The human carnitine transporter SLC22A16 mediates high affinity uptake of the anticancer polyamine analogue bleomycin-A5

Journal of Biological Chemistry

Volumn 285, Issue 9, 2010, Pages 6275-6284

  Aouida, Mustapha ^a   Poulin, Richard ^b   Ramotar, Dindial ^a  

^a UNIVERSITY OF MONTREAL   (Canada)

^b UNIVERSITÉ LAVAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENTS; BLEOMYCINS; CANCER CELLS; CARNITINE; DIFFERENTIAL RESPONSE; FUSION PROTEINS; GENOTOXICITIES; HIGH AFFINITY; HUMAN BREAST CANCER CELLS; HUMAN COLON; INDUCED RESISTANCE; L-CARNITINE; LETHAL EFFECTS; OVER-EXPRESSION; POLYAMINES; SACCHAROMYCES CEREVISIAE; SQUAMOUS CELL CARCINOMA; THERAPEUTIC BENEFITS; TRANSIENT TRANSFECTION;

AMINES; CELLS; ELECTRIC RESISTANCE; NUCLEIC ACIDS;

PEPTIDES;

BLEOMYCIN; BLEOMYCIN SULFATE; FLUORESCEIN; PERMEASE; PROTEIN SLC22A16; RECOMBINANT CARNITINE TRANSPORTER; RECOMBINANT PROTEIN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; ANTINEOPLASTIC ANTIBIOTIC; BLEOMYCIN A5; DRUG DERIVATIVE; ORGANIC CATION TRANSPORTER; POLYAMINE; SLC22A16 PROTEIN, HUMAN;

ARTICLE; BINDING AFFINITY; CELL STRAIN HCT116; CELL STRAIN MCF 7; DRUG SENSITIVITY; GENOTOXICITY; HUMAN; HUMAN CELL; LETHALITY; MALE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN TRANSPORT; BREAST TUMOR; COLON TUMOR; DRUG RESISTANCE; FEMALE; METABOLISM; PHARMACOKINETICS; TESTIS TUMOR; TUMOR CELL LINE;

SACCHAROMYCES CEREVISIAE;

ANTIBIOTICS, ANTINEOPLASTIC; BLEOMYCIN; BREAST NEOPLASMS; CELL LINE, TUMOR; COLONIC NEOPLASMS; DRUG RESISTANCE, NEOPLASM; FEMALE; HUMANS; MALE; ORGANIC CATION TRANSPORT PROTEINS; PHARMACOKINETICS; POLYAMINES; TESTICULAR NEOPLASMS;

EID: 77949909138     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.046151     Document Type: Article

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