Cannabinoid Receptor Type 1 (CB1R) signaling regulates hepatic gluconeogenesis via induction of endoplasmic reticulum-bound transcription factor cAMP-responsive element-binding protein H (CREBH) in primary hepatocytes

Journal of Biological Chemistry

Volumn 286, Issue 32, 2011, Pages 27971-27979

  Chanda, Dipanjan ^a   Kim, Don Kyu ^a   Li, Tiangang ^c   Kim, Yong Hoon ^d   Koo, Seung Hoi ^e   Lee, Chul Ho ^d   Chiang, John Y L ^c   Choi, Hueng Sik ^a,b  

^a Chonnam National University   (South Korea)

^b Chonnam National University Medical School   (South Korea)

^c Northeastern Ohio Medical University   (United States)

^d Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^e Sungkyunkwan University School of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CANNABINOID RECEPTORS; DIRECT ACTIVATION; ELEMENT-BINDING PROTEINS; ENDOCANNABINOID; ENDOPLASMIC RETICULUM; FATTY LIVER; GENE INDUCTION; GENE PROMOTER; GLUCONEOGENESIS; GLUCONEOGENIC GENES; GLUCOSE HOMEOSTASIS; GLUCOSE METABOLISM; GLUCOSE PRODUCTION; HEPATIC GLUCONEOGENESIS; HUMAN HEPATOCYTES; HUMAN PRIMARY HEPATOCYTES; INSULIN RESISTANCE; MECHANISM OF ACTION; METABOLIC PATHWAYS; PRIMARY HEPATOCYTES; PROTEIN LEVEL; SIGNALING MECHANISMS; SIGNALING PATHWAYS; TRANSCRIPTIONAL ANALYSIS;

FETAL MONITORING; GENES; GLUCOSE; INSULIN; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; RATS; SIGNALING; TRANSCRIPTION FACTORS;

TRANSCRIPTION;

1 (2,4 DICHLOROPHENYL) 5 (4 IODOPHENYL) 4 METHYL N (1 PIPERIDYL) 1H PYRAZOLE 3 CARBOXAMIDE; 2 ARACHIDONOYLGLYCEROL; CANNABINOID 1 RECEPTOR; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN H; INSULIN; PROTEIN C JUN; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING SITE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; G6PC GENE; GENE; GENE EXPRESSION; GLUCONEOGENESIS; GLUCOSE HOMEOSTASIS; GLUCOSE METABOLISM; HUMAN; HUMAN CELL; LIVER CELL; NONHUMAN; PEPCK GENE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; UPREGULATION;

ANIMALS; ARACHIDONIC ACIDS; CELL LINE; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; ENDOCANNABINOIDS; ENDOPLASMIC RETICULUM; GLUCONEOGENESIS; GLUCOSE; GLYCERIDES; HEPATOCYTES; HUMANS; LIVER; MAP KINASE KINASE 4; MUTATION; PROTO-ONCOGENE PROTEINS C-JUN; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, CANNABINOID, CB1; RESPONSE ELEMENTS; RNA, MESSENGER; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR AP-1;

RATTUS;

EID: 80051504630     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.224352     Document Type: Article

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