메뉴 건너뛰기




Volumn 53, Issue 4, 2010, Pages 724-731

Down-regulation of SREBP-1c is associated with the development of burned-out NASH

Author keywords

Burned out NASH; SREBP 1c; TNF

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; ALANINE AMINOTRANSFERASE; ALBUMIN; ASPARTATE AMINOTRANSFERASE; C REACTIVE PROTEIN; DIACYLGLYCEROL ACYLTRANSFERASE 1; FATTY ACID; FATTY ACID SYNTHASE; FERRITIN; GAMMA GLUTAMYLTRANSFERASE; GLUCOSE; GLYCOSYLATED HEMOGLOBIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 1BETA; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MESSENGER RNA; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA; VERY LOW DENSITY LIPOPROTEIN;

EID: 77956268548     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2010.04.033     Document Type: Article
Times cited : (96)

References (38)
  • 1
    • 40849083460 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease: The mist gradually clears
    • N.M. de Alwis, and C.P. Day Non-alcoholic fatty liver disease: the mist gradually clears J Hepatol 48 2008 S104 S112
    • (2008) J Hepatol , vol.48
    • De Alwis, N.M.1    Day, C.P.2
  • 5
    • 77953739548 scopus 로고    scopus 로고
    • Development from simple steatosis to liver cirrhosis and hepatocellular carcinoma: A 27-year follow-up case
    • T. Nagaya, N. Tanaka, M. Komatsu, T. Ichijo, K. Sano, and A. Horiuchi Development from simple steatosis to liver cirrhosis and hepatocellular carcinoma: a 27-year follow-up case Clin J Gastroenterol 1 2008 116 121
    • (2008) Clin J Gastroenterol , vol.1 , pp. 116-121
    • Nagaya, T.1    Tanaka, N.2    Komatsu, M.3    Ichijo, T.4    Sano, K.5    Horiuchi, A.6
  • 6
    • 4043077961 scopus 로고    scopus 로고
    • Molecular mediators of hepatic steatosis and liver injury
    • J.D. Browning, and J.D. Horton Molecular mediators of hepatic steatosis and liver injury J Clin Invest 114 2004 147 152
    • (2004) J Clin Invest , vol.114 , pp. 147-152
    • Browning, J.D.1    Horton, J.D.2
  • 7
    • 0025178612 scopus 로고
    • The natural history of nonalcoholic steatohepatitis: A follow-up study of forty-two patients for up to 21 years
    • E.E. Powell, W.G. Cooksley, R. Hanson, J. Searle, J.W. Halliday, and L.W. Powell The natural history of nonalcoholic steatohepatitis: a follow-up study of forty-two patients for up to 21 years Hepatology 11 1990 74 80
    • (1990) Hepatology , vol.11 , pp. 74-80
    • Powell, E.E.1    Cooksley, W.G.2    Hanson, R.3    Searle, J.4    Halliday, J.W.5    Powell, L.W.6
  • 9
    • 33748304407 scopus 로고    scopus 로고
    • Useful parameters for distinguishing nonalcoholic steatohepatitis with mild steatosis from cryptogenic chronic hepatitis in the Japanese population
    • N. Tanaka, E. Tanaka, Y. Sheena, M. Komatsu, W. Okiyama, and N. Misawa Useful parameters for distinguishing nonalcoholic steatohepatitis with mild steatosis from cryptogenic chronic hepatitis in the Japanese population Liver Int 26 2006 956 963
    • (2006) Liver Int , vol.26 , pp. 956-963
    • Tanaka, N.1    Tanaka, E.2    Sheena, Y.3    Komatsu, M.4    Okiyama, W.5    Misawa, N.6
  • 10
    • 53249111691 scopus 로고    scopus 로고
    • Citrin deficiency as a cause of chronic liver disorder mimicking non-alcoholic fatty liver disease
    • M. Komatsu, M. Yazaki, N. Tanaka, K. Sano, E. Hashimoto, and Y. Takei Citrin deficiency as a cause of chronic liver disorder mimicking non-alcoholic fatty liver disease J Hepatol 49 2008 810 820
    • (2008) J Hepatol , vol.49 , pp. 810-820
    • Komatsu, M.1    Yazaki, M.2    Tanaka, N.3    Sano, K.4    Hashimoto, E.5    Takei, Y.6
  • 11
    • 48949099031 scopus 로고    scopus 로고
    • Insulin resistance and hepatitis C virus: A case-control study of non-obese, non-alcoholic and non-steatotic hepatitis virus carriers with persistently normal serum aminotransferase
    • N. Tanaka, T. Nagaya, M. Komatsu, A. Horiuchi, G. Tsuruta, and H. Shirakawa Insulin resistance and hepatitis C virus: a case-control study of non-obese, non-alcoholic and non-steatotic hepatitis virus carriers with persistently normal serum aminotransferase Liver Int 28 2008 1104 1111
    • (2008) Liver Int , vol.28 , pp. 1104-1111
    • Tanaka, N.1    Nagaya, T.2    Komatsu, M.3    Horiuchi, A.4    Tsuruta, G.5    Shirakawa, H.6
  • 13
    • 20044374023 scopus 로고    scopus 로고
    • Design and validation of a histological scoring system for nonalcoholic fatty liver disease
    • D.E. Kleiner, E.M. Brunt, M. Van Natta, C. Behling, M.J. Contos, and O.W. Cummings Design and validation of a histological scoring system for nonalcoholic fatty liver disease Hepatology 41 2005 1313 1321
    • (2005) Hepatology , vol.41 , pp. 1313-1321
    • Kleiner, D.E.1    Brunt, E.M.2    Van Natta, M.3    Behling, C.4    Contos, M.J.5    Cummings, O.W.6
  • 15
    • 0028960739 scopus 로고
    • Structure of the human gene encoding sterol regulatory element binding protein-1 (SREBF1) and localization of SREBF1 and SREBF2 to chromosomes 17p11.2 and 22q13
    • X. Hua, J. Wu, J.L. Goldstein, M.S. Brown, and H.H. Hobbs Structure of the human gene encoding sterol regulatory element binding protein-1 (SREBF1) and localization of SREBF1 and SREBF2 to chromosomes 17p11.2 and 22q13 Genomics 25 1995 667 673
    • (1995) Genomics , vol.25 , pp. 667-673
    • Hua, X.1    Wu, J.2    Goldstein, J.L.3    Brown, M.S.4    Hobbs, H.H.5
  • 16
    • 0030961960 scopus 로고    scopus 로고
    • Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells
    • I. Shimomura, H. Shimano, J.D. Horton, J.L. Goldstein, and M.S. Brown Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells J Clin Invest 99 1997 838 845
    • (1997) J Clin Invest , vol.99 , pp. 838-845
    • Shimomura, I.1    Shimano, H.2    Horton, J.D.3    Goldstein, J.L.4    Brown, M.S.5
  • 18
    • 0024412071 scopus 로고
    • Cytochrome P-450 hPCN3, a novel cytochrome P-450 IIIA gene product that is differentially expressed in adult human liver. CDNA and deduced amino acid sequence and distinct specificities of cDNA-expressed hPCN1 and hPCN3 for the metabolism of steroid hormones and cyclosporine
    • T. Aoyama, S. Yamano, D.J. Waxman, D.P. Lapenson, U.A. Meyer, and V. Fischer Cytochrome P-450 hPCN3, a novel cytochrome P-450 IIIA gene product that is differentially expressed in adult human liver. CDNA and deduced amino acid sequence and distinct specificities of cDNA-expressed hPCN1 and hPCN3 for the metabolism of steroid hormones and cyclosporine J Biol Chem 264 1989 10388 10395
    • (1989) J Biol Chem , vol.264 , pp. 10388-10395
    • Aoyama, T.1    Yamano, S.2    Waxman, D.J.3    Lapenson, D.P.4    Meyer, U.A.5    Fischer, V.6
  • 19
    • 0029078041 scopus 로고
    • Purification of human very-long-chain acyl-coenzyme A dehydrogenase and characterization of its deficiency in seven patients
    • T. Aoyama, M. Souri, S. Ushikubo, T. Kamijo, S. Yamaguchi, and R.I. Kelley Purification of human very-long-chain acyl-coenzyme A dehydrogenase and characterization of its deficiency in seven patients J Clin Invest 95 1995 2465 2473
    • (1995) J Clin Invest , vol.95 , pp. 2465-2473
    • Aoyama, T.1    Souri, M.2    Ushikubo, S.3    Kamijo, T.4    Yamaguchi, S.5    Kelley, R.I.6
  • 20
    • 34347406521 scopus 로고    scopus 로고
    • SREBP-1c transcription factor and lipid homeostasis: Clinical perspective
    • P. Ferré, and F. Foufelle SREBP-1c transcription factor and lipid homeostasis: clinical perspective Horm Res 68 2007 72 82
    • (2007) Horm Res , vol.68 , pp. 72-82
    • Ferré, P.1    Foufelle, F.2
  • 21
    • 0037716940 scopus 로고    scopus 로고
    • In vivo stabilization of nuclear retinoid X receptor α in the presence of peroxisome proliferator-activated receptor α
    • N. Tanaka, K. Hora, H. Makishima, Y. Kamijo, K. Kiyosawa, and F.J. Gonzalez In vivo stabilization of nuclear retinoid X receptor α in the presence of peroxisome proliferator-activated receptor α FEBS Lett 543 2003 120 124
    • (2003) FEBS Lett , vol.543 , pp. 120-124
    • Tanaka, N.1    Hora, K.2    Makishima, H.3    Kamijo, Y.4    Kiyosawa, K.5    Gonzalez, F.J.6
  • 22
    • 0032489437 scopus 로고    scopus 로고
    • Altered constitutive expression of fatty acid-metabolizing enzymes in mice lacking the peroxisome proliferator-activated receptor α (PPARα)
    • T. Aoyama, J.M. Peters, N. Iritani, T. Nakajima, K. Furihata, and T. Hashimoto Altered constitutive expression of fatty acid-metabolizing enzymes in mice lacking the peroxisome proliferator-activated receptor α (PPARα) J Biol Chem 273 1998 5678 5684
    • (1998) J Biol Chem , vol.273 , pp. 5678-5684
    • Aoyama, T.1    Peters, J.M.2    Iritani, N.3    Nakajima, T.4    Furihata, K.5    Hashimoto, T.6
  • 23
    • 1542283630 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor α target genes
    • S. Mandard, M. Müller, and S. Kersten Peroxisome proliferator-activated receptor α target genes Cell Mol Life Sci 61 2004 393 416
    • (2004) Cell Mol Life Sci , vol.61 , pp. 393-416
    • Mandard, S.1    Müller, M.2    Kersten, S.3
  • 24
    • 69449086702 scopus 로고    scopus 로고
    • Comparative analysis of gene regulation by the transcription factor PPARα between mouse and human
    • M. Rakhshandehroo, G. Hooiveld, M. Müller, and S. Kersten Comparative analysis of gene regulation by the transcription factor PPARα between mouse and human PLoS One 4 2009 e6796
    • (2009) PLoS One , vol.4 , pp. 6796
    • Rakhshandehroo, M.1    Hooiveld, G.2    Müller, M.3    Kersten, S.4
  • 25
    • 63849335660 scopus 로고    scopus 로고
    • Bezafibrate at clinically relevant doses decreases serum/liver triglycerides via down-regulation of sterol regulatory element-binding protein-1c in mice: A novel peroxisome proliferator-activated receptor α-independent mechanism
    • T. Nakajima, N. Tanaka, H. Kanbe, A. Hara, Y. Kamijo, and X. Zhang Bezafibrate at clinically relevant doses decreases serum/liver triglycerides via down-regulation of sterol regulatory element-binding protein-1c in mice: a novel peroxisome proliferator-activated receptor α-independent mechanism Mol Pharmacol 75 2009 782 792
    • (2009) Mol Pharmacol , vol.75 , pp. 782-792
    • Nakajima, T.1    Tanaka, N.2    Kanbe, H.3    Hara, A.4    Kamijo, Y.5    Zhang, X.6
  • 26
    • 21344434775 scopus 로고    scopus 로고
    • Diverging regulation of pyruvate dehydrogenase kinase isoform gene expression in cultured human muscle cells
    • E.L. Abbot, J.G. McCornack, C. Reynet, D.G. Hassall, K.W. Buchan, and S.J. Yeaman Diverging regulation of pyruvate dehydrogenase kinase isoform gene expression in cultured human muscle cells FEBS J 272 2005 3004 3014
    • (2005) FEBS J , vol.272 , pp. 3004-3014
    • Abbot, E.L.1    McCornack, J.G.2    Reynet, C.3    Hassall, D.G.4    Buchan, K.W.5    Yeaman, S.J.6
  • 27
    • 62749136195 scopus 로고    scopus 로고
    • Muscle-derived angiopoietin-like protein 4 is induced by fatty acids via peroxisome proliferator-activated receptor (PPAR)-δ and is of metabolic relevance in humans
    • H. Staiger, C. Haas, J. Machann, R. Werner, M. Weisser, and F. Schick Muscle-derived angiopoietin-like protein 4 is induced by fatty acids via peroxisome proliferator-activated receptor (PPAR)-δ and is of metabolic relevance in humans Diabetes 58 2009 579 589
    • (2009) Diabetes , vol.58 , pp. 579-589
    • Staiger, H.1    Haas, C.2    MacHann, J.3    Werner, R.4    Weisser, M.5    Schick, F.6
  • 28
    • 0346003777 scopus 로고    scopus 로고
    • Adipocyte-specific gene expression and adipogenic steatosis in the mouse liver due to peroxisome proliferator-activated receptor γ1 (PPARγ1) overexpression
    • S. Yu, K. Matsusue, P. Kashireddy, W.Q. Cao, V. Yeldandi, and A.V. Yeldandi Adipocyte-specific gene expression and adipogenic steatosis in the mouse liver due to peroxisome proliferator-activated receptor γ1 (PPARγ1) overexpression J Biol Chem 278 2003 498 505
    • (2003) J Biol Chem , vol.278 , pp. 498-505
    • Yu, S.1    Matsusue, K.2    Kashireddy, P.3    Cao, W.Q.4    Yeldandi, V.5    Yeldandi, A.V.6
  • 29
    • 41449098953 scopus 로고    scopus 로고
    • Hepatic steatosis in leptin-deficient mice is promoted by the PPARγ target gene Fsp27
    • K. Matsusue, T. Kusakabe, T. Noguchi, S. Takiguchi, T. Suzuki, and S. Yamano Hepatic steatosis in leptin-deficient mice is promoted by the PPARγ target gene Fsp27 Cell Metab 7 2008 302 311
    • (2008) Cell Metab , vol.7 , pp. 302-311
    • Matsusue, K.1    Kusakabe, T.2    Noguchi, T.3    Takiguchi, S.4    Suzuki, T.5    Yamano, S.6
  • 30
    • 33846174641 scopus 로고    scopus 로고
    • Tumor necrosis factor and interleukin 1 decrease RXRα, PPARα, PPARγ, LXRα, and the coactivators SRC-1, PGC-1α, and PGC-1β in liver cells
    • M.S. Kim, T.R. Sweeney, J.K. Shigenaga, L.G. Chui, A. Moser, and C. Grunfeld Tumor necrosis factor and interleukin 1 decrease RXRα, PPARα, PPARγ, LXRα, and the coactivators SRC-1, PGC-1α, and PGC-1β in liver cells Metabolism 56 2007 267 279
    • (2007) Metabolism , vol.56 , pp. 267-279
    • Kim, M.S.1    Sweeney, T.R.2    Shigenaga, J.K.3    Chui, L.G.4    Moser, A.5    Grunfeld, C.6
  • 31
    • 0033570119 scopus 로고    scopus 로고
    • Increased levels of nuclear SREBP-1c associated with fatty livers in two mouse models of diabetes mellitus
    • I. Shimomura, Y. Bashmakov, and J.D. Horton Increased levels of nuclear SREBP-1c associated with fatty livers in two mouse models of diabetes mellitus J Biol Chem 274 1999 30028 30032
    • (1999) J Biol Chem , vol.274 , pp. 30028-30032
    • Shimomura, I.1    Bashmakov, Y.2    Horton, J.D.3
  • 33
    • 53349153430 scopus 로고    scopus 로고
    • Liver X receptor in cooperation with SREBP-1c is a major lipid synthesis regulator in nonalcoholic fatty liver disease
    • N. Higuchi, M. Kato, Y. Shundo, H. Tajiri, M. Tanaka, and N. Yamashita Liver X receptor in cooperation with SREBP-1c is a major lipid synthesis regulator in nonalcoholic fatty liver disease Hepatol Res 38 2008 1122 1129
    • (2008) Hepatol Res , vol.38 , pp. 1122-1129
    • Higuchi, N.1    Kato, M.2    Shundo, Y.3    Tajiri, H.4    Tanaka, M.5    Yamashita, N.6
  • 34
    • 0032502704 scopus 로고    scopus 로고
    • Control of human muscle-type carnitine palmitoyltransferase i gene transcription by peroxisome proliferator-activated receptor
    • C. Mascaró, E. Acosta, J.A. Ortiz, P.F. Marrero, F.G. Hegardt, and D. Haro Control of human muscle-type carnitine palmitoyltransferase I gene transcription by peroxisome proliferator-activated receptor J Biol Chem 273 1998 8560 8563
    • (1998) J Biol Chem , vol.273 , pp. 8560-8563
    • Mascaró, C.1    Acosta, E.2    Ortiz, J.A.3    Marrero, P.F.4    Hegardt, F.G.5    Haro, D.6
  • 35
    • 34547589477 scopus 로고    scopus 로고
    • Modulation of PPAR activity via phosphorylation
    • K.A. Burns, and J.P. Vanden Heuvel Modulation of PPAR activity via phosphorylation Biochim Biophys Acta 1771 2007 952 960
    • (2007) Biochim Biophys Acta , vol.1771 , pp. 952-960
    • Burns, K.A.1    Vanden Heuvel, J.P.2
  • 36
    • 36749083957 scopus 로고    scopus 로고
    • Hepatitis C virus core protein induces spontaneous and persistent activation of peroxisome proliferator-activated receptor α in transgenic mice: Implications for HCV-associated hepatocarcinogenesis
    • N. Tanaka, K. Moriya, K. Kiyosawa, K. Koike, and T. Aoyama Hepatitis C virus core protein induces spontaneous and persistent activation of peroxisome proliferator-activated receptor α in transgenic mice: implications for HCV-associated hepatocarcinogenesis Int J Cancer 122 2008 124 131
    • (2008) Int J Cancer , vol.122 , pp. 124-131
    • Tanaka, N.1    Moriya, K.2    Kiyosawa, K.3    Koike, K.4    Aoyama, T.5
  • 37
    • 38849184816 scopus 로고    scopus 로고
    • PPARα activation is essential for HCV core protein-induced hepatic steatosis and hepatocellular carcinoma in mice
    • N. Tanaka, K. Moriya, K. Kiyosawa, K. Koike, F.J. Gonzalez, and T. Aoyama PPARα activation is essential for HCV core protein-induced hepatic steatosis and hepatocellular carcinoma in mice J Clin Invest 118 2008 683 694
    • (2008) J Clin Invest , vol.118 , pp. 683-694
    • Tanaka, N.1    Moriya, K.2    Kiyosawa, K.3    Koike, K.4    Gonzalez, F.J.5    Aoyama, T.6
  • 38
    • 67349132443 scopus 로고    scopus 로고
    • Polyenephosphatidylcholine prevents alcoholic liver disease in PPARα-null mice through attenuation of increases in oxidative stress
    • W. Okiyama, N. Tanaka, T. Nakajima, E. Tanaka, K. Kiyosawa, and F.J. Gonzalez Polyenephosphatidylcholine prevents alcoholic liver disease in PPARα-null mice through attenuation of increases in oxidative stress J Hepatol 50 2009 1236 1246
    • (2009) J Hepatol , vol.50 , pp. 1236-1246
    • Okiyama, W.1    Tanaka, N.2    Nakajima, T.3    Tanaka, E.4    Kiyosawa, K.5    Gonzalez, F.J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.