Critical role of cytochrome P450 2E1 (CYP2E1) in the development of high fat-induced non-alcoholic steatohepatitis

Journal of Hepatology

Volumn 57, Issue 4, 2012, Pages 860-866

  Abdelmegeed, Mohamed A ^a   Banerjee, Atrayee ^a   Yoo, Seong Ho ^a,b   Jang, Sehwan ^a   Gonzalez, Frank J ^c   Song, Byoung Joon ^a  

^a Laboratory of Membrane Biochemistry and Biophysics   (United States)

^b Seoul National University College of Medicine   (South Korea)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

CYP2E1; High fat diet; Inflammation; Insulin resistance; Liver; NAFLD; NASH; Null mice; Oxidative stress; Protein modifications

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CYTOCHROME P450 2E1; MALONALDEHYDE; MITOGEN ACTIVATED PROTEIN KINASE P38; MONOCYTE CHEMOTACTIC PROTEIN 1; OSTEOPONTIN; TUMOR NECROSIS FACTOR ALPHA;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CARBONYLATION; CONTROLLED STUDY; GLYCATION; IMPAIRED GLUCOSE TOLERANCE; INFLAMMATION; INSULIN RESISTANCE; LIPID PEROXIDATION; LIVER HISTOLOGY; LOW FAT DIET; MOUSE; NITRATION; NONALCOHOLIC FATTY LIVER; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; WILD TYPE;

ANIMALS; ANTIGENS, DIFFERENTIATION; BODY WEIGHT; CHEMOKINE CCL2; CYTOCHROME P-450 CYP2E1; DIET, HIGH-FAT; FATTY LIVER; GLUCOSE TOLERANCE TEST; GLYCOSYLATION END PRODUCTS, ADVANCED; INFLAMMATION; INSULIN RESISTANCE; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LIPID PEROXIDATION; MALE; MICE; MICE, KNOCKOUT; OSTEOPONTIN; OXIDATIVE STRESS; PHOSPHORYLATION; PROTEIN CARBONYLATION; RECEPTORS, IMMUNOLOGIC; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84866421262     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2012.05.019     Document Type: Article

References (41)

1. K. Begriche, A. Igoudjil, D. Pessayre, and B. Fromenty Mitochondrial dysfunction in NASH: causes, consequences and possible means to prevent it Mitochondrion 6 2006 1 28
2. B.Q. Starley, C.J. Calcagno, and S.A. Harrison Non-alcoholic fatty liver disease and hepatocellular carcinoma: a weighty connection Hepatology 51 2010 1820 1832
3. C.P. Day, and O.F. James Steatohepatitis: a tale of two "hits"? Gastroenterology 114 1998 842 845
4. S. Zelber-Sagi, V. Ratziu, and R. Oren Nutrition and physical activity in NAFLD: an overview of the epidemiological evidence World J Gastroenterol 17 2011 3377 3389
5. K.G. Alberti, P. Zimmet, and J. Shaw The metabolic syndrome-a new worldwide definition Lancet 366 2005 1059 1062
6. G. Marchesini, E. Bugianesi, G. Forlani, F. Cerrelli, M. Lenzi, and R. Manini Non-alcoholic fatty liver, steatohepatitis, and the metabolic syndrome Hepatology 37 2003 917 923
7. J. Aubert, K. Begriche, L. Knockaert, M.A. Robin, and B. Fromenty Increased expression of cytochrome P450 2E1 in Non-alcoholic fatty liver disease: mechanisms and pathophysiological role Clin Res Hepatol Gastroenterol 35 2011 630 637
8. B.J. Song, D.R. Koop, M. Ingelman-Sundberg, A. Nanji, and A.I. Cederbaum Ethanol-inducible cytochrome P450 (CYP2E1): biochemistry, molecular biology and clinical relevance. 1996 update Alcohol Clin Exp Res 20 1996 138A 146A
9. A.A. Caro, and A.I. Cederbaum Oxidative stress, toxicology, and pharmacology of CYP2E1 Annu Rev Pharmacol Toxicol 44 2004 27 42
10. C.S. Lieber, M.A. Leo, K.M. Mak, Y. Xu, Q. Cao, and C. Ren Model of non-alcoholic steatohepatitis Am J Clin Nutr 79 2004 502 509
11. M.A. Abdelmegeed, S.H. Yoo, L.E. Henderson, F.J. Gonzalez, K.J. Woodcroft, and B.J. Song PPARalpha expression protects male mice from high fat-induced Non-alcoholic fatty liver J Nutr 141 2011 603 610
12. J.M. Schattenberg, Y. Wang, R. Singh, R.M. Rigoli, and M.J. Czaja Hepatocyte CYP2E1 overexpression and steatohepatitis lead to impaired hepatic insulin signaling J Biol Chem 280 2005 9887 9894
13. S.S. Lee, J.T. Buters, T. Pineau, P. Fernandez-Salguero, and F.J. Gonzalez Role of CYP2E1 in the hepatotoxicity of acetaminophen J Biol Chem 271 1996 12063 12067
14. D.E. Kleiner, E.M. Brunt, M. Van Natta, C. Behling, M.J. Contos, and O.W. Cummings Design and validation of a histological scoring system for non-alcoholic fatty liver disease Hepatology 41 2005 1313 1321
15. M.A. Abdelmegeed, K.H. Moon, J.P. Hardwick, F.J. Gonzalez, and B.J. Song Role of peroxisome proliferator-activated receptor-alpha in fasting-mediated oxidative stress Free Radic Biol Med 47 2009 767 778
16. M.A. Abdelmegeed, K.H. Moon, C. Chen, F.J. Gonzalez, and B.J. Song Role of cytochrome P450 2E1 in protein nitration and ubiquitin-mediated degradation during acetaminophen toxicity Biochem Pharmacol 79 2010 57 66
17. Y.P. Yun, J.P. Casazza, D.H. Sohn, R.L. Veech, and B.J. Song Pretranslational activation of cytochrome P450IIE during ketosis induced by a high fat diet Mol Pharmacol 41 1992 474 479
18. J. Wu, M.Y. Zhao, H. Zheng, H. Zhang, and Y. Jiang Pentoxifylline alleviates high-fat diet-induced non-alcoholic steatohepatitis and early atherosclerosis in rats by inhibiting AGE and RAGE expression Acta Pharmacol Sin 31 2010 1367 1375
19. Y. Kimura, H. Hyogo, S. Yamagishi, M. Takeuchi, T. Ishitobi, and Y. Nabeshima Atorvastatin decreases serum levels of advanced glycation endproducts (AGEs) in non-alcoholic steatohepatitis (NASH) patients with dyslipidemia: clinical usefulness of AGEs as a biomarker for the attenuation of NASH J Gastroenterol 45 2010 750 757
20. Z. Cai, B. Zhao, and A. Ratka Oxidative stress and beta-amyloid protein in Alzheimer's disease Neuromolecular Med 13 2011 223 250
21. J. Chapman, P.D. Miles, J.M. Ofrecio, J.G. Neels, J.G. Yu, and J.L. Resnik Osteopontin is required for the early onset of high fat diet-induced IR in mice PLoS One 5 2010 e13959
22. R. Stienstra, S. Mandard, D. Patsouris, C. Maass, S. Kersten, and M. Muller Peroxisome proliferator-activated receptor alpha protects against obesity-induced hepatic inflammation Endocrinology 148 2007 2753 2763
23. T. Matono, M. Koda, S. Tokunaga, J. Kato, T. Sugihara, and M. Ueki Therapeutic effects of ezetimibe for non-alcoholic steatohepatitis in fatty liver shionogi-ob/ob mice Hepatol Res 41 2011 1240 1248
24. A.J. Gow, C.R. Farkouh, D.A. Munson, M.A. Posencheg, and H. Ischiropoulos Biological significance of nitric oxide-mediated protein modifications Am J Physiol Lung Cell Mol Physiol 287 2004 L262 268
25. C.S. Lieber Cytochrome P-4502E1: its physiological and pathological role Physiol Rev 77 1997 517 544
26. S.K. Mantena, D.P. Vaughn, K.K. Andringa, H.B. Eccleston, A.L. King, and G.A. Abrams High fat diet induces dysregulation of hepatic oxygen gradients and mitochondrial function in vivo Biochem J 417 2009 183 193
27. J.L. Raucy, J.M. Lasker, J.C. Kraner, D.E. Salazar, C.S. Lieber, and G.B. Corcoran Induction of cytochrome P450IIE1 in the obese overfed rat Mol Pharmacol 39 1991 275 280
28. V. Calvaruso, and A. Craxi Implication of normal liver enzymes in liver disease J Viral Hepat 16 2009 529 536
29. Y. Lu, J. Zhuge, X. Wang, J. Bai, and A.I. Cederbaum Cytochrome P450 2E1 contributes to ethanol-induced fatty liver in mice Hepatology 47 2008 1483 1494
30. A. Dey, and A.I. Cederbaum Induction of cytochrome P450 2E1 promotes liver injury in ob/ob mice Hepatology 45 2007 1355 1365
31. R. Radi Nitric oxide, oxidants, and protein tyrosine nitration Proc Natl Acad Sci USA 101 2004 4003 4008
32. K.H. Moon, B.L. Hood, P. Mukhopadhyay, M. Rajesh, M.A. Abdelmegeed, and Y.I. Kwon Oxidative inactivation of key mitochondrial proteins leads to dysfunction and injury in hepatic ischemia reperfusion Gastroenterology 135 2008 1344 1357
33. I. Garcia-Ruiz, C. Rodriguez-Juan, T. Diaz-Sanjuan, P. del Hoyo, F. Colina, and T. Munoz-Yague Uric acid and anti-TNF antibody improve mitochondrial dysfunction in ob/ob mice Hepatology 44 2006 581 591
34. S.F. Yan, R. Ramasamy, and A.M. Schmidt Mechanisms of disease: advanced glycation end-products and their receptor in inflammation and diabetes complications Nat Clin Pract Endocrinol Metab 4 2008 285 293
35. D. Wu, and A. Cederbaum Cytochrome P4502E1 sensitizes to tumor necrosis factor alpha-induced liver injury through activation of mitogen-activated protein kinases in mice Hepatology 47 2008 1005 1017
36. V. Braunersreuther, G.L. Viviani, F. Mach, and F. Montecucco Role of cytokines and chemokines in non-alcoholic fatty liver disease World J Gastroenterol 18 2012 727 735
37. A. Sahai, P. Malladi, H. Melin-Aldana, R.M. Green, and P.F. Whitington Upregulation of osteopontin expression is involved in the development of non-alcoholic steatohepatitis in a dietary murine model Am J Physiol Gastrointest Liver Physiol 287 2004 G264 273
38. K.M. Kassel, G.L. Guo, O. Tawfik, and J.P. Luyendyk Monocyte chemoattractant protein-1 deficiency does not affect steatosis or inflammation in livers of mice fed a methionine-choline-deficient diet Lab Invest 90 2010 1794 1804
39. Y. Wang, G. Millonig, J. Nair, E. Patsenker, F. Stickel, and S. Mueller Ethanol-induced cytochrome P4502E1 causes carcinogenic etheno-DNA lesions in alcoholic liver disease Hepatology 50 2009 453 461
40. E. Kathirvel, K. Morgan, S.W. French, and T.R. Morgan Overexpression of liver-specific cytochrome P4502E1 impairs hepatic insulin signaling in a transgenic mouse model of non-alcoholic fatty liver disease Eur J Gastroenterol Hepatol 21 2009 973 983
41. H. Zong, M. Armoni, C. Harel, E. Karnieli, and J.E. Pessin Cytochrome P-450 CYP2E1 knockout mice are protected against high-fat diet-induced obesity and IR Am J Physiol Endocrinol Metab 302 2012 E532 539