메뉴 건너뛰기




Volumn 296, Issue 3, 2009, Pages

Mechanisms of pH-gradient driven transport mediated by organic anion polypeptide transporters

Author keywords

Anion bicarbonate exchange

Indexed keywords

BICARBONATE; CHLORIDE; HISTIDINE; ORGANIC ANION TRANSPORTER; ORGANIC ANION TRANSPORTER POLYPEPTIDE 1 A1; ORGANIC ANION TRANSPORTER POLYPEPTIDE 1 A2; ORGANIC ANION TRANSPORTER POLYPEPTIDE 1 A4; ORGANIC ANION TRANSPORTER POLYPEPTIDE 1 A5; ORGANIC ANION TRANSPORTER POLYPEPTIDE 1 B1; ORGANIC ANION TRANSPORTER POLYPEPTIDE 1 B2; ORGANIC ANION TRANSPORTER POLYPEPTIDE 1 B3; ORGANIC ANION TRANSPORTER POLYPEPTIDE 1 C1; ORGANIC ANION TRANSPORTER POLYPEPTIDE 2 B1; ORGANIC ANION TRANSPORTER POLYPEPTIDE 3 A1 V1; ORGANIC ANION TRANSPORTER POLYPEPTIDE 3 A1 V2; ORGANIC ANION TRANSPORTER POLYPEPTIDE 4 A1; ORGANIC ANION TRANSPORTER POLYPEPTIDE 4 C1; PEPTIDE DERIVATIVE; POLYPEPTIDE; SULFONIC ACID DERIVATIVE; UNCLASSIFIED DRUG; 4,4' DIISOTHIOCYANATOSTILBENE 2,2' DISULFONIC ACID; ACETAZOLAMIDE; AMILORIDE; CARBONATE DEHYDRATASE; CARBONATE DEHYDRATASE INHIBITOR; SODIUM PROTON EXCHANGE PROTEIN;

EID: 65249143403     PISSN: 03636143     EISSN: 15221563     Source Type: Journal    
DOI: 10.1152/ajpcell.00436.2008     Document Type: Article
Times cited : (154)

References (65)
  • 1
    • 34250015651 scopus 로고    scopus 로고
    • +/organic cation antiporter multidrug and toxin extrusion (MATE)
    • DOI 10.1124/mol.106.032938
    • Asaka J, Terada T, Tsuda M, Katsura T, Inui K. Identification of essential histidine and cysteine residues of the H+/organic cation anti-porter multidrug and toxin extrusion (MATE). Mol Pharmacol 71: 1487-1493, 2007. (Pubitemid 47010901)
    • (2007) Molecular Pharmacology , vol.71 , Issue.6 , pp. 1487-1493
    • Asaka, J.-I.1    Terada, T.2    Tsuda, M.3    Katsura, T.4    Inui, K.-I.5
  • 3
    • 0026562055 scopus 로고
    • Hepatic transport systems regulating pHi, cell volume, and bile secretion
    • Boyer JL, Graf J, Meier PJ. Hepatic transport systems regulating pHi, cell volume, and bile secretion. Annu Rev Physiol 54: 415-438, 1992.
    • (1992) Annu Rev Physiol , vol.54 , pp. 415-438
    • Boyer, J.L.1    Graf, J.2    Meier, P.J.3
  • 4
    • 0034595593 scopus 로고    scopus 로고
    • Identification of organic anion transporting polypeptide 4 (Oatp4) as a major full-length isoform of the liver-specific transporter-1 (rlst-1) in rat liver
    • DOI 10.1016/S0014-5793(00)01596-9, PII S0014579300015969
    • Cattori V, Hagenbuch B, Hagenbuch N, Stieger B, Ha R, Winterhalter KE, Meier PJ. Identification of organic anion transporting polypeptide 4 (Oatp4) as a major full-length isoform of the liver-specific transporter-1 (rlst-1) in rat liver. FEBS Lett 474: 242-245, 2000. (Pubitemid 30330842)
    • (2000) FEBS Letters , vol.474 , Issue.2-3 , pp. 242-245
    • Cattori, V.1    Hagenbuch, B.2    Hagenbuch, N.3    Stieger, B.4    Ha, R.5    Winterhalter, K.E.6    Meier, P.J.7
  • 7
    • 0031037730 scopus 로고    scopus 로고
    • +/peptide cotransporters PEPT1 and PEPT2
    • DOI 10.1021/bi962058p
    • Fei YJ, Liu W, Prasad PD, Kekuda R, Oblak TG, Ganapathy V, Leibach FH. Identification of the histidyl residue obligatory for the catalytic activity of the human H+/peptide cotransporters PEPT1 and PEPT2. Biochemistry 36: 452-460, 1997. (Pubitemid 27043481)
    • (1997) Biochemistry , vol.36 , Issue.2 , pp. 452-460
    • Fei, Y.-J.1    Liu, W.2    Prasad, P.D.3    Kekuda, R.4    Oblak, T.G.5    Ganapathy, V.6    Leibach, F.H.7
  • 9
  • 11
    • 0032859340 scopus 로고    scopus 로고
    • Localization of the organic anion transporting polypeptide 2 (Oatp2) in capillary endothelium and choroid plexus epithelium of rat brain
    • Gao B, Stieger B, Noe B, Fritschy JM, Meier PJ. Localization of the organic anion transporting polypeptide 2 (Oatp2) in capillary endothelium and choroid plexus epithelium of rat brain. J Histochem Cytochem 47: 1255-1264, 1999. (Pubitemid 29455921)
    • (1999) Journal of Histochemistry and Cytochemistry , vol.47 , Issue.10 , pp. 1255-1263
    • Gao, B.1    Stieger, B.2    Noe, B.3    Fritschy, J.-M.4    Meier, P.J.5
  • 12
    • 0022632382 scopus 로고
    • Inactivation of the renal microvillus membrane Na+-H+ exchanger by histidine-specific reagents
    • Grillo FG, Aronson PS. Inactivation of the renal microvillus membrane Na+-H+ exchanger by histidine-specific reagents. J Biol Chem 261: 1120-1125, 1986.
    • (1986) J Biol Chem , vol.261 , pp. 1120-1125
    • Grillo, F.G.1    Aronson, P.S.2
  • 14
    • 1242272736 scopus 로고    scopus 로고
    • Organic anion transporting polypeptides of the OATP/SLC21 family: Phylogenetic classification as OATP/SLCO super-family, new nomenclature and molecular/functional properties
    • DOI 10.1007/s00424-003-1168-y, The ABCs of Solute Carriers: Physiological, Pathological and Therapeutic Implications of Human Membrane Transport Proteins
    • Hagenbuch B, Meier PJ. Organic anion transporting polypeptides of the OATP/SLC21 family: Phylogenetic classification as OATP/SLCO super-family, new nomenclature and molecular/functional properties. Pflügers Arch 447: 653-665, 2004. (Pubitemid 38241451)
    • (2004) Pflugers Archiv European Journal of Physiology , vol.447 , Issue.5 , pp. 653-665
    • Hagenbuch, B.1    Meier, P.J.2
  • 15
    • 0029822980 scopus 로고    scopus 로고
    • Effect of antisense oligonucleotides on the expression of hepatocellular bile acid and organic anion uptake systems in Xenopus laevis oocytes
    • Hagenbuch B, Scharschmidt BF, Meier PJ. Effect of antisense oligonucleotides on the expression of hepatocellular bile acid and organic anion uptake systems in Xenopus laevis oocytes. Biochem J 316: 901-904, 1996. (Pubitemid 26278444)
    • (1996) Biochemical Journal , vol.316 , Issue.3 , pp. 901-904
    • Hagenbuch, B.1    Scharschmidt, B.F.2    Meier, P.J.3
  • 16
    • 0024386378 scopus 로고
    • +/organic cation antiport system in rat renal brush-border membranes
    • Hori R, Maegawa H, Kato M, Katsura T, Inui K. Inhibitory effect of diethyl pyrocarbonate on the H+/organic cation antiport system in rat renal brush-border membranes. J Biol Chem 264: 12232-12237, 1989. (Pubitemid 19191108)
    • (1989) Journal of Biological Chemistry , vol.264 , Issue.21 , pp. 12232-12237
    • Hori, R.1    Maegawa, H.2    Kato, M.3    Katsura, T.4    Inui, K.5
  • 18
    • 0028330055 scopus 로고
    • Effect of perfusate pH on the influx of 5-5'-dimethyl-oxazolidine-2,4- Dione and dissociation of epidermal growth factor from the cell-surface receptor: The existence of the proton diffusion barrier in the Disse space
    • Ichikawa M, Kato Y, Miyauchi S, Sawada Y, Iga T, Fuwa T, Hanano M, Sugiyama Y. Effect of perfusate pH on the influx of 5-5′-dimethyl- oxazolidine- 2,4-dione and dissociation of epidermal growth factor from the cell-surface receptor: the existence of the proton diffusion barrier in the Disse space. J Hepatol 20: 190-200, 1994. (Pubitemid 24086832)
    • (1994) Journal of Hepatology , vol.20 , Issue.2 , pp. 190-200
    • Ichikawa, M.1    Kato, Y.2    Miyauchi, S.3    Sawada, Y.4    Iga, T.5    Fuwa, T.6    Hanano, M.7    Sugiyama, Y.8
  • 20
    • 0029876334 scopus 로고    scopus 로고
    • Transient expression of oatp organic anion transporter in mammalian cells: Identification of candidate substrates
    • Kanai N, Lu R, Bao Y, Wolkoff AW, Schuster VL. Transient expression of oatp organic anion transporter in mammalian cells: identification of candidate substrates. Am J Physiol Renal Fluid Electrolyte Physiol 270: F319-F325, 1996. (Pubitemid 126756323)
    • (1996) American Journal of Physiology , vol.270 , Issue.2 PART 2
    • Kanai, N.1    Lu, R.2    Bao, Y.I.3    Wolkoff, A.W.4    Schuster, V.L.5
  • 21
    • 0024313527 scopus 로고
    • + coupled transport of cephradine via dipeptide carriers in rabbit intestinal brush-border membranes: Role of histidine residues
    • Kato M, Maegawa H, Okano T, Inui K, Hori R. Effect of various chemical modifiers on H+ coupled transport of cephradine via dipeptide carriers in rabbit intestinal brush-border membranes: role of histidine residues. J Pharmacol Exp Ther 251: 745-749, 1989. (Pubitemid 20005626)
    • (1989) Journal of Pharmacology and Experimental Therapeutics , vol.251 , Issue.2 , pp. 745-749
    • Kato, M.1    Maegawa, H.2    Okano, T.3    Inui, K.-I.4    Hori, R.5
  • 22
    • 0023807201 scopus 로고
    • Amiloride and its analogs as tools in the study of ion transport
    • Kleyman TR, Cragoe EJ Jr. Amiloride and its analogs as tools in the study of ion transport. J Membr Biol 105: 1-21, 1988.
    • (1988) J Membr Biol , vol.105 , pp. 1-21
    • Kleyman, T.R.1    Cragoe Jr., E.J.2
  • 23
    • 0038637144 scopus 로고    scopus 로고
    • Involvement of human organic anion transporting polypeptide OATP-B (SLC21A9) in pH-dependent transport across intestinal apical membrane
    • DOI 10.1124/jpet.103.051300
    • Kobayashi D, Nozawa T, Imai K, Nezu J, Tsuji A, Tamai I. Involvement of human organic anion transporting polypeptide OATP-B (SLC21A9) in pH-dependent transport across intestinal apical membrane. J Pharmacol Exp Ther 306: 703-708, 2003. (Pubitemid 36886171)
    • (2003) Journal of Pharmacology and Experimental Therapeutics , vol.306 , Issue.2 , pp. 703-708
    • Kobayashi, D.1    Nozawa, T.2    Imai, K.3    Nezu, J.-I.4    Tsuji, A.5    Tamai, I.6
  • 24
    • 0034725617 scopus 로고    scopus 로고
    • Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide
    • DOI 10.1074/jbc.M001448200
    • Konig J, Cui Y, Nies AT, Keppler D. Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide. J Biol Chem 275: 23161-23168, 2000. (Pubitemid 30646210)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.30 , pp. 23161-23168
    • Konig, J.1    Cui, Y.2    Nies, A.T.3    Keppler, D.4
  • 27
    • 0035887256 scopus 로고    scopus 로고
    • Bidirectional electrogenic transport of peptides by the proton-coupled carrier PEPT1 in Xenopus laevis oocytes: Its asymmetry and symmetry
    • DOI 10.1111/j.1469-7793.2001.0495c.xd
    • Kottra G, Daniel H. Bidirectional electrogenic transport of peptides by the proton-coupled carrier PEPT1 in Xenopus laevis oocytes: its asymmetry and symmetry. J Physiol 536: 495-503, 2001. (Pubitemid 32976130)
    • (2001) Journal of Physiology , vol.536 , Issue.2 , pp. 495-503
    • Kottra, G.1    Daniel, H.2
  • 28
    • 0023660877 scopus 로고
    • At least six nucleotides preceding the AUG initiator codon enhance translation in mammalian cells
    • Kozak M. At least six nucleotides preceding the AUG initiator codon enhance translation in mammalian cells. J Mol Biol 196: 947-950, 1987.
    • (1987) J Mol Biol , vol.196 , pp. 947-950
    • Kozak, M.1
  • 29
    • 0023726164 scopus 로고
    • Inactivation of the intestinal uptake system for β-lactam antibiotics by diethylpyrocarbonate
    • DOI 10.1016/0005-2736(88)90560-3
    • Kramer W, Girbig F, Petzoldt E, Leipe I. Inactivation of the intestinal uptake system for beta-lactam antibiotics by diethylpyrocarbonate. Biochim Biophys Acta 943: 288-296, 1988. (Pubitemid 18193198)
    • (1988) Biochimica et Biophysica Acta - Biomembranes , vol.943 , Issue.2 , pp. 288-296
    • Kramer, W.1    Girbig, F.2    Petzholdt, E.3    Leipe, I.4
  • 32
    • 0032568838 scopus 로고    scopus 로고
    • 4 as a substrate for oatp1, the hepatic sinusoidal organic solute transporter
    • DOI 10.1074/jbc.273.26.16184
    • Li L, Lee TK, Meier PJ, Ballatori N. Identification of glutathione as a driving force and leukotriene C4 as a substrate for oatp1, the hepatic sinusoidal organic solute transporter. J Biol Chem 273: 16184-16191, 1998. (Pubitemid 28311391)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.26 , pp. 16184-16191
    • Li, L.1    Lee, T.K.2    Meier, P.J.3    Ballatori, N.4
  • 33
    • 0033943874 scopus 로고    scopus 로고
    • Oatp2 mediates bidirectional organic solute transport: A role for intracellular glutathione
    • Li L, Meier PJ, Ballatori N. Oatp2 mediates bidirectional organic solute transport: a role for intracellular glutathione. Mol Pharmacol 58: 335-340, 2000. (Pubitemid 30497477)
    • (2000) Molecular Pharmacology , vol.58 , Issue.2 , pp. 335-340
    • Li, L.1    Meier, P.J.2    Ballatori, N.3
  • 35
    • 3042550238 scopus 로고    scopus 로고
    • Identification of phalloidin uptake systems of rat and human liver
    • DOI 10.1016/j.bbamem.2004.04.004, PII S0005273604000999
    • Meier-Abt F, Faulstich H, Hagenbuch B. Identification of phalloidin uptake systems of rat and human liver. Biochim Biophys Acta 1664: 64-69, 2004. (Pubitemid 38829318)
    • (2004) Biochimica et Biophysica Acta - Biomembranes , vol.1664 , Issue.1 , pp. 64-69
    • Meier-Abt, F.1    Faulstich, H.2    Hagenbuch, B.3
  • 36
    • 33646442476 scopus 로고    scopus 로고
    • Organic anion transporting polypeptides of the OATP/SLCO superfamily: Identification of new members in nonmammalian species, comparative modeling and a potential transport mode
    • Meier-Abt F, Mokrab Y, Mizuguchi K. Organic anion transporting polypeptides of the OATP/SLCO superfamily: identification of new members in nonmammalian species, comparative modeling and a potential transport mode. J Membr Biol 208: 213-227, 2005.
    • (2005) J Membr Biol , vol.208 , pp. 213-227
    • Meier-Abt, F.1    Mokrab, Y.2    Mizuguchi, K.3
  • 38
    • 0017632673 scopus 로고
    • Modification of histidyl residues in proteins by diethylpyrocarbonate
    • Miles EW. Modification of histidyl residues in proteins by diethylpyrocarbonate. Methods Enzymol 47: 431-442, 1977.
    • (1977) Methods Enzymol , vol.47 , pp. 431-442
    • Miles, E.W.1
  • 39
    • 33845460145 scopus 로고    scopus 로고
    • Characterization of the uptake mechanism for a novel loop diuretic, M17055, in Caco-2 cells: Involvement of organic anion transporting polypeptide (OATP)-B
    • Nishimura T, Kubo Y, Kato Y, Sai Y, Ogihara T, Tsuji A. Characterization of the uptake mechanism for a novel loop diuretic, M17055, in Caco-2 cells: involvement of organic anion transporting polypeptide (OATP)-B. Pharm Res 24: 90-98, 2007.
    • (2007) Pharm Res , vol.24 , pp. 90-98
    • Nishimura, T.1    Kubo, Y.2    Kato, Y.3    Sai, Y.4    Ogihara, T.5    Tsuji, A.6
  • 41
    • 34547178337 scopus 로고    scopus 로고
    • Substrate-dependent drug-drug interactions between gemfibrozil, fluvastatin and other organic anion-transporting peptide (OATP) substrates on OATP1B1, OATP2B1, and OATP1B3
    • DOI 10.1124/dmd.106.012930
    • Noe J, Portmann R, Brun ME, Funk C. Substrate-dependent drug-drug interactions between gemfibrozil, fluvastatin and other organic anion-transporting peptide (OATP) substrates on OATP1B1, OATP2B1, and OATP1B3. Drug Metab Dispos 35: 1308-1314, 2007. (Pubitemid 47121771)
    • (2007) Drug Metabolism and Disposition , vol.35 , Issue.8 , pp. 1308-1314
    • Noe, J.1    Portmann, R.2    Brun, M.-E.3    Funk, C.4
  • 43
    • 0025860171 scopus 로고
    • Production of analytical quantities of recombinant proteins in Chinese hamster ovary cells using sodium butyrate to elevate gene expression
    • Palermo DP, DeGraaf ME, Marotti KR, Rehberg E, Post LE. Production of analytical quantities of recombinant proteins in Chinese hamster ovary cells using sodium butyrate to elevate gene expression. J Biotechnol 19: 35-47, 1991.
    • (1991) J Biotechnol , vol.19 , pp. 35-47
    • Palermo, D.P.1    Degraaf, M.E.2    Marotti, K.R.3    Rehberg, E.4    Post, L.E.5
  • 44
    • 0036793106 scopus 로고    scopus 로고
    • Identification of a novel human organic anion transporting polypeptide as a high affinity thyroxine transporter
    • DOI 10.1210/me.2001-0309
    • Pizzagalli F, Hagenbuch B, Stieger B, Klenk U, Folkers G, Meier PJ. Identification of a novel human organic anion transporting polypeptide as a high affinity thyroxine transporter. Mol Endocrinol 16: 2283-2296, 2002. (Pubitemid 35155540)
    • (2002) Molecular Endocrinology , vol.16 , Issue.10 , pp. 2283-2296
    • Pizzagalli, F.1    Hagenbuch, B.2    Stieger, B.3    Klenk, U.4    Folkers, G.5    Meier, P.J.6
  • 46
    • 33645581428 scopus 로고    scopus 로고
    • -2) transporters: Classification, function, structure, genetic diseases, and knockout models
    • -2) transporters: classification, function, structure, genetic diseases, and knockout models. Am J Physiol Renal Physiol 290: F580-F599, 2006.
    • (2006) Am J Physiol Renal Physiol , vol.290
    • Pushkin, A.1    Kurtz, I.2
  • 48
    • 0020401107 scopus 로고
    • 2+ in lymphocytes
    • DOI 10.1083/jcb.95.1.189
    • Rink TJ, Tsien RY, Pozzan T. Cytoplasmic pH and free Mg2+ in lymphocytes. J Cell Biol 95: 189-196, 1982. (Pubitemid 13197089)
    • (1982) Journal of Cell Biology , vol.95 , Issue.1 , pp. 189-196
    • Rink, T.J.1    Tsien, R.Y.2    Pozzan, T.3
  • 50
    • 0019554835 scopus 로고
    • Intracellular pH
    • Roos A, and Boron WF. Intracellular pH. Physiol Rev 61: 296-434, 1981.
    • (1981) Physiol Rev , vol.61 , pp. 296-434
    • Roos, A.1    Boron, W.F.2
  • 52
    • 33746048844 scopus 로고    scopus 로고
    • Predominant contribution of organic anion transporting polypeptide OATP-B (OATP2B1) to apical uptake of estrone-3-sulfate by human intestinal Caco-2 cells
    • DOI 10.1124/dmd.106.009530
    • Sai Y, Kaneko Y, Ito S, Mitsuoka K, Kato Y, Tamai I, Artursson P, Tsuji A. Predominant contribution of organic anion transporting polypeptide OATP-B (OATP2B1) to apical uptake of estrone-3-sulfate by human intestinal Caco-2 cells. Drug Metab Dispos 34: 1423-1431, 2006. (Pubitemid 44079886)
    • (2006) Drug Metabolism and Disposition , vol.34 , Issue.8 , pp. 1423-1431
    • Sai, Y.1    Kaneko, Y.2    Ito, S.3    Mitsuoka, K.4    Kato, Y.5    Tamai, I.6    Artursson, P.7    Tsuji, A.8
  • 53
    • 0027417994 scopus 로고
    • Folate transport in intestinal brush border membrane: Involvement of essential histidine residue(s)
    • Said HM, Mohammadkhani R. Folate transport in intestinal brush border membrane: involvement of essential histidine residue(s). Biochem J 290: 237-240, 1993. (Pubitemid 23081224)
    • (1993) Biochemical Journal , vol.290 , Issue.1 , pp. 237-240
    • Said, H.M.1    Mohammadkhani, R.2
  • 57
    • 0034704135 scopus 로고    scopus 로고
    • Molecular and functional characterization of organic cation/carnitine transporter family in mice
    • DOI 10.1074/jbc.M005340200
    • Tamai I, Nezu J, Uchino H, Sai Y, Oku A, Shimane M, Tsuji A. Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family. Biochem Biophys Res Commun 273: 251-260, 2000. (Pubitemid 32064631)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.51 , pp. 40064-40072
    • Tamai, I.1    Ohashi, R.2    Nezu, J.-I.3    Sai, Y.4    Kobayashi, D.5    Oku, A.6    Shimane, M.7    Tsuji, A.8
  • 58
    • 0017233517 scopus 로고
    • The effect of carbon dioxide on the intracellular pH and buffering power of snail neurones
    • Thomas RC. The effect of carbon dioxide on the intracellular pH and buffering power of snail neurones. J Physiol 255: 715-735, 1976.
    • (1976) J Physiol , vol.255 , pp. 715-735
    • Thomas, R.C.1
  • 59
    • 34347379290 scopus 로고    scopus 로고
    • H+-coupled nutrient, micronutrient and drug transporters in the mammalian small intestine
    • Thwaites DT, Anderson CM. H+-coupled nutrient, micronutrient and drug transporters in the mammalian small intestine. Exp Physiol 92: 603-619, 2007.
    • (2007) Exp Physiol , vol.92 , pp. 603-619
    • Thwaites, D.T.1    Anderson, C.M.2
  • 60
    • 34547212999 scopus 로고    scopus 로고
    • Bosentan is a substrate of human OATP1B1 and OATP1B3: Inhibition of hepatic uptake as the common mechanism of its interactions with cyclosporin A, rifampicin, and sildenafil
    • DOI 10.1124/dmd.106.013615
    • Treiber A, Schneiter R, Hausler S, Stieger B. Bosentan is a substrate of human OATP1B1 and OATP1B3: inhibition of hepatic uptake as the common mechanism of its interactions with cyclosporin A, rifampicin, and sildenafil. Drug Metab Dispos 35: 1400-1407, 2007. (Pubitemid 47121782)
    • (2007) Drug Metabolism and Disposition , vol.35 , Issue.8 , pp. 1400-1407
    • Treiber, A.1    Schneiter, R.2    Hausler, S.3    Stieger, B.4
  • 61
    • 0023213648 scopus 로고
    • + gradient-dependent and carrier-mediated transport of cefixime, a new cephalosporin antibiotic, across brush-border membrane vesicles from rat small intestine
    • Tsuji A, Terasaki T, Tamai I, Hirooka H. H+ gradient-dependent and carrier-mediated transport of cefixime, a new cephalosporin antibiotic, across brush-border membrane vesicles from rat small intestine. J Pharmacol Exp Ther 241: 594-601, 1987. (Pubitemid 17111568)
    • (1987) Journal of Pharmacology and Experimental Therapeutics , vol.241 , Issue.2 , pp. 594-601
    • Tsuji, A.1    Terasaki, T.2    Tamai, I.3    Hirooka, H.4
  • 63
    • 0028895506 scopus 로고
    • Mutational analysis of transmembrane histidines in the amiloride-sensitive Na+/H+ exchanger
    • Wang D, Balkovetz DF, Warnock DG. Mutational analysis of transmembrane histidines in the amiloride-sensitive Na+/H+ exchanger. Am J Physiol Cell Physiol 269: C392-C402, 1995.
    • (1995) Am J Physiol Cell Physiol , vol.269
    • Wang, D.1    Balkovetz, D.F.2    Warnock, D.G.3
  • 65
    • 44949099300 scopus 로고    scopus 로고
    • Pharmacogenetics of OATP (SLC21/SLCO), OAT and OCT (SLC22) and PEPT (SLC15) transporters in the intestine, liver and kidney
    • Zair ZM, Eloranta JJ, Stieger B, and Kullak-Ublick GA. Pharmacogenetics of OATP (SLC21/SLCO), OAT and OCT (SLC22) and PEPT (SLC15) transporters in the intestine, liver and kidney. Pharmacogenomics 9: 597-624, 2008.
    • (2008) Pharmacogenomics , vol.9 , pp. 597-624
    • Zair, Z.M.1    Eloranta, J.J.2    Stieger, B.3    Kullak-Ublick, G.A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.