372268
-
Vectorial transport of the peptide CCK-8 by double-transfected MDCKII cells stably expressing the organic anion transporter OATP1B3 (OATP8) and the export pump ABCC2
-
Letschert K, Komatsu M, Hummel-Eisenbeiss J, Keppler D (2005) Vectorial transport of the peptide CCK-8 by double-transfected MDCKII cells stably expressing the organic anion transporter OATP1B3 (OATP8) and the export pump ABCC2. J Pharmacol Exp Ther 313:549-556
-
(2005)
J Pharmacol Exp Ther
, vol.313
, pp. 549-556
-
-
Letschert, K.1
Komatsu, M.2
Hummel-Eisenbeiss, J.3
Keppler, D.4
-
110
-
-
0030009305
-
Multidrug resistance protein (MRP)-mediated transport of leukotriene C4 and chemotherapeutic agents in membrane vesicles. Demonstration of glutathione-dependent vincristine transport
-
Loe DW, Almquist KC, Deeley RG, Cole SP (1996) Multidrug resistance protein (MRP)-mediated transport of leukotriene C4 and chemotherapeutic agents in membrane vesicles. Demonstration of glutathione-dependent vincristine transport. J Biol Chem 271:9675-9682
-
(1996)
J Biol Chem
, vol.271
, pp. 9675-9682
-
-
Loe, D.W.1
Almquist, K.C.2
Deeley, R.G.3
Cole, S.P.4
-
111
-
-
15044359410
-
Mutation analysis of the multidrug resistance protein 2 (MRP2) gene in a Japanese patient with Dubin-Johnson syndrome
-
Machida I, Inagaki Y, Suzuki S, Hayashi H, Wakusawa S (2004) Mutation analysis of the multidrug resistance protein 2 (MRP2) gene in a Japanese patient with Dubin-Johnson syndrome. Hepatol Res 30:86-90
-
(2004)
Hepatol Res
, vol.30
, pp. 86-90
-
-
Machida, I.1
Inagaki, Y.2
Suzuki, S.3
Hayashi, H.4
Wakusawa, S.5
-
112
-
-
23844509951
-
Mutational analysis of the MRP2 gene and long-term follow-up of Dubin-Johnson syndrome in Japan
-
Machida I, Wakusawa S, Sanae F, Hayashi H, Kusakabe A, Ninomiya H, Yano M, Yoshioka K (2005) Mutational analysis of the MRP2 gene and long-term follow-up of Dubin-Johnson syndrome in Japan. J Gastroenterol 40:366-370
-
(2005)
J Gastroenterol
, vol.40
, pp. 366-370
-
-
Machida, I.1
Wakusawa, S.2
Sanae, F.3
Hayashi, H.4
Kusakabe, A.5
Ninomiya, H.6
Yano, M.7
Yoshioka, K.8
-
113
-
-
0030753176
-
Methotrexate is excreted into the bile by canalicular multispecific organic anion transporter in rats
-
Masuda M, I'izuka Y, Yamazaki M, Nishigaki R, Kato Y, Ni'inuma K, Suzuki H, Sugiyama Y (1997) Methotrexate is excreted into the bile by canalicular multispecific organic anion transporter in rats. Cancer Res 57:3506-3510
-
(1997)
Cancer Res
, vol.57
, pp. 3506-3510
-
-
Masuda, M.1
I'izuka, Y.2
Yamazaki, M.3
Nishigaki, R.4
Kato, Y.5
Ni'inuma, K.6
Suzuki, H.7
Sugiyama, Y.8
-
114
-
-
0029133131
-
Expression of the MRP gene-encoded conjugate export pump in liver and its selective absence from the canalicular membrane in transport-deficient mutant hepatocytes
-
Mayer R, Kartenbeck J, Büchler M, Jedlitschky G, Leier I, Keppler D (1995) Expression of the MRP gene-encoded conjugate export pump in liver and its selective absence from the canalicular membrane in transport-deficient mutant hepatocytes. J Cell Biol 131:137-150
-
(1995)
J Cell Biol
, vol.131
, pp. 137-150
-
-
Mayer, R.1
Kartenbeck, J.2
Büchler, M.3
Jedlitschky, G.4
Leier, I.5
Keppler, D.6
-
115
-
-
0033664346
-
Xenobiotic transport across isolated brain microvessels studied by confocal microscopy
-
Miller DS, Nobmann SN, Gutmann H, Toeroek M, Drewe J, Fricker G (2000) Xenobiotic transport across isolated brain microvessels studied by confocal microscopy. Mol Pharmacol 58:1357-1367
-
(2000)
Mol Pharmacol
, vol.58
, pp. 1357-1367
-
-
Miller, D.S.1
Nobmann, S.N.2
Gutmann, H.3
Toeroek, M.4
Drewe, J.5
Fricker, G.6
-
116
-
-
0032500601
-
The role of phosphoinositide 3-kinase in taurocholate-induced trafficking of ATP-dependent canalicular transporters in rat liver
-
Misra S, Ujhazy P, Gatmaitan Z, Varticovski L, Arias IM (1998) The role of phosphoinositide 3-kinase in taurocholate-induced trafficking of ATP-dependent canalicular transporters in rat liver. J Biol Chem 273:26638-26644
-
(1998)
J Biol Chem
, vol.273
, pp. 26638-26644
-
-
Misra, S.1
Ujhazy, P.2
Gatmaitan, Z.3
Varticovski, L.4
Arias, I.M.5
-
117
-
-
0035813178
-
Identification and functional analysis of two novel mutations in the multidrug resistance protein 2 gene in Israeli patients with Dubin-Johnson syndrome
-
Mor-Cohen R, Zivelin A, Rosenberg N, Shani M, Muallem S, Seligsohn U (2001) Identification and functional analysis of two novel mutations in the multidrug resistance protein 2 gene in Israeli patients with Dubin-Johnson syndrome. J Biol Chem 276:36923-36930
-
(2001)
J Biol Chem
, vol.276
, pp. 36923-36930
-
-
Mor-Cohen, R.1
Zivelin, A.2
Rosenberg, N.3
Shani, M.4
Muallem, S.5
Seligsohn, U.6
-
118
-
-
15044345453
-
A novel ancestral splicing mutation in the multidrug resistance protein 2 gene causes Dubin-Johnson syndrome in Ashkenazi Jewish patients
-
Mor-Cohen R, Zivelin A, Rosenberg N, Goldberg I, Seligsohn U (2005) A novel ancestral splicing mutation in the multidrug resistance protein 2 gene causes Dubin-Johnson syndrome in Ashkenazi Jewish patients. Hepatol Res 31:104-111
-
(2005)
Hepatol Res
, vol.31
, pp. 104-111
-
-
Mor-Cohen, R.1
Zivelin, A.2
Rosenberg, N.3
Goldberg, I.4
Seligsohn, U.5
-
119
-
-
0036614376
-
Altered localization and activity of canalicular Mrp2 in estradiol-17beta-D-glucuronide- induced cholestasis
-
Mottino AD, Cao J, Veggi LM, Crocenzi F, Roma MG, Vore M (2002) Altered localization and activity of canalicular Mrp2 in estradiol-17beta-D-glucuronide- induced cholestasis. Hepatology 35:1409-1419
-
(2002)
Hepatology
, vol.35
, pp. 1409-1419
-
-
Mottino, A.D.1
Cao, J.2
Veggi, L.M.3
Crocenzi, F.4
Roma, M.G.5
Vore, M.6
-
120
-
-
0028578004
-
Overexpression of the multidrug resistance associated protein (MRP) gene results in increased ATP-dependent glutathione S-conjugate transport
-
Müller M, Meijer C, Zaman GJR, Borst P, Scheper RJ, Mulder NH, de Vries EGE, Jansen PLM (1994) Overexpression of the multidrug resistance associated protein (MRP) gene results in increased ATP-dependent glutathione S-conjugate transport. Proc Natl Acad Sci USA 91:13033-13037
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 13033-13037
-
-
Müller, M.1
Meijer, C.2
Zaman, G.J.R.3
Borst, P.4
Scheper, R.J.5
Mulder, N.H.6
de Vries, E.G.E.7
Jansen, P.L.M.8
-
121
-
-
33645104459
-
Altered hepatobiliary disposition of 5 (and 6)-carboxy-2′,7′- dichlorofluorescein in Abcg2 (Bcrp1) and Abcc2 (Mrp2) knockout mice
-
Nezasa K, Tian X, Zamek-Gliszczynski MJ, Patel NJ, Raub TJ, Brouwer KL (2006) Altered hepatobiliary disposition of 5 (and 6)-carboxy-2′,7′- dichlorofluorescein in Abcg2 (Bcrp1) and Abcc2 (Mrp2) knockout mice. Drug Metab Dispos 34:718-723
-
(2006)
Drug Metab Dispos
, vol.34
, pp. 718-723
-
-
Nezasa, K.1
Tian, X.2
Zamek-Gliszczynski, M.J.3
Patel, N.J.4
Raub, T.J.5
Brouwer, K.L.6
-
122
-
-
0031758818
-
Expression of the apical conjugate export pump, Mrp2, in the polarized hepatoma cell line, WIF-B
-
Nies AT, Cantz T, Brom M, Leier I, Keppler D (1998) Expression of the apical conjugate export pump, Mrp2, in the polarized hepatoma cell line, WIF-B. Hepatology 28:1332-1340
-
(1998)
Hepatology
, vol.28
, pp. 1332-1340
-
-
Nies, A.T.1
Cantz, T.2
Brom, M.3
Leier, I.4
Keppler, D.5
-
123
-
-
0035889601
-
Expression of the multidrug resistance proteins MRP2 and MRP3 in human hepatocellular carcinoma
-
Nies AT, König J, Pfannschmidt M, Klar E, Hofmann WJ, Keppler D (2001) Expression of the multidrug resistance proteins MRP2 and MRP3 in human hepatocellular carcinoma. Int J Cancer 94:492-499
-
(2001)
Int J Cancer
, vol.94
, pp. 492-499
-
-
Nies, A.T.1
König, J.2
Pfannschmidt, M.3
Klar, E.4
Hofmann, W.J.5
Keppler, D.6
-
124
-
-
85047697477
-
Structural requirements for the apical sorting of human multidrug resistance protein 2 (ABCC2)
-
Nies AT, König J, Cui Y, Brom M, Spring H, Keppler D (2002) Structural requirements for the apical sorting of human multidrug resistance protein 2 (ABCC2). Eur J Biochem 269:1866-1876
-
(2002)
Eur J Biochem
, vol.269
, pp. 1866-1876
-
-
Nies, A.T.1
König, J.2
Cui, Y.3
Brom, M.4
Spring, H.5
Keppler, D.6
-
125
-
-
6344265573
-
Expression and immunolocalization of the multidrug resistance proteins, MRP1-MRP6 (ABCC1-ABCC6), in human brain
-
Nies AT, Jedlitschky G, König J, Herold-Mende C, Steiner HH, Schmitt HP, Keppler D (2004) Expression and immunolocalization of the multidrug resistance proteins, MRP1-MRP6 (ABCC1-ABCC6), in human brain. Neuroscience 129:349-360
-
(2004)
Neuroscience
, vol.129
, pp. 349-360
-
-
Nies, A.T.1
Jedlitschky, G.2
König, J.3
Herold-Mende, C.4
Steiner, H.H.5
Schmitt, H.P.6
Keppler, D.7
-
126
-
-
0030818770
-
Kinetic analysis of the primary active transport of conjugated metabolites across the bile canalicular membrane: Comparative study of S-(2,4-dinitrophenyl)-glutathione and 6-hydroxy-5,7-dimethyl-2-methylamino-4-(3- pyridylmethyl) benzothiazole glucuronide
-
Niinuma K, Takenaka O, Horie T, Kobayashi K, Kato Y, Suzuki H, Sugiyama Y (1997) Kinetic analysis of the primary active transport of conjugated metabolites across the bile canalicular membrane: comparative study of S-(2,4-dinitrophenyl)-glutathione and 6-hydroxy-5,7-dimethyl-2-methylamino-4-(3- pyridylmethyl) benzothiazole glucuronide. J Pharmacol Exp Ther 282:866-872
-
(1997)
J Pharmacol Exp Ther
, vol.282
, pp. 866-872
-
-
Niinuma, K.1
Takenaka, O.2
Horie, T.3
Kobayashi, K.4
Kato, Y.5
Suzuki, H.6
Sugiyama, Y.7
-
127
-
-
0026490803
-
Two distinct mechanisms for bilirubin glucuronide transport by rat bile canalicular membrane vesicles. Demonstration of defective ATP-dependent transport in rats (TR-) with inherited conjugated hyperbilirubinemia
-
Nishida T, Gatmaitan Z, Roy Chowdhury J, Arias IM (1992) Two distinct mechanisms for bilirubin glucuronide transport by rat bile canalicular membrane vesicles. Demonstration of defective ATP-dependent transport in rats (TR-) with inherited conjugated hyperbilirubinemia. J Clin Invest 90:2130-2135
-
(1992)
J Clin Invest
, vol.90
, pp. 2130-2135
-
-
Nishida, T.1
Gatmaitan, Z.2
Roy Chowdhury, J.3
Arias, I.M.4
-
128
-
-
0026516095
-
ATP-dependent organic anion transport system in normal and TR- rat liver canalicular membranes
-
Nishida T, Hardenbrook C, Gatmaitan Z, Arias IM (1992) ATP-dependent organic anion transport system in normal and TR- rat liver canalicular membranes. Am J Physiol 262:G629-G635
-
(1992)
Am J Physiol
, vol.262
-
-
Nishida, T.1
Hardenbrook, C.2
Gatmaitan, Z.3
Arias, I.M.4
-
129
-
-
0033574663
-
A unified nomenclature system for the nuclear receptor superfamily
-
Nuclear Receptors Nomenclature Committee
-
Nuclear Receptors Nomenclature Committee (1999) A unified nomenclature system for the nuclear receptor superfamily. Cell 97:161-163
-
(1999)
Cell
, vol.97
, pp. 161-163
-
-
-
130
-
-
0034916717
-
Expression of hepatic transporters OATP-C and MRP2 in primary sclerosing cholangitis
-
Oswald M, Kullak-Ublick GA, Paumgartner G, Beuers U (2001) Expression of hepatic transporters OATP-C and MRP2 in primary sclerosing cholangitis. Liver 21:247-253
-
(2001)
Liver
, vol.21
, pp. 247-253
-
-
Oswald, M.1
Kullak-Ublick, G.A.2
Paumgartner, G.3
Beuers, U.4
-
131
-
-
0029082150
-
Hepatobiliary secretion of organic compounds: Molecular mechanisms of membrane transport
-
Oude Elferink RPJ, Meijer DKF, Kuipers F, Jansen PLM, Groen AK, Groothuis GMM (1995) Hepatobiliary secretion of organic compounds: molecular mechanisms of membrane transport. Biochim Biophys Acta 1241:215-268
-
(1995)
Biochim Biophys Acta
, vol.1241
, pp. 215-268
-
-
Oude Elferink, R.P.J.1
Meijer, D.K.F.2
Kuipers, F.3
Jansen, P.L.M.4
Groen, A.K.5
Groothuis, G.M.M.6
-
132
-
-
0033591387
-
Bile acids: Natural ligands for an orphan nuclear receptor
-
Parks DJ, Blanchard SG, Bledsoe RK, Chandra G, Consler TG, Kliewer SA, Stimmel JB, Willson TM, Zavacki AM, Moore DD, Lehmann JM (1999) Bile acids: natural ligands for an orphan nuclear receptor. Science 284:1365-1368
-
(1999)
Science
, vol.284
, pp. 1365-1368
-
-
Parks, D.J.1
Blanchard, S.G.2
Bledsoe, R.K.3
Chandra, G.4
Consler, T.G.5
Kliewer, S.A.6
Stimmel, J.B.7
Willson, T.M.8
Zavacki, A.M.9
Moore, D.D.10
Lehmann, J.M.11
-
133
-
-
0029981430
-
Congenital jaundice in rats with a mutation in a multidrug resistance associated-protein gene
-
Paulusma CC, Bosma PJ, Zaman GJR, Bakker CTM, Otter M, Scheffer GL, Scheper RJ, Borst P, Oude Elferink RPJ (1996) Congenital jaundice in rats with a mutation in a multidrug resistance associated-protein gene. Science 271:1126-1128
-
(1996)
Science
, vol.271
, pp. 1126-1128
-
-
Paulusma, C.C.1
Bosma, P.J.2
Zaman, G.J.R.3
Bakker, C.T.M.4
Otter, M.5
Scheffer, G.L.6
Scheper, R.J.7
Borst, P.8
Oude Elferink, R.P.J.9
-
134
-
-
0030994468
-
A mutation in the human canalicular multispecific organic anion transporter gene causes the Dubin-Johnson syndrome
-
Paulusma CC, Kool M, Bosma PJ, Scheffer GL, ter Borg F, Scheper RJ, Tytgat GNJ, Borst P, Baas F, Oude Elferink RPJ (1997) A mutation in the human canalicular multispecific organic anion transporter gene causes the Dubin-Johnson syndrome. Hepatology 25:1539-1542
-
(1997)
Hepatology
, vol.25
, pp. 1539-1542
-
-
Paulusma, C.C.1
Kool, M.2
Bosma, P.J.3
Scheffer, G.L.4
ter Borg, F.5
Scheper, R.J.6
Tytgat, G.N.J.7
Borst, P.8
Baas, F.9
Oude Elferink, R.P.J.10
-
135
-
-
0033104810
-
Canalicular multispecific organic anion transporter/multidrug resistance protein 2 mediates low-affinity transport of reduced glutathione
-
Paulusma CC, van Meer MA, Evers R, Heijn M, Ottenhoff R, Borst P, Oude Elferink RP (1999) Canalicular multispecific organic anion transporter/multidrug resistance protein 2 mediates low-affinity transport of reduced glutathione. Biochem J 338:393-401
-
(1999)
Biochem J
, vol.338
, pp. 393-401
-
-
Paulusma, C.C.1
van Meer, M.A.2
Evers, R.3
Heijn, M.4
Ottenhoff, R.5
Borst, P.6
Oude Elferink, R.P.7
-
136
-
-
17544372167
-
Zonal down-regulation and redistribution of the multidrug resistance protein 2 during bile duct ligation in rat liver
-
Paulusma CC, Kothe MJ, Bakker CT, Bosma PJ, van Bokhoven I, van Marle J, Bolder U, Tytgat GN, Oude Elferink RP (2000) Zonal down-regulation and redistribution of the multidrug resistance protein 2 during bile duct ligation in rat liver. Hepatology 31:684-693
-
(2000)
Hepatology
, vol.31
, pp. 684-693
-
-
Paulusma, C.C.1
Kothe, M.J.2
Bakker, C.T.3
Bosma, P.J.4
van Bokhoven, I.5
van Marle, J.6
Bolder, U.7
Tytgat, G.N.8
Oude Elferink, R.P.9
-
137
-
-
0034815141
-
Reactive oxygen species-related induction of multidrug resistance-associated protein 2 expression in primary hepatocytes exposed to sulforaphane
-
Payen L, Courtois A, Loewert M, Guillouzo A, Fardel O (2001) Reactive oxygen species-related induction of multidrug resistance-associated protein 2 expression in primary hepatocytes exposed to sulforaphane. Biochem Biophys Res Commun 282:257-263
-
(2001)
Biochem Biophys Res Commun
, vol.282
, pp. 257-263
-
-
Payen, L.1
Courtois, A.2
Loewert, M.3
Guillouzo, A.4
Fardel, O.5
-
138
-
-
0036713510
-
Human non-synonymous SNPs: Server and survey
-
Ramensky V, Bork P, Sunyaev S (2002) Human non-synonymous SNPs: server and survey. Nucleic Acids Res 30:3894-3900
-
(2002)
Nucleic Acids Res
, vol.30
, pp. 3894-3900
-
-
Ramensky, V.1
Bork, P.2
Sunyaev, S.3
-
139
-
-
0031788953
-
From vacuolar GS-X pumps to multispecific ABC transporters
-
Rea PA, Li ZS, Lu YP, Drozdowicz YM, Martinoia E (1998) From vacuolar GS-X pumps to multispecific ABC transporters. Annu Rev Plant Physiol Plant Mol Biol 49:727-760
-
(1998)
Annu Rev Plant Physiol Plant Mol Biol
, vol.49
, pp. 727-760
-
-
Rea, P.A.1
Li, Z.S.2
Lu, Y.P.3
Drozdowicz, Y.M.4
Martinoia, E.5
-
140
-
-
0042766881
-
Cotransport of reduced glutathione with bile salts by MRP4 (ABCC4) localized to the basolateral hepatocyte membrane
-
Rius M, Nies AT, Hummel-Eisenbeiss J, Jedlitschky G, Keppler D (2003) Cotransport of reduced glutathione with bile salts by MRP4 (ABCC4) localized to the basolateral hepatocyte membrane. Hepatology 38:374-384
-
(2003)
Hepatology
, vol.38
, pp. 374-384
-
-
Rius, M.1
Nies, A.T.2
Hummel-Eisenbeiss, J.3
Jedlitschky, G.4
Keppler, D.5
-
142
-
-
0031979439
-
Cyclic AMP stimulates sorting of the canalicular organic anion transporter (Mrp2/cMoat) to the apical domain in hepatocyte couplets
-
Roelofsen H, Soroka CJ, Keppler D, Boyer JL (1998) Cyclic AMP stimulates sorting of the canalicular organic anion transporter (Mrp2/cMoat) to the apical domain in hepatocyte couplets. J Cell Sci 111:1137-1145
-
(1998)
J Cell Sci
, vol.111
, pp. 1137-1145
-
-
Roelofsen, H.1
Soroka, C.J.2
Keppler, D.3
Boyer, J.L.4
-
143
-
-
0033019479
-
Changes in the localization of the rat canalicular conjugate export pump Mrp2 in phalloidin-induced cholestasis
-
Rost D, Kartenbeck J, Keppler D (1999) Changes in the localization of the rat canalicular conjugate export pump Mrp2 in phalloidin-induced cholestasis. Hepatology 29:814-821
-
(1999)
Hepatology
, vol.29
, pp. 814-821
-
-
Rost, D.1
Kartenbeck, J.2
Keppler, D.3
-
144
-
-
0034760443
-
Expression and localization of the multidrug resistance proteins MRP2 and MRP3 in human gallbladder epithelia
-
Rost D, König J, Weiss G, Klar E, Stremmel W, Keppler D (2001) Expression and localization of the multidrug resistance proteins MRP2 and MRP3 in human gallbladder epithelia. Gastroenterology 121:1203-1208
-
(2001)
Gastroenterology
, vol.121
, pp. 1203-1208
-
-
Rost, D.1
König, J.2
Weiss, G.3
Klar, E.4
Stremmel, W.5
Keppler, D.6
-
145
-
-
1942505811
-
Disorders of bilirubin metabolism
-
Arias IM, Boyer JL, Chisari FV, Fausto N, Schachter D, Shafritz DA eds, Lippincott, Williams & Wilkins, Philadelphia, pp
-
Roy Chowdhury N, Arias IM, Wolkoff AW, Roy Chowdhury J (2001) Disorders of bilirubin metabolism. In: Arias IM, Boyer JL, Chisari FV, Fausto N, Schachter D, Shafritz DA (eds) The liver: biology and pathobiology. Lippincott, Williams & Wilkins, Philadelphia, pp 291-309
-
(2001)
The liver: Biology and pathobiology
, pp. 291-309
-
-
Roy Chowdhury, N.1
Arias, I.M.2
Wolkoff, A.W.3
Roy Chowdhury, J.4
-
146
-
-
0036246271
-
Identification of 779 genetic variations in eight genes encoding members of the ATP-binding cassette, subfamily C (ABCC/MRP/CFTR)
-
Saito S, Iida A, Sekine A, Miura Y, Ogawa C, Kawauchi S, Higuchi S, Nakamura Y (2002) Identification of 779 genetic variations in eight genes encoding members of the ATP-binding cassette, subfamily C (ABCC/MRP/CFTR). J Hum Genet 47:147-171
-
(2002)
J Hum Genet
, vol.47
, pp. 147-171
-
-
Saito, S.1
Iida, A.2
Sekine, A.3
Miura, Y.4
Ogawa, C.5
Kawauchi, S.6
Higuchi, S.7
Nakamura, Y.8
-
147
-
-
0035985610
-
Expression of multidrug resistance-associated protein 2 (MRP2) in normal human tissues and carcinomas using tissue microarrays
-
Sandusky GE, Mintze KS, Pratt SE, Dantzig AH (2002) Expression of multidrug resistance-associated protein 2 (MRP2) in normal human tissues and carcinomas using tissue microarrays. Histopathology 41:65-74
-
(2002)
Histopathology
, vol.41
, pp. 65-74
-
-
Sandusky, G.E.1
Mintze, K.S.2
Pratt, S.E.3
Dantzig, A.H.4
-
148
-
-
0031911625
-
Carrier-mediated mechanism for the biliary excretion of the quinolone antibiotic grepafloxacin and its glucuronide in rats
-
Sasabe H, Tsuji A, Sugiyama Y (1998) Carrier-mediated mechanism for the biliary excretion of the quinolone antibiotic grepafloxacin and its glucuronide in rats. J Pharmacol Exp Ther 284:1033-1039
-
(1998)
J Pharmacol Exp Ther
, vol.284
, pp. 1033-1039
-
-
Sasabe, H.1
Tsuji, A.2
Sugiyama, Y.3
-
149
-
-
0037155204
-
Transcellular transport of organic anions across a double-transfected Madin-Darby canine kidney II cell monolayer expressing both human organic anion-transporting polypeptide (OATP2/SLC21A6) and multidrug resistance-associated protein 2 (MRP2/ABCC2)
-
Sasaki M, Suzuki H, Ito K, Abe T, Sugiyama Y (2002) Transcellular transport of organic anions across a double-transfected Madin-Darby canine kidney II cell monolayer expressing both human organic anion-transporting polypeptide (OATP2/SLC21A6) and multidrug resistance-associated protein 2 (MRP2/ABCC2). J Biol Chem 277:6497-6503
-
(2002)
J Biol Chem
, vol.277
, pp. 6497-6503
-
-
Sasaki, M.1
Suzuki, H.2
Ito, K.3
Abe, T.4
Sugiyama, Y.5
-
150
-
-
0030832802
-
Expression of the conjugate export pump encoded by the mrp2 gene in the apical membrane of kidney proximal tubules
-
Schaub TP, Kartenbeck J, König J, Vogel O, Witzgall R, Kriz W, Keppler D (1997) Expression of the conjugate export pump encoded by the mrp2 gene in the apical membrane of kidney proximal tubules. J Am Soc Nephrol 8:1213-1221
-
(1997)
J Am Soc Nephrol
, vol.8
, pp. 1213-1221
-
-
Schaub, T.P.1
Kartenbeck, J.2
König, J.3
Vogel, O.4
Witzgall, R.5
Kriz, W.6
Keppler, D.7
-
151
-
-
0033032730
-
Expression of the MRP2 gene-encoded conjugate export pump in human kidney proximal tubules and in renal-cell carcinoma
-
Schaub TP, Kartenbeck J, König J, Spring H, Dörsam H, Stähler G, Störkel S, Thon WF, Keppler D (1999) Expression of the MRP2 gene-encoded conjugate export pump in human kidney proximal tubules and in renal-cell carcinoma. J Am Soc Nephrol 10:1159-1169
-
(1999)
J Am Soc Nephrol
, vol.10
, pp. 1159-1169
-
-
Schaub, T.P.1
Kartenbeck, J.2
König, J.3
Spring, H.4
Dörsam, H.5
Stähler, G.6
Störkel, S.7
Thon, W.F.8
Keppler, D.9
-
152
-
-
0014859813
-
Dubin-Johnson syndrome in Israel. I. Clinical, laboratory, and genetic aspects of 101 cases
-
Shani M, Seligsohn U, Gilon E, Sheba C, Adam A (1970) Dubin-Johnson syndrome in Israel. I. Clinical, laboratory, and genetic aspects of 101 cases. Q J Med 39:549-567
-
(1970)
Q J Med
, vol.39
, pp. 549-567
-
-
Shani, M.1
Seligsohn, U.2
Gilon, E.3
Sheba, C.4
Adam, A.5
-
153
-
-
0035668415
-
The expression levels of plasma membrane transporters in the cholestatic liver of patients undergoing biliary drainage and their association with the impairment of biliary secretory function
-
Shoda J, Kano M, Oda K, Kamiya J, Nimura Y, Suzuki H, Sugiyama Y, Miyazaki H, Todoroki T, Stengelin S, Kramer W, Matsuzaki Y, Tanaka N (2001) The expression levels of plasma membrane transporters in the cholestatic liver of patients undergoing biliary drainage and their association with the impairment of biliary secretory function. Am J Gastroenterol 96:3368-3378
-
(2001)
Am J Gastroenterol
, vol.96
, pp. 3368-3378
-
-
Shoda, J.1
Kano, M.2
Oda, K.3
Kamiya, J.4
Nimura, Y.5
Suzuki, H.6
Sugiyama, Y.7
Miyazaki, H.8
Todoroki, T.9
Stengelin, S.10
Kramer, W.11
Matsuzaki, Y.12
Tanaka, N.13
-
154
-
-
0346264728
-
Novel mutations identified in the human multidrug resistance-associated protein 2 (MRP2/ABCC2) gene in a Japanese patient with Dubin-Johnson syndrome
-
Shoda J, Suzuki H, Suzuki H, Sugiyama Y, Hirouchi M, Utsunomiya H, Oda K, Kawamoto T, Matsuzaki Y, Tanaka N (2003) Novel mutations identified in the human multidrug resistance-associated protein 2 (MRP2/ABCC2) gene in a Japanese patient with Dubin-Johnson syndrome. Hepatol Res 27:323-326
-
(2003)
Hepatol Res
, vol.27
, pp. 323-326
-
-
Shoda, J.1
Suzuki, H.2
Suzuki, H.3
Sugiyama, Y.4
Hirouchi, M.5
Utsunomiya, H.6
Oda, K.7
Kawamoto, T.8
Matsuzaki, Y.9
Tanaka, N.10
-
155
-
-
12144269640
-
Contribution of multidrug resistance protein 2 (MRP2/ABCC2) to the renal excretion of p-aminohippurate (PAH) and identification of MRP4 (ABCC4) as a novel PAH transporter
-
Smeets PH, van Aubel RA, Wouterse AC, van den Heuvel JJ, Russel FG (2004) Contribution of multidrug resistance protein 2 (MRP2/ABCC2) to the renal excretion of p-aminohippurate (PAH) and identification of MRP4 (ABCC4) as a novel PAH transporter. J Am Soc Nephrol 15:2828-2835
-
(2004)
J Am Soc Nephrol
, vol.15
, pp. 2828-2835
-
-
Smeets, P.H.1
van Aubel, R.A.2
Wouterse, A.C.3
van den Heuvel, J.J.4
Russel, F.G.5
-
156
-
-
0346497684
-
Role of multidrug resistance protein 2 (MRP2, ABCC2) in alkylating agent detoxification: MRP2 potentiates glutathione Stransferase A1-1-mediated resistance to chlorambucil cytotoxicity
-
Smitherman PK, Townsend AJ, Kute TE, Morrow CS (2004) Role of multidrug resistance protein 2 (MRP2, ABCC2) in alkylating agent detoxification: MRP2 potentiates glutathione Stransferase A1-1-mediated resistance to chlorambucil cytotoxicity. J Pharmacol Exp Ther 308:260-267
-
(2004)
J Pharmacol Exp Ther
, vol.308
, pp. 260-267
-
-
Smitherman, P.K.1
Townsend, A.J.2
Kute, T.E.3
Morrow, C.S.4
-
157
-
-
11844279093
-
Directional transepithelial transport of organic anions in porcine LLC-PK1 cells that co-express human OATP1B1 (OATP-C) and MRP2
-
Spears KJ, Ross J, Stenhouse A, Ward CJ, Goh LB, Wolf CR, Morgan P, Ayrton A, Friedberg TH (2005) Directional transepithelial transport of organic anions in porcine LLC-PK1 cells that co-express human OATP1B1 (OATP-C) and MRP2. Biochem Pharmacol 69:415-423
-
(2005)
Biochem Pharmacol
, vol.69
, pp. 415-423
-
-
Spears, K.J.1
Ross, J.2
Stenhouse, A.3
Ward, C.J.4
Goh, L.B.5
Wolf, C.R.6
Morgan, P.7
Ayrton, A.8
Friedberg, T.H.9
-
158
-
-
0001414260
-
Persistent nonhemolytic hyperbilirubinemia associated with lipochrome-like pigment in liver cells; report of four cases
-
Sprinz H, Nelson RS (1954) Persistent nonhemolytic hyperbilirubinemia associated with lipochrome-like pigment in liver cells; report of four cases. Ann Intern Med 41:952-962
-
(1954)
Ann Intern Med
, vol.41
, pp. 952-962
-
-
Sprinz, H.1
Nelson, R.S.2
-
159
-
-
0033681486
-
Expression of members of the multidrug resistance protein family in human term placenta
-
St-Pierre MV, Serrano MA, Macias RI, Dubs U, Hoechli M, Lauper U, Meier PJ, Marin JJ (2000) Expression of members of the multidrug resistance protein family in human term placenta. Am J Physiol Regul Integr Comp Physiol 279:R1495-R1503
-
(2000)
Am J Physiol Regul Integr Comp Physiol
, vol.279
-
-
St-Pierre, M.V.1
Serrano, M.A.2
Macias, R.I.3
Dubs, U.4
Hoechli, M.5
Lauper, U.6
Meier, P.J.7
Marin, J.J.8
-
160
-
-
0034105939
-
Characterization of the 5′-flanking region of the human multidrug resistance protein 2 (MRP2) gene and its regulation in comparison with the multidrug resistance protein 3 (MRP3)
-
Stöckel B, König J, Nies AT, Cui Y, Brom M, Keppler D (2000) Characterization of the 5′-flanking region of the human multidrug resistance protein 2 (MRP2) gene and its regulation in comparison with the multidrug resistance protein 3 (MRP3). Eur J Biochem 267:1347-1358
-
(2000)
Eur J Biochem
, vol.267
, pp. 1347-1358
-
-
Stöckel, B.1
König, J.2
Nies, A.T.3
Cui, Y.4
Brom, M.5
Keppler, D.6
-
161
-
-
0033525886
-
The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene
-
Sueyoshi T, Kawamoto T, Zelko I, Honkakoski P, Negishi M (1999) The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene. J Biol Chem 274:6043-6046
-
(1999)
J Biol Chem
, vol.274
, pp. 6043-6046
-
-
Sueyoshi, T.1
Kawamoto, T.2
Zelko, I.3
Honkakoski, P.4
Negishi, M.5
-
162
-
-
0037131880
-
Single nucleotide polymorphisms in multidrug resistance associated protein 2 (MRP2/ABCC2): Its impact on drug disposition
-
Suzuki H, Sugiyama Y (2002) Single nucleotide polymorphisms in multidrug resistance associated protein 2 (MRP2/ABCC2): its impact on drug disposition. Adv Drug Deliv Rev 54:1311-1331
-
(2002)
Adv Drug Deliv Rev
, vol.54
, pp. 1311-1331
-
-
Suzuki, H.1
Sugiyama, Y.2
-
163
-
-
0025744687
-
Biliary excretion of bile acid conjugates in a hyperbilirubinemic mutant Sprague-Dawley rat
-
Takikawa H, Sano N, Narita T, Uchida Y, Yamanaka M, Horie T, Mikami T, Tagaya O (1991) Biliary excretion of bile acid conjugates in a hyperbilirubinemic mutant Sprague-Dawley rat. Hepatology 14:352-360
-
(1991)
Hepatology
, vol.14
, pp. 352-360
-
-
Takikawa, H.1
Sano, N.2
Narita, T.3
Uchida, Y.4
Yamanaka, M.5
Horie, T.6
Mikami, T.7
Tagaya, O.8
-
164
-
-
0032745443
-
The human multidrug resistance protein 2 gene: Functional characterization of the 5′-flanking region and expression in hepatic cells
-
Tanaka T, Uchiumi T, Hinoshita E, Inokuchi A, Toh S, Wada M, Takano H, Kohno K, Kuwano M (1999) The human multidrug resistance protein 2 gene: functional characterization of the 5′-flanking region and expression in hepatic cells. Hepatology 30:1507-1512
-
(1999)
Hepatology
, vol.30
, pp. 1507-1512
-
-
Tanaka, T.1
Uchiumi, T.2
Hinoshita, E.3
Inokuchi, A.4
Toh, S.5
Wada, M.6
Takano, H.7
Kohno, K.8
Kuwano, M.9
-
165
-
-
9544233652
-
A human canalicular multispecific organic anion transporter (cMOAT) overexpressed in cisplatin-resistant human cancer cell lines with decreased drug accumulation
-
Taniguchi K, Wada M, Kohno K, Nakamura T, Kawabe T, Kawakami M, Kagotani K, Okumura K, Akiyama S, Kuwano M (1996) A human canalicular multispecific organic anion transporter (cMOAT) overexpressed in cisplatin-resistant human cancer cell lines with decreased drug accumulation. Cancer Res 56:4124-4129
-
(1996)
Cancer Res
, vol.56
, pp. 4124-4129
-
-
Taniguchi, K.1
Wada, M.2
Kohno, K.3
Nakamura, T.4
Kawabe, T.5
Kawakami, M.6
Kagotani, K.7
Okumura, K.8
Akiyama, S.9
Kuwano, M.10
-
166
-
-
0035989612
-
A new mutation of the ATP-binding cassette, sub-family C, member 2 (ABCC2) gene in a Japanese patient with Dubin-Johnson syndrome
-
Tate G, Li M, Suzuki T, Mitsuya T (2002) A new mutation of the ATP-binding cassette, sub-family C, member 2 (ABCC2) gene in a Japanese patient with Dubin-Johnson syndrome. Genes Genet Syst 77:117-121
-
(2002)
Genes Genet Syst
, vol.77
, pp. 117-121
-
-
Tate, G.1
Li, M.2
Suzuki, T.3
Mitsuya, T.4
-
167
-
-
0032526946
-
Binary specifications of nonsense codons by splicing and cytoplasmic translation
-
Thermann R, Neu-Yilik G, Deters A, Frede U, Wehr K, Hagemeier C, Hentze MW, Kulozik AE (1998) Binary specifications of nonsense codons by splicing and cytoplasmic translation. EMBO J 17:3484-3494
-
(1998)
EMBO J
, vol.17
, pp. 3484-3494
-
-
Thermann, R.1
Neu-Yilik, G.2
Deters, A.3
Frede, U.4
Wehr, K.5
Hagemeier, C.6
Hentze, M.W.7
Kulozik, A.E.8
-
168
-
-
0033361943
-
Genomic structure of the canalicular multispecific organic anion-transporter gene (MRP2/cMOAT) and mutations in the ATP-binding-cassette region in Dubin-Johnson syndrome
-
Toh S, Wada M, Uchiumi T, Inokuchi A, Makino Y, Horie Y, Adachi Y, Sakisaka S, KuwanoM(1999) Genomic structure of the canalicular multispecific organic anion-transporter gene (MRP2/cMOAT) and mutations in the ATP-binding-cassette region in Dubin-Johnson syndrome. Am J Hum Genet 64:739-746
-
(1999)
Am J Hum Genet
, vol.64
, pp. 739-746
-
-
Toh, S.1
Wada, M.2
Uchiumi, T.3
Inokuchi, A.4
Makino, Y.5
Horie, Y.6
Adachi, Y.7
Sakisaka, S.8
KuwanoM9
-
169
-
-
0030963906
-
The rat canalicular conjugate export pump (Mrp2) is down-regulated in intrahepatic and obstructive cholestasis
-
Trauner M, Arrese M, Soroka CJ, Ananthanarayanan M, Koeppel TA, Schlosser SF, Suchy FJ, Keppler D, Boyer JL (1997) The rat canalicular conjugate export pump (Mrp2) is down-regulated in intrahepatic and obstructive cholestasis. Gastroenterology 113:255-264
-
(1997)
Gastroenterology
, vol.113
, pp. 255-264
-
-
Trauner, M.1
Arrese, M.2
Soroka, C.J.3
Ananthanarayanan, M.4
Koeppel, T.A.5
Schlosser, S.F.6
Suchy, F.J.7
Keppler, D.8
Boyer, J.L.9
-
170
-
-
0032842748
-
Exon-intron organization of the human multidrug-resistance protein 2 (MRP2) gene mutated in Dubin-Johnson syndrome
-
Tsujii H, König J, Rost D, Stöckel B, Leuschner U, Keppler D (1999) Exon-intron organization of the human multidrug-resistance protein 2 (MRP2) gene mutated in Dubin-Johnson syndrome. Gastroenterology 117:653-660
-
(1999)
Gastroenterology
, vol.117
, pp. 653-660
-
-
Tsujii, H.1
König, J.2
Rost, D.3
Stöckel, B.4
Leuschner, U.5
Keppler, D.6
-
171
-
-
0031841605
-
Adenosine triphosphate-dependent transport of anionic conjugates by the rabbit multidrug resistance-associated protein Mrp2 expressed in insect cells
-
van Aubel RA, van Kuijck MA, Koenderink JB, Deen PM, van Os CH, Russel RG (1998) Adenosine triphosphate-dependent transport of anionic conjugates by the rabbit multidrug resistance-associated protein Mrp2 expressed in insect cells. Mol Pharmacol 53:1062-1067
-
(1998)
Mol Pharmacol
, vol.53
, pp. 1062-1067
-
-
van Aubel, R.A.1
van Kuijck, M.A.2
Koenderink, J.B.3
Deen, P.M.4
van Os, C.H.5
Russel, R.G.6
-
172
-
-
0034698247
-
Expression and immunolocalization of multidrug resistance protein 2 in rabbit small intestine
-
van Aubel RA, Hartog A, Bindels RJ, van Os CH, Russel FG (2000) Expression and immunolocalization of multidrug resistance protein 2 in rabbit small intestine. Eur J Pharmacol 400:195-198
-
(2000)
Eur J Pharmacol
, vol.400
, pp. 195-198
-
-
van Aubel, R.A.1
Hartog, A.2
Bindels, R.J.3
van Os, C.H.4
Russel, F.G.5
-
173
-
-
0033713976
-
Multidrug resistance protein mrp2 mediates ATP-dependent transport of classic renal organic anion p-aminohippurate
-
van Aubel RA, Peters JG, Masereeuw R, van Os CH, Russel FG (2000) Multidrug resistance protein mrp2 mediates ATP-dependent transport of classic renal organic anion p-aminohippurate. Am J Physiol Renal Physiol 279:F713-F717
-
(2000)
Am J Physiol Renal Physiol
, vol.279
-
-
van Aubel, R.A.1
Peters, J.G.2
Masereeuw, R.3
van Os, C.H.4
Russel, F.G.5
-
174
-
-
0036186107
-
The MRP4/ABCC4 gene encodes a novel apical organic anion transporter in human kidney proximal tubules: Putative efflux pump for urinary cAMP and cGMP
-
van Aubel RA, Smeets PH, Peters JG, Bindels RJ, Russel FG (2002) The MRP4/ABCC4 gene encodes a novel apical organic anion transporter in human kidney proximal tubules: putative efflux pump for urinary cAMP and cGMP. J Am Soc Nephrol 13:595-603
-
(2002)
J Am Soc Nephrol
, vol.13
, pp. 595-603
-
-
van Aubel, R.A.1
Smeets, P.H.2
Peters, J.G.3
Bindels, R.J.4
Russel, F.G.5
-
175
-
-
26444539011
-
Function and regulation of multidrug resistance proteins (MRPs) in the renal elimination of organic anions
-
van de Water FM, Masereeuw R, Russel FG (2005) Function and regulation of multidrug resistance proteins (MRPs) in the renal elimination of organic anions. Drug Metab Rev 37:443-471
-
(2005)
Drug Metab Rev
, vol.37
, pp. 443-471
-
-
van de Water, F.M.1
Masereeuw, R.2
Russel, F.G.3
-
176
-
-
27244436425
-
Expression of multidrug transporters MRP1, MRP2, and BCRP shortly after status epilepticus, during the latent period, and in chronic epileptic rats
-
van Vliet EA, Redeker S, Aronica E, Edelbroek PM, Gorter JA (2005) Expression of multidrug transporters MRP1, MRP2, and BCRP shortly after status epilepticus, during the latent period, and in chronic epileptic rats. Epilepsia 46:1569-1580
-
(2005)
Epilepsia
, vol.46
, pp. 1569-1580
-
-
van Vliet, E.A.1
Redeker, S.2
Aronica, E.3
Edelbroek, P.M.4
Gorter, J.A.5
-
177
-
-
33745236689
-
Carcinogen and anti-cancer drug transport by Mrp2 in vivo: Studies using Mrp2 (Abcc2) knockout mice
-
DOI:10.1124/jpet.106. 101774
-
Vlaming ML, Mohrmann K, Wagenaar E, de Waart DR, Oude Elferink RP, Lagas JS, van Tellingen O, Vainchtein LD, Rosing H, Beijnen JH, Schellens JH, Schinkel AH (2006) Carcinogen and anti-cancer drug transport by Mrp2 in vivo: studies using Mrp2 (Abcc2) knockout mice. J Pharmacol Exp Ther DOI:10.1124/jpet.106. 101774
-
(2006)
J Pharmacol Exp Ther
-
-
Vlaming, M.L.1
Mohrmann, K.2
Wagenaar, E.3
de Waart, D.R.4
Oude Elferink, R.P.5
Lagas, J.S.6
van Tellingen, O.7
Vainchtein, L.D.8
Rosing, H.9
Beijnen, J.H.10
Schellens, J.H.11
Schinkel, A.H.12
-
178
-
-
0031738416
-
Up-regulation of the multidrug resistance genes, Mrp1 and Mdr1b, and down-regulation of the organic anion transporter, Mrp2, and the bile salt transporter, Spgp, in endotoxemic rat liver
-
Vos TA, Hooiveld GJ, Koning H, Childs S, Meijer DK, Moshage H, Jansen PL, Müller M (1998) Up-regulation of the multidrug resistance genes, Mrp1 and Mdr1b, and down-regulation of the organic anion transporter, Mrp2, and the bile salt transporter, Spgp, in endotoxemic rat liver. Hepatology 28:1637-1644
-
(1998)
Hepatology
, vol.28
, pp. 1637-1644
-
-
Vos, T.A.1
Hooiveld, G.J.2
Koning, H.3
Childs, S.4
Meijer, D.K.5
Moshage, H.6
Jansen, P.L.7
Müller, M.8
-
179
-
-
33644806448
-
Single nucleotide polymorphisms in ABCC2 and ABCB1 genes and their clinical impact in physiology and drug response
-
Wada M (2006) Single nucleotide polymorphisms in ABCC2 and ABCB1 genes and their clinical impact in physiology and drug response. Cancer Lett 234:40-50
-
(2006)
Cancer Lett
, vol.234
, pp. 40-50
-
-
Wada, M.1
-
180
-
-
6844250107
-
Mutations in the canalicular multispecific organic anion transporter (cMOAT) gene, a novel ABC transporter, in patients with hyperbilirubinemia II/Dubin-Johnson syndrome
-
Wada M, Toh S, Taniguchi K, Nakamura T, Uchiumi T, Kohno K, Yoshida I, Kimura A, Sakisaka S, Adachi Y, Kuwano M (1998) Mutations in the canalicular multispecific organic anion transporter (cMOAT) gene, a novel ABC transporter, in patients with hyperbilirubinemia II/Dubin-Johnson syndrome. Hum Mol Genet 7:203-207
-
(1998)
Hum Mol Genet
, vol.7
, pp. 203-207
-
-
Wada, M.1
Toh, S.2
Taniguchi, K.3
Nakamura, T.4
Uchiumi, T.5
Kohno, K.6
Yoshida, I.7
Kimura, A.8
Sakisaka, S.9
Adachi, Y.10
Kuwano, M.11
-
181
-
-
0141867789
-
Identification of a novel 2026G->C mutation of the MRP2 gene in a Japanese patient with Dubin-Johnson syndrome
-
Wakusawa S, Machida I, Suzuki S, Hayashi H, Yano M, Yoshioka K (2003) Identification of a novel 2026G->C mutation of the MRP2 gene in a Japanese patient with Dubin-Johnson syndrome. J Hum Genet 48:425-429
-
(2003)
J Hum Genet
, vol.48
, pp. 425-429
-
-
Wakusawa, S.1
Machida, I.2
Suzuki, S.3
Hayashi, H.4
Yano, M.5
Yoshioka, K.6
-
182
-
-
0033847137
-
Efflux of dietary flavonoid quercetin 4′-beta-glucoside across human intestinal Caco-2 cell monolayers by apical multidrug resistance-associated protein-2
-
Walgren RA, Karnaky KJ Jr, Lindenmayer GE, Walle T (2000) Efflux of dietary flavonoid quercetin 4′-beta-glucoside across human intestinal Caco-2 cell monolayers by apical multidrug resistance-associated protein-2. J Pharmacol Exp Ther 294:830-836
-
(2000)
J Pharmacol Exp Ther
, vol.294
, pp. 830-836
-
-
Walgren, R.A.1
Karnaky Jr, K.J.2
Lindenmayer, G.E.3
Walle, T.4
-
183
-
-
18244399574
-
Role of the NH2 terminal membrane spanning domain of multidrug resistance protein 1/ABCC1 in protein processing and trafficking
-
Westlake CJ, Cole SP, Deeley RG (2005) Role of the NH2 terminal membrane spanning domain of multidrug resistance protein 1/ABCC1 in protein processing and trafficking. Mol Biol Cell 16:2483-2492
-
(2005)
Mol Biol Cell
, vol.16
, pp. 2483-2492
-
-
Westlake, C.J.1
Cole, S.P.2
Deeley, R.G.3
-
184
-
-
0033166685
-
Induction of the multispecific organic anion transporter (cMoat/mrp2) gene and biliary glutathione secretion by the herbicide 2,4,5- trichlorophenoxyacetic acid in the mouse liver
-
Wielandt AM, Vollrath V, Manzano M, Miranda S, Accatino L, Chianale J (1999) Induction of the multispecific organic anion transporter (cMoat/mrp2) gene and biliary glutathione secretion by the herbicide 2,4,5- trichlorophenoxyacetic acid in the mouse liver. Biochem J 341:105-111
-
(1999)
Biochem J
, vol.341
, pp. 105-111
-
-
Wielandt, A.M.1
Vollrath, V.2
Manzano, M.3
Miranda, S.4
Accatino, L.5
Chianale, J.6
-
185
-
-
0036707615
-
Mechanisms of impaired biliary excretion of acetaminophen glucuronide after acute phenobarbital treatment or phenobarbital pretreatment
-
Xiong H, Suzuki H, Sugiyama Y, Meier PJ, Pollack GM, Brouwer KL (2002) Mechanisms of impaired biliary excretion of acetaminophen glucuronide after acute phenobarbital treatment or phenobarbital pretreatment. Drug Metab Dispos 30:962-969
-
(2002)
Drug Metab Dispos
, vol.30
, pp. 962-969
-
-
Xiong, H.1
Suzuki, H.2
Sugiyama, Y.3
Meier, P.J.4
Pollack, G.M.5
Brouwer, K.L.6
-
186
-
-
24344497926
-
Impaired expression of hepatic multidrug resistance protein 2 is associated with posthepatectomy hyperbilirubinemia in patients with biliary cancer
-
Yamada T, Arai T, Nagino M, Oda K, Shoda J, Suzuki H, Sugiyama Y, Nimura Y (2005) Impaired expression of hepatic multidrug resistance protein 2 is associated with posthepatectomy hyperbilirubinemia in patients with biliary cancer. Langenbecks Arch Surg 390:421-429
-
(2005)
Langenbecks Arch Surg
, vol.390
, pp. 421-429
-
-
Yamada, T.1
Arai, T.2
Nagino, M.3
Oda, K.4
Shoda, J.5
Suzuki, H.6
Sugiyama, Y.7
Nimura, Y.8
-
187
-
-
0030862073
-
Biliary excretion of pravastatin in rats: Contribution of the excretion pathway mediated by canalicular multispecific organic anion transporter
-
Yamazaki M, Akiyama S, Ni'inuma K, Nishigaki R, Sugiyama Y (1997) Biliary excretion of pravastatin in rats: contribution of the excretion pathway mediated by canalicular multispecific organic anion transporter. Drug Metab Dispos 25:1123-1129
-
(1997)
Drug Metab Dispos
, vol.25
, pp. 1123-1129
-
-
Yamazaki, M.1
Akiyama, S.2
Ni'inuma, K.3
Nishigaki, R.4
Sugiyama, Y.5
-
188
-
-
6344240461
-
Plasma membrane localization of multidrug resistance-associated protein homologs in brain capillary endothelial cells
-
Zhang Y, Schuetz JD, Elmquist WF, Miller DW (2004) Plasma membrane localization of multidrug resistance-associated protein homologs in brain capillary endothelial cells. J Pharmacol Exp Ther 311:449-455
-
(2004)
J Pharmacol Exp Ther
, vol.311
, pp. 449-455
-
-
Zhang, Y.1
Schuetz, J.D.2
Elmquist, W.F.3
Miller, D.W.4
-
189
-
-
17744391290
-
Hepatobiliary transporter expression in percutaneous liver biopsies of patients with cholestatic liver diseases
-
Zollner G, Fickert P, Zenz R, Fuchsbichler A, Stumptner C, Kenner L, Ferenci P, Stauber RE, Krejs GJ, Denk H, Zatloukal K, Trauner M (2001) Hepatobiliary transporter expression in percutaneous liver biopsies of patients with cholestatic liver diseases. Hepatology 33:633-646
-
(2001)
Hepatology
, vol.33
, pp. 633-646
-
-
Zollner, G.1
Fickert, P.2
Zenz, R.3
Fuchsbichler, A.4
Stumptner, C.5
Kenner, L.6
Ferenci, P.7
Stauber, R.E.8
Krejs, G.J.9
Denk, H.10
Zatloukal, K.11
Trauner, M.12
-
190
-
-
17044400593
-
Hepatobiliary transporter expression in human hepatocellular carcinoma
-
Zollner G, Wagner M, Fickert P, Silbert D, Fuchsbichler A, Zatloukal K, Denk H, Trauner M (2005) Hepatobiliary transporter expression in human hepatocellular carcinoma. Liver Int 25:367-379
-
(2005)
Liver Int
, vol.25
, pp. 367-379
-
-
Zollner, G.1
Wagner, M.2
Fickert, P.3
Silbert, D.4
Fuchsbichler, A.5
Zatloukal, K.6
Denk, H.7
Trauner, M.8
|