New insights into the structure and function of fatty acid-binding proteins

Cellular and Molecular Life Sciences

Volumn 59, Issue 7, 2002, Pages 1096-1116

  Zimmerman, A W ^a   Veerkamp, J H ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Cancer; Diagnostic marker; Fatty acid transfer; Fatty acid binding protein; Gene transcription; Signal transduction; Site directed mutagenesis

Indexed keywords

FATTY ACID BINDING PROTEIN; LIPID BINDING PROTEIN;

CELL DIFFERENTIATION; CELL GROWTH; CELL PROTECTION; FATTY ACID METABOLISM; FATTY ACID TRANSPORT; GENETIC TRANSCRIPTION; KNOCKOUT MOUSE; NONHUMAN; PROTEIN FUNCTION; PROTEIN STRUCTURE; REVIEW; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; ANIMALS; BIOLOGICAL TRANSPORT; CARRIER PROTEINS; CELL DIFFERENTIATION; CELL DIVISION; FATTY ACID-BINDING PROTEINS; FATTY ACIDS; GENE EXPRESSION REGULATION; HUMANS; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NEOPLASM PROTEINS; NERVE TISSUE PROTEINS; SEQUENCE ALIGNMENT; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR SUPPRESSOR PROTEINS;

INVERTEBRATA; MAMMALIA; VERTEBRATA;

EID: 0036634367     PISSN: 1420682X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00018-002-8490-y     Document Type: Review

References (301)

1. Structure and lipid binding properties of serum albumin
2. The lipocalin protein family: Structure and function
3. Structural and functional features of different types of cytoplasmic fatty acid-binding proteins
4. Cytoplasmic fatty acid-binding proteins: Their structure and genes
5. PM
6. A binding protein for fatty acids in cytosol of intestinal mucosa, liver, myocardium, and other tissues
7. The cytoplasmic fatty-acid-binding proteins: Thirty years and counting
8. Retinoid-binding proteins: Mediators of retinoid action
9. Structural and functional aspects of cytosolic fatty acid binding proteins
10. Expression of human liver fatty acid-binding protein in Escherichia coli and comparative analysis of its binding characteristics with muscle fatty acid-binding protein
11. Mutations of recombinant rat liver fatty acid-binding protein at residues 102 and 122 alter its structural integrity and affinity for physiological ligands
12. Ligand specificity and conformational stability of human fatty acid-binding proteins
13. Lipid-binding proteins: A family of fatty acid and retinoid transport proteins
14. The crystal structure of the liver fatty acid-binding protein
15. The essentiality of n-3 fatty acids for the development and function of the retina and brain
16. Developmental changes in rat brain membrane lipids and fatty acids: The preferential prenatal accumulation of docosahexaenoic acid
17. Fatty acid-binding proteins of nervous tissue
18. Molecular cloning and expression of a novel keratinocyte protein (psoriasis-associated fatty acid-binding protein [PA-FABP]) that is highly up-regulated in psoriatic skin and that shares similarity to fatty acid-binding proteins
19. Tumor-specific overexpression of a novel keratinocyte lipid-binding protein: Identification and characterization of a cloned sequence activated during multistage carcinogenesis in mouse skin
20. Fatty acid binding protein is induced in neurons of the dorsal root ganglia after peripheral nerve injury
21. Lens epithelial cell mRNA, II. Expression of a mRNA encoding a lipid-binding protein in rat lens epithelial cells
22. LP2, a differentiation-associated lipid-binding protein expressed in bovine lens
23. Endothelial cells of the human microvasculature express epidermal fatty acid-binding protein
24. Expression, purification and crystal structure determination of recombinant human epidermal-type fatty acid binding protein
25. Disulfide bonds in rat cutaneous fatty acid-binding protein
26. Fatty acid-binding proteins: Chronological description and discussion of hypotheses involving their molecular evolution
27. Fatty acid binding proteins
28. Intracellular lipid-binding proteins and their genes
29. Cloning and characterization of the mouse gene encoding mammary-derived growth inhibitor/heart fatty acid-binding protein
30. Structure and chromosomal location of the rat gene encoding the heart fatty acid binding protein
31. The human mammary derived growth inhibitor (MDGI) gene: Genomic structure and mutation analysis in human breast tumors
32. Characterization, chromosomal localization and genetic variation of the porcine heart fatty acid-binding protein gene
33. Structure and localization of the gene encoding human peripheral myelin protein 2 (PMP2)
34. Structure of the mouse myelin P2 protein gene
35. The human and rodent intestinal fatty acid binding protein genes: A comparative analysis of their structure, expression, and linkage relationships
36. The nucleotide sequence of the rat liver fatty acid binding protein gene: Evidence that exon 1 encodes an oligopeptide domain shared by a family of proteins which bind hydrophobic ligands
37. Adipocyte P2 gene: Developmental expression and homology of 5′-flanking sequences among fat cell-specific genes
38. Cloning and chromosomal location of the murine keratinocyte lipid-binding protein gene
39. Cloning and chromosomal localisation of the murine epidermal-type fatty acid binding protein gene (Fabpe)
40. The mouse ileal lipid binding protein gene: A model for studying axial patterning during gut morphogenesis
41. The rabbit ileal lipid binding protein: Gene cloning and functional expression of the recombinant protein
42. A concise promoter region of the heart fatty acid binding protein gene dictates tissue-appropriate expression
43. Identification of a bile acid-responsive element in the human ileal bile acid-binding protein gene
44. Suppressor and activator functions mediated by a repeated heptad sequence in the liver fatty acid-binding protein gene (Fabp1): Effects on renal, small intestinal, and colonic epithelial cell gene expression in transgenic mice
45. Cloning of the cDNA encoding human skeletal muscle fatty acid binding protein, its peptide sequence and chromosomal localization
46. Localization of the gene for human heart fatty acid binding protein to chromosome 1p32-1p33
47. Analysis of the tissue specific expression, developmental regulation and linkage relationships of a rodent gene encoding heart fatty acid binding protein
48. Ileal lipid-binding protein (IIIbp) gene maps to mouse chromosome 11
49. Cloning and chromosomal localization of the human ileal lipid-binding protein
50. Assignment of the human adipocyte fatty acid-binding protein gene (FABP4) to chromosome 8q21 using somatic cell hybrid and fluorescence in situ hybridisation techniques
51. An amino acid substitution in the human intestinal fatty acid binding protein is associated with increased fatty acid binding, increased fat oxidation, and insulin resistance
52. Effects of an Ala54Thr polymorphism in the intestinal fatty acid-binding protein on responses to dietary fat in humans
53. A polymorphism in the human intestinal fatty acid binding protein alters fatty acid transport across Caco-2 cells
54. A review of intestinal fatty acid-binding protein gene variation and the plasma lipoprotein response to dietary components
55. Postprandial lipemic response is modified by the polymorphism at codon 54 of the fatty acid-binding protein 2 gene
56. Postprandial responses of individual fatty acids in subjects homozygous for the threonine- or alanine-encoding allele in codon 54 of the intestinal fatty acid-binding protein 2 gene
57. The A54T polymorphism at the intestinal fatty acid binding protein 2 is associated with insulin resistance in glucose tolerant Caucasians
58. Codon 54 polymorphism of the fatty acid binding protein gene and insulin resistance in the Japanese population
59. Codon 54 polymorphism of the fatty acid binding protein 2 gene is associated with increased fat oxidation and hyperinsulinemia, but not with intestinal fatty acid absoption in Korean men
60. Cardiac fatty acid-binding proteins: Isolation and characterization of the mitochondrial fatty acid-binding protein and its structural relationship with the cytosolic isoforms
61. Isoforms of fatty acid-binding protein in bovine heart are coded by distinct mRNA
62. Isolation and characterization of two distinct forms of liver fatty acid-binding protein from the rat
63. Isoforms of rat liver fatty acid binding protein differ in structure and affinity for fatty acids and fatty acyl CoAs
64. Isolation, characterization and binding properties of two rat liver fatty acid-binding protein isoforms
65. Isolation, amino acid sequence determination and binding properties of two fatty-acid-binding proteins from axolotl (Ambistoma mexicanum) liver: Evolutionary relationship
66. A cysteine to alanine mutation in recombinant rat liver fatty acid binding protein reduces charge isoforms
67. Differential influence of rat liver fatty acid binding protein isoforms on phospholipid fatty acid composition: Phosphatic acid biosynthesis and phospholipid fatty acid remodelling
68. Crystal structure of rat intestinal fatty acid-binding protein: Refinement and analysis of the Escherichia coli derived protein with bound palmitate
69. Three-dimensional structure of recombinant human muscle fatty acid-binding protein
70. Crystal structure of recombinant murine adipocyte lipid-binding protein
71. Crystallographic studies on a family of cellular lipophilic transport proteins: Refinement of P2 myelin protein and the structure determination and refinement of cellular retinal-binding protein in complex with all-trans retinol
72. Crystal structure and thermodynamic analysis of human brain fatty acid-binding protein
73. Three-dimensional structure of bovine heart fatty acid-binding protein with bound palmitic acid, determined by multidimensional NMR spectroscopy
74. The NMR solution structure of intestinal fatty acid-binding protein complexed with palmitate: Application of a novel distance geometry algorithm
75. Flexibility is a likely determinant of binding specificity in the case of ileal lipid-binding protein
76. Solution structure of ileal lipid binding protein in complex with glycocholate
77. Spin-system heterogeneities indicate a selected-fit mechanism in fatty acid binding to heart-type fatty acid-binding protein (H-FABP)
78. Muscle fatty acid-binding protein
79. Structural properties of the adipocyte lipid binding protein
80. Liver fatty acid binding protein: Species variation and the accommodation of different ligands
81. Structural studies on human muscle fatty acid binding protein at 1.4 Å resolution: Binding interactions with three C18 fatty acids
82. A "structural" water molecule in the family of fatty acid binding proteins
83. Simulations of fatty acid-binding proteins suggest sites important for function. I. Stearic acid
84. Simulations of fatty acid-binding proteins. II. Sites for discrimination of monounsaturated ligands
85. The three-dimensional structure of P2 myelin protein
86. Lipid binding activities of the P2 protein in peripheral nerve myelin
87. Structural and functional studies on different human FABP types
88. Ligand specificity of brain lipid-binding protein
89. Fatty acid binding proteins from different tissues show distinct patterns of fatty acid interactions
90. Gastrotropin: Not an enterooxyntin but a member of a family of cytoplasmic hydrophobic ligand binding proteins
91. Effect on ligand binding of arginine mutations in recombinant rat liver fatty acid-binding protein
92. Intestinal fatty acid-binding protein: The structure and stability of a helix-less variant
93. The three-dimensional structure of a helix-less variant of intestinal fatty acid-binding protein
94. Fatty acid interactions with a helix-less variant of intestinal fatty acid-binding protein
95. The helical domain of intestinal fatty acid binding protein is critical for collisional transfer of fatty acids to phospholipid membranes
96. Deletion of the helical motif in the intestinal fatty acid-binding protein reduces its interactions with membrane monolayers: Brewster angle microscopy, IR reflection-absorption spectroscopy, and surface pressure studies
97. Modulation of ligand binding affinity of the adipocyte lipid-binding protein by selective mutation: Analysis in vitro and in situ
98. Fatty acid binding and conformational stability of mutants of human muscle fatty acid-binding protein
99. Ligand-protein electrostatic interactions govern the specificity of retinol- and fatty acid-binding proteins
100. Functional and conformational characterization of new mutants of heart fatty acid-binding protein
101. Biochemical and crystallographic analyses of a portal mutant of the adipocyte lipid-binding protein
102. Analysis of a series of phenylalanine 57 mutants of the adipocyte lipid-binding protein
103. Backbone and side chain dynamics of uncomplexed human adipocyte and muscle fatty acid-binding proteins
104. Intestinal fatty acid binding protein: A specific residue in one turn appears to stabilize the native structure and be responsible for slow refolding
105. Turn-scanning by site-directed mutagenesis: Application to the protein folding problem using the intestinal fatty acid binding protein
106. Surface lysine residues modulate the collisional transfer of fatty acid from adipocyte fatty acid binding protein to membranes
107. Role of portal region lysine residues in electrostatic interactions between heart fatty acid binding protein and phospholipid membranes
108. Role of surface lysine residues of adipocyte fatty acid-binding protein in fatty acid transfer to phospholipid vesicles
109. Thermodynamics of fatty acid binding to engineered mutants of the adipocyte and intestinal fatty acid-binding protein
110. Binding kinetics of engineered mutants provide insight about the pathway for entering and exiting the intestinal fatty acid binding protein
111. Fatty acid interactions with native and mutant fatty acid binding proteins
112. Flip-flop: The transmembrane translocation of lipids
113. Fatty acid flip-flop in phospholipid bilayers is extremely fast
114. Fatty acids enter cells by simple diffusion
115. Fatty acid homeostasis in the normotoxic and ischemic heart
116. Gradient of fatty acids from blood plasma to skeletal muscle in dogs
117. How are free fatty acids transported in membranes? Is it by proteins or by free diffusion through the lipids?
118. Oleic acid uptake and binding by rat adipocytes define dual pathways for cellular fatty acid uptake
119. Oleate uptake by cardiac myocytes is carrier-mediated and involves a 40-kD plasma membrane fatty acid binding protein similar to that in liver, adipose tissue and gut
120. PM, but not FATP, are physiologically important fatty acid transport proteins
121. Mechanism of long chain fatty acid permeation in the isolated adipocyte
122. Permeation of long-chain fatty acid into adipocytes: Kinetics, specificity, and evidence for involvement of a membrane protein
123. Hepatocellular uptake of oleate is energy-dependent, sodium-linked, and inhibited by an antibody to a hepatocyte plasma membrane fatty acid binding protein
124. At physiologic albumin/oleate concentrations oleate uptake by isolated hepatocytes, cardiac myocytes, and adipocytes is a saturable function of the unbound oleate concentration: Uptake kinetics are consistent with the conventional theory
125. Isolation and partial characterization of a fatty acid binding protein in rat liver plasma membranes
126. Expression of the CD36 homolog (FAT) in fibroblast cells: Effects on fatty acid transport
127. Expression cloning and characterization of a novel adipocyte long chain fatty acid transport protein
128. Fatty acid transport proteins facilitate fatty acid uptake in skeletal muscle
129. Cellular fatty acid-binding proteins: Their function and physiological significance
130. Are fatty acid-binding proteins involved in fatty acid transfer?
131. The role of membranes and intracellular binding proteins in cytoplasmic transport of hydrophobic molecules: Fatty acid binding proteins
132. 125I]iodo-4-azido-N-hexadecylsalicylamide: Evidence for a role of fatty acid binding proteins in lipid uptake
133. 125I]iodo-4-azido-N-hexadecylsalicylamide
134. The fatty acid transport function of fatty acid-binding proteins
135. The adipocyte fatty acid-binding protein binds to membranes by electrostatic interactions
136. Regulation of fluorescent fatty acid transfer from adipocyte and heart fatty acid binding proteins by acceptor membrane lipid composition and structure
137. Liver and intestinal fatty acid-binding proteins obtain fatty acids from phospholipid membranes by different mechanisms
138. Inhibition of binding to fatty acid binding protein reduces the intracellular transport of fatty acids
139. L-FABP and I-FABP expression increase NBD-stearate uptake and cytoplasmic diffusion in L cells
140. Cytoplasmic codiffusion of fatty acids is not specific for fatty acid binding protein
141. Cytoplasmic transport of fatty acids in rat enterocytes: Role of binding to fatty acid-binding protein
142. Cytoplasmic transport of lipids: Role of binding proteins
143. Kinetic model of protein-mediated ligand transport: Influence of soluble binding proteins on the intermembrane diffusion of a fluorescent fatty acid
144. Transfer of fluorescent fatty acids from liver and heart fatty acid-binding proteins to model membranes
145. Free fatty acid transfer from rat liver fatty acid-binding protein to phospholipid vesicles: Effect of ligand and solution properties
146. Mechanism of free fatty acid transfer from rat heart fatty acid binding protein to phospholipid membranes: Evidence for a collisional process
147. Fatty acid transfer from liver and intestinal fatty acid binding proteins to membranes occurs by different mechanisms
148. Binding of recombinant rat liver fatty acid-binding protein to small anionic phospholipid vesicles results in ligand release: A model for interfacial binding and fatty acid targeting
149. Effect of fatty acid-binding proteins on intermembrane fatty acid transport: Studies on different types and mutant proteins
150. Intracellular transport of bile acids
151. Binding of bile acids, oleic acid and organic anions by rat and human hepatic Z protein
152. Output of liver fatty acid-binding protein (L-FABP) in bile
153. Role of fatty acids in signal transduction: Modulators and messengers
154. Fatty acids and cell signal transduction
155. Fatty acids involved in signal cross-talk between cell membrane and nucleus
156. Binding of cytochrome P450 monooxygenase and lipoxygenase pathway products by heart fatty acid-binding protein
157. Fatty acids inhibit growth-factor-induced diacylglycerol kinase α activation in vascular smooth muscle cells
158. n-6 and n-3 polyunsaturated fatty acids differentially modulate oncogenic Ras activation in colonocytes
159. Direct regulation of ion channels by fatty acids
160. + channels by directly binding to the channel proteins
161. Arachidonic acid both inhibits and enhances whole cell calcium currents in rat sympathetic neurons
162. 2+ currents by polyunsaturated fatty acids in adult and neonatal rat ventricular myocytes
163. + channel
164. Coordinate regulation of the expression of the fatty acid transport protein and acyl-CoA synthetase genes by PPARα and PPARγ activators
165. Polyunsaturated fatty acid regulation of hepatic gene transcription
166. Polyunsaturated fatty acid regulation of gene transcription: A mechanism to improve energy balance and insulin resistance
167. Linoleic acid controls neonatal tissue-specific stearoyl-CoA desaturase mRNA levels
168. Long-chain fatty acids regulate liver carnitine palmitoyltransferase I gene (L-CPT I) expression through a peroxisome proliferator-activated receptor α (PPARα)-independent pathway
169. Regulation of adipose cell differentiation. I. Fatty acids are inducers of the aP2 gene expression
170. Regulation of adipose cell differentiation. II. Kinetics of induction of the aP2 gene by fatty acids and modulation by dexamethasone
171. Fatty acids as signal transducing molecules: Involvement in the differentiation of preadipose to adipose cells
172. Fatty acid regulation of gene expression: Transcriptional and post-transcriptional mechanisms
173. Up-regulation of the expression of the gene for liver fatty acid-binding protein by long-chain fatty acids
174. Long-chain fatty acid-induced changes in gene expression in neonatal cardiac myocytes
175. Fatty acid regulation of gene transcription
176. Peroxisome proliferator-activated receptors: A nuclear receptor signalling pathway in lipid physiology
177. Peroxisome proliferator-activated receptors, orphans with ligands and functions
178. Mechanism of action of the nongenotoxic peroxisome proliferators: Role of the peroxisome proliferator-activated receptor α
179. Peroxisome proliferator-activated receptors: Nuclear control of metabolism
180. Peroxisome proliferator-activated receptors: A critical link among fatty acids, gene expression and carcinogenesis
181. Targeted disruption of the α isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators
182. Adipogenesis and obesity: Rounding out the big picture
183. Cloning of a protein that mediates transcriptional effects of fatty acids in preadipocytes: Homology to peroxisome proliferator-activated receptors
184. Peroxisome-proliferator-activated receptor δ mediates the effects of long-chain fatty acids on post-confluent cell proliferation
185. The PPARα-leukotriene B4 pathway to inflammation control
186. Peroxisome proliferator-activated receptor-alpha activators regulate genes governing lipoprotein metabolism, vascular inflammation and atherosclerosis
187. Differential effects of PPARα activators on induction of ectopic expression of tissue-specific fatty acid binding protein genes in the mouse liver
188. The expression of PPAR-associated genes is modulated through postnatal development of PPAR subtypes in the small intestine
189. Expression of peroxisome proliferator-activated receptor PPARδ promotes induction of PPARγ and adipocyte differentiation in 3T3C2 fibroblasts
190. Long chain fatty acids as modulators of gene transcription in preadipose cells
191. Fatty acid regulation of fatty acid-binding protein expression in the small intestine
192. Differential involvement of peroxisome proliferator-activated receptors α and δ in fibrate and fatty acid-mediated inductions of the gene encoding liver fatty acid-binding protein in the liver and the small intestine
193. Regulation of expression of human intestinal bile acid-binding protein in Caco-2 cells
194. Compartmentation of hepatic fatty acid-binding protein in liver cells and its effect on microsomal phosphatic acid biosynthesis
195. Localization of the heme-binding protein in the cytoplasm and of a heme-binding protein-like immunoreactive protein in the nucleus of rat liver parenchymal cells: Immunocytochemical evidence for the subcellular distribution corroborated by radioimmunoassay and immunoblotting
196. Subcellular distribution of cardiac fatty acid-binding protein in bovine heart muscle and quantitation with an enzyme-linked immunosorbent assay
197. Fatty acid-binding protein in locust flight muscle: Developmental changes of expression, concentration and intracellular distribution
198. Immunoreactivity for brain-fatty acid binding protein in Gomori-positive astrocytes
199. Ligand-dependent interaction of hepatic fatty acid binding protein with the nucleus
200. Fatty acids and hypolipidemic drugs regulate peroxisome proliferator-activated receptors α- and γ-mediated gene expression via liver fatty acid-binding protein: A signalling path to the nucleus
201. Requirement for the heart-type fatty acid binding protein in cardiac fatty acid utilization
202. Impaired long-chain fatty acid utilization by cardiac myocytes isolated from mice lacking the heart-type fatty acid binding protein gene
203. Uncoupling of obesity from insulin resistance through a targeted mutation in aP2, the adipocyte fatty acid binding protein
204. Targeted disruption of the adipocyte lipid-binding protein (aP2 protein) gene impairs fat cell lipolysis and increases cellular fatty acid levels
205. -/-) mice after short-term high-fat feeding: Functional compensation by the keratinocyte fatty acid binding protein
206. -/- mice
207. Improved glucose and lipid metabolism in genetically obese mice lacking aP2
208. Lack of macrophage fatty acid-binding protein aP2 protects mice deficient in apolipoprotein E against atherosclerosis
209. Oxidized LDL induces the expression of ALBP/aP2 mRNA and protein in human THP-1 macrophages
210. The intestinal fatty acid binding protein is not essential for dietary fat absorption in mice
211. Intracellular lipid binding proteins of the small intestine
212. Alteration of water barrier function of the skin in epidermal type fatty acid binding protein deficient mice
213. Fatty acid transport and fatty acid-binding proteins
214. Light microscopic immunocytochemical localization of hepatic and intestinal types of fatty acid-binding proteins in rat small intestine
215. Modulation of mitogenesis by liver fatty acid binding protein
216. Immunohistochemical studies on the localisation and ontogeny of heart fatty acid binding protein in the rat
217. Brain lipid-binding protein (BLBP): A novel signaling system in the developing mammalian CNS
218. The expression pattern of a novel gene encoding brain-fatty acid binding protein correlates with neuronal and glial cell development
219. Expression of DA11, a neuronal-injury-induced fatty acid binding protein, coincides with axon growth and neuronal differentiation during central nervous system development
220. Spatio-temporally differential expression of genes for three members of fatty acid binding proteins in developing and mature rat brains
221. Developmental role of fatty acid-binding proteins in mouse brain
222. In situ and immunocytochemical localization of E-FABP mRNA and protein during neuronal migration and differentiation in the rat brain
223. Hormonal regulation of liver fatty acid-binding protein in vivo and in vitro: Effects of growth hormone and insulin
224. Down-regulation of liver and heart specific fatty acid binding proteins by endotoxin and cytokines in vivo
225. Modulation of intestinal and liver fatty acid-binding proteins in Caco-2 cells by lipids, hormones and cytokines
226. Growth promotion of transfected hepatoma cells by liver fatty acid binding protein
227. Expression of liver fatty acid binding protein alters plasma membrane lipid composition and structure in transfected L-cell fibroblasts
228. Liver fatty acid-binding protein: Specific mediator of the mitogenesis induced by two classes of carcinogenic peroxisome proliferators
229. Changes in liver fatty acid-binding protein in rat enzyme-altered foci
230. Expression of liver fatty acid binding protein alters growth and differentiation of embryonic stem cells
231. Mammary derived growth inhibitor is not a distinct protein but a mix of heart-type and adipocyte-type fatty acid-binding protein
232. Identification of a polypeptide growth inhibitor from bovine mammary gland: Sequence homology to fatty acid- and retinoid-binding proteins
233. Members of the fatty acid binding protein family are differentiation factors for the mammary gland
234. Tumor suppressor activity of the gene encoding mammary-derived growth inhibitor
235. Response of different mammary epithelial cell lines to a mammary derived growth inhibitor (MDGI)
236. Effect of mammary-derived growth inhibitor on proliferation of MAC-T bovine mammary epithelial cells
237. Breast cancer growth inhibition by delivery of the MDGI-derived peptide P108
238. Fatty acid binding proteins and mammary-derived growth inhibitor
239. Differentiation-promoting effects of mammary-derived growth inhibitor (MDGI) on pluripotent embryonic stem cells
240. Heart fatty acid binding protein is a novel regulator of cardiac myocyte hypertrophy
241. Expression of a functionally active cardiac fatty acid-binding protein in the yeast, Saccharomyces cerevisiae
242. Transfection of L6 myoblasts with adipocyte fatty acid-binding protein cDNA does not affect fatty acid uptake but disturbs lipid metabolism and fusion
243. Differentiation-dependent expression of heart type fatty acid-binding protein in C2C12 muscle cells
244. The biochemical and structural maturation of human skeletal muscle cells in culture: The effect of the serum substitute ultroser G
245. Changes in oleic acid oxidation and incorporation into lipids of differentiating L6 myoblasts cultured in normal or fatty acid-supplemented growth medium
246. Fatty acid-binding proteins do not protect against induced cytotoxicity in a kidney cell model
247. Members of the fatty acid-binding protein family inhibit cell-free protein synthesis
248. Liver fatty acid-binding protein: A marker for studying cellular differentiation in gut epithelial neoplasms
249. Tissue and cell-specific patterns of expression of rat liver and intestinal fatty acid binding protein during development and in experimental colonic and small intestinal adenocarcinomas
250. Decreased cytosolic levels of the heme binding Z protein in rat hepatocyte nodules and hepatocellular carcinomas
251. Immunohistochemical demonstration of liver fatty acid-binding protein in human hepatocellular malignancies
252. Liver fatty acid-binding protein is a new prognostic factor for hepatic resection of colorectal cancer metastases
253. Immunohistochemical identification of tumours of adipocytic differentiation using an antibody to aP2 protein
254. Loss of adipocyte-type fatty acid binding protein and other protein biomarkers is associated with progression of human bladder transitional cell carcinomas
255. Protein abundancy and mRNA levels of the adipocyte-type fatty acid binding protein correlate in non-invasive and invasive bladder transitional cell carcinomas
256. Correlation of B-FABP and GFAP expression in malignant glioma
257. Regulation of brain fatty acid-binding protein expression by differential phosphorylation of nuclear factor I in malignant glioma cell lines
258. Increased expression of epidermal fatty acid binding protein, cofilin, and 14-3-3-σ (statifin) detected by two-dimensional gel electrophoresis, mass spectrometry and microsequencing of drug-resistant human adenocarcinoma of the pancreas
259. Protein profiling of bladder squamous cell carcinomas: Identification of markers that define their degree of differentiation
260. Immunohistological distribution of cutaneous fatty acid-binding protein in human skin
261. Identification of the mRNA for human cutaneous fatty acid-binding protein as a metastasis-inducer
262. Human cutaneous fatty acid-binding protein induces metastasis by up-regulating the expression of vascular endothelial growth factor gene in rat Rama 37 model cells
263. Release of fatty acid-binding protein and long chain fatty acids from isolated rat heart after ischemia and subsequent calcium paradox
264. Free radical scavenging by myocardial fatty acid binding protein
265. Modulation of the beta-adrenergic-response in cultured rat heart cells. II. Mammary-derived growth inhibitor (MDGI) blocks induction of beta-adrenergic supersensitivity. Dissociation from lipid-binding activity of MDGI
266. Significance of cytoplasmic fatty acid-binding protein for the ischemic heart
267. Serum and urinary human heart fatty acid-binding protein in acute myocardial infarction
268. A sandwich enzyme linked immuno-sorbent assay for the determination of rat heart fatty acid-binding protein using the streptavidin-biotin system: Application to tissue and effluent samples from normoxic rat heart perfusion
269. Release of heart fatty acid-binding protein into plasma after acute myocardial infarction in man
270. Development of a sandwich enzyme-linked immunosorbent assay for the determination of human heart type fatty acid-binding protein in plasma and wrine by using two different monoclonal antibodies specific for human heart fatty acid-binding protein
271. Fatty acid-binding protein as a plasma marker for the estimation of myocardial infarct size in humans
272. Biochemical markers of ischaemia for the early identification of acute myocardial infarction without ST segment elevation
273. Fatty acid-binding protein and the early detection of acute myocardial infarction
274. Discrimination between myocardial and skeletal muscle injury by assessment of the plasma ration of myoglobin over fatty acid-binding protein
275. Role of heart-type fatty acid-binding protein in early detection of acute myocardial infarction
276. Increased fatty acid-binding protein concentration in plas-ma of patients with chronic renal failure
277. A low molecular weight binding protein for organic anions (Z protein) from human hepatic cytosol: Purification and quantitation
278. Intestinal fatty acid binding protein in serum and urine reflects early ischemic injury to the small bowel
279. Intestinal fatty acid binding protein is available for diagnosis of intestinal ischaemia: Immunochemical analysis of two patients with ischaemic intestinal diseases
280. Intestinal fatty acid-binding protein is a useful diagnostic marker for mesenteric infarction in humans
281. Human intestinal fatty acid binding protein: Report of an assay with studies in normal volunteers and intestinal ischemia
282. Organ failure, infection, and the systemic inflammatory response syndrome are associated with elevated levels of urinary intestinal fatty acid binding protein: Study of 100 consecutive patients in a surgical intensive care unit
283. Plasma concentrations of intestinal and liver FABP in neonates suffering from necrotizing enterocolitis and in healthy preterm neonates
284. Biochemical detection of small intestinal allograft rejection by elevated circulating levels of serum intestinal fatty acid binding protein
285. Small bowel allograft rejection detected by serum intestinal fatty acid-binding protein is reversible
286. Lack of utility of intestinal fatty acid binding protein levels in predicting intestinal allograft rejection
287. Secretion of a novel, developmentally regulated fatty acid-binding protein into the perivitelline fluid of the parasitic nematode, Ascaris suum
288. Ascaridia galli fatty acid-binding protein, a member of the nematode polyprotein allergens family
289. 14-kDa Schistosoma mansoni polypeptide is homologous to a gene family of fatty acid binding proteins
290. Sj-FABPc fatty acid-binding protein of the human blood fluke Schistosoma japonicum: Structural and functional characterization and unusual solvent exposure of a portal-proximal tryptophan residue
291. Molecular and immunological characterisation of a polymorphic cytosolic fatty acid binding protein from the human blood fluke of humans, Schistosoma japonicum
292. Remarks on the phylogeny and structure of fatty acid binding proteins from parasitic platyhelminths
293. Cloning and IgE binding of a recombinant allergen from the mite Blomia tropicalis, homologous with fatty acid-binding proteins
294. Expression and immunogenicity of an Echinococcus granulosus fatty acid-binding protein in live attenuated Salmonella vaccine strains
295. A Schistosoma mansoni fatty acid-binding protein, Sm14, is the potential basis of a dual-purpose anti-helminth vaccine
296. The adipocyte fatty acid-binding protein locus: Characterization and association with intramuscular fat content in pigs
297. Trinucleotide repeat polymorphism at the human intestinal fatty acid binding protein gene (FABP2)
298. Codon 54 polymorphism of the human intestinal fatty acid binding protein 2 gene is associated with dyslipidemias but not with insulin resistance in patients with familial combined hyperlipidemia
299. Taq1 reveals a polymorphism in cattle when probing with the rat fatty acid binding protein (I-FABP)
300. A dimorphic microsatellite in the porcine H-FABP gene at chromosome 6
301. Dinucleotide repeat in the third intron of the FABP3/MDGI putative tumor suppressor gene