Prostaglandin transport

Prostaglandins and Other Lipid Mediators

Volumn 68-69, Issue , 2002, Pages 633-647

  Schuster, Victor L ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Biological transport; Carrier proteins; Eicosanoids; Molecular cloning

Indexed keywords

2 OXOGLUTARIC ACID; ANTIPORTER; CARRIER PROTEIN; GLUTATHIONE; LACTIC ACID; LEUKOTRIENE; MULTIDRUG RESISTANCE PROTEIN; NEUROTRANSMITTER; ORGANIC ANION TRANSPORTER; PROSTAGLANDIN; PROSTAGLANDIN RECEPTOR; PROSTAGLANDIN SYNTHASE; DNA BINDING PROTEIN; SLCO2A1 PROTEIN, HUMAN;

ANION EXCHANGE; ARTICLE; BINDING AFFINITY; CATALYSIS; CELL LEVEL; CELL MEMBRANE POTENTIAL; CELL PH; CELL POLARITY; CELL SECRETION; CYTOPLASM; DIFFUSION; ENERGY; EXCRETION; GENE; HUMAN; MEMBRANE TRANSPORT; METABOLIC CLEARANCE RATE; MOLECULAR CLONING; MULTIGENE FAMILY; NEUROTRANSMITTER RELEASE; NEUROTRANSMITTER UPTAKE; NONHUMAN; OXIDATION; PGT GENE; PROSTAGLANDIN METABOLISM; PROSTAGLANDIN SYNTHESIS; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN TRANSPORT; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; ANIMAL; GENETICS; METABOLISM; PHYSIOLOGY; REVIEW; TRANSPORT AT THE CELLULAR LEVEL;

ANIMALS; ANTIPORTERS; BIOLOGICAL TRANSPORT; CELL POLARITY; DNA-BINDING PROTEINS; HUMANS; ORGANIC ANION TRANSPORTERS; PROSTAGLANDINS; SIGNAL TRANSDUCTION;

EID: 0036669441     PISSN: 00906980     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0090-6980(02)00061-8     Document Type: Article

References (94)

1. Morita I., Schindler M., Regier M.K., Otto J.C., Hori T., DeWitt D.L.et al. Different intracellular locations for prostaglandin endoperoxide H synthase-1 and -2. J. Biol. Chem. 270:1995;10902-10908.
2. Tanaka Y., Ward S.L., Smith W.L. Immunochemical and kinetic evidence for two different prostaglandin H-prostaglandin E isomerases in sheep vesicular gland microsomes. J. Biol. Chem. 262:1987;1374-1381.
3. Ruan K.H., Wang L.H., Wu K.K., Kulmacz R.J. Amino-terminal topology of thromboxane synthase in the endoplasmic reticulum. J. Biol. Chem. 268:1993;19483-19490.
4. Morita I., Smith W.L., DeWitt D.L., Schindler M. Expression-activity profiles of cells transfected with prostaglandin endoperoxide H synthase measured by quantitative fluorescence microscopy. Biochemistry. 34:1995;7194-7199.
5. Chan B.S., Satriano J.A., Pucci M.L., Schuster V.L. Mechanism of prostaglandin E2 transport across the plasma membrane of HeLa cells and Xenopus oocytes expressing the prostaglandin transporter 'PGT'. J. Biol. Chem. 273:1998;6689-6697.
6. Roseman T.J., Yalkowsky S.H. Physicochemical properties of prostaglandin F2 alpha (tromethamine salt): solubility behavior, surface properties, and ionization constants. J. Pharm. Sci. 62:1973;1680-1685.
7. Uekama K., Hirayama F., Tanaka H., Takematsu K. Partition behaviour and ion pair formation of some prostaglandins. Chem. Pharm. Bull. 26:1978;F58.
8. 3-D-glucamine on the octanol-water partitioning of prostaglandins E1 and E2. J. Pharm. Sci. 84:1995;523-529.
9. Ussing H.H. The distinction by means of tracers between active transport and difusion. The transfer of iodide across the isolated frog skin. Acta. Physiol. Scand. 19:1949;43-56.
10. Churchill P.C., Churchill M.C., McDonald F.D. Quinacrine antagonizes the effects of Na-K-ATPase inhibitors on renal prostaglandin E2 release but not their effects on renin secretion. Life Sci. 36:1985;277-282.
11. + and prostaglandin E release in the guinea-pig Taenia coli. Biochim. Biophys. Acta. 557:1979;217-229.
12. Roos A., Boron W.F. Intracellular pH. Physiol. Rev. 61:1981;296-434.
13. Bito L.Z., Baroody R.A. Impermeability of rabbit erythrocytes to prostaglandins. Am. J. Physiol. 229:1975;1580-1584.
14. Baroody R.A., Bito L.Z. The impermeability of the basic cell membrane to thromboxane-B2, prostacyclin and 6-keto-PGF1-alpha. Prostaglandins. 21:1981;133-142.
15. Garcia-Perez A., Smith W.L. Apical-basolateral membrane asymmetry in canine cortical collecting tubule cells. Bradykinin, arginine vasopressin, prostaglandin E2 interrelationships. J. Clin. Invest. 74:1984;63-74.
16. Kanai N., Lu R., Satriano J.A., Bao Y., Wolkoff A.W., Schuster V.L. Identification and characterization of a prostaglandin transporter. Science. 268:1995;866-869.
17. Itoh S., Lu R., Bao Y., Morrow J.D., Roberts L.J., Schuster V.L. Structural determinants of substrates for the prostaglandin transporter PGT. Mol. Pharm. 50:1996;736-742.
18. Lu R., Kanai N., Bao Y., Schuster V.L. Cloning, in vitro expression, and tissue distribution of a human prostaglandin transporter cDNA (hPGT). J. Clin. Invest. 98:1996;1142-1149.
19. Schuster V.L. Molecular mechanisms of prostaglandin transport. Ann. Rev. Physiol. 60:1998;221-242.
20. Bito L.Z., Baroody R.A. Inhibition of pulmonary prostaglandin metabolism by inhibitors of prostaglandin biotransport (probenecid and bromcresol green). Prostaglandins. 10:1975;633-639.
21. Bito L.Z., Baroody R.A., Reitz M.E. Dependence of pulmonary prostaglandin metabolism on carrier-mediated transport processes. Am. J. Physiol. 232:1977;E382-E387.
22. Eling T.E., Hawkins H.J., Anderson M.W. Structural requirements for, and the effects of chemicals on, the rat pulmonary inactivation of prostaglandins. Prostaglandins. 14:1977;51-60.
23. Dusting G.J., Moncada S., Vane J.R. Recirculation of prostacyclin (PGI2) in the dog. Br. J. Pharmacol. 64:1978;315-320.
24. Tsunoda S., Jackson E.K., Branch R.A., Gerkens J.F. Comparison of the pulmonary, hepatic and renal extraction of PGI2 and 6-keto-PGE1. Eur. J. Pharmacol. 77:1982;147-151.
25. Pucci M.L., Bao Y., Chan B., Itoh S., Lu R., Copeland N.G.et al. Cloning of mouse prostaglandin transporter PGT cDNA: species-specific substrate affinities. Am. J. Physiol. 277:1999;R734-R741.
26. Schuster V.L., Itoh S., Andrews S.W., Burk R.M., Chen J., Kedzie K.M.et al. Synthetic modification of prostaglandin F-2alpha indicates different structural determinants for binding to the prostaglandin F receptor versus the prostaglandin transporter. Mol. Pharm. 58:2000;1511-1516.
27. Eling T.E., Anderson M.W. Studies on the biosynthesis, metabolism and transport of prostaglandins by the lung. Agents Actions. 6:1976;543-546.
28. Anderson M.W., Eling T.E. Prostaglandin removal and metabolism by isolated perfused rat lung. Prostaglandins. 11:1976;645-677.
29. Hawkins H.J., Wilson A.G., Anderson M.W., Eling T.E. Uptake and metabolism of prostaglandins by isolated perfused lung: species comparisons and the role of plasma protein binding. Prostaglandins. 14:1977;251-259.
30. Robinson C., Hoult J.R.S. Inactivation of prostaglandins in the perfused rat lung. Biochem. Pharmacol. 31:1982;633-638.
31. 3H ]prostaglandin E1 removal in vivo J. Pharmacol. Exp. Ther. 227:1983;531-537.
32. Schuster V.L., Lu R., Coca-Prados M. The prostaglandin transporter is widely expressed in ocular tissues. Survey Ophthalmol. 41(Suppl 2):1997;S41-S45.
33. Tamai I., Nezu J., Uchino H., Sai Y., Oku A., Shimane M.et al. Molecular identification and characterization of novel members of the human organic anion transporter (oatp) family. Biochem. Biophys. Res. Commun. 273:2000;251-260.
34. Topper J.N., Cai J., Stavrakis G., Anderson K.R., Woolf E.A., Sampson B.A.et al. Human prostaglandin transporter gene (hPGT) is regulated by fluid mechanical stimuli in cultured endothelial cells and expressed in vascular endothelium in vivo. Circulation. 98:1998;2396-2403.
35. McCormick S.M., Eskin S.G., McIntire L.V., Teng C.L., Lu C.M., Russell C.G.et al. DNA microarray reveals changes in gene expression of shear stressed human umbilical vein endothelial cells. Proc. Natl. Acad. Sci. U.S.A. 98:2001;8955-8960.
36. Bao Y, Pucci ML, Chan BS, Lu R, Ito S, Schuster VL. The prostaglandin transporter PGT is expressed in cell types that synthesize and release prostaglandins. Am J Physiol (Renal) 2002;282:F1103-10.
37. Itoh S., Bao Y., Schuster V.L. Expression pattern of the prostaglandin (PG) transporter PGT in the genitourinary (GU) system of the male rat suggests a role in release of newly-synthesized PGs. J. Am. Soc. Nephrol. 9:1998;A2105.
38. +-dependent 15-hydroxyprostaglandin dehydrogenase activity in the rat kidney. Pflügers Arch. 404:1985;278-284.
39. Larsson C., Anggard E. Regional differences in the formation and metabolism of prostaglandins in the rabbit kidney. Eur. J. Pharmacol. 21:1973;30-36.
40. +-15-hydroxyprostaglandin dehydrogenase distribution in rat kidney. J. Histochem. Cytochem. 27:1979;657-664.
41. Borden L.A. GABA transporter heterogeneity: pharmacology and cellular localization. Neurochem. Int. 29:1996;335-356.
42. Wu S.M. Synaptic transmission in the outer retina. Ann. Rev. Physiol. 56:1994;141-168.
43. Chan B.S., Satriano J.A., Schuster V.L. Mapping the substrate binding site of the prostaglandin transporter PGT by cysteine scanning mutagenesis. J. Biol. Chem. 274:1999;25564-25570.
44. Chan BS, Bao Y, Schuster VL. Role of charged residues in the function of the prostaglandin transporter 'PGT'. Biochemistry 2002 (in press).
45. Chan BS, Endo S, Kanai N, Schuster VL. Identification of lactate as a substrate and a driving force for prostanoid transport by the prostaglandin transporter PGT. Am J Physiol (Renal) 2002;282:F1097-102.
46. Tannenbaum J., Sweetman B.J., Nies A.S., Aulsebrook K., Oates J.A. The effect of glucose on the synthesis of prostaglandins by the renal papilla of the rat in vitro. Prostaglandins. 17:1979;337-350.
47. Herman C.A., Zenser T.V., Davis B.B. Prostaglandin E2 production by renal inner medullary tissue slices: effect of metabolic inhibitors. Prostaglandins. 14:1977;679-687.
48. Endo S, Nomura T, Chan BS, Lu R, Pucci ML, Bao Y, Schuster VL. Expression of PGT in MDCK cell monolayers: Polarized apical localization and induction of active PG transport. Am J Physiol 2002;282:F618-22.
49. +-ATPase in renal cell line MDCK. Am. J. Physiol. 253:1987;C269-C276.
50. 2. J. Am. Soc. Nephrol. 12:2001;A0278.
51. Bito L.Z. Saturable, energy-dependent, transmembrane transport of prostaglandins against concentration gradients. Nature (London). 256:1975;134-136.
52. Lu R., Schuster V.L. Molecular cloning of the gene for the human prostaglandin transporter hPGT: gene organization, promoter activity, and chromosomal localization. Biochem. Biophys. Res. Commun. 246:1998;805-812.
53. van der Zwaag B, Verzijl HTFM, Beltran-Valero de Bernabe D, Schuster VL, van Bokhoven H, Kremer H, et al. Mutation analysis in the candidate Möbius syndrome genes PGT and GATA2 on chromosome 3, and EGR2 on chromosome 10. J Med Genet 2002;39:e30.
54. Kremer H., Kuyt L.P., van den Helm B., van Reen M., Leunissen J.A., Hamel B.C.et al. Localization of a gene for Mobius syndrome to chromosome 3q by linkage analysis in a Dutch family. Hum. Mol. Genet. 5:1996;1367-1371.
55. Pastuszak A.L., Schuler L., Speck-Martins C.E., Coelho K.E., Cordello S.M., Vargas F.et al. Use of misoprostol during pregnancy and Mobius syndrome in infants. N. Engl. J. Med. 338:1998;1881-1885.
56. Gonzalez C.H., Marques-Dias M.J., Kim C.A., Sugayama S.M., Da Paz J.A., Huson S.M.et al. Congenital abnormalities in Brazilian children associated with misoprostol misuse in first trimester of pregnancy. Lancet. 351:1998;1624-1627.
57. Vezza R., Rokach J., Fitzgerald G.F. Prostaglandin F2alpha receptor-dependent regulation of prostaglandin transport. Mol. Pharmacol. 59:2001;1506-1513.
58. Lu R., Pucci M.L., Nomura T., Schuster V.L. Characterization and regulation of the prostaglandin transporter PGT in the mouse Swiss 3T3 fibroblast cell line. J. Am. Soc. Nephrol. 12:2001;A3035.
59. Kawamura T., Horie S., Maruyama T., Akira T., Imagawa T., Nakamura N. Prostaglandin E1 transported into cells blocks the apoptotic signals induced by nerve growth factor deprivation. J. Neurochem. 72:1999;1907-1914.
60. Bhattacharya M., Peri K.G., Almazan G., Ribeiro-da-Silva A., Shichi H., Durocher Y.et al. Nuclear localization of prostaglandin E2 receptors. Proc. Natl. Acad. Sci. U.S.A. 95:1998;15792-15797.
61. Bhattacharya M., Peri K., Ribeiro-da-Silva A., Almazan G., Shichi H., Hou X.et al. Localization of functional prostaglandin E2 receptors EP3 and EP4 in the nuclear envelope. J. Biol. Chem. 274:1999;15719-15724.
62. +-independent organic anion transporter. Proc. Natl. Acad. Sci. U.S.A. 91:1994;133-137.
63. Kanai N., Lu R., Bao Y., Wolkoff A.W., Schuster V.L. Transient expression of the organic anion transporter 'oatp' in mammalian cells: identification of candidate substrates. Am. J. Physiol. 270:1996;F319-F325.
64. Abe T., Kakyo M., Tokui T., Nakagomi R., Nishio T., Nakai D.et al. Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1. J. Biol. Chem. 274:1999;17159-17163.
65. -. Gastroenterology. 117:1999;770-775.
66. Nishio T., Adachi H., Nakagomi R., Tokui T., Sato E., Tanemoto M.et al. Molecular identification of a rat novel organic anion transporter moat1, which transports prostaglandin D(2), leukotriene C(4), and taurocholate. Biochem. Biophys. Res. Commun. 275:2000;831-838.
67. Kanai N., Lu R., Bao Y., Wolkoff A.W., Vore M., Schuster V.L. Estradiol 17-beta D-glucuronide is a high-affinity substrate for the organic anion transporter oatp. Am. J. Physiol. 270:1996;F326-F331.
68. Masuda S., Ibaramoto K., Takeuchi A., Saito H., Hashimoto Y., Inui K.I. Cloning and functional characterization of a new multispecific organic anion transporter, OAT-K2, in rat kidney. Mol. Pharm. 55:1999;743-752.
69. Irish J.M. Secretion of prostaglandin E2 by rabbit proximal tubules. Am. J. Physiol. 237:1979;F268-F273.
70. Pritchard J.B. Intracellular alpha-ketoglutarate controls the efficacy of renal organic anion transport. J. Pharmacol. Exp. Ther. 274:1995;1278-1284.
71. Sweet D.H., Bush K.T., Nigam S.K. The organic anion transporter family: from physiology to ontogeny and the clinic. Am. J. Physiol. 281:2001;F197-205.
72. Van Aubel R.A., Masereeuw R., Russel F.G. Molecular pharmacology of renal organic anion transporters. Am. J. Physiol. 279:2000;F216-232.
73. Burckhardt G., Wolff N.A. Structure of renal organic anion and cation transporters. Am. J. Physiol. 278:2000;F853-866.
74. Sekine T., Watanabe N., Hosoyamada M., Kanai Y., Endou H. Expression cloning and characterization of a novel multispecific organic anion transporter. J. Biol. Chem. 272:1997;18526-18529.
75. Tojo A., Sekine T., Nakajima N., Hosoyamada M., Kanai Y., Kimura K.et al. Immunohistochemical localization of multispecific renal organic anion transporter 1 in rat kidney. J. Am. Soc. Nephrol. 10:1999;464-471.
76. Hosoyamada M., Sekine T., Kanai Y., Endou H. Molecular cloning and functional expression of a multispecific organic anion transporter from human kidney. Am. J. Physiol. 276:1999;F122-F128.
77. Lu R., Chan B.S., Schuster V.L. Cloning of the human kidney PAH transporter: narrow substrate specificity and regulation by protein kinase C. Am. J. Physiol. 276:1999;F295-F303.
78. Sekine T., Cha S.H., Tsuda M., Apiwattanakul N., Nakajima N., Kanai Y.et al. Identification of multispecific organic anion transporter 2 expressed predominantly in the liver. FEBS Lett. 429:1998;179-182.
79. Pavlova A., Sakurai H., Leclercq B., Beier D.R., Yu A.S., Nigam S.K. Developmentally regulated expression of organic ion transporters nkt (oat1), oct1, nlt (oat2), and roct. Am. J. Physiol. 278:2000;F635-F643.
80. Sekine T., Cha S.H., Endou H. The multispecific organic anion transporter (oat) family. Pflugers Arch. 440:2000;337-350.
81. Bito L.Z., Baroody R.A. Comparison of renal prostaglandin and p-aminohippuric acid transport processes. Am. J. Physiol. 234:1978;F80-F88.
82. Bito L.Z., Salvador E.V. Effects of anti-inflammatory agents and some other drugs on prostaglandin biotransport. J. Pharmacol. Exp. Ther. 198:1976;481-488.
83. Melendez E., Reyes J.L. Renal handling of indomethacin and its relationship with the secretory pathway of prostaglandins. J. Pharm. Pharmacol. 34:1982;648-652.
84. Rennick B.R. Renal tubular transport of prostaglandins: inhibition by probenecid and indomethacin. Am. J. Physiol. 233:1977;F133-F137.
85. DiBenedetto F.E., Bito L.Z. The kinetics and energy dependence of prostaglandin transport processes. Part I. In vitro studies on the rate of PGF2alpha accumulation by the rabbit anterior uvea. Exp. Eye Res. 30:1980;175-182.
86. DiBenedetto F.E., Bito L.Z. Transport of prostaglandins and other eicosanoids by the choroid plexus: its characterization and physiological significance. J. Neurochem. 46:1986;1725-1731.
87. Bikhazi A.B., Lakkis N.M., Abu-Chehade K.D. Sodium-dependent retention of prostaglandins in rat ileum. J. Pharm. Sci. 80:1991;1110-1113.
88. Kusuhara H., Sekine T., Utsunomiya-Tate N., Tsuda M., Kojima R., Cha S.H.et al. Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain. J. Biol. Chem. 274:1999;13675-13680.
89. Keppler D., Leier I., Jedlitschky G. Transport of glutathione conjugates and glucuronides by the multidrug resistance proteins MRP1 and MRP2. Biol. Chem. 378:1997;787-791.
90. Evers R., Cnubben N.H., Wijnholds J., van Deemter L., van Bladeren P.J., Borst P. Transport of glutathione prostaglandin a conjugates by the multidrug resistance protein 1. FEBS Lett. 419:1997;112-116.
91. Evers R., Kool M., van Deemter L., Janssen H., Calafat J., Oomen L.C.et al. Drug export activity of the human canalicular multispecific organic anion transporter in polarized kidney MDCK cells expressing cMOAT (mrp2) cDNA. J. Clin. Invest. 101:1998;1310-1319.
92. Cui Y., Konig J., Buchholz J.K., Spring H., Leier I., Keppler D. Drug resistance and ATP-dependent conjugate transport mediated by the apical multidrug resistance protein, MRP2, permanently expressed in human and canine cells. Mol. Pharm. 55:1999;929-937.
93. van Aubel R.A., van Kuijck M.A., Koenderink J.B., Deen P.M., van Os C.H., Russel F.G. Adenosine triphosphate-dependent transport of anionic conjugates by the rabbit multidrug resistance-associated protein mrp2 expressed in insect cells. Mol. Pharm. 53:1998;1062-1067.
94. Enomoto A, Takeda M, Shimoda M, et al. Interaction of Human Organic Anion Transporters 2 and 4 with Organic Anion Transport Inhibitors. J Pharm Exp Ther 2002;301:797-802.