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Volumn 7, Issue 1, 2014, Pages 221-239

Molecular pathways in non-alcoholic fatty liver disease

Author keywords

Fatty acid metabolism; Insulin resistance; Molecular pathways; Non alcoholic fatty liver disease

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; ADIPONECTIN; CANNABINOID 1 RECEPTOR; CANNABINOID 2 RECEPTOR; CARNITINE PALMITOYLTRANSFERASE I; CAVEOLIN; CD36 ANTIGEN; FARNESOID X RECEPTOR; FAS ANTIGEN; FATTY ACID; FATTY ACID BINDING PROTEIN; FATTY ACID TRANSPORTER; INTERLEUKIN 6; LIVER X RECEPTOR; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PIOGLITAZONE; PROTEIN CHREBP; ROSIGLITAZONE; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR FKHR; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

EID: 84904070301     PISSN: None     EISSN: 11787023     Source Type: Journal    
DOI: 10.2147/CEG.S62831     Document Type: Review
Times cited : (333)

References (230)
  • 1
    • 34547491854 scopus 로고    scopus 로고
    • Obesity and nonalcoholic fatty liver disease
    • Angulo P. Obesity and nonalcoholic fatty liver disease. Nutr Rev. 2007;65(6 Pt 2):57-63.
    • (2007) Nutr Rev , vol.65 , Issue.6 PART 2 , pp. 57-63
    • Angulo, P.1
  • 2
    • 56649123256 scopus 로고    scopus 로고
    • The epidemiology of nonalcoholic fatty liver disease: A global perspective
    • Lazo M, Clark JM. The epidemiology of nonalcoholic fatty liver disease: a global perspective. Semin Liver Dis. 2008;28(4):339-350.
    • (2008) Semin Liver Dis , vol.28 , Issue.4 , pp. 339-350
    • Lazo, M.1    Clark, J.M.2
  • 3
    • 78650486196 scopus 로고    scopus 로고
    • Prevalence of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis among a largely middle-aged population utilizing ultrasound and liver biopsy: A prospective study
    • Williams CD, Stengel J, Asike MI, et al. Prevalence of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis among a largely middle-aged population utilizing ultrasound and liver biopsy: a prospective study. Gastroenterolog y. 2011;140(1):124-131.
    • (2011) Gastroenterolog Y , vol.140 , Issue.1 , pp. 124-131
    • Williams, C.D.1    Stengel, J.2    Asike, M.I.3
  • 4
    • 29244465372 scopus 로고    scopus 로고
    • Evaluation of fatty acid metabolism-related gene expression in nonalcoholic fatty liver disease
    • Nakamuta M, Kohjima M, Morizono S, et al. Evaluation of fatty acid metabolism-related gene expression in nonalcoholic fatty liver disease. Int J Mol Med. 2005;16(4):631-635.
    • (2005) Int J Mol Med , vol.16 , Issue.4 , pp. 631-635
    • Nakamuta, M.1    Kohjima, M.2    Morizono, S.3
  • 5
    • 33748110788 scopus 로고    scopus 로고
    • Hepatic histology in obese patients undergoing bariatric surgery
    • Machado M, Marques-Vidal P, Cortez-Pinto H. Hepatic histology in obese patients undergoing bariatric surgery. J Hepatol. 2006;45(4): 600-606.
    • (2006) J Hepatol , vol.45 , Issue.4 , pp. 600-606
    • Machado, M.1    Marques-Vidal, P.2    Cortez-Pinto, H.3
  • 6
    • 44949233003 scopus 로고    scopus 로고
    • Increased hepatic and circulating interleukin-6 levels in human nonalcoholic steatohepatitis
    • Wieckowska A, Papouchado BG, Li Z, Lopez R, Zein NN, Feldstein AE. Increased hepatic and circulating interleukin-6 levels in human nonalcoholic steatohepatitis. Am J Gastroenterol. 2008;103(6):1372-1379.
    • (2008) Am J Gastroenterol , vol.103 , Issue.6 , pp. 1372-1379
    • Wieckowska, A.1    Papouchado, B.G.2    Li, Z.3    Lopez, R.4    Zein, N.N.5    Feldstein, A.E.6
  • 7
    • 33750606061 scopus 로고    scopus 로고
    • Long-Term Follow-up of Patients with NAFLD and Elevated Liver Enzymes
    • Ekstedt M, Franzén LE, Mathiesen UL, et al. Long-Term Follow-up of Patients with NAFLD and Elevated Liver Enzymes. Hepatology. 2006;44(4):865-873.
    • (2006) Hepatology , vol.44 , Issue.4 , pp. 865-873
    • Ekstedt, M.1    Franzén, L.E.2    Mathiesen, U.L.3
  • 8
    • 33644547706 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: From steatosis to cirrhosis
    • Farrell GC, Larter CZ. Nonalcoholic fatty liver disease: from steatosis to cirrhosis. Hepatology. 2006;43(2 Suppl 1):S99-S112.
    • (2006) Hepatology , vol.43 , Issue.2 SUPPL. 1
    • Farrell, G.C.1    Larter, C.Z.2
  • 9
    • 79251524594 scopus 로고    scopus 로고
    • Systematic review: The diagnosis and staging of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis
    • Dowman JK, Tomlinson J W, Newsome PN. Systematic review: the diagnosis and staging of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis. Aliment Pharmacol Ther. 2011;33(5): 525-540.
    • (2011) Aliment Pharmacol Ther , vol.33 , Issue.5 , pp. 525-540
    • Dowman, J.K.1    Tomlinson, J.W.2    Newsome, P.N.3
  • 10
    • 0037382786 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome
    • Marchesini G, Bugianesi E, Forlani G, et al. Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome. Hepatology. 2003;37(4): 917-923.
    • (2003) Hepatology , vol.37 , Issue.4 , pp. 917-923
    • Marchesini, G.1    Bugianesi, E.2    Forlani, G.3
  • 11
    • 65449156905 scopus 로고    scopus 로고
    • NAFLD as a risk factor for the development of diabetes and the metabolic syndrome: An eleven-year follow-up study
    • Adams LA, Waters OR, Knuiman MW, Elliott RR, Olynyk JK. NAFLD as a risk factor for the development of diabetes and the metabolic syndrome: an eleven-year follow-up study. Am J Gastroenterol. 2009;104(4):861-867.
    • (2009) Am J Gastroenterol , vol.104 , Issue.4 , pp. 861-867
    • Adams, L.A.1    Waters, O.R.2    Knuiman, M.W.3    Elliott, R.R.4    Olynyk, J.K.5
  • 12
    • 79251535913 scopus 로고    scopus 로고
    • Non-invasive diagnosis of nonalcoholic fatty liver and nonalcoholic steatohepatitis
    • Adams LA, Feldstein AE. Non-invasive diagnosis of nonalcoholic fatty liver and nonalcoholic steatohepatitis. J Dig Dis. 2011;12(1):10-16.
    • (2011) J Dig Dis , vol.12 , Issue.1 , pp. 10-16
    • Adams, L.A.1    Feldstein, A.E.2
  • 13
    • 34948822317 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: Pathogenesis, identifcation, progression, and management
    • Yan E, Durazo F, Tong M, Hong K. Nonalcoholic fatty liver disease: pathogenesis, identifcation, progression, and management. Nutr Rev. 2007;65(8 Pt 1):376-384.
    • (2007) Nutr Rev , vol.65 , Issue.8 PART 1 , pp. 376-384
    • Yan, E.1    Durazo, F.2    Tong, M.3    Hong, K.4
  • 14
    • 0033119425 scopus 로고    scopus 로고
    • The ratio of aspartate aminotransferase to alanine aminotransferase: Potential value in differentiating nonalcoholic steatohepatitis from alcoholic liver disease
    • Sorbi D, Boynton J, Lindor KD. The ratio of aspartate aminotransferase to alanine aminotransferase: potential value in differentiating nonalcoholic steatohepatitis from alcoholic liver disease. Am J Gastroenterol. 1999;94(4):1018-1022.
    • (1999) Am J Gastroenterol , vol.94 , Issue.4 , pp. 1018-1022
    • Sorbi, D.1    Boynton, J.2    Lindor, K.D.3
  • 15
    • 17444417085 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease
    • Adams LA, Angulo P, Lindor KD. Nonalcoholic fatty liver disease. CMAJ. 2005;172(7):899-905.
    • (2005) CMAJ , vol.172 , Issue.7 , pp. 899-905
    • Adams, L.A.1    Angulo, P.2    Lindor, K.D.3
  • 16
    • 84872686317 scopus 로고    scopus 로고
    • Review article: The diagnosis of non-alcoholic fatty liver disease - availability and accuracy of non-invasive methods
    • Festi D, Schiumerini R, Marzi L, et al. Review article: the diagnosis of non-alcoholic fatty liver disease - availability and accuracy of non-invasive methods. Aliment Pharmacol Ther. 2013;37(4):392-400.
    • (2013) Aliment Pharmacol Ther , vol.37 , Issue.4 , pp. 392-400
    • Festi, D.1    Schiumerini, R.2    Marzi, L.3
  • 17
    • 33748946051 scopus 로고    scopus 로고
    • Treatment of patients with non-alcoholic fatty liver disease: Current views and perspectives
    • Federico A, Trappoliere M, Loguercio C. Treatment of patients with non-alcoholic fatty liver disease: current views and perspectives. Dig Liver Dis. 2006;38(11):789-801.
    • (2006) Dig Liver Dis , vol.38 , Issue.11 , pp. 789-801
    • Federico, A.1    Trappoliere, M.2    Loguercio, C.3
  • 18
    • 33947547651 scopus 로고    scopus 로고
    • MRI and ultrasound for hepatic fat quantification: Relationships to clinical and metabolic characteristics of pediatric nonalcoholic fatty liver disease
    • Pacifco L, Celestre M, Anania C, Paolantonio P, Chiesa C, Laghi A. MRI and ultrasound for hepatic fat quantification: relationships to clinical and metabolic characteristics of pediatric nonalcoholic fatty liver disease. Acta Paediatr. 2007;96(4):542-547.
    • (2007) Acta Paediatr , vol.96 , Issue.4 , pp. 542-547
    • Pacifco, L.1    Celestre, M.2    Anania, C.3    Paolantonio, P.4    Chiesa, C.5    Laghi, A.6
  • 19
    • 77949311823 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: A review and update
    • Lewis JR, Mohanty SR. Nonalcoholic fatty liver disease: a review and update. Dig Dis Sci. 2010;55(3):560-578.
    • (2010) Dig Dis Sci , vol.55 , Issue.3 , pp. 560-578
    • Lewis, J.R.1    Mohanty, S.R.2
  • 20
    • 53849130970 scopus 로고    scopus 로고
    • A "biomarker biopsy" for the diagnosis of NASH: Promises from CK-18 fragments
    • author reply 1509-1510
    • Yilmaz Y, Ulukaya E, Dolar E. A "biomarker biopsy" for the diagnosis of NASH: promises from CK-18 fragments. Obes Surg. 2008;18(11):1507-1508; author reply 1509-1510.
    • (2008) Obes Surg , vol.18 , Issue.11 , pp. 1507-1508
    • Yilmaz, Y.1    Ulukaya, E.2    Dolar, E.3
  • 21
    • 84894257853 scopus 로고    scopus 로고
    • Clinical approaches to non-alcoholic fatty liver disease
    • Schwenger KJ, Allard J P. Clinical approaches to non-alcoholic fatty liver disease. World J Gastroenterol. 2014;20(7):1712-1723.
    • (2014) World J Gastroenterol , vol.20 , Issue.7 , pp. 1712-1723
    • Schwenger, K.J.1    Allard, J.P.2
  • 22
    • 84857668720 scopus 로고    scopus 로고
    • The role of diet and nutrient composition in nonalcoholic fatty liver disease
    • McCarthy EM, Rinella ME. The role of diet and nutrient composition in nonalcoholic fatty liver disease. J Acad Nutr Diet. 2012;112(3):401-409.
    • (2012) J Acad Nutr Diet , vol.112 , Issue.3 , pp. 401-409
    • McCarthy, E.M.1    Rinella, M.E.2
  • 23
    • 73449116035 scopus 로고    scopus 로고
    • Randomized controlled trial testing the effects of weight loss on nonalcoholic steatohepatitis
    • Promrat K, Kleiner DE, Niemeier HM, et al. Randomized controlled trial testing the effects of weight loss on nonalcoholic steatohepatitis. Hepatology. 2010;51(1):121-129.
    • (2010) Hepatology , vol.51 , Issue.1 , pp. 121-129
    • Promrat, K.1    Kleiner, D.E.2    Niemeier, H.M.3
  • 24
    • 63049120544 scopus 로고    scopus 로고
    • Effect of a lifestyle intervention in patients with abnormal liver enzymes and metabolic risk factors
    • St George A, Bauman A, Johnston A, Farrell G, Chey T, George J. Effect of a lifestyle intervention in patients with abnormal liver enzymes and metabolic risk factors. J Gastroenterol Hepatol. 2009;24(3):399-407.
    • (2009) J Gastroenterol Hepatol , vol.24 , Issue.3 , pp. 399-407
    • St. George, A.1    Bauman, A.2    Johnston, A.3    Farrell, G.4    Chey, T.5    George, J.6
  • 25
    • 70350662659 scopus 로고    scopus 로고
    • Metformin in patients with non-alcoholic fatty liver disease: A randomized, controlled trial
    • Haukeland J W, Konopski Z, Eggesbø HB, et al. Metformin in patients with non-alcoholic fatty liver disease: a randomized, controlled trial. Scand J Gastroenterol. 2009;44(7):853-860.
    • (2009) Scand J Gastroenterol , vol.44 , Issue.7 , pp. 853-860
    • Haukeland, J.W.1    Konopski, Z.2    Eggesbø, H.B.3
  • 26
    • 48449103834 scopus 로고    scopus 로고
    • Review article: Diagnosis and treatment of non-alcoholic fatty liver disease
    • Oh MK, Winn J, Poordad F. Review article: diagnosis and treatment of non-alcoholic fatty liver disease. Aliment Pharmacol Ther. 2008;28(5): 503-522.
    • (2008) Aliment Pharmacol Ther , vol.28 , Issue.5 , pp. 503-522
    • Oh, M.K.1    Winn, J.2    Poordad, F.3
  • 27
    • 79959554252 scopus 로고    scopus 로고
    • The role of insulin-sensitizing agents in the treatment of nonalcoholic steatohepatitis
    • Van Wagner LB, Rinella ME. The role of insulin-sensitizing agents in the treatment of nonalcoholic steatohepatitis. Therap Adv Gastroenterol. 2011;4(4):249-263.
    • (2011) Therap Adv Gastroenterol , vol.4 , Issue.4 , pp. 249-263
    • van Wagner, L.B.1    Rinella, M.E.2
  • 28
    • 34548306770 scopus 로고    scopus 로고
    • The effects of discontinuing pioglitazone in patients with nonalcoholic steatohepatitis
    • Lutchman G, Modi A, Kleiner DE, et al. The effects of discontinuing pioglitazone in patients with nonalcoholic steatohepatitis. Hepatology. 2007;46(2):424-429.
    • (2007) Hepatology , vol.46 , Issue.2 , pp. 424-429
    • Lutchman, G.1    Modi, A.2    Kleiner, D.E.3
  • 29
    • 53049101877 scopus 로고    scopus 로고
    • Randomized, placebo- controlled trial of pioglitazone in nondiabetic subjects with nonalcoholic steatohepatitis
    • Aithal G P, Thomas JA, Kaye P V, et al. Randomized, placebo- controlled trial of pioglitazone in nondiabetic subjects with nonalcoholic steatohepatitis. Gastroenterology. 2008;135(4):1176-1184.
    • (2008) Gastroenterology , vol.135 , Issue.4 , pp. 1176-1184
    • Aithal, G.P.1    Thomas, J.A.2    Kaye, P.V.3
  • 30
    • 80055036005 scopus 로고    scopus 로고
    • Lipid targets during statin treatment in dyslipidemic patients affected by nonalcoholic fatty liver disease
    • Maroni L, Guasti L, Castiglioni L, et al. Lipid targets during statin treatment in dyslipidemic patients affected by nonalcoholic fatty liver disease. Am J Med Sci. 2011;342(5):383-387.
    • (2011) Am J Med Sci , vol.342 , Issue.5 , pp. 383-387
    • Maroni, L.1    Guasti, L.2    Castiglioni, L.3
  • 31
    • 34249342305 scopus 로고    scopus 로고
    • Statins in non-alcoholic fatty liver disease and chronically elevated liver enzymes: A histopathological follow-up study
    • Ekstedt M, Franzén LE, Mathiesen UL, Holmqvist M, Bodemar G, Kechagias S. Statins in non-alcoholic fatty liver disease and chronically elevated liver enzymes: a histopathological follow-up study. J Hepatol. 2007;47(1):135-141.
    • (2007) J Hepatol , vol.47 , Issue.1 , pp. 135-141
    • Ekstedt, M.1    Franzén, L.E.2    Mathiesen, U.L.3    Holmqvist, M.4    Bodemar, G.5    Kechagias, S.6
  • 33
    • 84861543083 scopus 로고    scopus 로고
    • The diagnosis and management of non-alcoholic fatty liver disease: Practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association
    • Chalasani N, Younossi Z, Lavine JE, et al. The diagnosis and management of non-alcoholic fatty liver disease: practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association. Hepatology. 2012;55(6):2005-2023.
    • (2012) Hepatology , vol.55 , Issue.6 , pp. 2005-2023
    • Chalasani, N.1    Younossi, Z.2    Lavine, J.E.3
  • 34
    • 57649214103 scopus 로고    scopus 로고
    • Recent insights into hepatic lipid metabolism in non-alcoholic fatty liver disease (NAFLD)
    • Musso G, Gambino R, Cassader M. Recent insights into hepatic lipid metabolism in non-alcoholic fatty liver disease (NAFLD). Prog Lipid Res. 2009;48(1):1-26.
    • (2009) Prog Lipid Res , vol.48 , Issue.1 , pp. 1-26
    • Musso, G.1    Gambino, R.2    Cassader, M.3
  • 35
    • 68049142588 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease pathogenesis: The present and the future
    • Petta S, Muratore C, Craxì A. Non-alcoholic fatty liver disease pathogenesis: the present and the future. Dig Liver Dis. 2009;41(9): 615-625.
    • (2009) Dig Liver Dis , vol.41 , Issue.9 , pp. 615-625
    • Petta, S.1    Muratore, C.2    Craxì, A.3
  • 36
    • 33845490856 scopus 로고    scopus 로고
    • Review: The role of insulin resistance in nonalcoholic fatty liver disease
    • Utzschneider KM, Kahn SE. Review: the role of insulin resistance in nonalcoholic fatty liver disease. J Clin Endocrinol Metab. 2006;91(12): 4753-4761.
    • (2006) J Clin Endocrinol Metab , vol.91 , Issue.12 , pp. 4753-4761
    • Utzschneider, K.M.1    Kahn, S.E.2
  • 37
    • 33845866857 scopus 로고    scopus 로고
    • Inflammation and metabolic disorders
    • Hotamisligil GS. Inflammation and metabolic disorders. Nature. 2006;444(7121):860-867.
    • (2006) Nature , vol.444 , Issue.7121 , pp. 860-867
    • Hotamisligil, G.S.1
  • 38
    • 77954956697 scopus 로고    scopus 로고
    • Recent insights into fatty liver, metabolic dyslipidaemia and their links to insulin resistance
    • Savage DB, Semple RK. Recent insights into fatty liver, metabolic dyslipidaemia and their links to insulin resistance. Curr Opin Lipidol. 2010;21(4):329-336.
    • (2010) Curr Opin Lipidol , vol.21 , Issue.4 , pp. 329-336
    • Savage, D.B.1    Semple, R.K.2
  • 39
    • 40549135297 scopus 로고    scopus 로고
    • Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: Lessons from genetically engineered mice
    • Postic C, Girard J. Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice. J Clin Invest. 2008;118(3):829-838.
    • (2008) J Clin Invest , vol.118 , Issue.3 , pp. 829-838
    • Postic, C.1    Girard, J.2
  • 40
    • 0036217052 scopus 로고    scopus 로고
    • Disordered fat storage and mobilization in the pathogenesis of insulin resistance and type 2 diabetes
    • Lewis GF, Carpentier A, Adeli K, Giacca A. Disordered fat storage and mobilization in the pathogenesis of insulin resistance and type 2 diabetes. Endocr Rev. 2002;23(2):201-229.
    • (2002) Endocr Rev , vol.23 , Issue.2 , pp. 201-229
    • Lewis, G.F.1    Carpentier, A.2    Adeli, K.3    Giacca, A.4
  • 41
    • 78049522194 scopus 로고    scopus 로고
    • Evolution of inflammation in nonalcoholic fatty liver disease: The multiple parallel hits hypothesis
    • Tilg H, Moschen AR. Evolution of inflammation in nonalcoholic fatty liver disease: the multiple parallel hits hypothesis. Hepatology. 2010;52(5):1836-1846.
    • (2010) Hepatology , vol.52 , Issue.5 , pp. 1836-1846
    • Tilg, H.1    Moschen, A.R.2
  • 42
    • 77949690002 scopus 로고    scopus 로고
    • DGAT1-dependent triacylg-lycerol storage by macrophages protects mice from diet-induced insulin resistance and inflammation
    • Koliwad SK, Streeper RS, Monetti M, et al. DGAT1-dependent triacylg-lycerol storage by macrophages protects mice from diet-induced insulin resistance and inflammation. J Clin Invest. 2010;120(3):756-767.
    • (2010) J Clin Invest , vol.120 , Issue.3 , pp. 756-767
    • Koliwad, S.K.1    Streeper, R.S.2    Monetti, M.3
  • 43
    • 34250356015 scopus 로고    scopus 로고
    • Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fbrosis in obese mice with nonalcoholic steatohepatitis
    • Yamaguchi K, Yang L, McCall S, et al. Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fbrosis in obese mice with nonalcoholic steatohepatitis. Hepatology. 2007;45(6):1366-1374.
    • (2007) Hepatology , vol.45 , Issue.6 , pp. 1366-1374
    • Yamaguchi, K.1    Yang, L.2    McCall, S.3
  • 44
    • 77953893410 scopus 로고    scopus 로고
    • Dissociation between intra-hepatic triglyceride content and insulin resistance in familial hypobetalipoproteinemia
    • Amaro A, Fabbrini E, Kars M, et al. Dissociation between intra-hepatic triglyceride content and insulin resistance in familial hypobetalipoproteinemia. Gastroenterolog y. 2010;139(1):149-153.
    • (2010) Gastroenterolog Y , vol.139 , Issue.1 , pp. 149-153
    • Amaro, A.1    Fabbrini, E.2    Kars, M.3
  • 45
    • 3042824524 scopus 로고    scopus 로고
    • Free fatty acids promote hepatic lipotoxicity by stimulating TNF-alpha expression via a lysosomal pathway
    • Feldstein AE, Werneburg N W, Canbay A, et al. Free fatty acids promote hepatic lipotoxicity by stimulating TNF-alpha expression via a lysosomal pathway. Hepatolog y. 2004;40(1):185-194.
    • (2004) Hepatolog Y , vol.40 , Issue.1 , pp. 185-194
    • Feldstein, A.E.1    Werneburg, N.W.2    Canbay, A.3
  • 46
    • 33747626511 scopus 로고    scopus 로고
    • Mitochondrial free cholesterol loading sensitizes to TNF- and Fas-mediated steatohepatitis
    • Marí M, Caballero F, Colell A, et al. Mitochondrial free cholesterol loading sensitizes to TNF- and Fas-mediated steatohepatitis. Cell Metab. 2006;4(3):185-198.
    • (2006) Cell Metab , vol.4 , Issue.3 , pp. 185-198
    • Marí, M.1    Caballero, F.2    Colell, A.3
  • 47
    • 56649085036 scopus 로고    scopus 로고
    • Abnormalities of lipid metabolism in nonalcoholic fatty liver disease
    • Cheung O, Sanyal AJ. Abnormalities of lipid metabolism in nonalcoholic fatty liver disease. Semin Liver Dis. 2008;28(4):351-359.
    • (2008) Semin Liver Dis , vol.28 , Issue.4 , pp. 351-359
    • Cheung, O.1    Sanyal, A.J.2
  • 48
    • 56649094325 scopus 로고    scopus 로고
    • Molecular mechanisms of lipotoxicity in nonalcoholic fatty liver disease
    • Malhi H, Gores GJ. Molecular mechanisms of lipotoxicity in nonalcoholic fatty liver disease. Semin Liver Dis. 2008;28(4):360-369.
    • (2008) Semin Liver Dis , vol.28 , Issue.4 , pp. 360-369
    • Malhi, H.1    Gores, G.J.2
  • 49
    • 29244465509 scopus 로고    scopus 로고
    • Human fat cell lipolysis: Biochemistry, regulation and clinical role
    • Arner P. Human fat cell lipolysis: biochemistry, regulation and clinical role. Best Pract Res Clin Endocrinol Metab. 2005;19(4):471-482.
    • (2005) Best Pract Res Clin Endocrinol Metab , vol.19 , Issue.4 , pp. 471-482
    • Arner, P.1
  • 50
  • 51
    • 56149127703 scopus 로고    scopus 로고
    • Regulatable fatty acid transport mechanisms are central to the pathophysiology of obesity, fatty liver, and metabolic syndrome
    • Berk PD. Regulatable fatty acid transport mechanisms are central to the pathophysiology of obesity, fatty liver, and metabolic syndrome. Hepatolog y. 2008;48(5):1362-1376.
    • (2008) Hepatolog Y , vol.48 , Issue.5 , pp. 1362-1376
    • Berk, P.D.1
  • 52
    • 0034659344 scopus 로고    scopus 로고
    • The human fatty acid transport protein-1 (SLC27A1; FATP-1) cDNA and gene: Organization, chromosomal localization, and expression
    • Martin G, Nemoto M, Gelman L, et al. The human fatty acid transport protein-1 (SLC27A1; FATP-1) cDNA and gene: organization, chromosomal localization, and expression. Genomics. 2000;66(3):296-304.
    • (2000) Genomics , vol.66 , Issue.3 , pp. 296-304
    • Martin, G.1    Nemoto, M.2    Gelman, L.3
  • 53
    • 77957371584 scopus 로고    scopus 로고
    • Insulin- and leptin-regulated fatty acid uptake plays a key causal role in hepatic steatosis in mice with intact leptin signaling but not in ob/ob or db/db mice
    • Ge F, Zhou S, Hu C, Lobdell H, Berk PD. Insulin- and leptin-regulated fatty acid uptake plays a key causal role in hepatic steatosis in mice with intact leptin signaling but not in ob/ob or db/db mice. Am J Physiol Gastrointest Liver Physiol. 2010;299(4):G855-G866.
    • (2010) Am J Physiol Gastrointest Liver Physiol , vol.299 , Issue.4
    • Ge, F.1    Zhou, S.2    Hu, C.3    Lobdell, H.4    Berk, P.D.5
  • 54
    • 0026681654 scopus 로고
    • Adipocyte differentiation of 3T3-L1 cells involves augmented expression of a 43-kDa plasma membrane fatty acid-binding protein
    • Zhou SL, Stump D, Sorrentino D, Potter BJ, Berk PD. Adipocyte differentiation of 3T3-L1 cells involves augmented expression of a 43-kDa plasma membrane fatty acid-binding protein. J Biol Chem. 1992;267(20):14456-14461.
    • (1992) J Biol Chem , vol.267 , Issue.20 , pp. 14456-14461
    • Zhou, S.L.1    Stump, D.2    Sorrentino, D.3    Potter, B.J.4    Berk, P.D.5
  • 55
    • 0028905711 scopus 로고
    • Mitochondrial aspartate aminotransferase expressed on the surface of 3T3-L1 adi-pocytes mediates saturable fatty acid uptake
    • Zhou SL, Stump D, Kiang CL, Isola LM, Berk PD. Mitochondrial aspartate aminotransferase expressed on the surface of 3T3-L1 adi-pocytes mediates saturable fatty acid uptake. Proc Soc Exp Biol Med. 1995;208(3):263-270.
    • (1995) Proc Soc Exp Biol Med , vol.208 , Issue.3 , pp. 263-270
    • Zhou, S.L.1    Stump, D.2    Kiang, C.L.3    Isola, L.M.4    Berk, P.D.5
  • 57
    • 33746625148 scopus 로고    scopus 로고
    • Protein-mediated fatty acid uptake: Novel insights from in vivo models
    • Doege H, Stahl A. Protein-mediated fatty acid uptake: novel insights from in vivo models. Physiology (Bethesda). 2006;21:259-268.
    • (2006) Physiology (Bethesda) , vol.21 , pp. 259-268
    • Doege, H.1    Stahl, A.2
  • 58
    • 33645994508 scopus 로고    scopus 로고
    • Targeted deletion of FATP5 reveals multiple functions in liver metabolism: Alterations in hepatic lipid homeostasis
    • Doege H, Baillie RA, Ortegon AM, et al. Targeted deletion of FATP5 reveals multiple functions in liver metabolism: alterations in hepatic lipid homeostasis. Gastroenterolog y. 2006;130(4):1245-1258.
    • (2006) Gastroenterolog Y , vol.130 , Issue.4 , pp. 1245-1258
    • Doege, H.1    Baillie, R.A.2    Ortegon, A.M.3
  • 59
    • 78649331070 scopus 로고    scopus 로고
    • A promoter polymorphism in the liver-specific fatty acid transport protein 5 is associated with features of the metabolic syndrome and steatosis
    • Auinger A, Valenti L, Pfeuffer M, et al. A promoter polymorphism in the liver-specific fatty acid transport protein 5 is associated with features of the metabolic syndrome and steatosis. Horm Metab Res. 2010;42(12):854-849.
    • (2010) Horm Metab Res , vol.42 , Issue.12 , pp. 849-854
    • Auinger, A.1    Valenti, L.2    Pfeuffer, M.3
  • 60
    • 33748773325 scopus 로고    scopus 로고
    • Caveolin-1 is essential for liver regeneration
    • Fernández MA, Albor C, Ingelmo-Torres M, et al. Caveolin-1 is essential for liver regeneration. Science. 2006;313(5793):1628-1632.
    • (2006) Science , vol.313 , Issue.5793 , pp. 1628-1632
    • Fernández, M.A.1    Albor, C.2    Ingelmo-Torres, M.3
  • 61
    • 79955599893 scopus 로고    scopus 로고
    • Altered distribution of caveolin-1 in early liver steatosis
    • Mastrodonato M, Calamita G, Rossi R, et al. Altered distribution of caveolin-1 in early liver steatosis. Eur J Clin Invest. 2011;41(6): 642-651.
    • (2011) Eur J Clin Invest , vol.41 , Issue.6 , pp. 642-651
    • Mastrodonato, M.1    Calamita, G.2    Rossi, R.3
  • 62
    • 80052596785 scopus 로고    scopus 로고
    • Hepatic fatty acid translocase CD36 upregulation is associated with insulin resistance, hyperinsulinaemia and increased steatosis in nonalcoholic steatohepatitis and chronic hepatitis C
    • Miquilena-Colina ME, Lima-Cabello E, Sánchez-Campos S, et al. Hepatic fatty acid translocase CD36 upregulation is associated with insulin resistance, hyperinsulinaemia and increased steatosis in nonalcoholic steatohepatitis and chronic hepatitis C. Gut. 2011;60(10): 1394-1402.
    • (2011) Gut , vol.60 , Issue.10 , pp. 1394-1402
    • Miquilena-Colina, M.E.1    Lima-Cabello, E.2    Sánchez-Campos, S.3
  • 63
    • 24344468717 scopus 로고    scopus 로고
    • Increased expression of PPARgamma in high fat diet-induced liver steatosis in mice
    • Inoue M, Ohtake T, Motomura W, et al. Increased expression of PPARgamma in high fat diet-induced liver steatosis in mice. Biochem Biophys Res Commun. 2005;336(1):215-222.
    • (2005) Biochem Biophys Res Commun , vol.336 , Issue.1 , pp. 215-222
    • Inoue, M.1    Ohtake, T.2    Motomura, W.3
  • 64
    • 77950612089 scopus 로고    scopus 로고
    • A subset of dysregulated metabolic and survival genes is associated with severity of hepatic steatosis in obese Zucker rats
    • Buqué X, Martínez MJ, Cano A, et al. A subset of dysregulated metabolic and survival genes is associated with severity of hepatic steatosis in obese Zucker rats. J Lipid Res. 2010;51(3):500-513.
    • (2010) J Lipid Res , vol.51 , Issue.3 , pp. 500-513
    • Buqué, X.1    Martínez, M.J.2    Cano, A.3
  • 65
    • 33845593356 scopus 로고    scopus 로고
    • Upregulation of liver VLDL receptor and FAT/CD36 expression in LDLR-/- apoB100/100 mice fed trans-10, cis-12 conjugated linoleic acid
    • Degrace P, Moindrot B, Mohamed I, et al. Upregulation of liver VLDL receptor and FAT/CD36 expression in LDLR-/- apoB100/100 mice fed trans-10, cis-12 conjugated linoleic acid. J Lipid Res. 2006;47(12):2647-2655.
    • (2006) J Lipid Res , vol.47 , Issue.12 , pp. 2647-2655
    • Degrace, P.1    Moindrot, B.2    Mohamed, I.3
  • 66
    • 38649096259 scopus 로고    scopus 로고
    • Hepatic fatty acid transporter Cd36 is a common target of LXR, PXR, and PPARgamma in promoting steatosis
    • Zhou J, Febbraio M, Wada T, et al. Hepatic fatty acid transporter Cd36 is a common target of LXR, PXR, and PPARgamma in promoting steatosis. Gastroenterology. 2008;134(2):556-567.
    • (2008) Gastroenterology , vol.134 , Issue.2 , pp. 556-567
    • Zhou, J.1    Febbraio, M.2    Wada, T.3
  • 68
    • 77954363354 scopus 로고    scopus 로고
    • Apoptosis is associated with CD36/fatty acid translocase upregulation in non-alcoholic steatohepatitis
    • Bechmann L P, Gieseler RK, Sowa J-P, et al. Apoptosis is associated with CD36/fatty acid translocase upregulation in non-alcoholic steatohepatitis. Liver Int. 2010;30(6):850-859.
    • (2010) Liver Int , vol.30 , Issue.6 , pp. 850-859
    • Bechmann, L.P.1    Gieseler, R.K.2    Sowa, J.-P.3
  • 69
    • 44449118921 scopus 로고    scopus 로고
    • Fatty acid-binding proteins: Role in metabolic diseases and potential as drug targets
    • Furuhashi M, Hotamisligil GS. Fatty acid-binding proteins: role in metabolic diseases and potential as drug targets. Nat Rev Drug Discov. 2008;7(6):489-503.
    • (2008) Nat Rev Drug Discov , vol.7 , Issue.6 , pp. 489-503
    • Furuhashi, M.1    Hotamisligil, G.S.2
  • 70
    • 66349128493 scopus 로고    scopus 로고
    • Serum fatty acid binding protein 4, free fatty acids, and metabolic risk markers
    • Karakas SE, Almario RU, Kim K. Serum fatty acid binding protein 4, free fatty acids, and metabolic risk markers. Metabolism. 2009;58(7): 1002-1007.
    • (2009) Metabolism , vol.58 , Issue.7 , pp. 1002-1007
    • Karakas, S.E.1    Almario, R.U.2    Kim, K.3
  • 71
    • 0036634367 scopus 로고    scopus 로고
    • New insights into the structure and function of fatty acid-binding proteins
    • Zimmerman AW, Veerkamp JH. New insights into the structure and function of fatty acid-binding proteins. Cell Mol Life Sci. 2002;59(7): 1096-1116.
    • (2002) Cell Mol Life Sci , vol.59 , Issue.7 , pp. 1096-1116
    • Zimmerman, A.W.1    Veerkamp, J.H.2
  • 72
    • 32544436435 scopus 로고    scopus 로고
    • The multigene family of fatty acid-binding proteins (FABPs): Function, structure and polymorphism
    • Chmurzyńska A. The multigene family of fatty acid-binding proteins (FABPs): function, structure and polymorphism. J Appl Genet. 2006;47(1):39-48.
    • (2006) J Appl Genet , vol.47 , Issue.1 , pp. 39-48
    • Chmurzyńska, A.1
  • 73
    • 56949105162 scopus 로고    scopus 로고
    • Fatty acid binding proteins in adipose tissue: A promising link between metabolic syndrome and atherosclerosis?
    • Krusinová E, Pelikánová T. Fatty acid binding proteins in adipose tissue: a promising link between metabolic syndrome and atherosclerosis? Diabetes Res Clin Pract. 2008;82 Suppl 2:S127-S134.
    • (2008) Diabetes Res Clin Pract , vol.82 , Issue.SUPPL. 2
    • Krusinová, E.1    Pelikánová, T.2
  • 74
    • 80052175601 scopus 로고    scopus 로고
    • Dual metabolic defects are required to produce hypertriglyceridemia in obese subjects
    • Taskinen MR, Adiels M, Westerbacka J, et al. Dual metabolic defects are required to produce hypertriglyceridemia in obese subjects. Arterioscler Thromb Vasc Biol. 2011;31(9):2144-2150.
    • (2011) Arterioscler Thromb Vasc Biol , vol.31 , Issue.9 , pp. 2144-2150
    • Taskinen, M.R.1    Adiels, M.2    Westerbacka, J.3
  • 75
    • 35748972366 scopus 로고    scopus 로고
    • Genes involved in fatty acid partitioning and binding, lipolysis, monocyte/macrophage recruitment, and inflammation are overexpressed in the human fatty liver of insulin-resistant subjects
    • Westerbacka J, Kolak M, Kiviluoto T, et al. Genes involved in fatty acid partitioning and binding, lipolysis, monocyte/macrophage recruitment, and inflammation are overexpressed in the human fatty liver of insulin-resistant subjects. Diabetes. 2007;56(11):2759-2765.
    • (2007) Diabetes , vol.56 , Issue.11 , pp. 2759-2765
    • Westerbacka, J.1    Kolak, M.2    Kiviluoto, T.3
  • 76
    • 77956803815 scopus 로고    scopus 로고
    • FATP2 is a hepatic fatty acid transporter and peroxisomal very long-chain acyl-CoA synthetase
    • Falcon A, Doege H, Fluitt A, et al. FATP2 is a hepatic fatty acid transporter and peroxisomal very long-chain acyl-CoA synthetase. Am J Physiol Endocrinol Metab. 2010;299(3):E384-E393.
    • (2010) Am J Physiol Endocrinol Metab , vol.299 , Issue.3
    • Falcon, A.1    Doege, H.2    Fluitt, A.3
  • 77
    • 52049117445 scopus 로고    scopus 로고
    • Silencing of hepatic fatty acid transporter protein 5 in vivo reverses diet-induced non-alcoholic fatty liver disease and improves hyperglycemia
    • Doege H, Grimm D, Falcon A, et al. Silencing of hepatic fatty acid transporter protein 5 in vivo reverses diet-induced non-alcoholic fatty liver disease and improves hyperglycemia. J Biol Chem. 2008;283(32): 22186-22192.
    • (2008) J Biol Chem , vol.283 , Issue.32 , pp. 22186-22192
    • Doege, H.1    Grimm, D.2    Falcon, A.3
  • 78
    • 84864365408 scopus 로고    scopus 로고
    • Specific bile acids inhibit hepatic fatty acid uptake in mice
    • Nie B, Park HM, Kazantzis M, et al. Specific bile acids inhibit hepatic fatty acid uptake in mice. Hepatology. 2012;56(4):1300-1310.
    • (2012) Hepatology , vol.56 , Issue.4 , pp. 1300-1310
    • Nie, B.1    Park, H.M.2    Kazantzis, M.3
  • 79
    • 77953515715 scopus 로고    scopus 로고
    • Role of histone methyla-tion and demethylation in adipogenesis and obesity
    • Okamura M, Inagaki T, Tanaka T, Sakai J. Role of histone methyla-tion and demethylation in adipogenesis and obesity. Organogenesis. 2010;6(1):24-32.
    • (2010) Organogenesis , vol.6 , Issue.1 , pp. 24-32
    • Okamura, M.1    Inagaki, T.2    Tanaka, T.3    Sakai, J.4
  • 80
    • 77951874018 scopus 로고    scopus 로고
    • Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis
    • Sanyal AJ, Chalasani N, Kowdley K V, et al. Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis. N Engl J Med. 2010;362(18): 1675-1685.
    • (2010) N Engl J Med , vol.362 , Issue.18 , pp. 1675-1685
    • Sanyal, A.J.1    Chalasani, N.2    Kowdley, K.V.3
  • 81
    • 75449094816 scopus 로고    scopus 로고
    • Obesity and nonalcoholic fatty liver disease: Biochemical, metabolic, and clinical implications
    • Fabbrini E, Sullivan S, Klein S. Obesity and nonalcoholic fatty liver disease: biochemical, metabolic, and clinical implications. Hepatology. 2010;51(2):679-689.
    • (2010) Hepatology , vol.51 , Issue.2 , pp. 679-689
    • Fabbrini, E.1    Sullivan, S.2    Klein, S.3
  • 83
    • 84886558949 scopus 로고    scopus 로고
    • Mechanisms of hepatic triglyceride accumulation in non-alcoholic fatty liver disease
    • Kawano Y, Cohen DE. Mechanisms of hepatic triglyceride accumulation in non-alcoholic fatty liver disease. J Gastroenterol. 2013;48(4): 434-441.
    • (2013) J Gastroenterol , vol.48 , Issue.4 , pp. 434-441
    • Kawano, Y.1    Cohen, D.E.2
  • 84
    • 84863427742 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease: The bile acid-activated farnesoid x receptor as an emerging treatment target
    • Fuchs M. Non-alcoholic fatty liver disease: the bile acid-activated farnesoid x receptor as an emerging treatment target. J Lipids. 2012;2012:934396.
    • (2012) J Lipids , vol.2012 , pp. 934396
    • Fuchs, M.1
  • 85
    • 77957302090 scopus 로고    scopus 로고
    • Hepatic steatosis: A role for de novo lipogenesis and the transcription factor SREBP-1c
    • Ferré P, Foufelle F. Hepatic steatosis: a role for de novo lipogenesis and the transcription factor SREBP-1c. Diabetes Obes Metab. 2010; 12 Suppl 2:83-92.
    • (2010) Diabetes Obes Metab , vol.12 , Issue.SUPPL. 2 , pp. 83-92
    • Ferré, P.1    Foufelle, F.2
  • 86
    • 63649104470 scopus 로고    scopus 로고
    • Analysis of hepatic genes involved in the metabolism of fatty acids and iron in nonalcoholic fatty liver disease
    • Mitsuyoshi H, Yasui K, Harano Y, et al. Analysis of hepatic genes involved in the metabolism of fatty acids and iron in nonalcoholic fatty liver disease. Hepatol Res. 2009;39(4):366-373.
    • (2009) Hepatol Res , vol.39 , Issue.4 , pp. 366-373
    • Mitsuyoshi, H.1    Yasui, K.2    Harano, Y.3
  • 87
    • 44649111219 scopus 로고    scopus 로고
    • SREBP-1c, regulated by the insulin and AMPK signaling pathways, plays a role in nonalcoholic fatty liver disease
    • Kohjima M, Higuchi N, Kato M, et al. SREBP-1c, regulated by the insulin and AMPK signaling pathways, plays a role in nonalcoholic fatty liver disease. Int J Mol Med. 2008;21(4):507-511.
    • (2008) Int J Mol Med , vol.21 , Issue.4 , pp. 507-511
    • Kohjima, M.1    Higuchi, N.2    Kato, M.3
  • 88
    • 63649087890 scopus 로고    scopus 로고
    • Biological role of liver X receptors
    • Baranowski M. Biological role of liver X receptors. J Physiol Pharmacol. 2008;59 Suppl 7:31-55.
    • (2008) J Physiol Pharmacol , vol.59 , Issue.SUPPL. 7 , pp. 31-55
    • Baranowski, M.1
  • 89
    • 78149496368 scopus 로고    scopus 로고
    • Molecular biology and functional genomics of liver X receptors (LXR) in relationship to metabolic diseases
    • Faulds MH, Zhao C, Dahlman-Wright K. Molecular biology and functional genomics of liver X receptors (LXR) in relationship to metabolic diseases. Curr Opin Pharmacol. 2010;10(6):692-697.
    • (2010) Curr Opin Pharmacol , vol.10 , Issue.6 , pp. 692-697
    • Faulds, M.H.1    Zhao, C.2    Dahlman-Wright, K.3
  • 90
    • 0037088683 scopus 로고    scopus 로고
    • Diminished hepatic response to fasting/refeeding and liver X receptor agonists in mice with selective deficiency of sterol regulatory element-binding protein-1c
    • Liang G, Yang J, Horton JD, Hammer RE, Goldstein JL, Brown MS. Diminished hepatic response to fasting/refeeding and liver X receptor agonists in mice with selective deficiency of sterol regulatory element-binding protein-1c. J Biol Chem. 2002;277(11):9520-9528.
    • (2002) J Biol Chem , vol.277 , Issue.11 , pp. 9520-9528
    • Liang, G.1    Yang, J.2    Horton, J.D.3    Hammer, R.E.4    Goldstein, J.L.5    Brown, M.S.6
  • 91
    • 0013199471 scopus 로고    scopus 로고
    • Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha
    • Peet DJ, Turley SD, Ma W, et al. Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha. Cell. 1998;93(5):693-704.
    • (1998) Cell , vol.93 , Issue.5 , pp. 693-704
    • Peet, D.J.1    Turley, S.D.2    Ma, W.3
  • 92
    • 0034669025 scopus 로고    scopus 로고
    • Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta
    • Repa JJ, Liang G, Ou J, et al. Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta. Genes Dev. 2000;14(22):2819-2830.
    • (2000) Genes Dev , vol.14 , Issue.22 , pp. 2819-2830
    • Repa, J.J.1    Liang, G.2    Ou, J.3
  • 93
    • 0034669171 scopus 로고    scopus 로고
    • Role of LXRs in control of lipogenesis
    • Schultz JR, Tu H, Luk A, et al. Role of LXRs in control of lipogenesis. Genes Dev. 2000;14(22):2831-2838.
    • (2000) Genes Dev , vol.14 , Issue.22 , pp. 2831-2838
    • Schultz, J.R.1    Tu, H.2    Luk, A.3
  • 94
    • 53349153430 scopus 로고    scopus 로고
    • Liver X receptor in cooperation with SREBP-1c is a major lipid synthesis regulator in nonalcoholic fatty liver disease
    • Higuchi N, Kato M, Shundo Y, et al. Liver X receptor in cooperation with SREBP-1c is a major lipid synthesis regulator in nonalcoholic fatty liver disease. Hepatol Res. 2008;38(11):1122-1129.
    • (2008) Hepatol Res , vol.38 , Issue.11 , pp. 1122-1129
    • Higuchi, N.1    Kato, M.2    Shundo, Y.3
  • 95
    • 79251639639 scopus 로고    scopus 로고
    • Enhanced expression of pro-inflammatory mediators and liver X-receptor-regulated lipogenic genes in non-alcoholic fatty liver disease and hepatitis C
    • Lima-Cabello E, Garcia-Mediavilla M V, Miquilena-Colina ME, et al. Enhanced expression of pro-inflammatory mediators and liver X-receptor-regulated lipogenic genes in non-alcoholic fatty liver disease and hepatitis C. Clin Sci (Lond). 2011;120(6):239-250.
    • (2011) Clin Sci (Lond) , vol.120 , Issue.6 , pp. 239-250
    • Lima-Cabello, E.1    Garcia-Mediavilla, M.V.2    Miquilena-Colina, M.E.3
  • 96
    • 0036251153 scopus 로고    scopus 로고
    • Critical review SREBPs: Activators of the complete program of cholesterol and fatty acid synthesis in the liver
    • Horton JD, Goldstein JL, Brown MS. Critical review SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J Clin Invest. 2002;109(9):1125-1131.
    • (2002) J Clin Invest , vol.109 , Issue.9 , pp. 1125-1131
    • Horton, J.D.1    Goldstein, J.L.2    Brown, M.S.3
  • 97
    • 0030961960 scopus 로고    scopus 로고
    • Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells
    • Shimomura I, Shimano H, Horton JD, Goldstein JL, Brown MS. Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells. J Clin Invest. 1997;99(5):838-845.
    • (1997) J Clin Invest , vol.99 , Issue.5 , pp. 838-845
    • Shimomura, I.1    Shimano, H.2    Horton, J.D.3    Goldstein, J.L.4    Brown, M.S.5
  • 99
    • 0032933626 scopus 로고    scopus 로고
    • ADD1/SREBP-1c is required in the activation of hepatic lipogenic gene expression by glucose
    • Foretz M, Pacot C, Dugail I, et al. ADD1/SREBP-1c is required in the activation of hepatic lipogenic gene expression by glucose. Mol Cell Biol. 1999;19(5):3760-3768.
    • (1999) Mol Cell Biol , vol.19 , Issue.5 , pp. 3760-3768
    • Foretz, M.1    Pacot, C.2    Dugail, I.3
  • 100
    • 0034283596 scopus 로고    scopus 로고
    • Insulin effects on sterol regulatory-element-binding protein-1c (SREBP-1c) tran-scriptional activity in rat hepatocytes
    • Azzout-Marniche D, Bécard D, Guichard C, et al. Insulin effects on sterol regulatory-element-binding protein-1c (SREBP-1c) tran-scriptional activity in rat hepatocytes. Biochem J. 2000;350 Pt 2: 389-393.
    • (2000) Biochem J , vol.350 , Issue.PART 2 , pp. 389-393
    • Azzout-Marniche, D.1    Bécard, D.2    Guichard, C.3
  • 101
    • 0034693259 scopus 로고    scopus 로고
    • Sterol regulatory element-binding proteins (SREBPs): Key regulators of nutritional homeostasis and insulin action
    • Osborne TF. Sterol regulatory element-binding proteins (SREBPs): key regulators of nutritional homeostasis and insulin action. J Biol Chem. 2000;275(42):32379-32382.
    • (2000) J Biol Chem , vol.275 , Issue.42 , pp. 32379-32382
    • Osborne, T.F.1
  • 102
    • 0035860743 scopus 로고    scopus 로고
    • Sterol regulatory element-binding protein-1c mimics the negative effect of insulin on phospho-enolpyruvate carboxykinase (GTP) gene transcription
    • Chakravarty K, Leahy P, Becard D, et al. Sterol regulatory element-binding protein-1c mimics the negative effect of insulin on phospho-enolpyruvate carboxykinase (GTP) gene transcription. J Biol Chem. 2001;276(37):34816-34823.
    • (2001) J Biol Chem , vol.276 , Issue.37 , pp. 34816-34823
    • Chakravarty, K.1    Leahy, P.2    Becard, D.3
  • 103
    • 0034804783 scopus 로고    scopus 로고
    • Sterol regulatory element-binding proteins (SREBPs): Transcriptional regulators of lipid synthetic genes
    • Shimano H. Sterol regulatory element-binding proteins (SREBPs): transcriptional regulators of lipid synthetic genes. Prog Lipid Res. 2001;40(6):439-452.
    • (2001) Prog Lipid Res , vol.40 , Issue.6 , pp. 439-452
    • Shimano, H.1
  • 104
    • 0032568557 scopus 로고    scopus 로고
    • Regulation of sterol regulatory element binding proteins in livers of fasted and reefed mice
    • Horton JD, Bashmakov Y, Shimomura I, Shimano H. Regulation of sterol regulatory element binding proteins in livers of fasted and reefed mice. Proc Natl Acad Sci U S A. 1998;95(11):5987-5992.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , Issue.11 , pp. 5987-5992
    • Horton, J.D.1    Bashmakov, Y.2    Shimomura, I.3    Shimano, H.4
  • 105
    • 0031963963 scopus 로고    scopus 로고
    • Nutritional and insulin regulation of fatty acid synthetase and leptin gene expression through ADD1/ SREBP1
    • Kim JB, Sarraf P, Wright M, et al. Nutritional and insulin regulation of fatty acid synthetase and leptin gene expression through ADD1/ SREBP1. J Clin Invest. 1998;101(1):1-9.
    • (1998) J Clin Invest , vol.101 , Issue.1 , pp. 1-9
    • Kim, J.B.1    Sarraf, P.2    Wright, M.3
  • 106
    • 77956268548 scopus 로고    scopus 로고
    • Down-regulation of SREBP-1c is associated with the development of burned-out NASH
    • Nagaya T, Tanaka N, Suzuki T, et al. Down-regulation of SREBP-1c is associated with the development of burned-out NASH. J Hepatol. 2010;53(4):724-731.
    • (2010) J Hepatol , vol.53 , Issue.4 , pp. 724-731
    • Nagaya, T.1    Tanaka, N.2    Suzuki, T.3
  • 107
    • 37349081571 scopus 로고    scopus 로고
    • Role of ChREBP in hepatic steatosis and insulin resistance
    • Denechaud PD, Dentin R, Girard J, Postic C. Role of ChREBP in hepatic steatosis and insulin resistance. FEBS Lett. 2008;582(1):68-73.
    • (2008) FEBS Lett , vol.582 , Issue.1 , pp. 68-73
    • Denechaud, P.D.1    Dentin, R.2    Girard, J.3    Postic, C.4
  • 108
    • 0036711553 scopus 로고    scopus 로고
    • New perspectives in the regulation of hepatic glycolytic and lipogenic genes by insulin and glucose: A role for the transcription factor sterol regulatory element binding protein-1c
    • Foufelle F, Ferré P. New perspectives in the regulation of hepatic glycolytic and lipogenic genes by insulin and glucose: a role for the transcription factor sterol regulatory element binding protein-1c. Biochem J. 2002;366(Pt 2):377-391.
    • (2002) Biochem J , vol.366 , Issue.PART 2 , pp. 377-391
    • Foufelle, F.1    Ferré, P.2
  • 109
    • 2442489891 scopus 로고    scopus 로고
    • Hepatic glucokinase is required for the synergistic action of ChREBP and SREBP-1c on glycolytic and lipogenic gene expression
    • Dentin R, Pégorier J P, Benhamed F, et al. Hepatic glucokinase is required for the synergistic action of ChREBP and SREBP-1c on glycolytic and lipogenic gene expression. J Biol Chem. 2004;279(19): 20314-20326.
    • (2004) J Biol Chem , vol.279 , Issue.19 , pp. 20314-20326
    • Dentin, R.1    Pégorier, J.P.2    Benhamed, F.3
  • 110
    • 8144229872 scopus 로고    scopus 로고
    • Carbohydrate response element binding protein directly promotes lipogenic enzyme gene transcription
    • Ishii S, Iizuka K, Miller BC, Uyeda K. Carbohydrate response element binding protein directly promotes lipogenic enzyme gene transcription. Proc Natl Acad Sci U S A. 2004;101(44):15597-15602.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , Issue.44 , pp. 15597-15602
    • Ishii, S.1    Iizuka, K.2    Miller, B.C.3    Uyeda, K.4
  • 111
    • 15744376705 scopus 로고    scopus 로고
    • Direct role of ChREBP.Mlx in regulating hepatic glucose-responsive genes
    • Ma L, Tsatsos NG, Towle HC. Direct role of ChREBP.Mlx in regulating hepatic glucose-responsive genes. J Biol Chem. 2005;280(12): 12019-12027.
    • (2005) J Biol Chem , vol.280 , Issue.12 , pp. 12019-12027
    • Ma, L.1    Tsatsos, N.G.2    Towle, H.C.3
  • 112
    • 33847006599 scopus 로고    scopus 로고
    • The liver X receptor (LXR) and hepatic lipogenesis. The carbohydrate-response element-binding protein is a target gene of LXR
    • Cha JY, Repa JJ. The liver X receptor (LXR) and hepatic lipogenesis. The carbohydrate-response element-binding protein is a target gene of LXR. J Biol Chem. 2007;282(1):743-751.
    • (2007) J Biol Chem , vol.282 , Issue.1 , pp. 743-751
    • Cha, J.Y.1    Repa, J.J.2
  • 114
    • 3843061127 scopus 로고    scopus 로고
    • Central role for liver X receptor in insulin-mediated activation of Srebp-1c transcription and stimulation of fatty acid synthesis in liver
    • Chen G, Liang G, Ou J, Goldstein JL, Brown MS. Central role for liver X receptor in insulin-mediated activation of Srebp-1c transcription and stimulation of fatty acid synthesis in liver. Proc Natl Acad Sci U S A. 2004;101(31):11245-11250.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , Issue.31 , pp. 11245-11250
    • Chen, G.1    Liang, G.2    Ou, J.3    Goldstein, J.L.4    Brown, M.S.5
  • 115
    • 0037192797 scopus 로고    scopus 로고
    • Direct and indirect mechanisms for regulation of fatty acid synthase gene expression by liver X receptors
    • Joseph SB, Lafftte B, Patel PH, et al. Direct and indirect mechanisms for regulation of fatty acid synthase gene expression by liver X receptors. J Biol Chem. 2002;277(13):11019-11025.
    • (2002) J Biol Chem , vol.277 , Issue.13 , pp. 11019-11025
    • Joseph, S.B.1    Lafftte, B.2    Patel, P.H.3
  • 116
    • 0142060202 scopus 로고    scopus 로고
    • SREBP-1 integrates the actions of thyroid hormone, insulin, cAMP, and medium-chain fatty acids on ACCalpha transcription in hepatocytes
    • Zhang Y, Yin L, Hillgartner FB. SREBP-1 integrates the actions of thyroid hormone, insulin, cAMP, and medium-chain fatty acids on ACCalpha transcription in hepatocytes. J Lipid Res. 2003;44(2): 356-368.
    • (2003) J Lipid Res , vol.44 , Issue.2 , pp. 356-368
    • Zhang, Y.1    Yin, L.2    Hillgartner, F.B.3
  • 117
    • 33748655454 scopus 로고    scopus 로고
    • Stearoyl-coenzyme A desaturase 1 defciency protects against hypertriglyceridemia and increases plasma high-density lipoprotein cholesterol induced by liver X receptor activation
    • Chu K, Miyazaki M, Man WC, Ntambi JM. Stearoyl-coenzyme A desaturase 1 defciency protects against hypertriglyceridemia and increases plasma high-density lipoprotein cholesterol induced by liver X receptor activation. Mol Cell Biol. 2006;26(18):6786-6798.
    • (2006) Mol Cell Biol , vol.26 , Issue.18 , pp. 6786-6798
    • Chu, K.1    Miyazaki, M.2    Man, W.C.3    Ntambi, J.M.4
  • 118
    • 33846208252 scopus 로고    scopus 로고
    • The nuclear receptor LXR is a glucose sensor
    • Mitro N, Mak PA, Vargas L, et al. The nuclear receptor LXR is a glucose sensor. Nature. 2007;445(7124):219-223.
    • (2007) Nature , vol.445 , Issue.7124 , pp. 219-223
    • Mitro, N.1    Mak, P.A.2    Vargas, L.3
  • 119
    • 82255185907 scopus 로고    scopus 로고
    • Elevated glucose represses liver glucokinase and induces its regulatory protein to safeguard hepatic phosphate homeostasis
    • Arden C, Petrie JL, Tudhope SJ, et al. Elevated glucose represses liver glucokinase and induces its regulatory protein to safeguard hepatic phosphate homeostasis. Diabetes. 2011;60(12):3110-3120.
    • (2011) Diabetes , vol.60 , Issue.12 , pp. 3110-3120
    • Arden, C.1    Petrie, J.L.2    Tudhope, S.J.3
  • 120
    • 33749407193 scopus 로고    scopus 로고
    • ChREBP*Mlx is the principal mediator of glucose-induced gene expression in the liver
    • Ma L, Robinson LN, Towle HC. ChREBP*Mlx is the principal mediator of glucose-induced gene expression in the liver. J Biol Chem. 2006;281(39):28721-28730.
    • (2006) J Biol Chem , vol.281 , Issue.39 , pp. 28721-28730
    • Ma, L.1    Robinson, L.N.2    Towle, H.C.3
  • 121
    • 0034616107 scopus 로고    scopus 로고
    • The role of the regulatory protein of glucokinase in the glucose sensory mechanism of the hepatocyte
    • de la Iglesia N, Mukhtar M, Seoane J, Guinovart JJ, Agius L. The role of the regulatory protein of glucokinase in the glucose sensory mechanism of the hepatocyte. J Biol Chem. 2000;275(14): 10597-10603.
    • (2000) J Biol Chem , vol.275 , Issue.14 , pp. 10597-10603
    • de la Iglesia, N.1    Mukhtar, M.2    Seoane, J.3    Guinovart, J.J.4    Agius, L.5
  • 122
    • 2442435802 scopus 로고    scopus 로고
    • Defciency of carbohydrate response element-binding protein (ChREBP) reduces lipogenesis as well as glycolysis
    • Iizuka K, Bruick RK, Liang G, Horton JD, Uyeda K. Defciency of carbohydrate response element-binding protein (ChREBP) reduces lipogenesis as well as glycolysis. Proc Natl Acad Sci U S A. 2004;101(19):7281-7286.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , Issue.19 , pp. 7281-7286
    • Iizuka, K.1    Bruick, R.K.2    Liang, G.3    Horton, J.D.4    Uyeda, K.5
  • 123
    • 33745896223 scopus 로고    scopus 로고
    • Deficiency of carbohydrate-activated transcription factor ChREBP prevents obesity and improves plasma glucose control in leptin-deficient (ob/ob) mice
    • Iizuka K, Miller B, Uyeda K. Deficiency of carbohydrate-activated transcription factor ChREBP prevents obesity and improves plasma glucose control in leptin-deficient (ob/ob) mice. Am J Physiol Endocrinol Metab. 2006;291(2):E358-E364.
    • (2006) Am J Physiol Endocrinol Metab , vol.291 , Issue.2
    • Iizuka, K.1    Miller, B.2    Uyeda, K.3
  • 124
    • 33749370739 scopus 로고    scopus 로고
    • Liver-specific inhibition of ChREBP improves hepatic steatosis and insulin resistance in ob/ob mice
    • Dentin R, Benhamed F, Hainault I, et al. Liver-specific inhibition of ChREBP improves hepatic steatosis and insulin resistance in ob/ob mice. Diabetes. 2006;55(8):2159-2170.
    • (2006) Diabetes , vol.55 , Issue.8 , pp. 2159-2170
    • Dentin, R.1    Benhamed, F.2    Hainault, I.3
  • 125
    • 58149502922 scopus 로고    scopus 로고
    • Hepatic overexpression of dominant negative Mlx improves metabolic profile in diabetes-prone C57BL/6J mice
    • Iizuka K, Takeda J, Horikawa Y. Hepatic overexpression of dominant negative Mlx improves metabolic profile in diabetes-prone C57BL/6J mice. Biochem Biophys Res Commun. 2009;379(2):499-504.
    • (2009) Biochem Biophys Res Commun , vol.379 , Issue.2 , pp. 499-504
    • Iizuka, K.1    Takeda, J.2    Horikawa, Y.3
  • 126
    • 84861809881 scopus 로고    scopus 로고
    • The lipogenic transcription factor ChREBP dissociates hepatic steatosis from insulin resistance in mice and humans
    • Benhamed F, Denechaud P, Lemoine M, et al. The lipogenic transcription factor ChREBP dissociates hepatic steatosis from insulin resistance in mice and humans. J Clin Invest. 2012;122(6): 2176-2194.
    • (2012) J Clin Invest , vol.122 , Issue.6 , pp. 2176-2194
    • Benhamed, F.1    Denechaud, P.2    Lemoine, M.3
  • 127
    • 38649116056 scopus 로고    scopus 로고
    • Selective versus total insulin resistance: A pathogenic paradox
    • Brown MS, Goldstein JL. Selective versus total insulin resistance: a pathogenic paradox. Cell Metab. 2008;7(2):95-96.
    • (2008) Cell Metab , vol.7 , Issue.2 , pp. 95-96
    • Brown, M.S.1    Goldstein, J.L.2
  • 128
    • 0029046931 scopus 로고
    • Identification of a nuclear receptor that is activated by farnesol metabolites
    • Forman BM, Goode E, Chen J, et al. Identification of a nuclear receptor that is activated by farnesol metabolites. Cell. 1995;81(5): 687-693.
    • (1995) Cell , vol.81 , Issue.5 , pp. 687-693
    • Forman, B.M.1    Goode, E.2    Chen, J.3
  • 129
    • 0033636789 scopus 로고    scopus 로고
    • Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors
    • Lu TT, Makishima M, Repa JJ, et al. Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors. Mol Cell. 2000;6(3):507-515.
    • (2000) Mol Cell , vol.6 , Issue.3 , pp. 507-515
    • Lu, T.T.1    Makishima, M.2    Repa, J.J.3
  • 130
    • 0037414757 scopus 로고    scopus 로고
    • Natural structural variants of the nuclear receptor farnesoid X receptor affect transcriptional activation
    • Zhang Y, Kast-Woelbern HR, Edwards PA. Natural structural variants of the nuclear receptor farnesoid X receptor affect transcriptional activation. J Biol Chem. 2003;278(1):104-110.
    • (2003) J Biol Chem , vol.278 , Issue.1 , pp. 104-110
    • Zhang, Y.1    Kast-Woelbern, H.R.2    Edwards, P.A.3
  • 131
    • 0037738531 scopus 로고    scopus 로고
    • A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR
    • Downes M, Verdecia MA, Roecker AJ, et al. A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR. Mol Cell. 2003;11(4):1079-1092.
    • (2003) Mol Cell , vol.11 , Issue.4 , pp. 1079-1092
    • Downes, M.1    Verdecia, M.A.2    Roecker, A.J.3
  • 133
    • 0142211282 scopus 로고    scopus 로고
    • Enterohepatic circulation of bile salts in farnesoid X receptor-deficient mice: Efficient intestinal bile salt absorption in the absence of ileal bile acid-binding protein
    • Kok T, Hulzebos C V, Wolters H, et al. Enterohepatic circulation of bile salts in farnesoid X receptor-deficient mice: efficient intestinal bile salt absorption in the absence of ileal bile acid-binding protein. J Biol Chem. 2003;278(43):41930-41937.
    • (2003) J Biol Chem , vol.278 , Issue.43 , pp. 41930-41937
    • Kok, T.1    Hulzebos, C.V.2    Wolters, H.3
  • 134
    • 0034664729 scopus 로고    scopus 로고
    • Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis
    • Sinal CJ, Tohkin M, Miyata M, Ward JM, Lambert G, Gonzalez FJ. Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis. Cell. 2000;102(6):731-744.
    • (2000) Cell , vol.102 , Issue.6 , pp. 731-744
    • Sinal, C.J.1    Tohkin, M.2    Miyata, M.3    Ward, J.M.4    Lambert, G.5    Gonzalez, F.J.6
  • 135
    • 85047694456 scopus 로고    scopus 로고
    • Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c
    • Watanabe M, Houten SM, Wang L, et al. Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c. J Clin Invest. 2004;113(10):1408-1418.
    • (2004) J Clin Invest , vol.113 , Issue.10 , pp. 1408-1418
    • Watanabe, M.1    Houten, S.M.2    Wang, L.3
  • 136
    • 33645509321 scopus 로고    scopus 로고
    • Farnesoid X receptor is essential for normal glucose homeostasis
    • Ma K, Saha PK, Chan L, Moore DD. Farnesoid X receptor is essential for normal glucose homeostasis. J Clin Invest. 2006;116(4): 1102-1109.
    • (2006) J Clin Invest , vol.116 , Issue.4 , pp. 1102-1109
    • Ma, K.1    Saha, P.K.2    Chan, L.3    Moore, D.D.4
  • 137
    • 32244447570 scopus 로고    scopus 로고
    • Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice
    • Zhang Y, Lee FY, Barrera G, et al. Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice. Proc Natl Acad Sci U S A. 2006;103(4):1006-1011.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , Issue.4 , pp. 1006-1011
    • Zhang, Y.1    Lee, F.Y.2    Barrera, G.3
  • 138
    • 78649475438 scopus 로고    scopus 로고
    • Effects of nuclear receptor FXR on the regulation of liver lipid metabolism in patients with non-alcoholic fatty liver disease
    • Yang ZX, Shen W, Sun H. Effects of nuclear receptor FXR on the regulation of liver lipid metabolism in patients with non-alcoholic fatty liver disease. Hepatol Int. 2010;4(4):741-748.
    • (2010) Hepatol Int , vol.4 , Issue.4 , pp. 741-748
    • Yang, Z.X.1    Shen, W.2    Sun, H.3
  • 139
    • 82455164172 scopus 로고    scopus 로고
    • Hepatic FXR: Key regulator of whole-body energy metabolism
    • Teodoro JS, Rolo A P, Palmeira CM. Hepatic FXR: key regulator of whole-body energy metabolism. Trends Endocrinol Metab. 2011; 22(11):458-466.
    • (2011) Trends Endocrinol Metab , vol.22 , Issue.11 , pp. 458-466
    • Teodoro, J.S.1    Rolo, A.P.2    Palmeira, C.M.3
  • 141
    • 77956024846 scopus 로고    scopus 로고
    • Expression of fatty acid synthase in nonalcoholic fatty liver disease
    • Dorn C, Riener MO, Kirovski G, et al. Expression of fatty acid synthase in nonalcoholic fatty liver disease. Int J Clin Exp Pathol. 2010;3(5):505-514.
    • (2010) Int J Clin Exp Pathol , vol.3 , Issue.5 , pp. 505-514
    • Dorn, C.1    Riener, M.O.2    Kirovski, G.3
  • 142
    • 35148881190 scopus 로고    scopus 로고
    • Re-evaluation of fatty acid metabolism-related gene expression in nonalcoholic fatty liver disease
    • Kohjima M, Enjoji M, Higuchi N, et al. Re-evaluation of fatty acid metabolism-related gene expression in nonalcoholic fatty liver disease. Int J Mol Med. 2007;20(3):351-358.
    • (2007) Int J Mol Med , vol.20 , Issue.3 , pp. 351-358
    • Kohjima, M.1    Enjoji, M.2    Higuchi, N.3
  • 143
    • 58149277452 scopus 로고    scopus 로고
    • Altered expression of transcription factors and genes regulating lipogenesis in liver and adipose tissue of mice with high fat diet-induced obesity and nonalcoholic fatty liver disease
    • Morgan K, Uyuni A, Nandgiri G, et al. Altered expression of transcription factors and genes regulating lipogenesis in liver and adipose tissue of mice with high fat diet-induced obesity and nonalcoholic fatty liver disease. Eur J Gastroenterol Hepatol. 2008;20(9): 843-854.
    • (2008) Eur J Gastroenterol Hepatol , vol.20 , Issue.9 , pp. 843-854
    • Morgan, K.1    Uyuni, A.2    Nandgiri, G.3
  • 144
    • 33744515637 scopus 로고    scopus 로고
    • FoxO1 regulates multiple metabolic pathways in the liver: Effects on gluconeogenic, glycolytic, and lipo-genic gene expression
    • Zhang W, Patil S, Chauhan B, et al. FoxO1 regulates multiple metabolic pathways in the liver: effects on gluconeogenic, glycolytic, and lipo-genic gene expression. J Biol Chem. 2006;281(15):10105-10117.
    • (2006) J Biol Chem , vol.281 , Issue.15 , pp. 10105-10117
    • Zhang, W.1    Patil, S.2    Chauhan, B.3
  • 145
    • 33751507689 scopus 로고    scopus 로고
    • Aberrant Forkhead box O1 function is associated with impaired hepatic metabolism
    • Qu S, Altomonte J, Perdomo G, et al. Aberrant Forkhead box O1 function is associated with impaired hepatic metabolism. Endocrinology. 2006;147(12):5641-5652.
    • (2006) Endocrinology , vol.147 , Issue.12 , pp. 5641-5652
    • Qu, S.1    Altomonte, J.2    Perdomo, G.3
  • 146
    • 33748312093 scopus 로고    scopus 로고
    • Dual role of transcription factor FoxO1 in controlling hepatic insulin sensitivity and lipid metabolism
    • Matsumoto M, Han S, Kitamura T, Accili D. Dual role of transcription factor FoxO1 in controlling hepatic insulin sensitivity and lipid metabolism. J Clin Invest. 2006;116(9):2464-2472.
    • (2006) J Clin Invest , vol.116 , Issue.9 , pp. 2464-2472
    • Matsumoto, M.1    Han, S.2    Kitamura, T.3    Accili, D.4
  • 147
    • 45749114635 scopus 로고    scopus 로고
    • Increased expression and activity of the transcription factor FOXO1 in nonalcoholic steatohepatitis
    • Valenti L, Rametta R, Dongiovanni P, et al. Increased expression and activity of the transcription factor FOXO1 in nonalcoholic steatohepatitis. Diabetes. 2008;57(5):1355-1362.
    • (2008) Diabetes , vol.57 , Issue.5 , pp. 1355-1362
    • Valenti, L.1    Rametta, R.2    Dongiovanni, P.3
  • 148
    • 33747047885 scopus 로고    scopus 로고
    • Targeting foxo1 in mice using antisense oligonucleotide improves hepatic and peripheral insulin action
    • Samuel VT, Choi CS, Phillips TG, et al. Targeting foxo1 in mice using antisense oligonucleotide improves hepatic and peripheral insulin action. Diabetes. 2006;55(7):2042-2050.
    • (2006) Diabetes , vol.55 , Issue.7 , pp. 2042-2050
    • Samuel, V.T.1    Choi, C.S.2    Phillips, T.G.3
  • 149
    • 0036787607 scopus 로고    scopus 로고
    • Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1
    • Nakae J, Biggs WH, Kitamura T, et al. Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1. Nat Genet. 2002;32(2): 245-253.
    • (2002) Nat Genet , vol.32 , Issue.2 , pp. 245-253
    • Nakae, J.1    Biggs, W.H.2    Kitamura, T.3
  • 150
    • 1542283630 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor alpha target genes
    • Mandard S, Müller M, Kersten S. Peroxisome proliferator-activated receptor alpha target genes. Cell Mol Life Sci. 2004;61(4):393-416.
    • (2004) Cell Mol Life Sci , vol.61 , Issue.4 , pp. 393-416
    • Mandard, S.1    Müller, M.2    Kersten, S.3
  • 151
    • 0032699670 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting
    • Kersten S, Seydoux J, Peters JM, Gonzalez FJ, Desvergne B, Wahli W. Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting. J Clin Invest. 1999;103(11):1489-1498.
    • (1999) J Clin Invest , vol.103 , Issue.11 , pp. 1489-1498
    • Kersten, S.1    Seydoux, J.2    Peters, J.M.3    Gonzalez, F.J.4    Desvergne, B.5    Wahli, W.6
  • 152
    • 33646812161 scopus 로고    scopus 로고
    • Fenofibrate, a peroxisome proliferator-activated receptor alpha agonist, reduces hepatic steatosis and lipid peroxidation in fatty liver Shionogi mice with hereditary fatty liver
    • Harano Y, Yasui K, Toyama T, et al. Fenofibrate, a peroxisome proliferator-activated receptor alpha agonist, reduces hepatic steatosis and lipid peroxidation in fatty liver Shionogi mice with hereditary fatty liver. Liver Int. 2006;26(5):613-620.
    • (2006) Liver Int , vol.26 , Issue.5 , pp. 613-620
    • Harano, Y.1    Yasui, K.2    Toyama, T.3
  • 153
    • 0038643427 scopus 로고    scopus 로고
    • Central role of PPARalpha-dependent hepatic lipid turnover in dietary steato-hepatitis in mice
    • Ip E, Farrell GC, Robertson G, Hall P, Kirsch R, Leclercq I. Central role of PPARalpha-dependent hepatic lipid turnover in dietary steato-hepatitis in mice. Hepatology. 2003;38(1):123-132.
    • (2003) Hepatology , vol.38 , Issue.1 , pp. 123-132
    • Ip, E.1    Farrell, G.C.2    Robertson, G.3    Hall, P.4    Kirsch, R.5    Leclercq, I.6
  • 154
    • 0037025390 scopus 로고    scopus 로고
    • WY14,643, a peroxisome proliferator-activated receptor alpha (PPARalpha) agonist, improves hepatic and muscle steatosis and reverses insulin resistance in lipoa-trophic A-ZIP/F-1 mice
    • Chou CJ, Haluzik M, Gregory C, et al. WY14,643, a peroxisome proliferator-activated receptor alpha (PPARalpha) agonist, improves hepatic and muscle steatosis and reverses insulin resistance in lipoa-trophic A-ZIP/F-1 mice. J Biol Chem. 2002;277(27):24484-24489.
    • (2002) J Biol Chem , vol.277 , Issue.27 , pp. 24484-24489
    • Chou, C.J.1    Haluzik, M.2    Gregory, C.3
  • 155
    • 0034666132 scopus 로고    scopus 로고
    • Defect in peroxisome proliferator-activated receptor alpha-inducible fatty acid oxidation determines the severity of hepatic steatosis in response to fasting
    • Hashimoto T, Cook WS, Qi C, Yeldandi AV, Reddy JK, Rao MS. Defect in peroxisome proliferator-activated receptor alpha-inducible fatty acid oxidation determines the severity of hepatic steatosis in response to fasting. J Biol Chem. 2000;275(37):28918-28928.
    • (2000) J Biol Chem , vol.275 , Issue.37 , pp. 28918-28928
    • Hashimoto, T.1    Cook, W.S.2    Qi, C.3    Yeldandi, A.V.4    Reddy, J.K.5    Rao, M.S.6
  • 156
    • 0034939632 scopus 로고    scopus 로고
    • Peroxisomal beta-oxidation and peroxisome proliferator-activated receptor alpha: An adaptive metabolic system
    • Reddy JK, Hashimoto T. Peroxisomal beta-oxidation and peroxisome proliferator-activated receptor alpha: an adaptive metabolic system. Annu Rev Nutr. 2001;21:193-230.
    • (2001) Annu Rev Nutr , vol.21 , pp. 193-230
    • Reddy, J.K.1    Hashimoto, T.2
  • 157
    • 4644370807 scopus 로고    scopus 로고
    • Lack of peroxisome proliferator-activated receptor alpha in mice enhances methionine and choline defcient diet-induced steatohepatitis
    • Kashireddy P V, Rao MS. Lack of peroxisome proliferator-activated receptor alpha in mice enhances methionine and choline defcient diet-induced steatohepatitis. Hepatol Res. 2004;30(2):104-110.
    • (2004) Hepatol Res , vol.30 , Issue.2 , pp. 104-110
    • Kashireddy, P.V.1    Rao, M.S.2
  • 158
    • 0035984958 scopus 로고    scopus 로고
    • Prevention/ reversal of choline defciency-induced steatohepatitis by a peroxisome pro-liferator-activated receptor alpha ligand in rats
    • Rao MS, Papreddy K, Musunuri S, Okonkwo A. Prevention/ reversal of choline defciency-induced steatohepatitis by a peroxisome pro-liferator-activated receptor alpha ligand in rats. In Vivo. 2002;16(2): 145-152.
    • (2002) In Vivo , vol.16 , Issue.2 , pp. 145-152
    • Rao, M.S.1    Papreddy, K.2    Musunuri, S.3    Okonkwo, A.4
  • 159
    • 2342644813 scopus 로고    scopus 로고
    • Administration of the potent PPARalpha agonist, Wy-14,643, reverses nutritional fbrosis and steatohepatitis in mice
    • Ip E, Farrell G, Hall P, Robertson G, Leclercq I. Administration of the potent PPARalpha agonist, Wy-14,643, reverses nutritional fbrosis and steatohepatitis in mice. Hepatology. 2004;39(5):1286-1296.
    • (2004) Hepatology , vol.39 , Issue.5 , pp. 1286-1296
    • Ip, E.1    Farrell, G.2    Hall, P.3    Robertson, G.4    Leclercq, I.5
  • 160
    • 84859157277 scopus 로고    scopus 로고
    • Roles of PPARs in NAFLD: Potential therapeutic targets
    • Tailleux A, Wouters K, Staels B. Roles of PPARs in NAFLD: potential therapeutic targets. Triglyceride Metab Dis. 2012;1821(5): 809-818.
    • (2012) Triglyceride Metab Dis , vol.1821 , Issue.5 , pp. 809-818
    • Tailleux, A.1    Wouters, K.2    Staels, B.3
  • 162
    • 0033527569 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor alpha negatively regulates the vascular infamma-tory gene response by negative cross-talk with transcription factors NF-kappa B and AP-1
    • Delerive P, De Bosscher K, Besnard S, et al. Peroxisome proliferator-activated receptor alpha negatively regulates the vascular infamma-tory gene response by negative cross-talk with transcription factors NF-kappa B and AP-1. J Biol Chem. 1999;274(45):32048-32054.
    • (1999) J Biol Chem , vol.274 , Issue.45 , pp. 32048-32054
    • Delerive, P.1    de Bosscher, K.2    Besnard, S.3
  • 163
    • 0034711185 scopus 로고    scopus 로고
    • Induction of IkappaBalpha expression as a mechanism contributing to the anti-infammatory activities of peroxisome proliferator-activated receptor-alpha activators
    • Delerive P, Gervois P, Fruchart JC, Staels B. Induction of IkappaBalpha expression as a mechanism contributing to the anti-infammatory activities of peroxisome proliferator-activated receptor-alpha activators. J Biol Chem. 2000;275(47):36703-36707.
    • (2000) J Biol Chem , vol.275 , Issue.47 , pp. 36703-36707
    • Delerive, P.1    Gervois, P.2    Fruchart, J.C.3    Staels, B.4
  • 164
    • 0035823551 scopus 로고    scopus 로고
    • Negative regulation of human fbrinogen gene expression by peroxisome proliferator-activated receptor alpha agonists via inhibition of CCAAT box/enhancer-binding protein beta
    • Gervois P, Vu-Dac N, Kleemann R, et al. Negative regulation of human fbrinogen gene expression by peroxisome proliferator-activated receptor alpha agonists via inhibition of CCAAT box/enhancer-binding protein beta. J Biol Chem. 2001;276(36):33471-33477.
    • (2001) J Biol Chem , vol.276 , Issue.36 , pp. 33471-33477
    • Gervois, P.1    Vu-Dac, N.2    Kleemann, R.3
  • 165
    • 1942533537 scopus 로고    scopus 로고
    • Global suppression of IL-6-induced acute phase response gene expression after chronic in vivo treatment with the peroxisome proliferator-activated receptor-alpha activator fenofbrate
    • Gervois P, Kleemann R, Pilon A, et al. Global suppression of IL-6-induced acute phase response gene expression after chronic in vivo treatment with the peroxisome proliferator-activated receptor-alpha activator fenofbrate. J Biol Chem. 2004;279(16):16154-16160.
    • (2004) J Biol Chem , vol.279 , Issue.16 , pp. 16154-16160
    • Gervois, P.1    Kleemann, R.2    Pilon, A.3
  • 166
    • 84887064874 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: Molecular pathways and therapeutic strategies
    • Huang YY, Gusdon AM, Qu S. Nonalcoholic fatty liver disease: molecular pathways and therapeutic strategies. Lipids Health Dis. 2013;12:171.
    • (2013) Lipids Health Dis , vol.12 , pp. 171
    • Huang, Y.Y.1    Gusdon, A.M.2    Qu, S.3
  • 167
    • 41649093318 scopus 로고    scopus 로고
    • Infammatory mechanisms in the regulation of insulin resistance
    • Tilg H, Moschen AR. Infammatory mechanisms in the regulation of insulin resistance. Mol Med. 2008;14(3-4):222-231.
    • (2008) Mol Med , vol.14 , Issue.3-4 , pp. 222-231
    • Tilg, H.1    Moschen, A.R.2
  • 168
    • 77953496579 scopus 로고    scopus 로고
    • Adipocytokines in nonalcoholic fatty liver disease: Key players regulating steatosis, infammation and fbrosis
    • Tilg H. Adipocytokines in nonalcoholic fatty liver disease: key players regulating steatosis, infammation and fbrosis. Curr Pharm Des. 2010;16(17):1893-1895.
    • (2010) Curr Pharm Des , vol.16 , Issue.17 , pp. 1893-1895
    • Tilg, H.1
  • 169
    • 0035462629 scopus 로고    scopus 로고
    • PPARgamma ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein
    • Maeda N, Takahashi M, Funahashi T, et al. PPARgamma ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein. Diabetes. 2001;50(9):2094-2099.
    • (2001) Diabetes , vol.50 , Issue.9 , pp. 2094-2099
    • Maeda, N.1    Takahashi, M.2    Funahashi, T.3
  • 170
    • 4544334655 scopus 로고    scopus 로고
    • Adiponectin induces the anti-infammatory cytokines IL-10 and IL-1RA in human leukocytes
    • Wolf AM, Wolf D, Rumpold H, Enrich B, Tilg H. Adiponectin induces the anti-infammatory cytokines IL-10 and IL-1RA in human leukocytes. Biochem Biophys Res Commun. 2004;323(2):630-635.
    • (2004) Biochem Biophys Res Commun , vol.323 , Issue.2 , pp. 630-635
    • Wolf, A.M.1    Wolf, D.2    Rumpold, H.3    Enrich, B.4    Tilg, H.5
  • 171
    • 33748992313 scopus 로고    scopus 로고
    • Adipocytokines: Mediators linking adipose tissue, infammation and immunity
    • Tilg H, Moschen AR. Adipocytokines: mediators linking adipose tissue, infammation and immunity. Nat Rev Immunol. 2006;6(10): 772-783.
    • (2006) Nat Rev Immunol , vol.6 , Issue.10 , pp. 772-783
    • Tilg, H.1    Moschen, A.R.2
  • 172
    • 0041302377 scopus 로고    scopus 로고
    • The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice
    • Xu A, Wang Y, Keshaw H, Xu LY, Lam KS, Cooper GJ. The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice. J Clin Invest. 2003;112(1):91-100.
    • (2003) J Clin Invest , vol.112 , Issue.1 , pp. 91-100
    • Xu, A.1    Wang, Y.2    Keshaw, H.3    Xu, L.Y.4    Lam, K.S.5    Cooper, G.J.6
  • 174
    • 33748946404 scopus 로고    scopus 로고
    • Gene expression of leptin, resistin, and adiponectin in the white adipose tissue of obese patients with non-alcoholic fatty liver disease and insulin resistance
    • Baranova A, Gowder SJ, Schlauch K, et al. Gene expression of leptin, resistin, and adiponectin in the white adipose tissue of obese patients with non-alcoholic fatty liver disease and insulin resistance. Obes Surg. 2006;16(9):1118-1125.
    • (2006) Obes Surg , vol.16 , Issue.9 , pp. 1118-1125
    • Baranova, A.1    Gowder, S.J.2    Schlauch, K.3
  • 175
    • 10844220730 scopus 로고    scopus 로고
    • Adiponectin and its receptors in non-alcoholic steatohepatitis
    • Kaser S, Moschen A, Cayon A, et al. Adiponectin and its receptors in non-alcoholic steatohepatitis. Gut. 2005;54(1):117-121.
    • (2005) Gut , vol.54 , Issue.1 , pp. 117-121
    • Kaser, S.1    Moschen, A.2    Cayon, A.3
  • 176
    • 70249115442 scopus 로고    scopus 로고
    • Effects of weight loss induced by bariatric surgery on hepatic adipocytokine expression
    • Moschen AR, Molnar C, Wolf AM, et al. Effects of weight loss induced by bariatric surgery on hepatic adipocytokine expression. J Hepatol. 2009;51(4):765-777.
    • (2009) J Hepatol , vol.51 , Issue.4 , pp. 765-777
    • Moschen, A.R.1    Molnar, C.2    Wolf, A.M.3
  • 177
    • 70349238777 scopus 로고    scopus 로고
    • Adipokines in liver diseases
    • Marra F, Bertolani C. Adipokines in liver diseases. Hepatology. 2009;50(3):957-969.
    • (2009) Hepatology , vol.50 , Issue.3 , pp. 957-969
    • Marra, F.1    Bertolani, C.2
  • 178
    • 0027459878 scopus 로고
    • Adipose expression of tumor necrosis factor-alpha: Direct role in obesity-linked insulin resistance
    • Hotamisligil GS, Shargill NS, Spiegelman BM. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science. 1993;259(5091):87-91.
    • (1993) Science , vol.259 , Issue.5091 , pp. 87-91
    • Hotamisligil, G.S.1    Shargill, N.S.2    Spiegelman, B.M.3
  • 179
    • 0028968879 scopus 로고
    • The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase
    • Kern PA, Saghizadeh M, Ong JM, Bosch RJ, Deem R, Simsolo RB. The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase. J Clin Invest. 1995;95(5):2111-2119.
    • (1995) J Clin Invest , vol.95 , Issue.5 , pp. 2111-2119
    • Kern, P.A.1    Saghizadeh, M.2    Ong, J.M.3    Bosch, R.J.4    Deem, R.5    Simsolo, R.B.6
  • 180
    • 77956114717 scopus 로고    scopus 로고
    • Anti-inflammatory effects of excessive weight loss: Potent suppression of adipose interleukin 6 and tumour necrosis factor alpha expression
    • Moschen AR, Molnar C, Geiger S, et al. Anti-inflammatory effects of excessive weight loss: potent suppression of adipose interleukin 6 and tumour necrosis factor alpha expression. Gut. 2010;59(9):1259-1264.
    • (2010) Gut , vol.59 , Issue.9 , pp. 1259-1264
    • Moschen, A.R.1    Molnar, C.2    Geiger, S.3
  • 181
    • 0026549669 scopus 로고
    • Tumor necrosis factor impairs insulin action on peripheral glucose disposal and hepatic glucose output
    • Lang CH, Dobrescu C, Bagby GJ. Tumor necrosis factor impairs insulin action on peripheral glucose disposal and hepatic glucose output. Endocrinolog y. 1992;130(1):43-52.
    • (1992) Endocrinolog Y , vol.130 , Issue.1 , pp. 43-52
    • Lang, C.H.1    Dobrescu, C.2    Bagby, G.J.3
  • 182
    • 0035183475 scopus 로고    scopus 로고
    • Gene expression of tumor necrosis factor alpha and TNF-receptors, p55 and p75, in nonalcoholic steatohepatitis patients
    • Crespo J, Cayón A, Fernández-Gil P, et al. Gene expression of tumor necrosis factor alpha and TNF-receptors, p55 and p75, in nonalcoholic steatohepatitis patients. Hepatology. 2001;34(6): 1158-1163.
    • (2001) Hepatology , vol.34 , Issue.6 , pp. 1158-1163
    • Crespo, J.1    Cayón, A.2    Fernández-Gil, P.3
  • 183
    • 68149182338 scopus 로고    scopus 로고
    • Diagnostic value of a group of biochemical markers of liver fbrosis in patients with nonalcoholic steatohepatitis
    • Lesmana CRA, Hasan I, Budihusodo U, et al. Diagnostic value of a group of biochemical markers of liver fbrosis in patients with nonalcoholic steatohepatitis. J Dig Dis. 2009;10(3):201-206.
    • (2009) J Dig Dis , vol.10 , Issue.3 , pp. 201-206
    • Lesmana, C.R.A.1    Hasan, I.2    Budihusodo, U.3
  • 184
    • 0036165809 scopus 로고    scopus 로고
    • Tumor necrosis factor alpha promoter polymorphisms and insulin resistance in nonalcoholic fatty liver disease
    • Valenti L, Fracanzani AL, Dongiovanni P, et al. Tumor necrosis factor alpha promoter polymorphisms and insulin resistance in nonalcoholic fatty liver disease. Gastroenterology. 2002;122(2):274-280.
    • (2002) Gastroenterology , vol.122 , Issue.2 , pp. 274-280
    • Valenti, L.1    Fracanzani, A.L.2    Dongiovanni, P.3
  • 185
    • 77950158252 scopus 로고    scopus 로고
    • Influence of polygenetic polymorphisms on the susceptibility to non-alcoholic fatty liver disease of Chinese people
    • Zhou YJ, Li YY, Nie YQ, et al. Influence of polygenetic polymorphisms on the susceptibility to non-alcoholic fatty liver disease of Chinese people. J Gastroenterol Hepatol. 2010;25(4):772-777.
    • (2010) J Gastroenterol Hepatol , vol.25 , Issue.4 , pp. 772-777
    • Zhou, Y.J.1    Li, Y.Y.2    Nie, Y.Q.3
  • 186
    • 0033545342 scopus 로고    scopus 로고
    • Acute-phase proteins and other systemic responses to infammation
    • Gabay C, Kushner I. Acute-phase proteins and other systemic responses to infammation. N Engl J Med. 1999;340(6):448-454.
    • (1999) N Engl J Med , vol.340 , Issue.6 , pp. 448-454
    • Gabay, C.1    Kushner, I.2
  • 187
    • 0029846756 scopus 로고    scopus 로고
    • Liver failure and defective hepatocyte regeneration in interleukin-6-defcient mice
    • Cressman DE, Greenbaum LE, DeAngelis RA, et al. Liver failure and defective hepatocyte regeneration in interleukin-6-defcient mice. Science. 1996;274(5291):1379-1383.
    • (1996) Science , vol.274 , Issue.5291 , pp. 1379-1383
    • Cressman, D.E.1    Greenbaum, L.E.2    Deangelis, R.A.3
  • 188
    • 33646161443 scopus 로고    scopus 로고
    • Systemic inflammation in nonalcoholic fatty liver disease is characterized by elevated levels of CCL2
    • Haukeland J W, Damås JK, Konopski Z, et al. Systemic inflammation in nonalcoholic fatty liver disease is characterized by elevated levels of CCL2. J Hepatol. 2006;44(6):1167-1174.
    • (2006) J Hepatol , vol.44 , Issue.6 , pp. 1167-1174
    • Haukeland, J.W.1    Damås, J.K.2    Konopski, Z.3
  • 189
    • 0037853260 scopus 로고    scopus 로고
    • Suppressor of cytokine signaling-3 (SOCS-3), a potential mediator of interleukin-6- dependent insulin resistance in hepatocytes
    • Senn JJ, Klover PJ, Nowak IA, et al. Suppressor of cytokine signaling-3 (SOCS-3), a potential mediator of interleukin-6- dependent insulin resistance in hepatocytes. J Biol Chem. 2003;278(16):13740-13746.
    • (2003) J Biol Chem , vol.278 , Issue.16 , pp. 13740-13746
    • Senn, J.J.1    Klover, P.J.2    Nowak, I.A.3
  • 190
    • 0027958452 scopus 로고
    • Cloning and characterization of the cDNA encoding a novel human pre-B-cell colony-enhancing factor
    • Samal B, Sun Y, Stearns G, Xie C, Suggs S, McNiece I. Cloning and characterization of the cDNA encoding a novel human pre-B-cell colony-enhancing factor. Mol Cell Biol. 1994;14(2):1431-1437.
    • (1994) Mol Cell Biol , vol.14 , Issue.2 , pp. 1431-1437
    • Samal, B.1    Sun, Y.2    Stearns, G.3    Xie, C.4    Suggs, S.5    McNiece, I.6
  • 191
    • 77953530684 scopus 로고    scopus 로고
    • Pre-B Cell colony enhancing factor/NAMPT/visfatin in inflammation and obesity-related disorders
    • Moschen AR, Gerner RR, Tilg H. Pre-B Cell colony enhancing factor/NAMPT/visfatin in inflammation and obesity-related disorders. Curr Pharm Des. 2010;16(17):1913-1920.
    • (2010) Curr Pharm Des , vol.16 , Issue.17 , pp. 1913-1920
    • Moschen, A.R.1    Gerner, R.R.2    Tilg, H.3
  • 192
    • 67649911291 scopus 로고    scopus 로고
    • Influence of visfatin on histo-pathological changes of non-alcoholic fatty liver disease
    • Aller R, de Luis DA, Izaola O, et al. Influence of visfatin on histo-pathological changes of non-alcoholic fatty liver disease. Dig Dis Sci. 2009;54(8):1772-1777.
    • (2009) Dig Dis Sci , vol.54 , Issue.8 , pp. 1772-1777
    • Aller, R.1    de Luis, D.A.2    Izaola, O.3
  • 193
    • 38349107613 scopus 로고    scopus 로고
    • Adipokines and cytok-ines in non-alcoholic fatty liver disease
    • Jarrar MH, Baranova A, Collantes R, et al. Adipokines and cytok-ines in non-alcoholic fatty liver disease. Aliment Pharmacol Ther. 2008;27(5):412-421.
    • (2008) Aliment Pharmacol Ther , vol.27 , Issue.5 , pp. 412-421
    • Jarrar, M.H.1    Baranova, A.2    Collantes, R.3
  • 194
    • 84872000593 scopus 로고    scopus 로고
    • Plasma visfatin levels and gene expression in morbidly obese women with associated fatty liver disease
    • Auguet T, Terra X, Porras JA, et al. Plasma visfatin levels and gene expression in morbidly obese women with associated fatty liver disease. Clin Biochem. 2013;46(3):202-208.
    • (2013) Clin Biochem , vol.46 , Issue.3 , pp. 202-208
    • Auguet, T.1    Terra, X.2    Porras, J.A.3
  • 195
    • 84872151568 scopus 로고    scopus 로고
    • Misregulation of PPAR functioning and its pathogenic consequences associated with nonalcoholic fatty liver disease in human obesity
    • Videla LA, Pettinelli P. Misregulation of PPAR functioning and its pathogenic consequences associated with nonalcoholic fatty liver disease in human obesity. P PA R Res. 2012;2012:107434.
    • (2012) P PA R Res , vol.2012 , pp. 107434
    • Videla, L.A.1    Pettinelli, P.2
  • 196
    • 0035942162 scopus 로고    scopus 로고
    • A selective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transport
    • Oliver WR Jr, Shenk JL, Snaith MR, et al. A selective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transport. Proc Natl Acad Sci U S A. 2001;98(9):5306-5311.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , Issue.9 , pp. 5306-5311
    • Oliver Jr., W.R.1    Shenk, J.L.2    Snaith, M.R.3
  • 197
    • 78651384181 scopus 로고    scopus 로고
    • Role of peroxisome proliferator-activated receptor {delta}/{beta} in hepatic metabolic regulation
    • Liu S, Hatano B, Zhao M, et al. Role of peroxisome proliferator-activated receptor {delta}/{beta} in hepatic metabolic regulation. J Biol Chem. 2011;286(2):1237-1247.
    • (2011) J Biol Chem , vol.286 , Issue.2 , pp. 1237-1247
    • Liu, S.1    Hatano, B.2    Zhao, M.3
  • 198
    • 39649101196 scopus 로고    scopus 로고
    • Activation of peroxisome proliferator-activated receptor (PPAR)delta Promotes reversal of multiple metabolic abnormalities, reduces oxidative stress, and increases fatty acid oxidation in moderately obese men
    • Risérus U, Sprecher D, Johnson T, et al. Activation of peroxisome proliferator-activated receptor (PPAR)delta Promotes reversal of multiple metabolic abnormalities, reduces oxidative stress, and increases fatty acid oxidation in moderately obese men. Diabetes. 2008;57(2):332-339.
    • (2008) Diabetes , vol.57 , Issue.2 , pp. 332-339
    • Risérus, U.1    Sprecher, D.2    Johnson, T.3
  • 199
    • 80053521381 scopus 로고    scopus 로고
    • Mechanism of action of a peroxisome proliferator-activated receptor (PPAR)-delta agonist on lipoprotein metabolism in dyslipidemic subjects with central obesity
    • Ooi EMM, Watts GF, Sprecher DL, Chan DC, Barrett PHR. Mechanism of action of a peroxisome proliferator-activated receptor (PPAR)-delta agonist on lipoprotein metabolism in dyslipidemic subjects with central obesity. J Clin Endocrinol Metab. 2011;96(10): E1568-E1576.
    • (2011) J Clin Endocrinol Metab , vol.96 , Issue.10
    • Ooi, E.M.M.1    Watts, G.F.2    Sprecher, D.L.3    Chan, D.C.4    Barrett, P.H.R.5
  • 200
    • 33646052892 scopus 로고    scopus 로고
    • Increased plasma visfatin concentrations in morbidly obese subjects are reduced after gastric banding
    • Haider DG, Schindler K, Schaller G, Prager G, Wolzt M, Ludvik B. Increased plasma visfatin concentrations in morbidly obese subjects are reduced after gastric banding. J Clin Endocrinol Metab. 2006; 91(4):1578-1581.
    • (2006) J Clin Endocrinol Metab , vol.91 , Issue.4 , pp. 1578-1581
    • Haider, D.G.1    Schindler, K.2    Schaller, G.3    Prager, G.4    Wolzt, M.5    Ludvik, B.6
  • 201
    • 61949261267 scopus 로고    scopus 로고
    • Inflammatory pathways in liver homeo-stasis and liver injury
    • Tacke F, Luedde T, Trautwein C. Inflammatory pathways in liver homeo-stasis and liver injury. Clin Rev Allergy Immunol. 2009;36(1):4-12.
    • (2009) Clin Rev Allergy Immunol , vol.36 , Issue.1 , pp. 4-12
    • Tacke, F.1    Luedde, T.2    Trautwein, C.3
  • 202
    • 77955690182 scopus 로고    scopus 로고
    • Hepatic lipotoxicity and the pathogenesis of nonalcoholic steatohepatitis: The central role of nontriglyceride fatty acid metabolites
    • Neuschwander-Tetri BA. Hepatic lipotoxicity and the pathogenesis of nonalcoholic steatohepatitis: the central role of nontriglyceride fatty acid metabolites. Hepatology. 2010;52(2):774-788.
    • (2010) Hepatology , vol.52 , Issue.2 , pp. 774-788
    • Neuschwander-Tetri, B.A.1
  • 203
    • 79957605136 scopus 로고    scopus 로고
    • Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity
    • Fu S, Yang L, Li P, et al. Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity. Nature. 2011;473(7348):528-531.
    • (2011) Nature , vol.473 , Issue.7348 , pp. 528-531
    • Fu, S.1    Yang, L.2    Li, P.3
  • 204
    • 65949090538 scopus 로고    scopus 로고
    • Differential effect of oleic and palmitic acid on lipid accumulation and apoptosis in cultured hepatocytes
    • Ricchi M, Odoardi MR, Carulli L, et al. Differential effect of oleic and palmitic acid on lipid accumulation and apoptosis in cultured hepatocytes. J Gastroenterol Hepatol. 2009;24(5):830-840.
    • (2009) J Gastroenterol Hepatol , vol.24 , Issue.5 , pp. 830-840
    • Ricchi, M.1    Odoardi, M.R.2    Carulli, L.3
  • 205
    • 38049186666 scopus 로고    scopus 로고
    • Lysophosphatidylcholine as a death effector in the lipoapoptosis of hepatocytes
    • Han MS, Park SY, Shinzawa K, et al. Lysophosphatidylcholine as a death effector in the lipoapoptosis of hepatocytes. J Lipid Res. 2008;49(1):84-97.
    • (2008) J Lipid Res , vol.49 , Issue.1 , pp. 84-97
    • Han, M.S.1    Park, S.Y.2    Shinzawa, K.3
  • 206
    • 65949087032 scopus 로고    scopus 로고
    • Lipotoxicity: Why do saturated fatty acids cause and monounsaturates protect against it?
    • Nolan CJ, Larter CZ. Lipotoxicity: why do saturated fatty acids cause and monounsaturates protect against it? J Gastroenterol Hepatol. 2009;24(5):703-706.
    • (2009) J Gastroenterol Hepatol , vol.24 , Issue.5 , pp. 703-706
    • Nolan, C.J.1    Larter, C.Z.2
  • 207
    • 79952211574 scopus 로고    scopus 로고
    • Molecular therapy for obesity and diabetes based on a long-term increase in hepatic fatty-acid oxidation
    • Orellana-Gavalda JM, Herrero L, Malandrino MI, et al. Molecular therapy for obesity and diabetes based on a long-term increase in hepatic fatty-acid oxidation. Hepatology. 2011;53(3):821-832.
    • (2011) Hepatology , vol.53 , Issue.3 , pp. 821-832
    • Orellana-Gavalda, J.M.1    Herrero, L.2    Malandrino, M.I.3
  • 208
    • 34247604581 scopus 로고    scopus 로고
    • TNF-alpha induces hepatic steatosis in mice by enhancing gene expression of sterol regulatory element binding protein-1c (SREBP-1c)
    • Endo M, Masaki T, Seike M, Yoshimatsu H. TNF-alpha induces hepatic steatosis in mice by enhancing gene expression of sterol regulatory element binding protein-1c (SREBP-1c). Exp Biol Med (Maywood). 2007;232(5):614-621.
    • (2007) Exp Biol Med (Maywood) , vol.232 , Issue.5 , pp. 614-621
    • Endo, M.1    Masaki, T.2    Seike, M.3    Yoshimatsu, H.4
  • 209
    • 70350046669 scopus 로고    scopus 로고
    • Cytokeratin-18 fragment levels as noninvasive biomarkers for nonalcoholic steatohepatitis: A multicenter validation study
    • Feldstein AE, Wieckowska A, Lopez AR, Liu YC, Zein NN, McCullough AJ. Cytokeratin-18 fragment levels as noninvasive biomarkers for nonalcoholic steatohepatitis: a multicenter validation study. Hepatolog y. 2009;50(4):1072-1078.
    • (2009) Hepatolog Y , vol.50 , Issue.4 , pp. 1072-1078
    • Feldstein, A.E.1    Wieckowska, A.2    Lopez, A.R.3    Liu, Y.C.4    Zein, N.N.5    McCullough, A.J.6
  • 210
    • 77958183243 scopus 로고    scopus 로고
    • Novel insights into the pathophysiology of nonalcoholic fatty liver disease
    • Feldstein AE. Novel insights into the pathophysiology of nonalcoholic fatty liver disease. Semin Liver Dis. 2010;30(4):391-401.
    • (2010) Semin Liver Dis , vol.30 , Issue.4 , pp. 391-401
    • Feldstein, A.E.1
  • 211
    • 84866421262 scopus 로고    scopus 로고
    • Critical role of cyto-chrome P450 2E1 (CYP2E1) in the development of high fat-induced non-alcoholic steatohepatitis
    • Abdelmegeed MA, Banerjee A, Yo o SH, et al. Critical role of cyto-chrome P450 2E1 (CYP2E1) in the development of high fat-induced non-alcoholic steatohepatitis. J Hepatol. 2012;57(4):860-866.
    • (2012) J Hepatol , vol.57 , Issue.4 , pp. 860-866
    • Abdelmegeed, M.A.1    Banerjee, A.2    Yoo, S.H.3
  • 212
    • 84889591319 scopus 로고    scopus 로고
    • CYP2E1-dependent and leptin-mediated hepatic CD57 expression on CD8+ T cells aid progression of environment-linked nonalcoholic steatohepatitis
    • Seth RK, Das S, Kumar A, et al. CYP2E1-dependent and leptin-mediated hepatic CD57 expression on CD8+ T cells aid progression of environment-linked nonalcoholic steatohepatitis. Toxicol Appl Pharmacol. 2014;274(1):42-54.
    • (2014) Toxicol Appl Pharmacol , vol.274 , Issue.1 , pp. 42-54
    • Seth, R.K.1    Das, S.2    Kumar, A.3
  • 213
    • 84890342238 scopus 로고    scopus 로고
    • Purinergic receptor X7 is a key modulator of metabolic oxidative stress-mediated autophagy and infammation in experimental nonalcoholic steatohepatitis
    • Das S, Seth RK, Kumar A, et al. Purinergic receptor X7 is a key modulator of metabolic oxidative stress-mediated autophagy and infammation in experimental nonalcoholic steatohepatitis. Am J Physiol Gastrointest Liver Physiol. 2013;305(12):G950-G963.
    • (2013) Am J Physiol Gastrointest Liver Physiol , vol.305 , Issue.12
    • Das, S.1    Seth, R.K.2    Kumar, A.3
  • 214
    • 79955632246 scopus 로고    scopus 로고
    • Cannabinoids and endocan-nabinoids in metabolic disorders with focus on diabetes
    • Di Marzo V, Piscitelli F, Mechoulam R. Cannabinoids and endocan-nabinoids in metabolic disorders with focus on diabetes. Handb Exp Pharmacol. 2011;(203):75-104.
    • (2011) Handb Exp Pharmacol , Issue.203 , pp. 75-104
    • Di Marzo, V.1    Piscitelli, F.2    Mechoulam, R.3
  • 215
    • 79952198989 scopus 로고    scopus 로고
    • Is lipid signaling through cannabinoid 2 receptors part of a protective system?
    • Pacher P, Mechoulam R. Is lipid signaling through cannabinoid 2 receptors part of a protective system? Prog Lipid Res. 2011;50(2): 193-211.
    • (2011) Prog Lipid Res , vol.50 , Issue.2 , pp. 193-211
    • Pacher, P.1    Mechoulam, R.2
  • 216
    • 33748703859 scopus 로고    scopus 로고
    • The endocannabinoid system as an emerging target of pharmacotherapy
    • Pacher P, Bátkai S, Kunos G. The endocannabinoid system as an emerging target of pharmacotherapy. Pharmacol Rev. 2006;58(3): 389-462.
    • (2006) Pharmacol Rev , vol.58 , Issue.3 , pp. 389-462
    • Pacher, P.1    Bátkai, S.2    Kunos, G.3
  • 217
    • 85047690626 scopus 로고    scopus 로고
    • The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis
    • Cota D, Marsicano G, Tschap M, et al. The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis. J Clin Invest. 2003;112(3):423-431.
    • (2003) J Clin Invest , vol.112 , Issue.3 , pp. 423-431
    • Cota, D.1    Marsicano, G.2    Tschap, M.3
  • 218
    • 20944436157 scopus 로고    scopus 로고
    • Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesity
    • Osei-Hyiaman D, DePetrillo M, Pacher P, et al. Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesity. J Clin Invest. 2005;115(5): 1298-1305.
    • (2005) J Clin Invest , vol.115 , Issue.5 , pp. 1298-1305
    • Osei-Hyiaman, D.1    Depetrillo, M.2    Pacher, P.3
  • 219
    • 38649114788 scopus 로고    scopus 로고
    • Paracrine activation of hepatic CB1 receptors by stellate cell-derived endocannabinoids mediates alcoholic fatty liver
    • Jeong W, Osei-Hyiaman D, Park O, et al. Paracrine activation of hepatic CB1 receptors by stellate cell-derived endocannabinoids mediates alcoholic fatty liver. Cell Metab. 2008;7(3):227-235.
    • (2008) Cell Metab , vol.7 , Issue.3 , pp. 227-235
    • Jeong, W.1    Osei-Hyiaman, D.2    Park, O.3
  • 220
    • 79960297797 scopus 로고    scopus 로고
    • The endocannabinoid system as a key mediator during liver diseases: New insights and therapeutic openings
    • Mallat A, Teixeira-Clerc F, Deveaux V, Manin S, Lotersztajn S. The endocannabinoid system as a key mediator during liver diseases: new insights and therapeutic openings. Br J Pharmacol. 2011;163(7): 1432-1440.
    • (2011) Br J Pharmacol , vol.163 , Issue.7 , pp. 1432-1440
    • Mallat, A.1    Teixeira-Clerc, F.2    Deveaux, V.3    Manin, S.4    Lotersztajn, S.5
  • 221
    • 51349153318 scopus 로고    scopus 로고
    • Hepatic CB1 receptor is required for development of diet-induced steatosis, dyslipidemia, and insulin and leptin resistance in mice
    • Osei-Hyiaman D, Liu J, Zhou L, et al. Hepatic CB1 receptor is required for development of diet-induced steatosis, dyslipidemia, and insulin and leptin resistance in mice. J Clin Invest. 2008;118(9):3160-3169.
    • (2008) J Clin Invest , vol.118 , Issue.9 , pp. 3160-3169
    • Osei-Hyiaman, D.1    Liu, J.2    Zhou, L.3
  • 222
    • 77955286305 scopus 로고    scopus 로고
    • Peripheral CB1 cannabinoid receptor blockade improves cardiometabolic risk in mouse models of obesity
    • Tam J, Vemuri VK, Liu J, et al. Peripheral CB1 cannabinoid receptor blockade improves cardiometabolic risk in mouse models of obesity. J Clin Invest. 2010;120(8):2953-2966.
    • (2010) J Clin Invest , vol.120 , Issue.8 , pp. 2953-2966
    • Tam, J.1    Vemuri, V.K.2    Liu, J.3
  • 223
    • 34547423962 scopus 로고    scopus 로고
    • Rimonabant reduces obesity-associated hepatic steatosis and features of metabolic syndrome in obese Zucker fa/fa rats
    • Gary-Bobo M, Elachouri G, Gallas J F, et al. Rimonabant reduces obesity-associated hepatic steatosis and features of metabolic syndrome in obese Zucker fa/fa rats. Hepatology. 2007;46(1): 122-129.
    • (2007) Hepatology , vol.46 , Issue.1 , pp. 122-129
    • Gary-Bobo, M.1    Elachouri, G.2    Gallas, J.F.3
  • 224
    • 84857445031 scopus 로고    scopus 로고
    • Antagonism of peripheral hepatic cannabinoid receptor-1 improves liver lipid metabolism in mice: Evidence from cultured explants
    • Jourdan T, Demizieux L, Gresti J, et al. Antagonism of peripheral hepatic cannabinoid receptor-1 improves liver lipid metabolism in mice: evidence from cultured explants. Hepatology. 2012;55(3):790-799.
    • (2012) Hepatology , vol.55 , Issue.3 , pp. 790-799
    • Jourdan, T.1    Demizieux, L.2    Gresti, J.3
  • 225
    • 77951184370 scopus 로고    scopus 로고
    • CB1 antagonism exerts specific molecular effects on visceral and subcutaneous fat and reverses liver steatosis in diet-induced obese mice
    • Jourdan T, Djaouti L, Demizieux L, Gresti J, Vergès B, Degrace P. CB1 antagonism exerts specific molecular effects on visceral and subcutaneous fat and reverses liver steatosis in diet-induced obese mice. Diabetes. 2010;59(4):926-934.
    • (2010) Diabetes , vol.59 , Issue.4 , pp. 926-934
    • Jourdan, T.1    Djaouti, L.2    Demizieux, L.3    Gresti, J.4    Vergès, B.5    Degrace, P.6
  • 226
    • 80051504630 scopus 로고    scopus 로고
    • Cannabinoid receptor type 1 (CB1R) signaling regulates hepatic gluconeogenesis via induction of endo-plasmic reticulum-bound transcription factor cAMP-responsive element-binding protein H (CREBH) in primary hepatocytes
    • Chanda D, Kim DK, Li T, et al. Cannabinoid receptor type 1 (CB1R) signaling regulates hepatic gluconeogenesis via induction of endo-plasmic reticulum-bound transcription factor cAMP-responsive element-binding protein H (CREBH) in primary hepatocytes. J Biol Chem. 2011;286(32):27971-27979.
    • (2011) J Biol Chem , vol.286 , Issue.32 , pp. 27971-27979
    • Chanda, D.1    Kim, D.K.2    Li, T.3
  • 227
    • 21344472982 scopus 로고    scopus 로고
    • Daily cannabis smoking as a risk factor for progression of fbrosis in chronic hepatitis C
    • Hézode C, Roudot-Thoraval F, Nguyen S, et al. Daily cannabis smoking as a risk factor for progression of fbrosis in chronic hepatitis C. Hepatolog y. 2005;42(1):63-71.
    • (2005) Hepatolog Y , vol.42 , Issue.1 , pp. 63-71
    • Hézode, C.1    Roudot-Thoraval, F.2    Nguyen, S.3
  • 228
    • 38749134463 scopus 로고    scopus 로고
    • Regression of fbrosis after chronic stimulation of cannabinoid CB2 receptor in cirrhotic rats
    • Muñoz-Luque J, Ros J, Fernández-Varo G, et al. Regression of fbrosis after chronic stimulation of cannabinoid CB2 receptor in cirrhotic rats. J Pharmacol Exp Ther. 2008;324(2):475-483.
    • (2008) J Pharmacol Exp Ther , vol.324 , Issue.2 , pp. 475-483
    • Muñoz-Luque, J.1    Ros, J.2    Fernández-Varo, G.3
  • 229
    • 33745003240 scopus 로고    scopus 로고
    • CB1 cannabinoid receptor antagonism: A new strategy for the treatment of liver fbrosis
    • Teixeira-Clerc F, Julien B, Grenard P, et al. CB1 cannabinoid receptor antagonism: a new strategy for the treatment of liver fbrosis. Nat Med. 2006;12(6):671-676.
    • (2006) Nat Med , vol.12 , Issue.6 , pp. 671-676
    • Teixeira-Clerc, F.1    Julien, B.2    Grenard, P.3
  • 230
    • 41149130137 scopus 로고    scopus 로고
    • Efficacy and safety of rimonabant for improvement of multiple cardiometabolic risk factors in overweight/obese patients: Pooled 1-year data from the Rimonabant in Obesity (RIO) program
    • Van Gaal L, Pi-Sunyer X, Després J P, McCarthy C, Scheen A. Efficacy and safety of rimonabant for improvement of multiple cardiometabolic risk factors in overweight/obese patients: pooled 1-year data from the Rimonabant in Obesity (RIO) program. Diabetes Care. 2008; 31 Suppl 2:S229-S240.
    • (2008) Diabetes Care , vol.31 , Issue.SUPPL. 2
    • van Gaal, L.1    Pi-Sunyer, X.2    Després, J.P.3    McCarthy, C.4    Scheen, A.5


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