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Volumn 20, Issue 14, 2014, Pages 2251-2273

Dual-specificity phosphatases as molecular targets for inhibition in human disease

Author keywords

[No Author keywords available]

Indexed keywords

ANTHRAQUINONE; BR 1; CG 707; DUAL SPECIFICITY PHOSPHATASE; DUAL SPECIFICITY PHOSPHATASE INHIBITOR; EMODIN; ENZYME INHIBITOR; GINKGETIN; MITOGEN ACTIVATED PROTEIN KINASE PHOSPHATASE; PENTAMIDINE; PRL3 INHIBITOR 1; RHODANINE; THIENOPYRIDONE; UNCLASSIFIED DRUG;

EID: 84898657084     PISSN: 15230864     EISSN: 15577716     Source Type: Journal    
DOI: 10.1089/ars.2013.5709     Document Type: Review
Times cited : (63)

References (207)
  • 1
    • 84862996806 scopus 로고    scopus 로고
    • The safe use of a PTEN inhibitor for the activation of dormant mouse primordial follicles and generation of fertilizable eggs
    • Adhikari D, Gorre N, Risal S, Zhao Z, Zhang H, Shen Y, and Liu K. The safe use of a PTEN inhibitor for the activation of dormant mouse primordial follicles and generation of fertilizable eggs. PLoS One 7: e39034, 2012.
    • (2012) PLoS One , vol.7
    • Adhikari, D.1    Gorre, N.2    Risal, S.3    Zhao, Z.4    Zhang, H.5    Shen, Y.6    Liu, K.7
  • 4
    • 78649878760 scopus 로고    scopus 로고
    • PRL-3 phosphatase and cancer metastasis
    • Al-Aidaroos AQ and Zeng Q. PRL-3 phosphatase and cancer metastasis. J Cell Biochem 111: 1087-1098, 2010.
    • (2010) J Cell Biochem , vol.111 , pp. 1087-1098
    • Al-Aidaroos, A.Q.1    Zeng, Q.2
  • 5
    • 77957224853 scopus 로고    scopus 로고
    • Over-expression of mitogen-activated protein kinase phosphatase-2 enhances adhesion molecule expression and protects against apoptosis in human endothelial cells
    • Al-Mutairi M, Al-Harthi S, Cadalbert L, and Plevin R. Over-expression of mitogen-activated protein kinase phosphatase-2 enhances adhesion molecule expression and protects against apoptosis in human endothelial cells. Br J Pharmacol 161: 782-798, 2010.
    • (2010) Br J Pharmacol , vol.161 , pp. 782-798
    • Al-Mutairi, M.1    Al-Harthi, S.2    Cadalbert, L.3    Plevin, R.4
  • 9
    • 56449110281 scopus 로고    scopus 로고
    • The mitogen-activated protein kinase phosphatase vaccinia H1-related protein inhibits apoptosis in prostate cancer cells and is overexpressed in prostate cancer
    • Arnoldussen YJ, Lorenzo PI, Pretorius ME, Waehre H, Risberg B, Maelandsmo GM, Danielsen HE, and Saatcioglu F. The mitogen-activated protein kinase phosphatase vaccinia H1-related protein inhibits apoptosis in prostate cancer cells and is overexpressed in prostate cancer. Cancer Res 68: 9255-9264, 2008.
    • (2008) Cancer Res , vol.68 , pp. 9255-9264
    • Arnoldussen, Y.J.1    Lorenzo, P.I.2    Pretorius, M.E.3    Waehre, H.4    Risberg, B.5    Maelandsmo, G.M.6    Danielsen, H.E.7    Saatcioglu, F.8
  • 12
    • 2942736803 scopus 로고    scopus 로고
    • ZBP-89-induced apoptosis is p53-independent and requires JNK
    • Bai L, Yoon SO, King PD, and Merchant JL. ZBP-89-induced apoptosis is p53-independent and requires JNK. Cell Death Differ 11: 663-673, 2004.
    • (2004) Cell Death Differ , vol.11 , pp. 663-673
    • Bai, L.1    Yoon, S.O.2    King, P.D.3    Merchant, J.L.4
  • 13
    • 58149250722 scopus 로고    scopus 로고
    • Toward a molecular understanding of the interaction of dual specificity phosphatases with substrates: Insights from structure-based modeling and high throughput screening
    • Bakan A, Lazo JS, Wipf P, Brummond KM, and Bahar I. Toward a molecular understanding of the interaction of dual specificity phosphatases with substrates: insights from structure-based modeling and high throughput screening. Curr Med Chem 15: 2536-2544, 2008.
    • (2008) Curr Med Chem , vol.15 , pp. 2536-2544
    • Bakan, A.1    Lazo, J.S.2    Wipf, P.3    Brummond, K.M.4    Bahar, I.5
  • 16
    • 3042836359 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase (MAPK) phosphatase-1 and-4 attenuate p38 MAPK during dexamethasone-induced insulin resistance in 3T3-L1 adipocytes
    • Bazuine M, Carlotti F, Tafrechi RS, Hoeben RC, and Maassen JA. Mitogen-activated protein kinase (MAPK) phosphatase-1 and-4 attenuate p38 MAPK during dexamethasone-induced insulin resistance in 3T3-L1 adipocytes. Mol Endocrinol 18: 1697-1707, 2004.
    • (2004) Mol Endocrinol , vol.18 , pp. 1697-1707
    • Bazuine, M.1    Carlotti, F.2    Tafrechi, R.S.3    Hoeben, R.C.4    Maassen, J.A.5
  • 18
    • 78049253973 scopus 로고    scopus 로고
    • Post-transcriptional regulation of the DUSP6/MKP-3 phosphatase by MEK/ERK signaling and hypoxia
    • Bermudez O, Jouandin P, Rottier J, Bourcier C, Pàges G, and Gimond C. Post-transcriptional regulation of the DUSP6/MKP-3 phosphatase by MEK/ERK signaling and hypoxia. J Cell Physiol 226: 276-284, 2011.
    • (2011) J Cell Physiol , vol.226 , pp. 276-284
    • Bermudez, O.1    Jouandin, P.2    Rottier, J.3    Bourcier, C.4    Pàges, G.5    Gimond, C.6
  • 19
    • 77955907279 scopus 로고    scopus 로고
    • The dual-specificity MAP kinase phosphatases: Critical roles in development and cancer
    • Bermudez O, Pàges G, and Gimond C. The dual-specificity MAP kinase phosphatases: critical roles in development and cancer. Am J Physiol Cell Physiol 299: C189-C202, 2010.
    • (2010) Am J Physiol Cell Physiol , vol.299
    • Bermudez, O.1    Pàges, G.2    Gimond, C.3
  • 20
    • 43049131055 scopus 로고    scopus 로고
    • PRL PTPs: mediators and markers of cancer progression
    • Bessette DC, Qiu D, and Pallen CJ. PRL PTPs: mediators and markers of cancer progression. Cancer Metastasis Rev 27: 231-252, 2008.
    • (2008) Cancer Metastasis Rev , vol.27 , pp. 231-252
    • Bessette, D.C.1    Qiu, D.2    Pallen, C.J.3
  • 21
    • 0030764689 scopus 로고    scopus 로고
    • Induction of the dual specificity phosphatase PAC1 in rat brain following seizure activity
    • Boschert U, Muda M, Camps M, Dickinson R, and Arkinstall S. Induction of the dual specificity phosphatase PAC1 in rat brain following seizure activity. Neuroreport 8: 3077-3080, 1997.
    • (1997) Neuroreport , vol.8 , pp. 3077-3080
    • Boschert, U.1    Muda, M.2    Camps, M.3    Dickinson, R.4    Arkinstall, S.5
  • 22
    • 54049141728 scopus 로고    scopus 로고
    • Mitogen-activated protein (MAP) kinase/MAP kinase phosphatase regulation: Roles in cell growth, death, and cancer
    • Boutros T, Chevet E, and Metrakos P. Mitogen-activated protein (MAP) kinase/MAP kinase phosphatase regulation: roles in cell growth, death, and cancer. Pharmacol Rev 60: 261-310, 2008.
    • (2008) Pharmacol Rev , vol.60 , pp. 261-310
    • Boutros, T.1    Chevet, E.2    Metrakos, P.3
  • 24
    • 75449115350 scopus 로고    scopus 로고
    • Transition from compensated hypertrophy to systolic heart failure in the spontaneously hypertensive rat: Structure, function, and transcript analysis
    • Brooks WW, Shen SS, Conrad CH, Goldstein RH, and Bing OH. Transition from compensated hypertrophy to systolic heart failure in the spontaneously hypertensive rat: structure, function, and transcript analysis. Genomics 95: 84-92, 2010.
    • (2010) Genomics , vol.95 , pp. 84-92
    • Brooks, W.W.1    Shen, S.S.2    Conrad, C.H.3    Goldstein, R.H.4    Bing, O.H.5
  • 25
    • 22144498128 scopus 로고    scopus 로고
    • Conditional expression of MAP kinase phosphatase-2 protects against genotoxic stress-induced apoptosis by binding and selective dephosphorylation of nuclear activated c-jun Nterminal kinase
    • Cadalbert L, Sloss CM, Cameron P, and Plevin R. Conditional expression of MAP kinase phosphatase-2 protects against genotoxic stress-induced apoptosis by binding and selective dephosphorylation of nuclear activated c-jun Nterminal kinase. Cell Signal 17: 1254-1264, 2005.
    • (2005) Cell Signal , vol.17 , pp. 1254-1264
    • Cadalbert, L.1    Sloss, C.M.2    Cameron, P.3    Plevin, R.4
  • 27
    • 62149092568 scopus 로고    scopus 로고
    • Bioactivities of simplified adociaquinone B and naphthoquinone derivatives against Cdc25B, MKP-1, and MKP-3 phosphatases
    • Cao S, Murphy BT, Foster C, Lazo JS, and Kingston DG. Bioactivities of simplified adociaquinone B and naphthoquinone derivatives against Cdc25B, MKP-1, and MKP-3 phosphatases. Bioorg Med Chem 17: 2276-2281, 2009.
    • (2009) Bioorg Med Chem , vol.17 , pp. 2276-2281
    • Cao, S.1    Murphy, B.T.2    Foster, C.3    Lazo, J.S.4    Kingston, D.G.5
  • 29
    • 51849123638 scopus 로고    scopus 로고
    • Loss of MKP3 mediated by oxidative stress enhances tumorigenicity and chemoresistance of ovarian cancer cells
    • Chan DW, Liu VW, Tsao GS, Yao KM, Furukawa T, Chan KK, and Ngan HY. Loss of MKP3 mediated by oxidative stress enhances tumorigenicity and chemoresistance of ovarian cancer cells. Carcinogenesis 29: 1742-1750, 2008.
    • (2008) Carcinogenesis , vol.29 , pp. 1742-1750
    • Chan, D.W.1    Liu, V.W.2    Tsao, G.S.3    Yao, K.M.4    Furukawa, T.5    Chan, K.K.6    Ngan, H.Y.7
  • 30
    • 84655167683 scopus 로고    scopus 로고
    • Microinjection of sanguinarine into the ventrolateral orbital cortex inhibits Mkp-1 and exerts an antidepressantlike effect in rats
    • Chen Y, Wang H, Zhang R, Peng Z, Sun R, and Tan Q. Microinjection of sanguinarine into the ventrolateral orbital cortex inhibits Mkp-1 and exerts an antidepressantlike effect in rats. Neurosci Lett 506: 327-331, 2012.
    • (2012) Neurosci Lett , vol.506 , pp. 327-331
    • Chen, Y.1    Wang, H.2    Zhang, R.3    Peng, Z.4    Sun, R.5    Tan, Q.6
  • 31
    • 0037131419 scopus 로고    scopus 로고
    • Phenylethyl isothiocyanate induces apoptotic signaling via suppressing phosphatase activity against c-Jun N-terminal kinase
    • Chen YR, Han J, Kori R, Kong AN, and Tan TH. Phenylethyl isothiocyanate induces apoptotic signaling via suppressing phosphatase activity against c-Jun N-terminal kinase. J Biol Chem 277: 39334-39342, 2002.
    • (2002) J Biol Chem , vol.277 , pp. 39334-39342
    • Chen, Y.R.1    Han, J.2    Kori, R.3    Kong, A.N.4    Tan, T.H.5
  • 32
    • 0035905754 scopus 로고    scopus 로고
    • Down-regulation of the c-Jun N-terminal kinase (JNK) phosphatase M3/6 and activation of JNK by hydrogen peroxide and pyrrolidine dithiocarbamate
    • Chen YR, Shrivastava A, and Tan TH. Down-regulation of the c-Jun N-terminal kinase (JNK) phosphatase M3/6 and activation of JNK by hydrogen peroxide and pyrrolidine dithiocarbamate. Oncogene 20: 367-374, 2001.
    • (2001) Oncogene , vol.20 , pp. 367-374
    • Chen, Y.R.1    Shrivastava, A.2    Tan, T.H.3
  • 33
    • 84870026541 scopus 로고    scopus 로고
    • Dual specificity phosphatase 4 mediates cardiomyopathy caused by lamin A/C (LMNA) gene mutation
    • Choi JC, Wu W, Muchir A, Iwata S, Homma S, and Worman HJ. Dual specificity phosphatase 4 mediates cardiomyopathy caused by lamin A/C (LMNA) gene mutation. J Biol Chem 287: 40513-40524, 2012.
    • (2012) J Biol Chem , vol.287 , pp. 40513-40524
    • Choi, J.C.1    Wu, W.2    Muchir, A.3    Iwata, S.4    Homma, S.5    Worman, H.J.6
  • 34
    • 79952443190 scopus 로고    scopus 로고
    • The essential role of FKBP38 in regulating phosphatase of regenerating liver 3 (PRL-3) protein stability
    • Choi MS, Min SH, Jung H, Lee JD, Lee TH, Lee HK, and Yoo OJ. The essential role of FKBP38 in regulating phosphatase of regenerating liver 3 (PRL-3) protein stability. Biochem Biophys Res Commun 406: 305-309, 2011.
    • (2011) Biochem Biophys Res Commun , vol.406 , pp. 305-309
    • Choi, M.S.1    Min, S.H.2    Jung, H.3    Lee, J.D.4    Lee, T.H.5    Lee, H.K.6    Yoo, O.J.7
  • 38
    • 84870619521 scopus 로고    scopus 로고
    • Systemic perturbation of the ERK signaling pathway by the proteasome inhibitor, MG132
    • Cirit M, Grant KG, and Haugh JM. Systemic perturbation of the ERK signaling pathway by the proteasome inhibitor, MG132. PLoS One 7: e50975, 2012.
    • (2012) PLoS One , vol.7
    • Cirit, M.1    Grant, K.G.2    Haugh, J.M.3
  • 39
    • 54449097818 scopus 로고    scopus 로고
    • Role of dual specificity phosphatases in biological responses to glucocorticoids
    • Clark AR, Martins JR, and Tchen CR. Role of dual specificity phosphatases in biological responses to glucocorticoids. J Biol Chem 283: 25765-25769, 2008.
    • (2008) J Biol Chem , vol.283 , pp. 25765-25769
    • Clark, A.R.1    Martins, J.R.2    Tchen, C.R.3
  • 40
    • 0036097632 scopus 로고    scopus 로고
    • Reciprocal modulation of mitogen-activated protein kinases and mitogen-activated protein kinase phosphatase 1 and 2 in failing human myocardium
    • Communal C, Colucci WS, Remondino A, Sawyer DB, Port JD, Wichman SE, Bristow MR, and Singh K. Reciprocal modulation of mitogen-activated protein kinases and mitogen-activated protein kinase phosphatase 1 and 2 in failing human myocardium. J Card Fail 8: 86-92, 2002.
    • (2002) J Card Fail , vol.8 , pp. 86-92
    • Communal, C.1    Colucci, W.S.2    Remondino, A.3    Sawyer, D.B.4    Port, J.D.5    Wichman, S.E.6    Bristow, M.R.7    Singh, K.8
  • 42
    • 77952725007 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase phosphatase 2 regulates the inflammatory response in sepsis
    • Cornell TT, Rodenhouse P, Cai Q, Sun L, and Shanley TP. Mitogen-activated protein kinase phosphatase 2 regulates the inflammatory response in sepsis. Infect Immun 78: 2868-2876, 2010.
    • (2010) Infect Immun , vol.78 , pp. 2868-2876
    • Cornell, T.T.1    Rodenhouse, P.2    Cai, Q.3    Sun, L.4    Shanley, T.P.5
  • 46
    • 0032554611 scopus 로고    scopus 로고
    • Specific and reversible inactivation of protein tyrosine phosphatases by hydrogen peroxide: Evidence for a sulfenic acid intermediate and implications for redox regulation
    • Denu JM and Tanner KG. Specific and reversible inactivation of protein tyrosine phosphatases by hydrogen peroxide: evidence for a sulfenic acid intermediate and implications for redox regulation. Biochemistry 37: 5633-5642, 1998.
    • (1998) Biochemistry , vol.37 , pp. 5633-5642
    • Denu, J.M.1    Tanner, K.G.2
  • 48
    • 84857608933 scopus 로고    scopus 로고
    • Targeting mitogen-activated protein kinase phosphatase-1 (MKP-1): Structure-based design of MKP-1 inhibitors and upregulators
    • Doddareddy MR, Rawling T, and Ammit AJ. Targeting mitogen-activated protein kinase phosphatase-1 (MKP-1): structure-based design of MKP-1 inhibitors and upregulators. Curr Med Chem 19: 163-173, 2012.
    • (2012) Curr Med Chem , vol.19 , pp. 163-173
    • Doddareddy, M.R.1    Rawling, T.2    Ammit, A.J.3
  • 49
    • 79953169173 scopus 로고    scopus 로고
    • Dual-specific phosphatase-6 (Dusp6) and ERK mediate AMPA receptor-induced oligodendrocyte death
    • Domercq M, Alberdi E, Sánchez-Gómez MV, Ariz U, Pérez-Samartin A, and Matute C. Dual-specific phosphatase-6 (Dusp6) and ERK mediate AMPA receptor-induced oligodendrocyte death. J Biol Chem 286: 11825-11836, 2011.
    • (2011) J Biol Chem , vol.286 , pp. 11825-11836
    • Domercq, M.1    Alberdi, E.2    Sánchez-Gómez, M.V.3    Ariz, U.4    Pérez-Samartin, A.5    Matute, C.6
  • 50
    • 84866346272 scopus 로고    scopus 로고
    • Phosphatase of regenerating liver 2 (PRL2) is essential for placental development by down-regulating PTEN (phosphatase and tensin homologue deleted on chromosome 10) and activating Akt protein
    • Dong Y, Zhang L, Zhang S, Bai Y, Chen H, Sun X, Yong W, Li W, Colvin SC, Rhodes SJ, Shou W, and Zhang ZY. Phosphatase of regenerating liver 2 (PRL2) is essential for placental development by down-regulating PTEN (phosphatase and tensin homologue deleted on chromosome 10) and activating Akt protein. J Biol Chem 287: 32172-32179, 2012.
    • (2012) J Biol Chem , vol.287 , pp. 32172-32179
    • Dong, Y.1    Zhang, L.2    Zhang, S.3    Bai, Y.4    Chen, H.5    Sun, X.6    Yong, W.7    Li, W.8    Colvin, S.C.9    Rhodes, S.J.10    Shou, W.11    Zhang, Z.Y.12
  • 52
    • 33751250221 scopus 로고    scopus 로고
    • Cellular localization of PRL-1 and PRL-2 gene expression in normal adult human tissues
    • Dumaual CM, Sandusky GE, Crowell PL, and Randall SK. Cellular localization of PRL-1 and PRL-2 gene expression in normal adult human tissues. J Histochem Cytochem 54: 1401-1412, 2006.
    • (2006) J Histochem Cytochem , vol.54 , pp. 1401-1412
    • Dumaual, C.M.1    Sandusky, G.E.2    Crowell, P.L.3    Randall, S.K.4
  • 54
    • 42149155999 scopus 로고    scopus 로고
    • Overexpression of the dual-specificity phosphatase MKP-4/DUSP-9 protects against stress-induced insulin resistance
    • Emanuelli B, Eberle D, Suzuki R, and Kahn CR. Overexpression of the dual-specificity phosphatase MKP-4/DUSP-9 protects against stress-induced insulin resistance. Proc Natl Acad Sci USA 105: 3545-3550, 2008.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 3545-3550
    • Emanuelli, B.1    Eberle, D.2    Suzuki, R.3    Kahn, C.R.4
  • 55
    • 84864331936 scopus 로고    scopus 로고
    • MEK/ERK pathway mediates insulin-promoted degradation of MKP-3 protein in liver cells
    • Feng B, Jiao P, Yang Z, and Xu H. MEK/ERK pathway mediates insulin-promoted degradation of MKP-3 protein in liver cells. Mol Cell Endocrinol 361: 116-123, 2012.
    • (2012) Mol Cell Endocrinol , vol.361 , pp. 116-123
    • Feng, B.1    Jiao, P.2    Yang, Z.3    Xu, H.4
  • 57
    • 0038243934 scopus 로고    scopus 로고
    • Potential tumor suppressive pathway involving DUSP6/MKP-3 in pancreatic cancer
    • Furukawa T, Sunamura M, Motoi F, Matsuno S, and Horii A. Potential tumor suppressive pathway involving DUSP6/MKP-3 in pancreatic cancer. Am J Pathol 162: 1807-1815, 2003.
    • (2003) Am J Pathol , vol.162 , pp. 1807-1815
    • Furukawa, T.1    Sunamura, M.2    Motoi, F.3    Matsuno, S.4    Horii, A.5
  • 61
    • 84873094424 scopus 로고    scopus 로고
    • Expression of the MAP kinase phosphatase DUSP4 is associated with microsatellite instability in colorectal cancer (CRC) and causes increased cell proliferation
    • Groschl B, Bettstetter M, Giedl C, Woenckhaus M, Edmonston T, Hofstadter F, and Dietmaier W. Expression of the MAP kinase phosphatase DUSP4 is associated with microsatellite instability in colorectal cancer (CRC) and causes increased cell proliferation. Int J Cancer 132: 1537-1546, 2013.
    • (2013) Int J Cancer , vol.132 , pp. 1537-1546
    • Groschl, B.1    Bettstetter, M.2    Giedl, C.3    Woenckhaus, M.4    Edmonston, T.5    Hofstadter, F.6    Dietmaier, W.7
  • 63
    • 33750359173 scopus 로고    scopus 로고
    • PRL-3 initiates tumor angiogenesis by recruiting endothelial cells in vitro and in vivo
    • Guo K, Li J, Wang H, Osato M, Tang JP, Quah SY, Gan BQ, and Zeng Q. PRL-3 initiates tumor angiogenesis by recruiting endothelial cells in vitro and in vivo. Cancer Res 66: 9625-9635, 2006.
    • (2006) Cancer Res , vol.66 , pp. 9625-9635
    • Guo, K.1    Li, J.2    Wang, H.3    Osato, M.4    Tang, J.P.5    Quah, S.Y.6    Gan, B.Q.7    Zeng, Q.8
  • 65
    • 56149086212 scopus 로고    scopus 로고
    • Monoclonal antibodies target intracellular PRL phosphatases to inhibit cancer metastases in mice
    • Guo K, Tang JP, Tan CP, Wang H, and Zeng Q. Monoclonal antibodies target intracellular PRL phosphatases to inhibit cancer metastases in mice. Cancer Biol Ther 7: 750-757, 2008.
    • (2008) Cancer Biol Ther , vol.7 , pp. 750-757
    • Guo, K.1    Tang, J.P.2    Tan, C.P.3    Wang, H.4    Zeng, Q.5
  • 66
    • 79953019177 scopus 로고    scopus 로고
    • PRL-3, an emerging marker of carcinogenesis, is strongly associated with poor prognosis
    • Guzinska-Ustymowicz K and Pryczynicz A. PRL-3, an emerging marker of carcinogenesis, is strongly associated with poor prognosis. Anticancer Agents Med Chem 11: 99-108, 2011.
    • (2011) Anticancer Agents Med Chem , vol.11 , pp. 99-108
    • Guzinska-Ustymowicz, K.1    Pryczynicz, A.2
  • 67
    • 33644871737 scopus 로고    scopus 로고
    • Gene expression profiling of 30 cancer cell lines predicts resistance towards 11 anticancer drugs at clinically achieved concentrations
    • Gyorffy B, Surowiak P, Kiesslich O, Denkert C, Schafer R, Dietel M, and Lage H. Gene expression profiling of 30 cancer cell lines predicts resistance towards 11 anticancer drugs at clinically achieved concentrations. Int J Cancer 118: 1699-1712, 2006.
    • (2006) Int J Cancer , vol.118 , pp. 1699-1712
    • Gyorffy, B.1    Surowiak, P.2    Kiesslich, O.3    Denkert, C.4    Schafer, R.5    Dietel, M.6    Lage, H.7
  • 68
    • 77349114891 scopus 로고    scopus 로고
    • The role of MAP kinases and MAP kinase phosphatase-1 in resistance to breast cancer treatment
    • Haagenson KK and Wu GS. The role of MAP kinases and MAP kinase phosphatase-1 in resistance to breast cancer treatment. Cancer Metastasis Rev 29: 143-149, 2010.
    • (2010) Cancer Metastasis Rev , vol.29 , pp. 143-149
    • Haagenson, K.K.1    Wu, G.S.2
  • 69
    • 68849121642 scopus 로고    scopus 로고
    • Candidate genes for sensitivity and resistance of human glioblastoma multiforme cell lines to erlotinib. Laboratory investigation
    • Halatsch ME, Low S, Mursch K, Hielscher T, Schmidt U, Unterberg A, Vougioukas VI, and Feuerhake F. Candidate genes for sensitivity and resistance of human glioblastoma multiforme cell lines to erlotinib. Laboratory investigation. J Neurosurg 111: 211-218, 2009.
    • (2009) J Neurosurg , vol.111 , pp. 211-218
    • Halatsch, M.E.1    Low, S.2    Mursch, K.3    Hielscher, T.4    Schmidt, U.5    Unterberg, A.6    Vougioukas, V.I.7    Feuerhake, F.8
  • 70
    • 0029084113 scopus 로고
    • RK-682, a potent inhibitor of tyrosine phosphatase, arrested the mammalian cell cycle progression at G1phase
    • Hamaguchi T, Sudo T, and Osada H. RK-682, a potent inhibitor of tyrosine phosphatase, arrested the mammalian cell cycle progression at G1phase. FEBS Lett 372: 54-58, 1995.
    • (1995) FEBS Lett , vol.372 , pp. 54-58
    • Hamaguchi, T.1    Sudo, T.2    Osada, H.3
  • 71
    • 84655165080 scopus 로고    scopus 로고
    • Emodin inhibits migration and invasion of DLD-1 (PRL-3) cells via inhibition of PRL-3 phosphatase activity
    • Han YM, Lee SK, Jeong DG, Ryu SE, Han DC, Kim DK, and Kwon BM. Emodin inhibits migration and invasion of DLD-1 (PRL-3) cells via inhibition of PRL-3 phosphatase activity. Bioorg Med Chem Lett 22: 323-326, 2012.
    • (2012) Bioorg Med Chem Lett , vol.22 , pp. 323-326
    • Han, Y.M.1    Lee, S.K.2    Jeong, D.G.3    Ryu, S.E.4    Han, D.C.5    Kim, D.K.6    Kwon, B.M.7
  • 72
    • 80053476859 scopus 로고    scopus 로고
    • Conformation-sensing antibodies stabilize the oxidized form of PTP1B and inhibit its phosphatase activity
    • Haque A, Andersen JN, Salmeen A, Barford D, and Tonks NK. Conformation-sensing antibodies stabilize the oxidized form of PTP1B and inhibit its phosphatase activity. Cell 147: 185-198, 2011.
    • (2011) Cell , vol.147 , pp. 185-198
    • Haque, A.1    Andersen, J.N.2    Salmeen, A.3    Barford, D.4    Tonks, N.K.5
  • 73
    • 78449277431 scopus 로고    scopus 로고
    • Overexpression of the protein tyrosine phosphatase PRL-2 correlates with breast tumor formation and progression
    • Hardy S, Wong NN, Muller WJ, Park M, and Tremblay ML. Overexpression of the protein tyrosine phosphatase PRL-2 correlates with breast tumor formation and progression. Cancer Res 70: 8959-8967, 2010.
    • (2010) Cancer Res , vol.70 , pp. 8959-8967
    • Hardy, S.1    Wong, N.N.2    Muller, W.J.3    Park, M.4    Tremblay, M.L.5
  • 75
    • 84872783533 scopus 로고    scopus 로고
    • Small molecule tools for functional interrogation of protein tyrosine phosphatases
    • He R, Zeng LF, He Y, Zhang S, and Zhang ZY. Small molecule tools for functional interrogation of protein tyrosine phosphatases. FEBS J 280: 731-750, 2013.
    • (2013) FEBS J , vol.280 , pp. 731-750
    • He, R.1    Zeng, L.F.2    He, Y.3    Zhang, S.4    Zhang, Z.Y.5
  • 76
    • 84858766192 scopus 로고    scopus 로고
    • Finding the smoking gun: Protein tyrosine phosphatases as tools and targets of unicellular microorganisms and viruses
    • Heneberg P. Finding the smoking gun: protein tyrosine phosphatases as tools and targets of unicellular microorganisms and viruses. Curr Med Chem 19: 1530-1566, 2012.
    • (2012) Curr Med Chem , vol.19 , pp. 1530-1566
    • Heneberg, P.1
  • 78
    • 79953038422 scopus 로고    scopus 로고
    • Development of a Vaccinia H1-related (VHR) phosphatase inhibitor with a nonacidic phosphate-mimicking core structure
    • Hirai G, Tsuchiya A, Koyama Y, Otani Y, Oonuma K, Dodo K, Simizu S, Osada H, and Sodeoka M. Development of a Vaccinia H1-related (VHR) phosphatase inhibitor with a nonacidic phosphate-mimicking core structure. Chem Med Chem 6: 617-622, 2011.
    • (2011) Chem Med Chem , vol.6 , pp. 617-622
    • Hirai, G.1    Tsuchiya, A.2    Koyama, Y.3    Otani, Y.4    Oonuma, K.5    Dodo, K.6    Simizu, S.7    Osada, H.8    Sodeoka, M.9
  • 79
    • 41549115946 scopus 로고    scopus 로고
    • Reactive oxygen species-mediated pancreatic beta-cell death is regulated by interactions between stress-activated protein kinases, p38 and c-Jun N-terminal kinase, and mitogen-activated protein kinase phosphatases
    • Hou N, Torii S, Saito N, Hosaka M, and Takeuchi T. Reactive oxygen species-mediated pancreatic beta-cell death is regulated by interactions between stress-activated protein kinases, p38 and c-Jun N-terminal kinase, and mitogen-activated protein kinase phosphatases. Endocrinology 149: 1654-1665, 2008.
    • (2008) Endocrinology , vol.149 , pp. 1654-1665
    • Hou, N.1    Torii, S.2    Saito, N.3    Hosaka, M.4    Takeuchi, T.5
  • 80
    • 35748980594 scopus 로고    scopus 로고
    • Cutting edge: Selective tyrosine dephosphorylation of interferon-activated nuclear STAT5 by the VHR phosphatase
    • Hoyt R, Zhu W, Cerignoli F, Alonso A, Mustelin T, and David M. Cutting edge: selective tyrosine dephosphorylation of interferon-activated nuclear STAT5 by the VHR phosphatase. J Immunol 179: 3402-3406, 2007.
    • (2007) J Immunol , vol.179 , pp. 3402-3406
    • Hoyt, R.1    Zhu, W.2    Cerignoli, F.3    Alonso, A.4    Mustelin, T.5    David, M.6
  • 81
    • 33645817920 scopus 로고    scopus 로고
    • Association and regulation of heat shock transcription factor 4b with both extracellular signal-regulated kinase mitogen-activated protein kinase and dual-specificity tyrosine phosphatase DUSP26
    • Hu Y and Mivechi NF. Association and regulation of heat shock transcription factor 4b with both extracellular signal-regulated kinase mitogen-activated protein kinase and dual-specificity tyrosine phosphatase DUSP26. Mol Cell Biol 26: 3282-3294, 2006.
    • (2006) Mol Cell Biol , vol.26 , pp. 3282-3294
    • Hu, Y.1    Mivechi, N.F.2
  • 82
    • 84862933832 scopus 로고    scopus 로고
    • DUSP4 deficiency enhances CD25 expression and CD4+ T-cell proliferation without impeding T-cell development
    • Huang CY, Lin YC, Hsiao WY, Liao FH, Huang PY, and Tan TH. DUSP4 deficiency enhances CD25 expression and CD4+ T-cell proliferation without impeding T-cell development. Eur J Immunol 42: 476-488, 2012.
    • (2012) Eur J Immunol , vol.42 , pp. 476-488
    • Huang, C.Y.1    Lin, Y.C.2    Hsiao, W.Y.3    Liao, F.H.4    Huang, P.Y.5    Tan, T.H.6
  • 83
    • 84874849715 scopus 로고    scopus 로고
    • Thioredoxin-related protein 32 (TRP32) specifically reduces oxidized phosphatase of regenerating liver (PRL)
    • Ishii T, Funato Y, andMiki H. Thioredoxin-related protein 32 (TRP32) specifically reduces oxidized phosphatase of regenerating liver (PRL). J Biol Chem288: 7263-7270, 2013.
    • (2013) J Biol Chem , vol.288 , pp. 7263-7270
    • Ishii, T.1    Funato, Y.2    Miki, H.3
  • 85
    • 34248210189 scopus 로고    scopus 로고
    • Targeting dual-specificity phosphatases: Manipulating MAP kinase signalling and immune responses
    • Jeffrey KL, Camps M, Rommel C, and Mackay CR. Targeting dual-specificity phosphatases: manipulating MAP kinase signalling and immune responses. Nat Rev Drug Discov 6: 391-403, 2007.
    • (2007) Nat Rev Drug Discov , vol.6 , pp. 391-403
    • Jeffrey, K.L.1    Camps, M.2    Rommel, C.3    MacKay, C.R.4
  • 86
    • 9644295701 scopus 로고    scopus 로고
    • Trimeric structure of PRL-1 phosphatase reveals an active enzyme conformation and regulation mechanisms
    • Jeong DG, Kim SJ, Kim JH, Son JH, Park MR, Lim SM, Yoon TS, and Ryu SE. Trimeric structure of PRL-1 phosphatase reveals an active enzyme conformation and regulation mechanisms. J Mol Biol 345: 401-413, 2005.
    • (2005) J Mol Biol , vol.345 , pp. 401-413
    • Jeong, D.G.1    Kim, S.J.2    Kim, J.H.3    Son, J.H.4    Park, M.R.5    Lim, S.M.6    Yoon, T.S.7    Ryu, S.E.8
  • 87
    • 43049129579 scopus 로고    scopus 로고
    • Targeting PTPs with small molecule inhibitors in cancer treatment
    • Jiang ZX and Zhang ZY. Targeting PTPs with small molecule inhibitors in cancer treatment. Cancer Metastasis Rev 27: 263-272, 2008.
    • (2008) Cancer Metastasis Rev , vol.27 , pp. 263-272
    • Jiang, Z.X.1    Zhang, Z.Y.2
  • 88
    • 84864335535 scopus 로고    scopus 로고
    • Mapping MKP-3/FOXO1 interaction and evaluating the effect on gluconeogenesis
    • Jiao P, Feng B, and Xu H. Mapping MKP-3/FOXO1 interaction and evaluating the effect on gluconeogenesis. PLoS One 7: e41168, 2012.
    • (2012) PLoS One , vol.7
    • Jiao, P.1    Feng, B.2    Xu, H.3
  • 89
    • 61849135453 scopus 로고    scopus 로고
    • Tumor suppressors and cell metabolism: A recipe for cancer growth
    • Jones RG and Thompson CB. Tumor suppressors and cell metabolism: a recipe for cancer growth. Genes Dev 23: 537-548, 2009.
    • (2009) Genes Dev , vol.23 , pp. 537-548
    • Jones, R.G.1    Thompson, C.B.2
  • 90
    • 84867600845 scopus 로고    scopus 로고
    • Potential opposite roles of the extracellular signal-regulated kinase (ERK) pathway in autism spectrum and bipolar disorders
    • Kalkman HO. Potential opposite roles of the extracellular signal-regulated kinase (ERK) pathway in autism spectrum and bipolar disorders. Neurosci Biobehav Rev 36: 2206-2213, 2012.
    • (2012) Neurosci Biobehav Rev , vol.36 , pp. 2206-2213
    • Kalkman, H.O.1
  • 91
    • 14844327760 scopus 로고    scopus 로고
    • Reactive oxygen species promote TNFa-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases
    • Kamata H, Honda S, Maeda S, Chang L, Hirata H, and Karin M. Reactive oxygen species promote TNFa-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases. Cell 120: 649-661, 2005.
    • (2005) Cell , vol.120 , pp. 649-661
    • Kamata, H.1    Honda, S.2    Maeda, S.3    Chang, L.4    Hirata, H.5    Karin, M.6
  • 92
    • 43049101029 scopus 로고    scopus 로고
    • Dual-specificity MAP kinase phosphatases (MKPs) and cancer
    • Keyse SM. Dual-specificity MAP kinase phosphatases (MKPs) and cancer. Cancer Metastasis Rev 27: 253-261, 2008.
    • (2008) Cancer Metastasis Rev , vol.27 , pp. 253-261
    • Keyse, S.M.1
  • 93
    • 84867339768 scopus 로고    scopus 로고
    • Redox regulation of MAPK phosphatase 1 controls monocyte migration and macrophage recruitment
    • Kim HS, Ullevig SL, Zamora D, Lee CF, and Asmis R. Redox regulation of MAPK phosphatase 1 controls monocyte migration and macrophage recruitment. Proc Natl Acad Sci USA 109: E2803-E2812, 2012.
    • (2012) Proc Natl Acad Sci USA , vol.109
    • Kim, H.S.1    Ullevig, S.L.2    Zamora, D.3    Lee, C.F.4    Asmis, R.5
  • 94
    • 0034307222 scopus 로고    scopus 로고
    • Effects of metal ions on the activity of protein tyrosine phosphatase VHR: Highly potent and reversible oxidative inactivation by Cu2 + ion
    • Kim JH, Cho H, Ryu SE, and Choi MU. Effects of metal ions on the activity of protein tyrosine phosphatase VHR: highly potent and reversible oxidative inactivation by Cu2 + ion. Arch Biochem Biophys 382: 72-80, 2000.
    • (2000) Arch Biochem Biophys , vol.382 , pp. 72-80
    • Kim, J.H.1    Cho, H.2    Ryu, S.E.3    Choi, M.U.4
  • 97
    • 40949118132 scopus 로고    scopus 로고
    • Increasing GLP-1-induced beta-cell proliferation by silencing the negative regulators of signaling cAMP response element modulator-alpha and DUSP14
    • Klinger S, Poussin C, Debril MB, Dolci W, Halban PA, and Thorens B. Increasing GLP-1-induced beta-cell proliferation by silencing the negative regulators of signaling cAMP response element modulator-alpha and DUSP14. Diabetes 57: 584-593, 2008.
    • (2008) Diabetes , vol.57 , pp. 584-593
    • Klinger, S.1    Poussin, C.2    Debril, M.B.3    Dolci, W.4    Halban, P.A.5    Thorens, B.6
  • 98
    • 34347369084 scopus 로고    scopus 로고
    • Post-translational modifications and regulation of the RAS superfamily of GTPases as anticancer targets
    • Konstantinopoulos PA, Karamouzis MV, and Papavassiliou AG. Post-translational modifications and regulation of the RAS superfamily of GTPases as anticancer targets. Nat Rev Drug Discov 6: 541-555, 2007.
    • (2007) Nat Rev Drug Discov , vol.6 , pp. 541-555
    • Konstantinopoulos, P.A.1    Karamouzis, M.V.2    Papavassiliou, A.G.3
  • 100
    • 1642482862 scopus 로고    scopus 로고
    • Structural insights into molecular function of the metastasis-associated phosphatase PRL-3
    • Kozlov G, Cheng J, Ziomek E, Banville D, Gehring K, and Ekiel I. Structural insights into molecular function of the metastasis-associated phosphatase PRL-3. J Biol Chem 279: 11882-11889, 2004.
    • (2004) J Biol Chem , vol.279 , pp. 11882-11889
    • Kozlov, G.1    Cheng, J.2    Ziomek, E.3    Banville, D.4    Gehring, K.5    Ekiel, I.6
  • 101
    • 77955494865 scopus 로고    scopus 로고
    • Tyrosine phosphatase inhibitor-3 sensitizes melanoma and colon cancer to biotherapeutics and chemotherapeutics
    • Kundu S, Fan K, Cao M, Lindner DJ, Tuthill R, Liu L, Gerson S, Borden E, and Yi T. Tyrosine phosphatase inhibitor-3 sensitizes melanoma and colon cancer to biotherapeutics and chemotherapeutics. Mol Cancer Ther 9: 2287-2296, 2010.
    • (2010) Mol Cancer Ther , vol.9 , pp. 2287-2296
    • Kundu, S.1    Fan, K.2    Cao, M.3    Lindner, D.J.4    Tuthill, R.5    Liu, L.6    Gerson, S.7    Borden, E.8    Yi, T.9
  • 102
    • 84870872419 scopus 로고    scopus 로고
    • New aspects of the phosphatase VHZ revealed by a high-resolution structure with vanadate and substrate screening
    • Kuznetsov VI, Hengge AC, and Johnson SJ. New aspects of the phosphatase VHZ revealed by a high-resolution structure with vanadate and substrate screening. Biochemistry 51: 9869-9879, 2012.
    • (2012) Biochemistry , vol.51 , pp. 9869-9879
    • Kuznetsov, V.I.1    Hengge, A.C.2    Johnson, S.J.3
  • 103
    • 79953862239 scopus 로고    scopus 로고
    • Deletion of the dual specific phosphatase-4 (DUSP-4) gene reveals an essential non-redundant role for MAP kinase phosphatase-2 (MKP-2) in proliferation and cell survival
    • Lawan A, Al-Harthi S, Cadalbert L, McCluskey AG, Shweash M, Grassia G, Grant A, Boyd M, Currie S, and Plevin R. Deletion of the dual specific phosphatase-4 (DUSP-4) gene reveals an essential non-redundant role for MAP kinase phosphatase-2 (MKP-2) in proliferation and cell survival. J Biol Chem 286: 12933-12943, 2011.
    • (2011) J Biol Chem , vol.286 , pp. 12933-12943
    • Lawan, A.1    Al-Harthi, S.2    Cadalbert, L.3    McCluskey, A.G.4    Shweash, M.5    Grassia, G.6    Grant, A.7    Boyd, M.8    Currie, S.9    Plevin, R.10
  • 109
    • 84870293512 scopus 로고    scopus 로고
    • Decline in miR-181a expression with age impairs T cell receptor sensitivity by increasing DUSP6 activity
    • Li G, Yu M, Lee WW, Tsang M, Krishnan E, Weyand CM, and Goronzy JJ. Decline in miR-181a expression with age impairs T cell receptor sensitivity by increasing DUSP6 activity. Nat Med 18: 1518-1524, 2012.
    • (2012) Nat Med , vol.18 , pp. 1518-1524
    • Li, G.1    Yu, M.2    Lee, W.W.3    Tsang, M.4    Krishnan, E.5    Weyand, C.M.6    Goronzy, J.J.7
  • 111
    • 36049006140 scopus 로고    scopus 로고
    • Modulation of immediate early gene expression by tristetraprolin in the differentiation of 3T3-L1 cells
    • Lin NY, Lin CT, and Chang CJ. Modulation of immediate early gene expression by tristetraprolin in the differentiation of 3T3-L1 cells. Biochem Biophys Res Commun 365: 69-74, 2008.
    • (2008) Biochem Biophys Res Commun , vol.365 , pp. 69-74
    • Lin, N.Y.1    Lin, C.T.2    Chang, C.J.3
  • 112
    • 79952106497 scopus 로고    scopus 로고
    • Triptolide and its expanding multiple pharmacological functions
    • Liu Q. Triptolide and its expanding multiple pharmacological functions. Int Immunopharmacol 11: 377-383, 2011.
    • (2011) Int Immunopharmacol , vol.11 , pp. 377-383
    • Liu, Q.1
  • 114
    • 84860777615 scopus 로고    scopus 로고
    • Increased expression of PRL-1 protein correlates with shortened patient survival in human hepatocellular carcinoma
    • Lu JW, Chang JG, Yeh KT, Chen RM, Tsai JJ, Su WW, and Hu RM. Increased expression of PRL-1 protein correlates with shortened patient survival in human hepatocellular carcinoma. Clin Transl Oncol 14: 287-293, 2012.
    • (2012) Clin Transl Oncol , vol.14 , pp. 287-293
    • Lu, J.W.1    Chang, J.G.2    Yeh, K.T.3    Chen, R.M.4    Tsai, J.J.5    Su, W.W.6    Hu, R.M.7
  • 115
    • 84864022640 scopus 로고    scopus 로고
    • An essential function for MKP5 in the formation of oxidized low density lipid-induced foam cells
    • Luo LJ, Liu F, Wang XY, Dai TY, Dai YL, Dong C, and Ge BX. An essential function for MKP5 in the formation of oxidized low density lipid-induced foam cells. Cell Signal 24: 1889-1898, 2012.
    • (2012) Cell Signal , vol.24 , pp. 1889-1898
    • Luo, L.J.1    Liu, F.2    Wang, X.Y.3    Dai, T.Y.4    Dai, Y.L.5    Dong, C.6    Ge, B.X.7
  • 116
    • 84881475138 scopus 로고    scopus 로고
    • Suppression of breast tumor growth by DNA vaccination against phosphatase of regenerating liver 3
    • Epub ahead of print]; DOI: 10.1038/gt.2013.5
    • Lv J, Liu C, Huang H, Meng L, Jiang B, Cao Y, Zhou Z, She T, Qu L, Wei Song S, and Shou C. Suppression of breast tumor growth by DNA vaccination against phosphatase of regenerating liver 3. Gene Ther [Epub ahead of print]; DOI: 10.1038/gt.2013.5, 2013.
    • (2013) Gene Ther
    • Lv, J.1    Liu, C.2    Huang, H.3    Meng, L.4    Jiang, B.5    Cao, Y.6    Zhou, Z.7    She, T.8    Qu, L.9    Wei Song, S.10    Shou, C.11
  • 117
    • 0035159453 scopus 로고    scopus 로고
    • Negative-feedback regulation of CD28 costimulation by a novel mitogen-activated protein kinase phosphatase, MKP6
    • Marti F, Krause A, Post NH, Lyddane C, Dupont B, Sadelain M, and King PD. Negative-feedback regulation of CD28 costimulation by a novel mitogen-activated protein kinase phosphatase, MKP6. J Immunol 166: 197-206, 2001.
    • (2001) J Immunol , vol.166 , pp. 197-206
    • Marti, F.1    Krause, A.2    Post, N.H.3    Lyddane, C.4    Dupont, B.5    Sadelain, M.6    King, P.D.7
  • 122
    • 34047195222 scopus 로고    scopus 로고
    • PTEN, the Achilles' heel of myocardial ischaemia/reperfusion injury?
    • Mocanu MM and Yellon DM. PTEN, the Achilles' heel of myocardial ischaemia/reperfusion injury? Br J Pharmacol 150: 833-838, 2007.
    • (2007) Br J Pharmacol , vol.150 , pp. 833-838
    • Mocanu, M.M.1    Yellon, D.M.2
  • 124
    • 78751558541 scopus 로고    scopus 로고
    • Inhibitory activities of anthraquinones from Rubia akane on phosphatase regenerating liver-3
    • Moon MK, Han YM, Lee YJ, Lee LH, Yang JH, Kwon BM, and Kim DK. Inhibitory activities of anthraquinones from Rubia akane on phosphatase regenerating liver-3. Arch Pharm Res 33: 1747-1751, 2010.
    • (2010) Arch Pharm Res , vol.33 , pp. 1747-1751
    • Moon, M.K.1    Han, Y.M.2    Lee, Y.J.3    Lee, L.H.4    Yang, J.H.5    Kwon, B.M.6    Kim, D.K.7
  • 125
    • 84876082175 scopus 로고    scopus 로고
    • MAP kinase phosphatase-3 (MKP-3) is transcriptionally and post-translationally up-regulated by hCG and modulates cAMP-induced p21 expression in MA-10 Leydig cells
    • Mori Sequeiros Garcia M, Gomez NV, Gorostizaga A, Acquier A, Gonzalez-Calvar SI, Mendez CF, and Paz C. MAP kinase phosphatase-3 (MKP-3) is transcriptionally and post-translationally up-regulated by hCG and modulates cAMP-induced p21 expression in MA-10 Leydig cells. Mol Cell Endocrinol 371: 174-181, 2013.
    • (2013) Mol Cell Endocrinol , vol.371 , pp. 174-181
    • Mori Sequeiros Garcia, M.1    Gomez, N.V.2    Gorostizaga, A.3    Acquier, A.4    Gonzalez-Calvar, S.I.5    Mendez, C.F.6    Paz, C.7
  • 126
    • 55449130109 scopus 로고    scopus 로고
    • The thioredoxin system: A key target in tumour and endothelial cells
    • Mukherjee A and Martin SG. The thioredoxin system: a key target in tumour and endothelial cells. Br J Radiol 81 Spec No 1: S57-S68, 2008.
    • (2008) Br J Radiol , vol.81 , Issue.1
    • Mukherjee, A.1    Martin, S.G.2
  • 127
    • 84872246940 scopus 로고    scopus 로고
    • Downregulation of the mitochondrial phosphatase PTPMT1 is sufficient to promote cancer cell death
    • Niemi NM, Lanning NJ, Westrate LM, and MacKeigan JP. Downregulation of the mitochondrial phosphatase PTPMT1 is sufficient to promote cancer cell death. PLoS One 8: e53803, 2013.
    • (2013) PLoS One , vol.8
    • Niemi, N.M.1    Lanning, N.J.2    Westrate, L.M.3    MacKeigan, J.P.4
  • 129
    • 84871926261 scopus 로고    scopus 로고
    • Prevention of JNK phosphorylation as a mechanism for rosiglitazone in neuroprotection after transient cerebral ischemia: Activation of dual specificity phosphatase
    • Okami N, Narasimhan P, Yoshioka H, Sakata H, Kim GS, Jung JE, Maier CM, and Chan PH. Prevention of JNK phosphorylation as a mechanism for rosiglitazone in neuroprotection after transient cerebral ischemia: activation of dual specificity phosphatase. J Cereb Blood Flow Metab 33: 106-114, 2013.
    • (2013) J Cereb Blood Flow Metab , vol.33 , pp. 106-114
    • Okami, N.1    Narasimhan, P.2    Yoshioka, H.3    Sakata, H.4    Kim, G.S.5    Jung, J.E.6    Maier, C.M.7    Chan, P.H.8
  • 130
    • 34248595035 scopus 로고    scopus 로고
    • Differential regulation of MAP kinase signalling by dual-specificity protein phosphatases
    • Owens DM and Keyse SM. Differential regulation of MAP kinase signalling by dual-specificity protein phosphatases. Oncogene 26: 3203-3213, 2007.
    • (2007) Oncogene , vol.26 , pp. 3203-3213
    • Owens, D.M.1    Keyse, S.M.2
  • 132
    • 22544454482 scopus 로고    scopus 로고
    • Involvement of a mitochondrial phosphatase in the regulation of ATP production and insulin secretion in pancreatic beta cells
    • Pagliarini DJ, Wiley SE, Kimple ME, Dixon JR, Kelly P, Worby CA, Casey PJ, and Dixon JE. Involvement of a mitochondrial phosphatase in the regulation of ATP production and insulin secretion in pancreatic beta cells. Mol Cell 19: 197-207, 2005.
    • (2005) Mol Cell , vol.19 , pp. 197-207
    • Pagliarini, D.J.1    Wiley, S.E.2    Kimple, M.E.3    Dixon, J.R.4    Kelly, P.5    Worby, C.A.6    Casey, P.J.7    Dixon, J.E.8
  • 133
    • 84870040131 scopus 로고    scopus 로고
    • Virtual screening and biochemical evaluation of mitogen-activated protein kinase phosphatase 4 inhibitors
    • Park H, Jeon JY, and Ryu ER. Virtual screening and biochemical evaluation of mitogen-activated protein kinase phosphatase 4 inhibitors. Bull. Korean Chem. Soc. 33: 3772-3776, 2012.
    • (2012) Bull. Korean Chem. Soc. , vol.33 , pp. 3772-3776
    • Park, H.1    Jeon, J.Y.2    Ryu, E.R.3
  • 134
    • 41149089362 scopus 로고    scopus 로고
    • Discovery of novel PRL-3 inhibitors based on the structurebased virtual screening
    • Park H, Jung SK, Jeong DG, Ryu SE, and Kim SJ. Discovery of novel PRL-3 inhibitors based on the structurebased virtual screening. Bioorg Med Chem Lett 18: 2250-2255, 2008.
    • (2008) Bioorg Med Chem Lett , vol.18 , pp. 2250-2255
    • Park, H.1    Jung, S.K.2    Jeong, D.G.3    Ryu, S.E.4    Kim, S.J.5
  • 135
    • 84855675692 scopus 로고    scopus 로고
    • Structure-based virtual screening approach to the discovery of novel PTPMT1 phosphatase inhibitors
    • Park H, Kim SY, Kyung A, Yoon TS, Ryu SE, and Jeong DG. Structure-based virtual screening approach to the discovery of novel PTPMT1 phosphatase inhibitors. Bioorg Med Chem Lett 22: 1271-1275, 2012.
    • (2012) Bioorg Med Chem Lett , vol.22 , pp. 1271-1275
    • Park, H.1    Kim, S.Y.2    Kyung, A.3    Yoon, T.S.4    Ryu, S.E.5    Jeong, D.G.6
  • 138
    • 62149114138 scopus 로고    scopus 로고
    • Dual-specificity phosphatases: Critical regulators with diverse cellular targets
    • Patterson KI, Brummer T, O'Brien PM, and Daly RJ. Dual-specificity phosphatases: critical regulators with diverse cellular targets. Biochem J 418: 475-489, 2009.
    • (2009) Biochem J , vol.418 , pp. 475-489
    • Patterson, K.I.1    Brummer, T.2    O'Brien, P.M.3    Daly, R.J.4
  • 139
    • 36749022747 scopus 로고    scopus 로고
    • Thioredoxin and thioredoxin reductase as redox-sensitive molecular targets for cancer therapy
    • Pennington JD, Jacobs KM, Sun L, Bar-Sela G, Mishra M, and Gius D. Thioredoxin and thioredoxin reductase as redox-sensitive molecular targets for cancer therapy. Curr Pharm Des 13: 3368-3377, 2007.
    • (2007) Curr Pharm des , vol.13 , pp. 3368-3377
    • Pennington, J.D.1    Jacobs, K.M.2    Sun, L.3    Bar-Sela, G.4    Mishra, M.5    Gius, D.6
  • 140
    • 34548067718 scopus 로고    scopus 로고
    • Thioredoxin signaling as a target for cancer therapy
    • Powis G and Kirkpatrick DL. Thioredoxin signaling as a target for cancer therapy. Curr Opin Pharmacol 7: 392-397, 2007.
    • (2007) Curr Opin Pharmacol , vol.7 , pp. 392-397
    • Powis, G.1    Kirkpatrick, D.L.2
  • 141
    • 38949123682 scopus 로고    scopus 로고
    • Protein tyrosine phosphatases: Dual-specificity phosphatases in health and disease
    • Pulido R and Hooft van Huijsduijnen R. Protein tyrosine phosphatases: dual-specificity phosphatases in health and disease. FEBS J 275: 848-866, 2008.
    • (2008) FEBS J , vol.275 , pp. 848-866
    • Pulido, R.1    Hooft Van Huijsduijnen, R.2
  • 142
    • 70350573933 scopus 로고    scopus 로고
    • A non-redundant role for MKP5 in limiting ROS production and preventing LPS-induced vascular injury
    • Qian F, Deng J, Cheng N, Welch EJ, Zhang Y, Malik AB, Flavell RA, Dong C, and Ye RD. A non-redundant role for MKP5 in limiting ROS production and preventing LPS-induced vascular injury. EMBO J 28: 2896-2907, 2009.
    • (2009) EMBO J , vol.28 , pp. 2896-2907
    • Qian, F.1    Deng, J.2    Cheng, N.3    Welch, E.J.4    Zhang, Y.5    Malik, A.B.6    Flavell, R.A.7    Dong, C.8    Ye, R.D.9
  • 144
    • 48949116933 scopus 로고    scopus 로고
    • MAPK phosphatases as novel targets for rheumatoid arthritis
    • Ralph JA and Morand EF. MAPK phosphatases as novel targets for rheumatoid arthritis. Expert Opin Ther Targets 12: 795-808, 2008.
    • (2008) Expert Opin Ther Targets , vol.12 , pp. 795-808
    • Ralph, J.A.1    Morand, E.F.2
  • 145
    • 84872781756 scopus 로고    scopus 로고
    • Molecular mechanisms of the PRL phosphatases
    • Ŕos P, Li X, and Köhn M. Molecular mechanisms of the PRL phosphatases. FEBS J 280: 505-524, 2013.
    • (2013) FEBS J , vol.280 , pp. 505-524
    • Ŕos, P.1    Li, X.2    Köhn, M.3
  • 146
    • 35748973537 scopus 로고    scopus 로고
    • A novel phosphatase family, structurally related to dual-specificity phosphatases, that displays unique amino acid sequence and substrate specificity
    • Romá-Mateo C, Ŕos P, Tabernero L, Attwood TK, and Pulido R. A novel phosphatase family, structurally related to dual-specificity phosphatases, that displays unique amino acid sequence and substrate specificity. J Mol Biol 374: 899-909, 2007.
    • (2007) J Mol Biol , vol.374 , pp. 899-909
    • Romá-Mateo, C.1    Ŕos, P.2    Tabernero, L.3    Attwood, T.K.4    Pulido, R.5
  • 150
    • 33947698363 scopus 로고    scopus 로고
    • Regulation of innate immunity by MAPK dual-specificity phosphatases: Knockout models reveal new tricks of old genes
    • Salojin K and Oravecz T. Regulation of innate immunity by MAPK dual-specificity phosphatases: knockout models reveal new tricks of old genes. J Leukoc Biol 81: 860-869, 2007.
    • (2007) J Leukoc Biol , vol.81 , pp. 860-869
    • Salojin, K.1    Oravecz, T.2
  • 152
    • 1642380187 scopus 로고    scopus 로고
    • Downregulation of genes involved in DNA repair and differential expression of transcription regulators and phosphatases precede IgM-induced apoptosis in the Burkitt's lymphoma cell line BL60-BL62
    • Schories B, Janz M, Dorken B, and Bommert K. Downregulation of genes involved in DNA repair and differential expression of transcription regulators and phosphatases precede IgM-induced apoptosis in the Burkitt's lymphoma cell line BL60-BL62. Biochim Biophys Acta 1676: 83-95, 2004.
    • (2004) Biochim Biophys Acta , vol.1676 , pp. 83-95
    • Schories, B.1    Janz, M.2    Dorken, B.3    Bommert, K.4
  • 153
    • 77953510496 scopus 로고    scopus 로고
    • Targeting protein tyrosine phosphatases for anticancer drug discovery
    • Scott LM, Lawrence HR, Sebti SM, Lawrence NJ, and Wu J. Targeting protein tyrosine phosphatases for anticancer drug discovery. Curr Pharm Des 16: 1843-1862, 2010.
    • (2010) Curr Pharm des , vol.16 , pp. 1843-1862
    • Scott, L.M.1    Lawrence, H.R.2    Sebti, S.M.3    Lawrence, N.J.4    Wu, J.5
  • 154
    • 84255168615 scopus 로고    scopus 로고
    • Specific inhibition of DUSP14 by NSC-95397 in vitro
    • Seo H and Cho S. Specific inhibition of DUSP14 by NSC-95397 in vitro. Bull Korean Chem Soc 32: 4435-4437, 2011.
    • (2011) Bull Korean Chem Soc , vol.32 , pp. 4435-4437
    • Seo, H.1    Cho, S.2
  • 156
    • 83255187891 scopus 로고    scopus 로고
    • A critical role of mitochondrial phosphatase Ptpmt1 in embryogenesis reveals a mitochondrial metabolic stress-induced differentiation checkpoint in embryonic stem cells
    • Shen J, Liu X, Yu WM, Liu J, Nibbelink MG, Guo C, Finkel T, and Qu CK. A critical role of mitochondrial phosphatase Ptpmt1 in embryogenesis reveals a mitochondrial metabolic stress-induced differentiation checkpoint in embryonic stem cells. Mol Cell Biol 31: 4902-4916, 2011.
    • (2011) Mol Cell Biol , vol.31 , pp. 4902-4916
    • Shen, J.1    Liu, X.2    Yu, W.M.3    Liu, J.4    Nibbelink, M.G.5    Guo, C.6    Finkel, T.7    Qu, C.K.8
  • 158
    • 84875180848 scopus 로고    scopus 로고
    • Down-regulation of dual-specificity phosphatase 5 in gastric cancer by promoter CpG island hypermethylation and its potential role in carcinogenesis
    • Shin SH, Park SY, and Kang GH. Down-regulation of dual-specificity phosphatase 5 in gastric cancer by promoter CpG island hypermethylation and its potential role in carcinogenesis. Am J Pathol 182: 1275-1285, 2013.
    • (2013) Am J Pathol , vol.182 , pp. 1275-1285
    • Shin, S.H.1    Park, S.Y.2    Kang, G.H.3
  • 159
    • 84880891740 scopus 로고    scopus 로고
    • Antimetastatic effect of halichondramide, a trisoxazole macrolide from the marine sponge chondrosia corticata, on human prostate cancer cells via modulation of epithelialto-mesenchymal transition
    • Shin Y, Kim GD, Jeon JE, Shin J, and Lee SK. Antimetastatic effect of halichondramide, a trisoxazole macrolide from the marine sponge chondrosia corticata, on human prostate cancer cells via modulation of epithelialto- mesenchymal transition. Mar Drugs 11: 2472-2485, 2013.
    • (2013) Mar Drugs , vol.11 , pp. 2472-2485
    • Shin, Y.1    Kim, G.D.2    Jeon, J.E.3    Shin, J.4    Lee, S.K.5
  • 160
    • 66149160477 scopus 로고    scopus 로고
    • Enzyme activity of phosphatase of regenerating liver is controlled by the redox environment and its C-terminal residues
    • Skinner AL, Vartia AA, Williams TD, and Laurence JS. Enzyme activity of phosphatase of regenerating liver is controlled by the redox environment and its C-terminal residues. Biochemistry 48: 4262-4272, 2009.
    • (2009) Biochemistry , vol.48 , pp. 4262-4272
    • Skinner, A.L.1    Vartia, A.A.2    Williams, T.D.3    Laurence, J.S.4
  • 162
    • 24644519820 scopus 로고    scopus 로고
    • Structure and biochemical properties of PRL-1, a phosphatase implicated in cell growth, differentiation, and tumor invasion
    • Sun JP, Wang WQ, Yang H, Liu S, Liang F, Fedorov AA, Almo SC, and Zhang ZY. Structure and biochemical properties of PRL-1, a phosphatase implicated in cell growth, differentiation, and tumor invasion. Biochemistry 44: 12009-12021, 2005.
    • (2005) Biochemistry , vol.44 , pp. 12009-12021
    • Sun, J.P.1    Wang, W.Q.2    Yang, H.3    Liu, S.4    Liang, F.5    Fedorov, A.A.6    Almo, S.C.7    Zhang, Z.Y.8
  • 163
    • 84859471523 scopus 로고    scopus 로고
    • Downregulation of phosphatase of regenerating liver-3 is involved in the inhibition of proliferation and apoptosis induced by emodin in the SGC-7901 human gastric carcinoma cell line
    • Sun ZH and Bu P. Downregulation of phosphatase of regenerating liver-3 is involved in the inhibition of proliferation and apoptosis induced by emodin in the SGC-7901 human gastric carcinoma cell line. Exp Ther Med 3: 1077-1081, 2012.
    • (2012) Exp Ther Med , vol.3 , pp. 1077-1081
    • Zh, S.1    Bu, P.2
  • 166
    • 85047696523 scopus 로고    scopus 로고
    • Differential effects of stress stimuli on a JNK-inactivating phosphatase
    • Theodosiou A and Ashworth A. Differential effects of stress stimuli on a JNK-inactivating phosphatase. Oncogene 21: 2387-2397, 2002.
    • (2002) Oncogene , vol.21 , pp. 2387-2397
    • Theodosiou, A.1    Ashworth, A.2
  • 167
    • 0032569936 scopus 로고    scopus 로고
    • Cocaine and fluoxetine induce the expression of the hVH-5 gene encoding a MAP kinase phosphatase
    • Thiriet N, Humblot N, Burgun C, Aunis D, and Zwiller J. Cocaine and fluoxetine induce the expression of the hVH-5 gene encoding a MAP kinase phosphatase. Brain Res Mol Brain Res 62: 150-157, 1998.
    • (1998) Brain Res Mol Brain Res , vol.62 , pp. 150-157
    • Thiriet, N.1    Humblot, N.2    Burgun, C.3    Aunis, D.4    Zwiller, J.5
  • 168
    • 20444400257 scopus 로고    scopus 로고
    • Redox redux: Revisiting PTPs and the control of cell signaling
    • Tonks NK. Redox redux: revisiting PTPs and the control of cell signaling. Cell 121: 667-670, 2005.
    • (2005) Cell , vol.121 , pp. 667-670
    • Tonks, N.K.1
  • 169
    • 33847391938 scopus 로고    scopus 로고
    • A brake becomes an accelerator: PTP1B-a new therapeutic target for breast cancer
    • Tonks NK and Muthuswamy SK. A brake becomes an accelerator: PTP1B-a new therapeutic target for breast cancer. Cancer Cell 11: 214-216, 2007.
    • (2007) Cancer Cell , vol.11 , pp. 214-216
    • Tonks, N.K.1    Muthuswamy, S.K.2
  • 171
    • 0041836252 scopus 로고    scopus 로고
    • Dual-specificity phosphatase 5 (DUSP5) as a direct transcriptional target of tumor suppressor p53
    • Ueda K, Arakawa H, and Nakamura Y. Dual-specificity phosphatase 5 (DUSP5) as a direct transcriptional target of tumor suppressor p53. Oncogene 22: 5586-5591, 2003.
    • (2003) Oncogene , vol.22 , pp. 5586-5591
    • Ueda, K.1    Arakawa, H.2    Nakamura, Y.3
  • 172
    • 0041913991 scopus 로고    scopus 로고
    • Cell-active dual specificity phosphatase inhibitors identified by high-content screening
    • Vogt A, Cooley KA, Brisson M, Tarpley MG, Wipf P, and Lazo JS. Cell-active dual specificity phosphatase inhibitors identified by high-content screening. Chem Biol 10: 733-742, 2003.
    • (2003) Chem Biol , vol.10 , pp. 733-742
    • Vogt, A.1    Cooley, K.A.2    Brisson, M.3    Tarpley, M.G.4    Wipf, P.5    Lazo, J.S.6
  • 173
    • 39749109385 scopus 로고    scopus 로고
    • A cell-active inhibitor of mitogen-activated protein kinase phosphatases restores paclitaxel-induced apoptosis in dexamethasone-protected cancer cells
    • Vogt A, McDonald PR, Tamewitz A, Sikorski RP, Wipf P, Skoko JJ, 3rd, and Lazo JS. A cell-active inhibitor of mitogen-activated protein kinase phosphatases restores paclitaxel-induced apoptosis in dexamethasone-protected cancer cells. Mol Cancer Ther 7: 330-340, 2008.
    • (2008) Mol Cancer Ther , vol.7 , pp. 330-340
    • Vogt, A.1    McDonald, P.R.2    Tamewitz, A.3    Sikorski, R.P.4    Wipf, P.5    Lazo, J.S.6
  • 174
    • 21344451886 scopus 로고    scopus 로고
    • The benzo[c]phenanthridine alkaloid, sanguinarine, is a selective, cell-active inhibitor of mitogenactivated protein kinase phosphatase-1
    • Vogt A, Tamewitz A, Skoko J, Sikorski RP, Giuliano KA, and Lazo JS. The benzo[c]phenanthridine alkaloid, sanguinarine, is a selective, cell-active inhibitor of mitogenactivated protein kinase phosphatase-1. J Biol Chem 280: 19078-19086, 2005.
    • (2005) J Biol Chem , vol.280 , pp. 19078-19086
    • Vogt, A.1    Tamewitz, A.2    Skoko, J.3    Sikorski, R.P.4    Giuliano, K.A.5    Lazo, J.S.6
  • 176
    • 84856395989 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase phosphatase (MKP)-1 in immunology, physiology, and disease
    • Wancket LM, Frazier WJ, and Liu Y. Mitogen-activated protein kinase phosphatase (MKP)-1 in immunology, physiology, and disease. Life Sci 90: 237-248, 2012.
    • (2012) Life Sci , vol.90 , pp. 237-248
    • Wancket, L.M.1    Frazier, W.J.2    Liu, Y.3
  • 177
    • 34248155345 scopus 로고    scopus 로고
    • PRL-3 down-regulates PTEN expression and signals through PI3K to promote epithelial-mesenchymal transition
    • Wang H, Quah SY, Dong JM, Manser E, Tang JP, and Zeng Q. PRL-3 down-regulates PTEN expression and signals through PI3K to promote epithelial-mesenchymal transition. Cancer Res 67: 2922-2926, 2007.
    • (2007) Cancer Res , vol.67 , pp. 2922-2926
    • Wang, H.1    Quah, S.Y.2    Dong, J.M.3    Manser, E.4    Tang, J.P.5    Zeng, Q.6
  • 178
    • 0037195808 scopus 로고    scopus 로고
    • The tyrosine phosphatase PRL-1 localizes to the endoplasmic reticulum and the mitotic spindle and is required for normal mitosis
    • Wang J, Kirby CE, and Herbst R. The tyrosine phosphatase PRL-1 localizes to the endoplasmic reticulum and the mitotic spindle and is required for normal mitosis. J Biol Chem 277: 46659-46668, 2002.
    • (2002) J Biol Chem , vol.277 , pp. 46659-46668
    • Wang, J.1    Kirby, C.E.2    Herbst, R.3
  • 179
    • 33745092405 scopus 로고    scopus 로고
    • Biochemical and biological characterization of a neuroendocrine- associated phosphatase
    • Wang JY, Lin CH, Yang CH, Tan TH, and Chen YR. Biochemical and biological characterization of a neuroendocrine-associated phosphatase. J Neurochem 98: 89-101, 2006.
    • (2006) J Neurochem , vol.98 , pp. 89-101
    • Wang, J.Y.1    Lin, C.H.2    Yang, C.H.3    Tan, T.H.4    Chen, Y.R.5
  • 180
    • 56749177443 scopus 로고    scopus 로고
    • NEAP causes down-regulation of EGFR, subsequently induces the suppression of NGF-induced differentiation in PC12 cells
    • Wang JY, Yang CH, Yeh CL, Lin CH, and Chen YR. NEAP causes down-regulation of EGFR, subsequently induces the suppression of NGF-induced differentiation in PC12 cells. J Neurochem 107: 1544-1555, 2008.
    • (2008) J Neurochem , vol.107 , pp. 1544-1555
    • Wang, J.Y.1    Yang, C.H.2    Yeh, C.L.3    Ch, L.4    Chen, Y.R.5
  • 182
    • 73149088865 scopus 로고    scopus 로고
    • An anticancer effect of curcumin mediated by down-regulating phosphatase of regenerating liver-3 expression on highly metastatic melanoma cells
    • Wang L, Shen Y, Song R, Sun Y, Xu J, and Xu Q. An anticancer effect of curcumin mediated by down-regulating phosphatase of regenerating liver-3 expression on highly metastatic melanoma cells. Mol Pharmacol 76: 1238-1245, 2009.
    • (2009) Mol Pharmacol , vol.76 , pp. 1238-1245
    • Wang, L.1    Shen, Y.2    Song, R.3    Sun, Y.4    Xu, J.5    Xu, Q.6
  • 183
    • 84857115105 scopus 로고    scopus 로고
    • Metastasis-associated phosphatase PRL-2 regulates tumor cell migration and invasion
    • Wang Y and Lazo JS. Metastasis-associated phosphatase PRL-2 regulates tumor cell migration and invasion. Oncogene 31: 818-827, 2012.
    • (2012) Oncogene , vol.31 , pp. 818-827
    • Wang, Y.1    Lazo, J.S.2
  • 184
    • 84872942425 scopus 로고    scopus 로고
    • Dual-specificity phosphatases 2: Surprising positive effect at the molecular level and a potential biomarker of diseases
    • Wei W, Jiao Y, Postlethwaite A, Stuart JM, Wang Y, Sun D, and Gu W. Dual-specificity phosphatases 2: surprising positive effect at the molecular level and a potential biomarker of diseases. Genes Immun 14: 1-6, 2013.
    • (2013) Genes Immun , vol.14 , pp. 1-6
    • Wei, W.1    Jiao, Y.2    Postlethwaite, A.3    Stuart, J.M.4    Wang, Y.5    Sun, D.6    Gu, W.7
  • 185
    • 80055081332 scopus 로고    scopus 로고
    • Enteric commensal bacteria induce extracellular signal-regulated kinase pathway signaling via formyl peptide receptor-dependent redox modulation of dual specific phosphatase 3
    • Wentworth CC, Alam A, Jones RM, Nusrat A, and Neish AS. Enteric commensal bacteria induce extracellular signal-regulated kinase pathway signaling via formyl peptide receptor-dependent redox modulation of dual specific phosphatase 3. J Biol Chem 286: 38448-38455, 2011.
    • (2011) J Biol Chem , vol.286 , pp. 38448-38455
    • Wentworth, C.C.1    Alam, A.2    Jones, R.M.3    Nusrat, A.4    Neish, A.S.5
  • 186
    • 79957534572 scopus 로고    scopus 로고
    • Targeting hypoxia in cancer therapy
    • Wilson WR and Hay MP. Targeting hypoxia in cancer therapy. Nat Rev Cancer 11: 393-410, 2011.
    • (2011) Nat Rev Cancer , vol.11 , pp. 393-410
    • Wilson, W.R.1    Hay, M.P.2
  • 187
    • 0036899518 scopus 로고    scopus 로고
    • PTEN and myotubularin phosphatases: From 3-phosphoinositide dephosphorylation to disease
    • Wishart MJ and Dixon JE. PTEN and myotubularin phosphatases: from 3-phosphoinositide dephosphorylation to disease. Trends Cell Biol 12: 579-585, 2002.
    • (2002) Trends Cell Biol , vol.12 , pp. 579-585
    • Wishart, M.J.1    Dixon, J.E.2
  • 189
    • 36148978132 scopus 로고    scopus 로고
    • Role of mitogen-activated protein kinase phosphatases (MKPs) in cancer
    • Wu GS. Role of mitogen-activated protein kinase phosphatases (MKPs) in cancer. Cancer Metastasis Rev 26: 579-585, 2007.
    • (2007) Cancer Metastasis Rev , vol.26 , pp. 579-585
    • Wu, G.S.1
  • 190
    • 34948820665 scopus 로고    scopus 로고
    • PAC1 is a direct transcription target of E2F-1 in apoptotic signaling
    • Wu J, Jin YJ, Calaf GM, Huang WL, and Yin Y. PAC1 is a direct transcription target of E2F-1 in apoptotic signaling. Oncogene 26: 6526-6535, 2007.
    • (2007) Oncogene , vol.26 , pp. 6526-6535
    • Wu, J.1    Jin, Y.J.2    Calaf, G.M.3    Huang, W.L.4    Yin, Y.5
  • 193
    • 78049448761 scopus 로고    scopus 로고
    • MAPK phosphatase-3 promotes hepatic gluconeogenesis through dephosphorylation of forkhead box O1 in mice
    • Wu Z, Jiao P, Huang X, Feng B, Feng Y, Yang S, Hwang P, Du J, Nie Y, Xiao G, and Xu H. MAPK phosphatase-3 promotes hepatic gluconeogenesis through dephosphorylation of forkhead box O1 in mice. J Clin Invest 120: 3901-3911, 2010.
    • (2010) J Clin Invest , vol.120 , pp. 3901-3911
    • Wu, Z.1    Jiao, P.2    Huang, X.3    Feng, B.4    Feng, Y.5    Yang, S.6    Hwang, P.7    Du, J.8    Nie, Y.9    Xiao, G.10    Xu, H.11
  • 194
    • 34249284831 scopus 로고    scopus 로고
    • PTEN catalysis of phospholipid dephosphorylation reaction follows a two-step mechanism in which the conserved aspartate-92 does not function as the general acid-mechanistic analysis of a familial Cowden disease-associated PTEN mutation
    • Xiao Y, Yeong Chit Chia J, Gajewski JE, Sio Seng Lio D, Mulhern TD, Zhu HJ, Nandurkar H, and Cheng HC. PTEN catalysis of phospholipid dephosphorylation reaction follows a two-step mechanism in which the conserved aspartate-92 does not function as the general acid-mechanistic analysis of a familial Cowden disease-associated PTEN mutation. Cell Signal 19: 1434-1445, 2007.
    • (2007) Cell Signal , vol.19 , pp. 1434-1445
    • Xiao, Y.1    Yeong Chit Chia, J.2    Gajewski, J.E.3    Sio Seng Lio, D.4    Mulhern, T.D.5    Zhu, H.J.6    Nandurkar, H.7    Cheng, H.C.8
  • 195
    • 0042530516 scopus 로고    scopus 로고
    • Dual specificity mitogen-activated protein (MAP) kinase phosphatase-4 plays a potential role in insulin resistance
    • Xu H, Dembski M, Yang Q, Yang D, Moriarty A, Tayber O, Chen H, Kapeller R, and Tartaglia LA. Dual specificity mitogen-activated protein (MAP) kinase phosphatase-4 plays a potential role in insulin resistance. J Biol Chem 278: 30187-30192, 2003.
    • (2003) J Biol Chem , vol.278 , pp. 30187-30192
    • Xu, H.1    Dembski, M.2    Yang, Q.3    Yang, D.4    Moriarty, A.5    Tayber, O.6    Chen, H.7    Kapeller, R.8    Tartaglia, L.A.9
  • 196
    • 0036697292 scopus 로고    scopus 로고
    • Identification of downstream genes up-regulated by the tumor necrosis factor family member TALL-1
    • Xu LG, Wu M, Hu J, Zhai Z, and Shu HB. Identification of downstream genes up-regulated by the tumor necrosis factor family member TALL-1. J Leukoc Biol 72: 410-416, 2002.
    • (2002) J Leukoc Biol , vol.72 , pp. 410-416
    • Xu, L.G.1    Wu, M.2    Hu, J.3    Zhai, Z.4    Shu, H.B.5
  • 197
    • 84864398528 scopus 로고    scopus 로고
    • Ischemia/reperfusion-induced MKP-3 impairs endothelial NO formation via inactivation of ERK1/2 pathway
    • Yang D, Xie P, and Liu Z. Ischemia/reperfusion-induced MKP-3 impairs endothelial NO formation via inactivation of ERK1/2 pathway. PLoS One 7: e42076, 2012.
    • (2012) PLoS One , vol.7
    • Yang, D.1    Xie, P.2    Liu, Z.3
  • 198
    • 0037417281 scopus 로고    scopus 로고
    • PAC1 phosphatase is a transcription target of p53 in signalling apoptosis and growth suppression
    • Yin Y, Liu YX, Jin YJ, Hall EJ, and Barrett JC. PAC1 phosphatase is a transcription target of p53 in signalling apoptosis and growth suppression. Nature 422: 527-531, 2003.
    • (2003) Nature , vol.422 , pp. 527-531
    • Yin, Y.1    Liu, Y.X.2    Jin, Y.J.3    Hall, E.J.4    Barrett, J.C.5
  • 199
    • 84859574715 scopus 로고    scopus 로고
    • Signal inhibition by the dual-specific phosphatase 4 impairs T cell-dependent B-cell responses with age
    • Yu M, Li G, Lee WW, Yuan M, Cui D, Weyand CM, and Goronzy JJ. Signal inhibition by the dual-specific phosphatase 4 impairs T cell-dependent B-cell responses with age. Proc Natl Acad Sci USA 109: E879-E888, 2012.
    • (2012) Proc Natl Acad Sci USA , vol.109
    • Yu, M.1    Li, G.2    Lee, W.W.3    Yuan, M.4    Cui, D.5    Weyand, C.M.6    Goronzy, J.J.7
  • 201
    • 0034647510 scopus 로고    scopus 로고
    • Prenylation-dependent association of protein-tyrosine phosphatases PRL-1,-2, and-3 with the plasma membrane and the early endosome
    • Zeng Q, Si X, Horstmann H, Xu Y, Hong W, and Pallen CJ. Prenylation-dependent association of protein-tyrosine phosphatases PRL-1,-2, and-3 with the plasma membrane and the early endosome. J Biol Chem 275: 21444-21452, 2000.
    • (2000) J Biol Chem , vol.275 , pp. 21444-21452
    • Zeng, Q.1    Si, X.2    Horstmann, H.3    Xu, Y.4    Hong, W.5    Pallen, C.J.6
  • 204
    • 36949031937 scopus 로고    scopus 로고
    • PTEN: A promising pharmacological target to enhance epithelial wound healing
    • Zhao M. PTEN: a promising pharmacological target to enhance epithelial wound healing. Br J Pharmacol 152: 1141-1144, 2007.
    • (2007) Br J Pharmacol , vol.152 , pp. 1141-1144
    • Zhao, M.1
  • 205
    • 84872358122 scopus 로고    scopus 로고
    • The dual-specificity phosphatase DUSP14 negatively regulates tumor necrosis factor-and interleukin-1-induced nuclear factor-kappaB activation by dephosphorylating the protein kinase TAK1
    • Zheng H, Li Q, Chen R, Zhang J, Ran Y, He X, Li S, and Shu HB. The dual-specificity phosphatase DUSP14 negatively regulates tumor necrosis factor-and interleukin-1-induced nuclear factor-kappaB activation by dephosphorylating the protein kinase TAK1. J Biol Chem 288: 819-825, 2013.
    • (2013) J Biol Chem , vol.288 , pp. 819-825
    • Zheng, H.1    Li, Q.2    Chen, R.3    Zhang, J.4    Ran, Y.5    He, X.6    Li, S.7    Shu, H.B.8
  • 206
    • 78650643190 scopus 로고    scopus 로고
    • LanK, andGeBX.MicroRNA-101 targets MAPK phosphatase-1 to regulate the activation of MAPKs in macrophages
    • ZhuQY, LiuQ,Chen JX, LanK, andGeBX.MicroRNA-101 targets MAPK phosphatase-1 to regulate the activation of MAPKs in macrophages. J Immunol 185: 7435-7442, 2010.
    • (2010) J Immunol , vol.185 , pp. 7435-7442
    • Zhuqy Liuqchen, J.X.1
  • 207
    • 84875506390 scopus 로고    scopus 로고
    • Targeted deletion of the metastasis-associated phosphatase Ptp4a3 (PRL-3) suppresses murine colon cancer
    • Zimmerman MW, Homanics GE, and Lazo JS. Targeted deletion of the metastasis-associated phosphatase Ptp4a3 (PRL-3) suppresses murine colon cancer. PLoS One 8: e58300, 2013.
    • (2013) PLoS One , vol.8
    • Zimmerman, M.W.1    Homanics, G.E.2    Lazo, J.S.3


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