메뉴 건너뛰기




Volumn 31, Issue 9, 2011, Pages 2144-2150

Dual metabolic defects are required to produce hypertriglyceridemia in obese subjects

Author keywords

apolipoproteins; lipoproteins; metabolism; obesity

Indexed keywords

APOLIPOPROTEIN C3; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN;

EID: 80052175601     PISSN: 10795642     EISSN: 15244636     Source Type: Journal    
DOI: 10.1161/ATVBAHA.111.224808     Document Type: Article
Times cited : (130)

References (44)
  • 1
    • 33845914986 scopus 로고    scopus 로고
    • Mechanisms linking obesity with cardiovascular disease
    • DOI 10.1038/nature05487, PII NATURE05487
    • Van Gaal LF, Mertens IL, De Block CE. Mechanisms linking obesity with cardiovascular disease. Nature. 2006;444:875-880. (Pubitemid 46028447)
    • (2006) Nature , vol.444 , Issue.7121 , pp. 875-880
    • Van Gaal, L.F.1    Mertens, I.L.2    De Block, C.E.3
  • 3
    • 53849143606 scopus 로고    scopus 로고
    • Adipose tissue expandability: The metabolic problems of obesity may arise from the inability to become more obese
    • Tan CY, Vidal-Puig A. Adipose tissue expandability: the metabolic problems of obesity may arise from the inability to become more obese. Biochem Soc Trans. 2008;36:935-940.
    • (2008) Biochem Soc Trans , vol.36 , pp. 935-940
    • Tan, C.Y.1    Vidal-Puig, A.2
  • 5
    • 57349116780 scopus 로고    scopus 로고
    • Causes and metabolic consequences of fatty liver
    • Stefan N, Kantartzis K, Haring HU. Causes and metabolic consequences of fatty liver. Endocr Rev. 2008;29:939-960.
    • (2008) Endocr Rev , vol.29 , pp. 939-960
    • Stefan, N.1    Kantartzis, K.2    Haring, H.U.3
  • 6
    • 66149119340 scopus 로고    scopus 로고
    • Fatty liver is associated with insulin resistance, risk of coronary heart disease, and early atherosclerosis in a large European population
    • Gastaldelli A, Kozakova M, Hojlund K, Flyvbjerg A, Favuzzi A, Mitrakou A, Balkau B. Fatty liver is associated with insulin resistance, risk of coronary heart disease, and early atherosclerosis in a large European population. Hepatology. 2009;49:1537-1544.
    • (2009) Hepatology , vol.49 , pp. 1537-1544
    • Gastaldelli, A.1    Kozakova, M.2    Hojlund, K.3    Flyvbjerg, A.4    Favuzzi, A.5    Mitrakou, A.6    Balkau, B.7
  • 8
    • 77952529040 scopus 로고    scopus 로고
    • A position statement on NAFLD/NASH based on the EASL 2009 special conference
    • Ratziu V, Bellentani S, Cortez-Pinto H, Day C, Marchesini G. A position statement on NAFLD/NASH based on the EASL 2009 special conference. J Hepatol. 2010;53:372-384.
    • (2010) J Hepatol , vol.53 , pp. 372-384
    • Ratziu, V.1    Bellentani, S.2    Cortez-Pinto, H.3    Day, C.4    Marchesini, G.5
  • 10
    • 46249093117 scopus 로고    scopus 로고
    • Overproduction of very low-density lipoproteins is the hallmark of the dyslipidemia in the metabolic syndrome
    • Adiels M, Olofsson SO, Taskinen MR, Boren J. Overproduction of very low-density lipoproteins is the hallmark of the dyslipidemia in the metabolic syndrome. Arterioscler Thromb Vasc Biol. 2008;28:1225-1236.
    • (2008) Arterioscler Thromb Vasc Biol , vol.28 , pp. 1225-1236
    • Adiels, M.1    Olofsson, S.O.2    Taskinen, M.R.3    Boren, J.4
  • 11
    • 77951456827 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease as the transducer of hepatic oversecretion of very-low-density lipoprotein-apolipoprotein B-100 in obesity
    • Chan DC, Watts GF, Gan S, Wong AT, Ooi EM, Barrett PH. Nonalcoholic fatty liver disease as the transducer of hepatic oversecretion of very-low-density lipoprotein-apolipoprotein B-100 in obesity. Arterioscler Thromb Vasc Biol. 2010;30:1043-1050.
    • (2010) Arterioscler Thromb Vasc Biol , vol.30 , pp. 1043-1050
    • Chan, D.C.1    Watts, G.F.2    Gan, S.3    Wong, A.T.4    Ooi, E.M.5    Barrett, P.H.6
  • 14
    • 38649111018 scopus 로고    scopus 로고
    • Alterations in Adipose Tissue and Hepatic Lipid Kinetics in Obese Men and Women With Nonalcoholic Fatty Liver Disease
    • DOI 10.1053/j.gastro.2007.11.038, PII S0016508507021154
    • Fabbrini E, Mohammed BS, Magkos F, Korenblat KM, Patterson BW, Klein S. Alterations in adipose tissue and hepatic lipid kinetics in obese men and women with nonalcoholic fatty liver disease. Gastroenterology. 2008;134:424-431. (Pubitemid 351173050)
    • (2008) Gastroenterology , vol.134 , Issue.2 , pp. 424-431
    • Fabbrini, E.1    Mohammed, B.S.2    Magkos, F.3    Korenblat, K.M.4    Patterson, B.W.5    Klein, S.6
  • 15
    • 0023875069 scopus 로고
    • Independent regulation of plasma apolipoprotein C-II and C-III concentrations in very low density and high density lipoproteins: Implications for the regulation of the catabolism of these lipoproteins
    • Le NA, Gibson JC, Ginsberg HN. Independent regulation of plasma apolipoprotein C-II and C-III concentrations in very low density and high density lipoproteins: implications for the regulation of the catabolism of these lipoproteins. J Lipid Res. 1988;29:669-677.
    • (1988) J Lipid Res , vol.29 , pp. 669-677
    • Le, N.A.1    Gibson, J.C.2    Ginsberg, H.N.3
  • 16
    • 4043134745 scopus 로고    scopus 로고
    • Rate of production of plasma and Very-Low-Density Lipoprotein (VLDL) apolipoprotein C-III is strongly related to the concentration and level of production of VLDL triglyceride in male subjects with different body weights and levels of insulin sensitivity
    • DOI 10.1210/jc.2003-032056
    • Cohn JS, Patterson BW, Uffelman KD, Davignon J, Steiner G. Rate of production of plasma and very-low-density lipoprotein (VLDL) apolipoprotein C-III is strongly related to the concentration and level of production of VLDL triglyceride in male subjects with different body weights and levels of insulin sensitivity. J Clin Endocrinol Metab. 2004;89: 3949-3955. (Pubitemid 39071498)
    • (2004) Journal of Clinical Endocrinology and Metabolism , vol.89 , Issue.8 , pp. 3949-3955
    • Cohn, J.S.1    Patterson, B.W.2    Uffelman, K.D.3    Davignon, J.4    Steiner, G.5
  • 17
    • 39049083945 scopus 로고    scopus 로고
    • Plasma apolipoprotein C-III transport in centrally obese men: Associations with very low-density lipoprotein apolipoprotein B and high-density lipoprotein apolipoprotein A-I metabolism
    • DOI 10.1210/jc.2006-2676
    • Chan DC, Nguyen MN, Watts GF, Barrett PH. Plasma apolipoprotein C-III transport in centrally obese men: associations with very low-density lipoprotein apolipoprotein B and high-density lipoprotein apolipoprotein A-I metabolism. J Clin Endocrinol Metab. 2008;93:557-564. (Pubitemid 351240831)
    • (2008) Journal of Clinical Endocrinology and Metabolism , vol.93 , Issue.2 , pp. 557-564
    • Chan, D.C.1    Nguyen, M.N.2    Watts, G.F.3    Barrett, P.H.R.4
  • 18
    • 77951490605 scopus 로고    scopus 로고
    • Apolipoprotein C-III and the metabolic basis for hypertriglyceridemia and the dense low-density lipoprotein phenotype
    • Zheng C, Khoo C, Furtado J, Sacks FM. Apolipoprotein C-III and the metabolic basis for hypertriglyceridemia and the dense low-density lipoprotein phenotype. Circulation. 2010;121:1722-1734.
    • (2010) Circulation , vol.121 , pp. 1722-1734
    • Zheng, C.1    Khoo, C.2    Furtado, J.3    Sacks, F.M.4
  • 19
    • 0034680309 scopus 로고    scopus 로고
    • VLDL, apolipoproteins B, CIII, and E, and risk of recurrent coronary events in the Cholesterol and Recurrent Events (CARE) trial
    • Sacks FM, Alaupovic P, Moye LA, Cole TG, Sussex B, Stampfer MJ, Pfeffer MA, Braunwald E. VLDL, apolipoproteins B, CIII, and E, and risk of recurrent coronary events in the Cholesterol and Recurrent Events (CARE) trial. Circulation. 2000;102:1886-1892.
    • (2000) Circulation , vol.102 , pp. 1886-1892
    • Sacks, F.M.1    Alaupovic, P.2    Moye, L.A.3    Cole, T.G.4    Sussex, B.5    Stampfer, M.J.6    Pfeffer, M.A.7    Braunwald, E.8
  • 20
    • 0038222533 scopus 로고    scopus 로고
    • LDL containing apolipoprotein CIII is an independent risk factor for coronary events in diabetic patients
    • DOI 10.1161/01.ATV.0000066131.01313.EB
    • Lee SJ, Campos H, Moye LA, Sacks FM. LDL containing apolipoprotein CIII is an independent risk factor for coronary events in diabetic patients. Arterioscler Thromb Vasc Biol. 2003;23:853-858. (Pubitemid 36566177)
    • (2003) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.23 , Issue.5 , pp. 853-858
    • Lee, S.-J.1    Campos, H.2    Moye, L.A.3    Sacks, F.M.4
  • 22
    • 67650091466 scopus 로고    scopus 로고
    • APOC3 mutation, serum triglyceride concentrations, and coronary heart disease
    • Tsai MY, Ordovas JM. APOC3 mutation, serum triglyceride concentrations, and coronary heart disease. Clin Chem. 2009;55:1274-1276.
    • (2009) Clin Chem , vol.55 , pp. 1274-1276
    • Tsai, M.Y.1    Ordovas, J.M.2
  • 25
    • 77953507089 scopus 로고    scopus 로고
    • Characterizing human adipose tissue lipids by long echo time 1H-MRS in vivo at 1.5 tesla: Validation by gas chromatography
    • Lundbom J, Hakkarainen A, Fielding B, Soderlund S, Westerbacka J, Taskinen MR, Lundbom N. Characterizing human adipose tissue lipids by long echo time 1H-MRS in vivo at 1.5 tesla: validation by gas chromatography. NMR Biomed. 2010;23:466-472.
    • (2010) NMR Biomed , vol.23 , pp. 466-472
    • Lundbom, J.1    Hakkarainen, A.2    Fielding, B.3    Soderlund, S.4    Westerbacka, J.5    Taskinen, M.R.6    Lundbom, N.7
  • 26
    • 42949178538 scopus 로고    scopus 로고
    • Liver, Muscle, and Adipose Tissue Insulin Action Is Directly Related to Intrahepatic Triglyceride Content in Obese Subjects
    • DOI 10.1053/j.gastro.2008.01.075, PII S0016508508001819
    • Korenblat KM, Fabbrini E, Mohammed BS, Klein S. Liver, muscle, and adipose tissue insulin action is directly related to intrahepatic triglyceride content in obese subjects. Gastroenterology. 2008;134:1369-1375. (Pubitemid 351615354)
    • (2008) Gastroenterology , vol.134 , Issue.5 , pp. 1369-1375
    • Korenblat, K.M.1    Fabbrini, E.2    Mohammed, B.S.3    Klein, S.4
  • 28
    • 34249883032 scopus 로고    scopus 로고
    • Waist circumference and cardiometabolic risk: a consensus statement from Shaping America's Health: Association for Weight Management and Obesity Prevention; NAASO, the Obesity Society; the American Society for Nutrition; and the American Diabetes Association
    • Klein S, Allison DB, Heymsfield SB, Kelley DE, Leibel RL, Nonas C, Kahn R. Waist circumference and cardiometabolic risk: a consensus statement from Shaping America's Health: Association for Weight Management and Obesity Prevention; NAASO, the Obesity Society; the American Society for Nutrition; and the American Diabetes Association. Diabetes Care. 2007;30:1647-1652.
    • (2007) Diabetes Care , vol.30 , pp. 1647-1652
    • Klein, S.1    Allison, D.B.2    Heymsfield, S.B.3    Kelley, D.E.4    Leibel, R.L.5    Nonas, C.6    Kahn, R.7
  • 29
    • 85027927359 scopus 로고    scopus 로고
    • Increased whole-body adiposity without a concomitant increase in liver fat is not associated with augmented metabolic dysfunction
    • Magkos F, Fabbrini E, Mohammed BS, Patterson BW, Klein S. Increased whole-body adiposity without a concomitant increase in liver fat is not associated with augmented metabolic dysfunction. Obesity (Silver Spring). 2010;18:1510-1515.
    • (2010) Obesity (Silver Spring) , vol.18 , pp. 1510-1515
    • Magkos, F.1    Fabbrini, E.2    Mohammed, B.S.3    Patterson, B.W.4    Klein, S.5
  • 30
    • 75449094816 scopus 로고    scopus 로고
    • Obesity and nonalcoholic fatty liver disease: Biochemical, metabolic, and clinical implications
    • Fabbrini E, Sullivan S, Klein S. Obesity and nonalcoholic fatty liver disease: biochemical, metabolic, and clinical implications. Hepatology. 2010;51:679-689.
    • (2010) Hepatology , vol.51 , pp. 679-689
    • Fabbrini, E.1    Sullivan, S.2    Klein, S.3
  • 31
    • 18244387691 scopus 로고    scopus 로고
    • Contribution of adipose tissue and de novo lipogenesis to nonalcoholic fatty liver disease
    • DOI 10.1172/JCI200524930
    • Tamura S, Shimomura I. Contribution of adipose tissue and de novo lipogenesis to nonalcoholic fatty liver disease. J Clin Invest. 2005;115: 1139-1142. (Pubitemid 40629030)
    • (2005) Journal of Clinical Investigation , vol.115 , Issue.5 , pp. 1139-1142
    • Tamura, S.1    Shimomura, I.2
  • 35
    • 0018364379 scopus 로고
    • Transport of very low density lipoprotein triglycerides in varying degrees of obesity and hypertriglyceridemia
    • Grundy SM, Mok HYI, Zech L, Steinberg D, Berman M. Transport of very low density lipoprotein triglycerides in varying degrees of obesity and hypertriglyceridemia. J Clin Invest. 1979;63:1274-1283. (Pubitemid 9193223)
    • (1979) Journal of Clinical Investigation , vol.63 , Issue.6 , pp. 1274-1283
    • Grundy, S.M.1    Mok, H.Y.I.2    Zech, L.3
  • 36
    • 0023882815 scopus 로고
    • Very low density lipoprotein triglyceride metabolism in relatives of hypertriglyceridemic probands: Evidence for genetic control of triglyceride removal
    • Sane T, Nikkila EA. Very low density lipoprotein triglyceride metabolism in relatives of hypertriglyceridemic probands: evidence for genetic control of triglyceride removal. Arteriosclerosis. 1988;8:217-226.
    • (1988) Arteriosclerosis , vol.8 , pp. 217-226
    • Sane, T.1    Nikkila, E.A.2
  • 37
    • 0021368455 scopus 로고
    • Dual defect in metabolism of very-low-density lipoprotein triglycerides. Patients with type 5 hyperlipoproteinemia
    • DOI 10.1001/jama.251.19.2542
    • Kesaniemi YA, Grundy SM. Dual defect in metabolism of very-lowdensity lipoprotein triglycerides: patients with type 5 hyperlipoproteinemia. JAMA. 1984;251:2542-2547. (Pubitemid 14149008)
    • (1984) Journal of the American Medical Association , vol.251 , Issue.19 , pp. 2542-2547
    • Kesaniemi, Y.A.1    Grundy, S.M.2
  • 38
    • 42549109081 scopus 로고    scopus 로고
    • Apolipoprotein C-III: Understanding an emerging cardiovascular risk factor
    • DOI 10.1042/CS20070308
    • Ooi EM, Barrett PH, Chan DC, Watts GF. Apolipoprotein C-III: understanding an emerging cardiovascular risk factor. Clin Sci (Lond). 2008; 114:611-624. (Pubitemid 351589061)
    • (2008) Clinical Science , vol.114 , Issue.9-10 , pp. 611-624
    • Ooi, E.M.M.1    Barrett, P.H.R.2    Chan, D.C.3    Watts, G.F.4
  • 40
    • 67049143907 scopus 로고    scopus 로고
    • Foxo1 and hepatic lipid metabolism
    • Sparks JD, Dong HH. Foxo1 and hepatic lipid metabolism. Curr Opin Lipidol. 2009;20:217-226.
    • (2009) Curr Opin Lipidol , vol.20 , pp. 217-226
    • Sparks, J.D.1    Dong, H.H.2
  • 41
    • 51649087722 scopus 로고    scopus 로고
    • Triglyceride-rich lipoprotein-associated apolipoprotein C-III production is stimulated by plasma free fatty acids in humans
    • Pavlic M, Valero R, Duez H, Xiao C, Szeto L, Patterson BW, Lewis GF. Triglyceride-rich lipoprotein-associated apolipoprotein C-III production is stimulated by plasma free fatty acids in humans. Arterioscler Thromb Vasc Biol. 2008;28:1660-1665.
    • (2008) Arterioscler Thromb Vasc Biol , vol.28 , pp. 1660-1665
    • Pavlic, M.1    Valero, R.2    Duez, H.3    Xiao, C.4    Szeto, L.5    Patterson, B.W.6    Lewis, G.F.7
  • 42
    • 79956014824 scopus 로고    scopus 로고
    • Complexities of plasma apolipoprotein C-III metabolism
    • Sacks FM, Zheng C, Cohn JS. Complexities of plasma apolipoprotein C-III metabolism. J Lipid Res. 2011;52:1067-1070.
    • (2011) J Lipid Res , vol.52 , pp. 1067-1070
    • Sacks, F.M.1    Zheng, C.2    Cohn, J.S.3
  • 43
    • 21344446108 scopus 로고    scopus 로고
    • Alterations of lipids and apolipoprotein CIII in very low density lipoprotein subspecies in type 2 diabetes
    • DOI 10.1007/s00125-005-1753-z
    • Hiukka A, Fruchart-Najib J, Leinonen E, Hilden H, Fruchart JC, Taskinen MR. Alterations of lipids and apolipoprotein CIII in very low density lipoprotein subspecies in type 2 diabetes. Diabetologia. 2005;48: 1207-1215. (Pubitemid 40909658)
    • (2005) Diabetologia , vol.48 , Issue.6 , pp. 1207-1215
    • Hiukka, A.1    Fruchart-Najib, J.2    Leinonen, E.3    Hilden, H.4    Fruchart, J.-C.5    Taskinen, M.-R.6
  • 44
    • 77956942362 scopus 로고    scopus 로고
    • The hypertriglyceridemic-waist phenotype and the risk of coronary artery disease: Results from the Epic-Norfolk prospective population study
    • Arsenault BJ, Lemieux I, Despres JP, Wareham NJ, Kastelein JJ, Khaw KT, Boekholdt SM. The hypertriglyceridemic-waist phenotype and the risk of coronary artery disease: results from the Epic-Norfolk prospective population study. CMAJ. 2010;182:1427-1432.
    • (2010) CMAJ , vol.182 , pp. 1427-1432
    • Arsenault, B.J.1    Lemieux, I.2    Despres, J.P.3    Wareham, N.J.4    Kastelein, J.J.5    Khaw, K.T.6    Boekholdt, S.M.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.