Sex-related differences in the clearance of cytochrome P450 3A4 substrates may be caused by P-glycoprotein

Clinical Pharmacology and Therapeutics

Volumn 72, Issue 5, 2002, Pages 474-489

  Cummins, Carolyn L ^a   Wu, Chi Yuan ^a   Benet, Leslie Z ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALFENTANIL; ATORVASTATIN; BUSPIRONE; CERIVASTATIN; CYCLOSPORIN A; CYSTEINE PROTEINASE INHIBITOR; CYTOCHROME P450 3A4; DIAZEPAM; DIGOXIN; DILTIAZEM; DOXORUBICIN; EBASTINE; ELACRIDAR; ERYTHROMYCIN; ESTROGEN; ETOPOSIDE; FELODIPINE; FEXOFENADINE; GLYCOPROTEIN P; K 11777; LIDOCAINE; METHADONE; MEVINOLIN; MIDAZOLAM; PACLITAXEL; PREDNISOLONE; PROGESTERONE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VERAPAMIL; VINBLASTINE;

ANIMAL EXPERIMENT; CELL STRAIN CACO 2; CONTROLLED STUDY; DEMETHYLATION; DRUG DISPOSITION; DRUG HYDROXYLATION; DRUG METABOLISM; FEMALE; FIRST PASS EFFECT; HORMONAL REGULATION; HUMAN; HUMAN CELL; KNOCKOUT MOUSE; LIVER MICROSOME; MALE; MOUSE; NONHUMAN; NOTE; PRIORITY JOURNAL; SEX DIFFERENCE;

ANIMALS; CYTOCHROME P-450 ENZYME SYSTEM; ERYTHROMYCIN; HUMANS; METABOLIC CLEARANCE RATE; MIDAZOLAM; P-GLYCOPROTEIN; SEX CHARACTERISTICS;

EID: 0036881095     PISSN: 00099236     EISSN: None     Source Type: Journal    
DOI: 10.1067/mcp.2002.128388     Document Type: Note

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